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Enhancing the functionality of mesenchymal stem cells:An attractive treatment strategy for metabolic dysfunction-associated steatotic liver disease?

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World Journal of Stem Cells 2024年第10期16卷 854-859页

作者： Xiao-Qian Shan lan zhao First Teaching Hospital of Tianjin University of Traditional Chinese Medicine National Clinical Research Center for Chinese Medicine Acupuncture and MoxibustionTianjin 300381China

The intrinsic heterogeneity of metabolic dysfunction-associated fatty liver disease(MASLD)and the intricate pathogenesis have impeded the advancement and clinical implementation of therapeutic interventions,underscoring the critical demand for novel treatments.A recent publication by Li et al proposes mesenchymal stem cells as promising effectors for the treatment of *** editorial is a continuum of the article published by Jiang et al which focuses on the significance of strategies to enhance the functionality of mesenchymal stem cells to improve efficacy in curing MASLD,including physical pretreatment,drug or chemical pretreatment,pretreatment with bioactive substances,and genetic engineering.

关键词： Metabolic dysfunction-associated fatty liver disease Mesenchymal stem cells Preprocess Cell survival Therapeutic strategy

Technical research on optimization design of contacts of electrical connector

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第3期8卷 506-510页

作者： LV Bin ZHOU Sheng-jun zhao lan-yan Hangzhou Aerospace Electronic Technology Co. Ltd Hangzhou 310015 China

Pin and socket contacts are the key parts of electrical connector as aerospace electronic components. The contacts are also the direct carriers for signal transmitting of electronic equipments, passing the signal from the input end to the output end of electrical connector. The reliability of pin and socket contacts directly influences signal transmission. The goal of this study is to enhance the contact reliability of aerospace electrical connector. Computer simulation analysis was made on contacts performance data by utilizing the simulation system developed by PCL language of MSC software. Furthermore, the results were experi- mentally validated so as to realize the objective of optimizing contacts design.

关键词： Electrical connector Contacts Simulation Optimization design

Narrowband time delay estimation based on correlation coefficient

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Journal of Systems Engineering and Electronics 2009年第5期20卷 937-941页

作者： Gao Yang Qiu Tianshuang Sha lan zhao Yanbin School of Electronic and Information Engineering Dalian Univ. of Technology Dalian 116024 P. R. China

The problems of time delay estimation of narrowband signals are presented. The disadvantages of the existing algorithms are analyzed, and a new narrowband time delay estimating algorithm based on correlation coefficient is proposed. The original time delay information is transfered into the delay between the autocorrelation and cross-correlation function, and the precise estimating result by wave-comparison is given. The algorithm proposed here is also compared with other algorithms and its advantages over other algorithms are proved. The theoretical analysis and simulation show the effectiveness of the proposed algorithm.

关键词： time delay estimation narrowband signal correlation coefficient.

Dynamic changes of ocular biometric parameters:a modified form-deprivation myopia model of young guinea pigs

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International Journal of Ophthalmology(English edition) 2011年第5期4卷 484-488页

作者： Hai-lan zhao, Jin Jiang Department of Ophthalmology Zhejiang Provincial People's Hospital Hangzhou 310014 Zhejiang Province China Department of Ophthalmology the Second Hospital Jilin University Changchun 130041 Jilin Province China

AIM: To evaluate the dynamic ocular biometric changes of a modified form-deprivation myopia model in young guinea pigs. METHODS: The animals were randomly assigned to two groups: the monocularly deprived facemask group (MDF, with all the right eyes covered, n=24) and the normal control group(free of facemask, n=24). Each group was then equally divided into four subgroups which were followed up for 2, 4, 6 and 8 weeks, respectively. Parameters measured from every eye included refraction, corneal curvature, axial length and the dry weight of sclera at the posterior pole. RESULTS: All the facemasks remained in place during the follow-up. The covered eyes developed myopia with the vitreous chamber lengthening and the dry weight of posterior sclera reduced at each time point compared with the contralateral uncovered (P0.05 at all time points). CONCLUSION: Monocular form deprivation with the facemask is highly effective and non-invasive in inducing axial myopia in guinea pigs. The axial myopia is mainly caused by the increased vitreous chamber length and the weakened posterior sclera rigidity. The form-deprivation eye didn't interfere with the natural development of the contralateral eye.

