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Application and Prospect of Platelet Multi-omics Technology in Study of Blood Stasis Syndrome

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Chinese Journal of Integrative Medicine 2022年第2期28卷 99-105页

作者： LI Ying SUN Ming-qian LI Lei ZHANG Ye-hao miao lan LIU Jian-xun Beijing Key Laboratory of Pharmacology of Chinese Materia Region Xiyuan HospitalChina Academy of Chinese Medical SciencesNational Clinical Research Center for Chinese Medicine CardiologyBeijing(100091)China

The abnormality of platelet function plays an important role in the pathogenesis and evolution of blood stasis syndrome(BSS).The explanation of its mechanism is a key scientific issue in the study of cardiovascular and cerebrovascular diseases and *** biology technology provides a good technical platform for further development of platelet multi-omics,which is conducive to the scientific interpretation of the biological mechanism of *** article summarized the pathogenesis of platelets in BSS,the mechanism of action of blood activating and stasis resolving drugs,and the application of genomics,proteomics,and metabonomics in platelet research,and put forward the concept of"plateletomics in BSS".Through the combination and cross-validation of multi-omics technology,it mainly focuses on the clinical and basic research of cardiovascular and cerebrovascular diseases;through the interactive verification of multi-omics technology and system biology,it mainly focuses on the platelet function and secretion *** article systematically explains the molecular biological mechanism of platelet activation,aggregation,release,and other stages in the formation and development of BSS,and provides a new research idea and method for clarifying the pathogenesis of BSS and the mechanism of action of blood activating and stasis resolving drugs.

关键词： blood stasis syndrome platelet transcriptomics metabonomics proteomics

Cimicifuga heracleifolia is therapeutically similar to black cohosh in relieving menopausal symptoms: evidence from pharmacological and metabolomics studies

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Chinese Journal of Natural Medicines 2019年第6期17卷 435-445页

作者： miao lan-Yun CHU Thi Thanh Huyen LI Ping JIANG Yan LI Hui-Jun State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China College of Chemical Engineering Nanjing Forestry UniversityNanjing 210037China

In the market of botanical dietary supplements, Cimicifuga heracleifolia(CH) has always been considered as an adulterated species of Cimicifuga racemosa(CR), a conventional American herb with promising benefits to counteract troubles arising from the menopause. However, the detailed comparison of their therapeutic effects is lacking. In present study, the pharmacological and metabolomics studies were comparatively conducted between CH and CR in ovariectomized(OVX) female rats. Specifically, estrogen-like, anti-hyperlipidemia and anti-osteoporosis effects were evaluated through measuring serum biochemical parameters, histopathological examination and micro computed tomography(Micro-CT) scanning. At the same time, a gas chromatography-mass spectrometry(GC-MS)-based serum metabolomics method was employed to profile the metabolite compositional changes. As a result, both CR and CH displayed anti-osteoporosis and anti-hyperlipemia on menopause syndrome. Meanwhile, their potentials in improving the OVX-induced metabolic disorders were discovered. In conclusion, these results demonstrated that CH is therapeutically similar to CR in relieving menopausal symptoms and CH could be considered as a promising alternative to CR instead of an adulterant in the market of botanical dietary supplements.

关键词： Cimicifuga heracleifolia Black cohosh Menopausal symptoms Metabolomics Substitute

Alkaloid profiling of the traditional Chinese medicine Rhizoma corydalis using high performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry

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Acta Pharmaceutica Sinica B 2014年第3期4卷 208-216页

作者： Mingqian Sun Jianxun Liu Chengren Lin lan miao Li Lin Research Center Xiyuan HospitalChina Academy of Chinese Medical Sciences and Beijing Key Laboratory of TCM PharmacologyBeijing 100091China

Since alkaloids are the major active constituents of Rhizoma corydalis(RC),a convenient and accurate analytical method is needed for their identification and *** we report a method to profile the alkaloids in RC based on liquid chromatography-tandem quadrupole time-of-flight mass spectrometry(LC–Q-TOF-MS/MS).A total of 16 alkaloids belonging to four different classes were identified by comparison with authentic *** fragmentation pathway of each class of alkaloid was clarified and their differences were ***,based on an analysis of fragmentation pathways and alkaloid profiling,a rapid and accurate method for the identification of unknown alkaloids in RC is *** method could also be useful for the quality control of RC.

