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Comparison of three transgenic Bt rice lines for insecticidal protein expression and resistance against a target pest, Chilo suppressalis （Lepidoptera： Crambidae）

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Insect Science 2016年第1期23卷 78-87页

作者： Ya-Nan Wang Kai-Qie Ke Yun-He Li lan-zhi han Yan-Min Liu Hong-Xia Hua Yu-Fa Peng State Key Laboratory for Biology of Plant Disease and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural ScienceBeUing 100193 College of Plant Science & Technology Huazhong Agricultural University Wuhan 430070 China

Two transgenic rice lines （T2A-1 and T1C-19b） expressing cry2A and crylC genes, respectively, were developed in China, targeting lepidopteran pests including Chilo suppressalis （Walker）（Lepidoptera： Crambidae）. The seasonal expression of Cry proteins in different tissues of the rice lines and their resistance to C. suppressalis were assessed in comparison to a Bt rice line expressing a crylAb/Ac fusion gene, Huahui 1, which has been granted a biosafety certificate. In general, levels of Cry proteins were T2A- 1 〉 Huahui I 〉 T1C-19b among rice lines, and leaf 〉 stern 〉 root among rice tissues. The expression patterns of Cry protein in the rice line plants were similar： higher level at early stages than at later stages with an exception that high Cry 1C level in T 1 C- 19b stems at the maturing stage. The bioassay results revealed that the three transgenic rice lines exhibited significantly high resistance against C. suppressalis larvae throughout the rice growing season. According to Cry protein levels in rice tissues, the raw and corrected mortalities of C. suppressalis caused by each Bt rice line were the highest in the seedling and declined through the j ointing stage with an exception for T1 C-19b providing an excellent performance at the maturing stage. By comparison, T1C-19b exhibited more stable and greater resistance to C. suppressalis larvae than T2A-1, being close to Huahui 1. The results suggest crylC is an ideal Bt gene for plant transformation for lepidopteran pest control, and T1C-19b is a promising Bt rice line for commercial use for tolerating lepidopteran rice pests.

关键词： Chilo suppressalis crylAb/Ac cryl C ery2A pest resistance transgenic rice

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大数据时代互联网金融犯罪特点及防控体系构建

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江苏警官学院学报 2017年第6期32卷 49-52页

作者：蓝之瀚曹凤中国人民公安大学北京100038 中国人民公安大学侦查与反恐怖学院北京100038

互联网金融犯罪既具有传统金融犯罪的特质,也兼具互联网时代的特点,并随着互联网技术的发展,朝高危害、高科技、专业化、产业化转变。在大数据时代,公安机关需通过"依托数据,合成作战,多维认证,科技强警,社会协同,区域合作"来搭建全方... 详细信息

互联网金融犯罪既具有传统金融犯罪的特质,也兼具互联网时代的特点,并随着互联网技术的发展,朝高危害、高科技、专业化、产业化转变。在大数据时代,公安机关需通过"依托数据,合成作战,多维认证,科技强警,社会协同,区域合作"来搭建全方位的互联网金融安全防控体系。

关键词：互联网金融金融犯罪网络安全

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Konjac glucomannan-graft-acrylic acid hydrogels containing azo cross linker for colon specific delivery

Konjac glucomannan-graft-acrylic acid hydrogels containing a...

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湖北省化学化工学会2006年年会暨循环经济专家论坛

作者： zhi-lan LIU han HU REN-XI ZHUO Key Laboratory of Biomedical Polymers (Wuhan University), Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China

The present paper reports the synthesis and characterization of novel hydrogel systems designed for colon targeting drug delivery. The gels were composed of konjac glucomannan (KGM), copolymerized with acrylic acid (AA) and cross linked by the aromatic azo agent bis(methacryloylamino)-azobenzene (BMAAB). The influence of various parameters on the dynamic and equilibrium swelling ratios of the hydrogels was investigated. It is shown that the swelling ratio was inversely proportional to the grafting degree of acrylic acid and the content of BMAAB. The dependence of swelling ratio on the pH indicates that obtained hydrogels are potential for drug delivery to colon. It was possible to modulate the degree of swelling and the pH-sensitivity of the gels by changing crosslinking density of the polymer. The main chain of hydrogels can be degradated by beta-glycosidase which is abundance in colon. They can be in vitro degradated for 73% in a month by Cereflo and 86% in 20 days by Mannaway25L. We have also prepared the hydrogels that loaded with bovine serum albumin (BSA) about 1.5%, 3%, 9%, and 20% by weight. In vitro release of model drug BSA was studied in the presence of Mannaway25L or Fungamyl 800L in pH 7.4 phosphate buffer at 37℃. The drug release can be controlled by the biodegradation of the hydrogels.

