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DEAD-box helicase 17(DDX17)protects cardiac function by promoting mitochondrial homeostasis in heart failure

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2774-2790页

作者： Mingjing Yan Junpeng Gao Ming lan Que Wang Yuan Cao Yuxuan zheng Yao Yang Wenlin Li Xiaoxue Yu Xiuqing Huang Lin Dou Bing Liu Junmeng Liu Hongqiang Cheng Kunfu Ouyang Kun Xu Shenghui Sun Jin Liu Weiqing Tang Xiyue Zhang Yong Man Liang Sun Jianping Cai Qing He Fuchou Tang Jian Li Tao Shen The Key Laboratory of Geriatrics Beijing Institute of GeriatricsInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing Hospital/National Center of Gerontology of National Health CommissionBeijing 100730China Peking University Fifth School of Clinical Medicine Beijing 100730China Department of Laboratory Medicine Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Biomedical Pioneering Innovation Center School of Life SciencesPeking UniversityBeijing 100871China Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Cardiology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Graduate School of Peking Union Medical College Beijing 100730China Department of Health Care Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Department of Pathology and Pathophysiology and Department of Cardiology at Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou 310058China Department of Cardiovascular Surgery Peking University Shenzhen HospitalShenzhen 518036China Experimental Technology Center for Life Sciences at Beijing Normal University Beijing 100875China

DEAD-box helicase 17(DDX17)is a typical member of the DEAD-box family with transcriptional cofactor *** DDX17 is abundantly expressed in the myocardium,its role in heart is not fully *** generated cardiomyocyte-specific Ddx17-knockout mice(Ddx17-cKO),cardiomyocyte-specific Ddx17 transgenic mice(Ddx17-Tg),and various models of cardiomyocyte injury and heart failure(HF).DDX17 is downregulated in the myocardium of mouse models of heart failure and cardiomyocyte ***-specific knockout of Ddx17 promotes autophagic flux blockage and cardiomyocyte apoptosis,leading to progressive cardiac dysfunction,maladaptive remodeling and progression to heart *** of DDX17 expression in cardiomyocytes protects cardiac function under pathological *** studies showed that DDX17 can bind to the transcriptional repressor B-cell lymphoma 6(BCL6)and inhibit the expression of dynamin-related protein 1(DRP1).When DDX17 expression is reduced,transcriptional repression of BCL6 is attenuated,leading to increased DRP1 expression and mitochondrial fission,which in turn leads to impaired mitochondrial homeostasis and heart *** also investigated the correlation of DDX17 expression with cardiac function and DRP1 expression in myocardial biopsy samples from patients with heart *** findings suggest that DDX17 protects cardiac function by promoting mitochondrial homeostasis through the BCL6-DRP1 pathway in heart failure.

关键词： DDX17 homeostasis cardiac

植酸修饰改性对TC4钛合金微弧氧化膜层性能的影响

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稀有金属材料与工程 2024年第4期53卷 954-962页

作者：兰欣悦王平龚泽宇罗许郑友平邓博文钒钛资源综合利用国家重点实验室四川攀枝花607000 西南石油大学新能源与材料学院四川成都610500 中国科学院大学中国科学院化学研究所北京100190

通过向电解液中添加有机酸植酸,提升了TC4钛合金微弧氧化涂层的耐腐蚀性能和热稳定性。通过扫描电子显微镜、X射线衍射仪、X射线光电子能谱仪和热冲击实验等技术手段,分析了植酸对涂层形成、形貌和性能的影响。结果显示,植酸的添加使放... 详细信息

通过向电解液中添加有机酸植酸,提升了TC4钛合金微弧氧化涂层的耐腐蚀性能和热稳定性。通过扫描电子显微镜、X射线衍射仪、X射线光电子能谱仪和热冲击实验等技术手段,分析了植酸对涂层形成、形貌和性能的影响。结果显示,植酸的添加使放电微孔更加细小,提高了涂层的形成效率并优化了相结构。通过动电位极化测试,发现添加植酸显著提高了微弧氧化涂层的耐腐蚀性能。将电解液中的植酸浓度调整为12 m L/L(最佳植酸浓度)后,腐蚀电流密度由8.406×10^(-5)A·cm^(-2)降低至2.580×10^(-6)A·cm^(-2)。循环高温氧化试验结果表明,TC4钛合金的耐热冲击性能和高温抗氧化性能得到了改善。