关键词： LC–Q-TOF-MS/MS Alkaloid Fragmentation pathway Rhizoma corydalis

Proteomics analysis of coronary atherosclerotic heart disease with different Traditional Chinese Medicine syndrome types before and after percutaneous coronary intervention

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Journal of Traditional Chinese Medicine 2024年第3期44卷 554-563页

作者： WANG Zhibo LI Ying WANG Daoping MA Bo miao lan REN Junguo LIU Jinghua LIU Jianxun Beijing Key Laboratory of Pharmacology of Chinese Materia Region Institute of Basic Medical SciencesXiyuan HospitalChina Academy of Chinese Medical SciencesNational Clinical Research Center of Cardiovascular Disease of Traditional Chinese MedicineBeijing 100000China the National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop ScienceChinese Academy of Agricultural ScienceBeijing 100098China Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

OBJECTIVE: To investigate the underlying protein molecular mechanisms of "Qi stagnation and blood stasis syndrome"(QS) and "Qi deficiency and blood stasis syndrome"(QD), as two subtypes of coronary artery disease(CAD) in Traditional Chinese Medicine(TCM),following percutaneous coronary intervention(PCI).METHODS: In this study, a total of 227 CAD patients with QS and 211 CAD patients with QD were enrolled;all participants underwent PCI. Label-free quantification proteomics were employed to analyze the changes in serum in two subtypes of CAD patients before and 6 months after PCI, aiming to elucidate the intervention mechanism of PCI in treating CAD characterized by two different TCM ***: Biochemical analysis revealed significant changes in tumor necrosis factor-α, high density lipoprotein cholesterol, blood stasis clinical symptoms observation, and Gensini levels in both patient groups post-PCI;Proteomic analysis identified 79 and 95 differentially expressed proteins in the QS and QD patient groups, respectively, compared to their control *** C8 alpha chain, complement factor H,apolipoprotein H, apolipoprotein B, plasminogen,carbonic anhydrase 2, and complement factor Ⅰ were altered in both comparison groups. Furthermore,enrichment analysis demonstrated that cell adhesion and connectivity-related processes underwent changes in QS patients post-PCI, whereas lipid metabolism-related pathways, including the peroxisome proliferator-activated receptor signaling pathway and extracellular matrix receptor interaction, underwent changes in the QD *** protein-protein interaction network analysis further enriched 52 node proteins, including apolipoprotein B,lipoprotein(a), complement C5, apolipoprotein A4,complement C8 alpha chain, complement C8 beta chain,complement C8 gamma chain, apolipoprotein H,apolipoprotein A-Ⅱ, albumin, complement C4-B,apolipoprotein C3, among others. The functional network of these proteins is posited to contribute to

关键词： percutaneous coronary intervention proteomics peptide mapping coronary atherosclerotic heart disease Traditional Chinese Medicine syndrome

Rab-H_1b is essential for trafficking of cellulose synthase and for hypocotyl growth in Arabidopsis thaliana

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Journal of Integrative Plant Biology 2018年第11期60卷 1051-1069页

作者： Ming He miao lan Baocai Zhang Yihua Zhou Youqun Wang Lei Zhu Ming Yuan Ying Fu State Key Laboratory of Plant Physiology and Biochemistry College of Biological Sciences China Agricultural University State Key Laboratory of Plant Genomics and National Plant Gene Research Center Institute of Genetics and Developmental Biologythe Chinese Academy of Sciences