关键词： dynamic change form-deprivation myopia model guinea pig

Synthesis,Structure and Luminescence of Zn_(4.5)Cu_3 Heteronuclear Coordination Polymer Comprising Macrocyclic Oxamide and 5-Sulfosalicylic Ion

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Chemical Research in Chinese Universities 2010年第4期26卷 501-504页

作者： SUN Ya-qiu WANG Jing FAN lan-lan GAO Dong-zhao Tianjin Key Laboratory of Structure and Performance for Functional Molecule College of Chemistry and Life Science Tianjin Normal University Tianjin 300387 P. R. China

The complex [Zn4.5（SSA）3（CuL）3（H2O）6]n was synthesized and structurally determined, where SSA is fully deprotonated 5-sulfosalicylic acid（CuL, H2L=2,3-dioxo-5,6,14,15-dibenzo-1,4,8,12-tetraazacyclo-pentadeca- 7,13-dien）. The title complex crystallized in the triclinic system with space group P1^-, a=1.19788（17） nm, b=1.4253（2） nm, c=2.2890（4） nm, α=90.211（2）°, ,β=93.076（2）°, γ=90.600（2）°. The complex displayed a 1D ladderlike chain. All these 1D chains were further interlinked via hydrogen bonds, resulting in a 2D architecture. The luminescent property of the compound was also discussed.

关键词： Heteronuclear complex Macrocyclic oxamide Luminescence

Structures of Syn-deformational Granites in the Longquanguan Shear Zone and Their Monazite Electronic Microprobe Dating

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Acta Geologica Sinica(English Edition) 2006年第6期80卷 864-874页

作者： ZHANG Jinjiang zhao lan LIU Shuwen The Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of EducationSchool of Earth and Space SciencesPeking UniversityBeijing 100871

The Longquanguan shear zone is an important structural belt in the North China Craton, separating the underlying Fuping complex from the overlying Wutai complex. This shear zone has experienced three episodes of deformation: the first and main episode is a ductile top-to-ESE shear along the gently northwest-west dipping foliations, while the other two episodes are later collapse sliding. Prolonged granites parallel to the shear foliations make one of the main compositions of the Longquanguan shear zone. These granites experienced deformation to form mylonitic rocks when they emplaced during the first episode of deformation. Structural characters of the granites and their contacts to the country rocks indicate that these granites possibly resulted from in-situ partial remelting by shearing, i.e., they are syn-deformational granites. Monazites in these mylonitic granites are magmatic minerals and their crystallization ages may represent ages of the magmatic events, and also the ages for the main deformation of the Longquanguan shear zone. Monazite electronic microprobe dating were carried on two samples of granite, which gives multiple peak ages, among which 1,846 Ma and 1,877 Ma are the main peak ages for the two samples. These ages represent the main deformation of the Longquanguan shear zone, which is consistent with the main regional geological event at about 1,850 Ma caused by the collision between the Eastern and Western Blocks in North China. The good match between the monazite ages and the corresponding regional tectono-thermal events shows the feasibility and reliability of monazite electronic microprobe dating.

关键词： Longquanguan shear zone syn-deformational granite monazite electronic microprobe dating

Heavy Metal Accumulation and Ecological Responses of Turfgrass to Rubbish Compost with EDTA Addition

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Journal of Integrative Plant Biology 2005年第9期47卷 1047-1054页

作者： Li-An DUO Yu-Bao GAO Shu-lan zhao College of Chemistry and Life Sciences Tianjin Normal University Tianjin 300074 China College of Life Sciences Nankai University Tianjin 300071 China

Domestic rubbish compost is a complex-polluted system, containing multiple heavy metals, which limits its application. In the present study, Cr, Mn, Ni, Cu, Zn, Cd, and Pb accumulation and ecological responses of turfgrass to rubbish compost were investigated following the addition of EDTA. The results showed that the addition of EDTA significantly increased heavy metal accumulation in Lolium perenne L. and Festuca arundinacea L. Most heavy metal concentrations in L. perenne increased with increasing EDTA supply. The concentrations of Cr, Mn, Ni, Cu, and Cd in L. perenne were highest following the addition of 30 mmol/kg EDTA and the concentrations of Cr and Ni at this point reached concentrations of 1 914.17 and 521.25 μg/g, respectively. When the EDTA level was 〈 20 mmol/kg, the accumulation of most heavy metals in F. arundinacea increased with increasing EDTA supply, but showed a tendency to decrease at EDTA concentrations 〉20 mmol/kg. The highest concentrations of Mn, Ni, Cu, and Zn in F. arundinacea reached 268.01, 110.94, 161.52 and 1 354.97 μg/g, respectively, following the addition of 20 mmol/kg EDTA. The EDTA-induced increase in the accumulation of heavy metals in turfgrass was plantand metal-specific. L. perenne had a relatively high ability to accumulate Cr, Ni, and Zn. The highest Zn concentration was 2 979.58 μg/g and, following the addition of EDTA, the concentrations of the three metals were increased 26.23, 20.03, and 10.49-fold, respectively, compared with control. However, F. arundinacea showed a high ability to accumulate Cr, with the highest concentration （596.02 μg/g） seen following the addition of 30 mmol/kg EDTA; the concentration of Cr increased 15.51-fold compared with control. With EDTA addition, ecological responses of both turfgrass species showed that EDTA at concentrations 〈10 mmol/kg increased seed germination and aboveground net primary production （ANP） of L. perenne and slightly inhibited those of F. arundinacea, but EDTA at concentra