关键词： konjac glucomannan hydrogels biodegradable drug delivery system

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Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-Fang Ying zhi-Qing Ben Min han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

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针刺后处理对心肌缺血再灌注大鼠心脏组织腺苷A1受体的触发作用研究

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成都中医药大学学报 2018年第1期41卷 25-29页

作者：宋雅兰陈芷涵葛爽爽任玉兰成都中医药大学针灸推拿学院四川成都610075

目的:观察针刺对大鼠心脏组织A1ADR mRNA及A1ADR蛋白的影响,探讨针刺后处理对腺苷A1受体的触发作用,为针刺后处理的运用提供新的科学依据和研究靶点。方法:将36只SD大鼠,随机分为空白组、模型组、再灌注前针刺组、再灌注即刻针刺组、再... 详细信息

目的:观察针刺对大鼠心脏组织A1ADR mRNA及A1ADR蛋白的影响,探讨针刺后处理对腺苷A1受体的触发作用,为针刺后处理的运用提供新的科学依据和研究靶点。方法:将36只SD大鼠,随机分为空白组、模型组、再灌注前针刺组、再灌注即刻针刺组、再灌注后针刺组、非经非穴针刺组,6只/组。采用荧光定量PCR技术检测大鼠心脏组织A1ADR mRNA的表达量,采用Western blot技术检测A1ADR蛋白的表达量。结果:1.A1ADR mRNA:再灌注前针刺与再灌注即刻针刺能明显上调A1ADR mRNA的表达量,且再灌注即刻针刺的上调最为明显(P<0.05)。2.A1ADR蛋白:再灌注即刻针刺与再灌注后针刺能明显上调A1ADR蛋白的表达量,且再灌注即刻针刺的上调最为明显(P<0.05)。结论:针刺后处理对腺苷A1受体有明显的触发作用,且以再灌注即刻针刺最为明显。

关键词：心肌缺血再灌注损伤后处理针刺腺苷受体

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Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen Fa Shen Chang Cheng Yu-han Wang Wen-Chao Cheng De-zhi Yuan Wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

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Adaptive Predictive Functional Control for Networked Control Systems with Random Delays

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International Journal of Automation and computing 2011年第1期8卷 62-68页

作者： Xiu-lan Wang Chun-Guo Fei Zheng-zhi han School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai 200030 PRC Department of Automation College of Aeronautical Automation Civil Aviation University of China Tianjin 300300 PRC

Nowadays, more and more field devices are connected to the central controller through a serial communication network such as fieldbus or industrial Ethernet. Some of these serial communication networks like controller area network （CAN） or industrial Ethernet will introduce random transfer delays into the networked control systems （NCS）, which causes control performance degradation and even system instability. To address this problem, the adaptive predictive functional control algorithm is derived by applying the concept of predictive functional control to a discrete state space model with variable delay. The method of estimating the networkinduced delay is also proposed to facilitate the control algorithm implementing. Then, an NCS simulation research based on TrueTime simulator is carried out to validate the proposed control algorithm. The numerical simulations show that the proposed adaptive predictive functional control algorithm is effective for NCS with random delays.

关键词： Delay systems network control distributed control predictive control computer networks.

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The interference between a giant atom and an internal resonator

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Communications in Theoretical Physics 2021年第11期73卷 102-107页

作者： Xiao-Pei Yang zhi-Kun han Wen Zheng Dong lan Yang Yu National Laboratory of Solid State Microstructures School of PhysicsNanjing UniversityNanjing 210093China

The Jaynes–Cummings model plays an important role in quantum entanglement and state ***,we discuss how to realize it in a waveguide-mediated interaction system,which comprises a giant atom and a *** show the vacuum Rabi splitting and discuss how to achieve a unidirectional *** extend the Purcell effect in c QED to this waveguide QED system,showing how to control the giant atom decay *** design can further be built experimentally and has application in quantum manipulation.

关键词： interference quantum optics waveguide QED

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Tautological Integrals on Symmetric Products of Curves

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Acta Mathematica Sinica,English Series 2016年第8期32卷 901-910页

作者： zhi lan WANG Institute of Mathematics Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 P. R. China

We propose a conjecture on the generating series of Chern numbers of tautological bundles on symmetric products of curves and establish the rank 1 and rank -1 case of this conjecture. Thus we compute explicitly the generating series of integrals of Segre classes of tautological bundles of line bundles on curves, which has a similar structure as Lehn＇s conjecture for surfaces.

关键词： Hilbert schemes tautological sheaves

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LAMDA-SSL:a comprehensive semi-supervised learning toolkit

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Science China(Information Sciences) 2024年第1期67卷 306-307页

作者： Lin-han JIA lan-Zhe GUO zhi ZHOU Yu-Feng LI National Key Laboratory for Novel Software Technology Nanjing University

Machine learning, particularly deep learning, has achieved remarkable success across a wide range of tasks. However,most of these tasks demand a substantial amount of labeled training data, which can be challenging to obtain in many real-world applications due to difficulties, costs, or time constraints associated with labeling. In this context,semi-supervised learning (SSL) has emerged as a promising paradigm to alleviate the dependency on large labeled datasets by harnessing the power of unlabeled data [1–3].

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