关键词： TC4钛合金微弧氧化耐腐蚀性能耐热冲击性能

技能型社会建设视阈中高等教育多样化发展研究

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华东师范大学学报（教育科学版） 2024年第4期42卷 110-122页

作者：郑杰兰金林李梦婷华东师范大学职业教育与成人教育研究所上海200062

多样化发展一直是推动高等教育内涵建设的重要方向。在技能型社会建设的背景下,高等教育多样化发展的关键在于对接技能型社会中技能的多层次需求、多向度培养和可持续发展3个鲜明特征做出相应变革。自20世纪90年代末高等教育扩招至今,... 详细信息

多样化发展一直是推动高等教育内涵建设的重要方向。在技能型社会建设的背景下,高等教育多样化发展的关键在于对接技能型社会中技能的多层次需求、多向度培养和可持续发展3个鲜明特征做出相应变革。自20世纪90年代末高等教育扩招至今,我国高等教育实现了形式上的多样化,但是高校评价与管理机制的束缚、办学目标和育人体制的僵化以及层次重心上移带来的过度教育,使其机构间同质化倾向严重、教育供给机会单一,难以支撑技能型社会建设。为进一步助力技能型社会建设,我国高等教育机构需围绕不同技能人才的认知层级要求进行分类发展,把握技能学习与积累的规律并加强横向多样性的内涵建设。同时,国家与政府也需积极推动高校评价与管理改革,营造高等教育多样化发展的制度环境。

关键词：高等教育多样化技能型社会多样性进程

Formation of mesophase microbeads from bulk mesophase pitch induced by fullerene

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新型炭材料（中英文） 2024年第4期39卷 645-654页

作者： CHEN Wen-sheng LIU lan-tao WANG zheng DUAN Chun-feng ZHANG Xing-wei MA Zhao-kun CHEN Xiao-hong SONG Huai-he State Key Laboratory of Chemical Resource Engineering Beijing Key Laboratory of Electrochemical Process and Technology for MaterialsBeijing Uni-versity of Chemical TechnologyBeijing 100029China

A transformation of naphthalene-based coalescenced mesophase pitch(NMP)to mesophase microbeads was achieved by heating a mixture of NMP and fullerene(C_(60)).This is different from the conventional process of the liquid-phase carbonization of isotropic pitch to the emergence of carbon microbeads in the matrix and finally their growth to form a 100%anisotropic bulk meso-phase,but rather a reverse *** effects of C_(60) loading and reaction temperature on the morphological transformation of mesophase were investigated by polarizing optical and scanning electron *** physical changes in the NMP induced by C_(60) were characterized by thermogravimetric analysis,Fourier transform infrared spectroscopy,X-ray diffractometry and Raman *** results show that the coalesced NMP can be converted to a spherical type at 300-320℃ with the addition of 5%C_(60),and the size of the mesophase microbeads increases with increasing ***,a model is established to ex-plain the unique induction effect of C_(60) in the transformation *** work makes the morphological transformation of MP con-trollable,and provides a new idea for the understanding and research of mesophase pitch.

关键词： Reversible transformation Fullerene induction mechanism Mesophase texture π-electron-induced effect Mesophase microbeads

Genome-wide CRISPR screens identify CLC-2 as a drug target for anti-herpesvirus therapy: tackling herpesvirus drug resistance

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Science China Life Sciences 2024年

作者： Fayu Yang Nan Wei Shuo Cai Jing Liu Qingping lan Hao Zhang Lu Shang Bo zheng Mi Wang yingchun Liu Lifang Zhang Chenzhong Fei Wu Tong Changlong Liu Ersheng Kuang Guangzhi Tong Feng Gu Shanghai Veterinary Research Institute Chinese Academy of Agricultural Sciences Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics Ministry of Agriculture and Rural Affairs State Key Laboratory for Animal Disease Control and Prevention College of Veterinary Medicine Lanzhou University Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Institute of Human Virology Zhongshan School of Medicine Sun Yat-Sen University School of Medicine Tsinghua University