关键词： accumulation domestic rubbish compost EDTA heavy metal remediation turfgrass.

Nest Site Preference and Fidelity of Chinese Alligator (Alligator sinensis)

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Asian Herpetological Research 2017年第4期18卷 244-252页

作者： Haiqiong YANG lan zhao Qunhua HAN Shengguo FANG The Key Laboratory of Conservation Biology for Endangered Wildlife of the Ministry of Education and StateConservation Center for Gene Resources of Endangered Wildlife College of Life Sciences Zhejiang UniversityHangzhou 310058 China

Oviparous female reptiles select nesting sites with optimal ecological factors that contribute to egg development. Chinese alligator （Alligator sinensis）, an oviparous reptile, is a critically endangered crocodilian with temperature-dependent sex determination. Research on its nesting behavior may facilitate the protection of this species. In this study, we monitored nesting behavior over eight years. We compared selected frequency of nest sites, distance from nest site to water, height from nest site top to the water surface, distance from nest site to human activity region, and canopy density between nest sites on the island and bank. The results showed that 45 nest sites were used by female alligators over eight years and each site was selected from one to 10 times. The selected frequency of nest site occurrence on the island was higher than that on the bank （P 〈 0.001）. We observed that 88% of the individual alligators （15/17） showed different degrees of nest site fidelity. However, Chinese alligators might not always be loyal to only one nest site because of environmental changes or interspecific competition at nest sites. Our findings suggest that female alligators prefer to nest at island, which might be because of the nests on the island had a higher canopy density （P = 0.010） and were further from the human activity region （P 〈 0.001） than those on the bank did. It would be beneficial to reduce human activities during the breeding season and protect the vegetation of Chinese alligator habitats in the future.

关键词： Chinese alligator ecological factor nest site preference nest site fidelity

Effect of Temperature, pH and Salt on Fluorescent Quality of Water Extractable Organic Matter in Black Soil

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Journal of Integrative Agriculture 2013年第7期12卷 1251-1257页

作者： LI Ming-tang zhao lan-po ZHANG Jin-jing College of Resource and Environmental Science Jilin Agricultural University

Water erosion is the major reason for the loss of soil organic carbon in the Northeast China, which leads to the soil quality deterioration and adjacent water pollution. In this study, the effect of extraction temperature, pH value, and salt on the water extractable organic matter （WEOM） was determined by means of the UV absorbance, fluorescence excitation-emission matrix, and derived fluorescence indexes. In general, the carbon content and aromaticity of WEOM increased with the increasing of extraction temperature, with the exception that there was no significant difference in the amount at 0 and 20℃. More fluorophores, especially microbially-derived organic matter were extracted at high temperature. The pH values of extractant, including 5, 7, and 10, showed no effect on the carbon amount of WEOM, whereas the aromaticity and microbially-derived component gradually increased with the increasing of pH values. The fluorescence intensity of humic acid-like fluorophore was stronger in neutral and alkali condition than that in acidic condition. The addition of 10 mmol L-1 CaCl2 significantly decreased the carbon amount of recovered WEOM. Moreover, it significantly decreased the aromaticity of WEOM and the quantity of fulvic acid-like and humic acid-like fluorophores, whereas increased the percentage of tyrosine-like and tryptophan-like fluorophores in the total fluorophores and the amount of microbially-derived organic matter. Generally, 10 mmol L-1 KCl showed the same influence trend, but with low influence degree.

关键词： black soil water extractable organic matter soil profile fluorescence spectroscopy