The emergence of drug resistance to virus(i.e., acyclovir(ACV) to herpesviruses) has been termed one of the common clinical issues,emphasizing the discovery of new antiviral agents. To address it, a genome-wide clustered regularly interspaced short palindromic repeats(CRISPR) screening was performed in mouse haploid embryonic stem cells infected with pseudorabies virus(PRV), an α-herpesvirus causing human and pig diseases. The results demonstrated that type 2 voltage-gated chloride channels(CLC-2) encoded by one of the identified genes, CLCN2, is a potential drug target for anti-herpesvirus therapy. CLC-2 inhibitors, omeprazole(OME) and 4,4′-diisothiocyanostilbene-2,2′-disulfonic acid(DIDS), can efficiently inhibit infection of multiple herpesviruses in cellulo(i.e., PRV, HSV and EBV), and effectively treat murine herpes simplex encephalitis(HSE). Additionally, DIDS was found to inhibit HSV-1 replication by blocking the PI3K/Akt *** importantly, both DIDS and OME were able to inhibit ACV-resistant HSV-1 strain infection. The study's findings suggest that targeting host-cell factors such as CLC-2 may be a promising approach to tackling herpesvirus drug resistance. The discovery of CLC-2 as a potential drug target for anti-herpesvirus therapy provides a new direction for the development of novel antiviral agents.

关键词：

基于数据增强策略和卷积神经网络的近红外光谱分析研究

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分析化学 2024年第9期52卷 1266-1276页

作者：郑运杨思雨王涛邓焯文兰维杰云永欢潘磊庆海南大学食品科学与工程学院南京农业大学食品科技学院

近红外光谱技术结合化学计量学算法已广泛应用于食品和药品等领域的定性和定量分析。然而，传统化学计量学方法，特别是线性分类方法，在解决多分类问题时的效果不佳。卷积神经网络（CNN）能够提取数据中的深层次特征，适合处理非线性... 详细信息

近红外光谱技术结合化学计量学算法已广泛应用于食品和药品等领域的定性和定量分析。然而，传统化学计量学方法，特别是线性分类方法，在解决多分类问题时的效果不佳。卷积神经网络（CNN）能够提取数据中的深层次特征，适合处理非线性关系，但其建模性能依赖样本量的大小和多样性，而近红外光谱样本数据的采集和预处理过程通常耗时且费力，获取样本成本较高。本研究提出了一种基于数据增强策略和CNN的近红外光谱定性分析方法。此数据增强策略分为两步：（1）分别采用Bootstrap重采样和生成对抗网络（GAN）方法对3个近红外光谱数据集（药片、咖啡和葡萄）进行样本扩增；（2）将原始样本（Y）分别与Bootstrap扩增样本（B）和GAN扩增样本（G）进行组合，得到3种增强数据集（Y-B、Y-G和Y-B-G）。在此基础上，设计了适用于此数据集的CNN模型结构，由2个一维卷积层、1个最大池化层和1个全连接层组成。与偏最小二乘判别分析（PLS-DA）、支持向量机（SVM）和BP神经网络（BP）的最优模型相比，基于Y-B数据集的CNN模型对药片（2类）分析的平均准确率分别提升了3.998%、9.364%和4.689%；基于Y-B-G数据集的CNN模型对咖啡（7类）分析的平均准确率分别提升了6.001%、2.004%和7.523%；基于Y-B数据集的CNN模型对葡萄（20类）分析的平均准确率分别提升了33.408%、51.994%和34.378%。此结果表明，基于数据增强策略和CNN在不同数据集和分类类别中建立的模型均表现出更好的分类准确率和泛化性能。

关键词：数据增强近红外光谱卷积神经网络化学计量学

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基于计算机视觉的锂电池连接片焊接检测系统

焊接学报 2024年第10期45卷 38-49页

作者：于强肖澜郑大伟彭昭鸿宋凯宏哈尔滨工程大学青岛创新发展基地青岛266000 海克斯康制造智能技术(青岛)有限公司青岛266000

为了满足锂电池生产企业对锂电池连接片的焊接质量进行自动化检测的需求,设计了一种基于计算机视觉的锂电池连接片焊接质量检测系统.针对正、负电极材料的光学特性和检测精度要求,设计了两套光学系统分别实现锂电池正、负电极的成像,提... 详细信息

为了满足锂电池生产企业对锂电池连接片的焊接质量进行自动化检测的需求,设计了一种基于计算机视觉的锂电池连接片焊接质量检测系统.针对正、负电极材料的光学特性和检测精度要求,设计了两套光学系统分别实现锂电池正、负电极的成像,提出了多重自适应模板匹配算法提取正、负电极焊缝区域,采用自适应阈值分割法对焊缝区域实现灰度化操作,使用灰度形态学运算弱化灰度图的噪点突出焊盘特征点,利用轮廓提取算法实现焊盘特征点的提取,依据特征点数量实现极耳裁切缺陷的检测,将U^(2)-Net语义分割模型引入焊接质量检测任务,采集正、负电极焊缝和烧穿、虚焊、焊接氧化缺陷数据集,利用数据增强技术扩充数据集,解决焊接缺陷的小样本和小目标问题,融合应用U^(2)-Net语义分割模型和轮廓提取算法实现焊缝尺寸测量以及虚焊等缺陷的检测.系统试运行结果表明,缺陷检出率为99.98%,误检率仅为0.06%,满足企业的实际需求,实现了快速、无接触且准确的自动化检测.

关键词：计算机视觉焊接检测语义分割图像处理锂电池

KLF6 facilitates differentiation of odontoblasts through modulating the expression of P21 in vitro

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International Journal of Oral Science 2022年第2期14卷 220-230页

作者： zhuo Chen Wenzhi Wu Chen zheng Yanhua lan Huizhi Xie Zhijian Xie Stomatology Hospital School of StomatologyZhejiang University School of MedicineClinical Research Center for Oral Diseases of Zhejiang ProvinceKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityHangzhouChina

Multiple signaling pathways are involved in the regulation of cell proliferation and differentiation in odontogenesis and dental tissue renewal,but the details of these mechanisms remain ***,we investigated the expression patterns of a transcription factor,Krüppel-like factor 6(KLF6),during the development of murine tooth germ and its function in odontoblastic ***6 was almost ubiquitously expressed in odontoblasts at various stages,and it was co-expressed with P21(to varying degrees)in mouse dental *** determine the function of Klf6,overexpression and knockdown experiments were performed in a mouse dental papilla cell line(iMDP-3).Klf6 functioned as a promoter of odontoblastic differentiation and inhibited the proliferation and cell cycle progression of i MDP-3 through p21 ***-luciferase reporter assay and chromatin immunoprecipitation showed that Klf6 directly activates p21 ***,the in vivo study showed that KLF6 and P21were also co-expressed in odontoblasts around the reparative *** conclusion,Klf6 regulates the transcriptional activity of p21,thus promoting the cell proliferation to odontoblastic differentiation transition in *** study provides a theoretical basis for odontoblast differentiation and the formation of reparative dentine regeneration.

关键词： KLF6 inhibited details

廊坊秋季大气污染过程中VOCs二次气溶胶生成潜势及来源分析

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环境科学 2024年第5期45卷 2622-2630页

作者：张敬巧刘铮丁文文朱瑶曹婷凌德印王淑兰王宏亮中国环境科学研究院北京100012 廊坊经济技术开发区环境保护局廊坊065001

于2018年10月9~17日廊坊市典型颗粒物污染过程期间,使用ZF-PKU-1007大气挥发性有机物(VOCs)在线连续监测系统对99种VOCs进行监测,并针对污染过程不同发展阶段的VOCs浓度特征、二次有机气溶胶(SOA)生成潜势及来源的变化情况进行了系统分... 详细信息

于2018年10月9~17日廊坊市典型颗粒物污染过程期间,使用ZF-PKU-1007大气挥发性有机物(VOCs)在线连续监测系统对99种VOCs进行监测,并针对污染过程不同发展阶段的VOCs浓度特征、二次有机气溶胶(SOA)生成潜势及来源的变化情况进行了系统分析.结果表明,污染过程期间ρ(PM_(2.5))最高值为198μg·m^(−3),是国家环境空气质量标准二级浓度限值的2.64倍.污染过程前期、中期及后期φ(VOCs)平均值分别为56.8×10^(−9)、127.8×10^(−9)和72.5×10^(−9),污染中期VOCs浓度上升明显;VOCs的SOA生成潜势与PM_(2.5)浓度明显正相关,芳香烃SOA生成潜势贡献较大且与PM_(2.5)浓度明显相关,污染中期SOA有所升高且芳香烃对SOA贡献比例明显上升,而烷烃和烯烃贡献占比明显降低,芳香烃在污染过程中对SOA生成影响较大,芳香烃中苯、甲苯、间/对-二甲苯、邻-二甲苯及乙苯等,烷烃中壬烷、正十一烷及甲基环己烷对SOA贡献相对较高,为颗粒物污染过程中VOCs的主要控制物种.溶剂使用源和机动车排放源(汽油车和柴油车)是影响廊坊市秋季污染过程中VOCs的主要来源,其中汽油车排放贡献在污染中期贡献明显升高,为重点管控源类.

关键词：污染过程臭氧(O_(3)) 挥发性有机物(VOCs) 污染特征来源解析生成潜势