Ceil-wall deposition of cellulose microfibrils is essential for plant growth and development. In plant cells, cellulose synthesis is accomplished by cellulose synthase complexes located in the plasma membrane. Trafficking of the complex between endomembrane compartments and the plasma membrane is vital for cellulose biosynthesis; however, the mechanism for this process is not well understood. We here report that, in Arabidopsis thaliana, Rab-H1b, a Golgi-localized small GTPase, participates in the trafficking of CELLULOSE SYNTHASE 6 （CESA6） to the plasma membrane. Loss of Rab-Hlb function resulted in altered distribution and motility of CESA6 in the plasma membrane and reduced cellulose content. Seedlings with this defect exhibited short, fragile etiolated *** of CESA6 was impaired in rab-Mb cells, and endocytosis in mutant cells was significantly reduced as well. We further observed accumulation of vesicles around an abnormal Golgi apparatus having an increased number of cisternae in rab-Mb cells, suggesting a defect in cisternal homeostasis caused by Rab-Hlb loss function. Our findings link Rab GTPases to cellulose biosynthesis, during hypo- cotyl growth, and suggest Rab-Hlb is crucial for modulating the trafficking of cellulose synthase complexes between endomembrane compartments and the plasma membrane and for maintaining Golgi organization and morphology.

关键词： Rab-H1b is essential for trafficking of cellulose synthase and for hypocotyl growth in Arabidopsis thaliana

Impact on Acidification Characteristics of Anaerobic Digestion of Kitchen Waste by F/M

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Meteorological and Environmental Research 2018年第6期9卷 34-39页

作者： Liu Yanping Xiao Xiong Cui Yue Yuan Yu lan miao Department of Environmental Science and Engineering Beijing University of Chemical Technology Beijing Drainage Group Co. Ltd.

The effect of F/M on acidification characteristics during anaerobic digestion of kitchen waste was investigated. Under different F/M,p H,alkalinity,ethyl alcohol,volatile fatty acids(VFAs),and biogas production status of acidification effluent in 96 h were observed. The study results showed that the content of propionic acid + acetic acid reached 56%-80% when F/M≤1. 0,which was mainly known as propionic acid type of fermentation and was accompanied by methane. The value of alkalinity was only 3 000-4 000 mg/L,which indicated that the stability was weak in the system. When 1. 0 < F/M≤2. 5,the concentration of butyric acid + acetic acid was in the range of 77%-85%,and acid production rate per unit load was more than 250 mg VFAs/g VS,which was known as butyric acid type of fermentation. The fermentation type was stable and could provide more available VFAs for subsequent methanation processes because the value of alkalinity reached 5 650 mg/L. When F/M≥2. 5,the content of ethanol + acetic acid was 80%-92%,which was known as ethanol type of fermentation. And p H of 96 h was only 5. 0( F/M = 3. 0) and 4. 3(F/M =4.0),and acidification was serious and the stability was weak in the system,which would hinder the subsequent methanation ***,F/M influenced fermentation type,and it can provide a target product for subsequent methanation process by controlling F/M in a reasonable range.

关键词： Kitchen waste Anaerobic digestion Food to microorganism ratios

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关于模p^α原根分布的推广

Journal of Mathematical Research and Exposition 2007年第2期27卷 403-407页

作者：钱淼岚复旦大学数学所上海200433

设p为奇素数,α为任意大于1的整数,对于任意给定的正整数k,k|pα-pα-1,本文主要研究模pα的k次剩余的分布性质．

关键词：原根三角和 Kloostermann和

Synthesis of DSPDA for second order nonlinear optical materials

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Synthesis of DSPDA for second order nonlinear optical materi...

第七届高性能特种光学薄膜技术及应用学术研讨会

作者： SHEN Li JIN Ning-ren SHEN miao-lan WANG Jia-an Shaoxing University Yuanpei College Zhejiang University of Technology

Second order nonlinear optical materials have been in a very important position because of its special excellent optical properties,The large nonlinear optical coefficient chromophore molecule is the key to the excellent nonlinear optical *** this study,the Industrialized synthetic process of multi-substituted group-E-diphenylethene compounds with push-pull electronic structure was studied,based on the properties of diphenylethene compounds and the advantage of diphenylethene compounds which have the push-pull electronic *** chromophore compounds N,N’-diacety1-2-(2,4-dimethoxystyryl)-5-nitro-l,4-phenylenediamine(DSPDA),were prepared and optimized to adjust the industrial production.

关键词： Second order nonlinear optical materials group-E-diphenylethene compounds N,N’diacetyl-2-(2,4-dimethoxystyryl)-5-nitro-1,4-phenylenediamine(DSPDA)

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关于破产时刻及破产时损失联合分布的讨论

复旦学报（自然科学版） 2005年第3期44卷 462-465页

作者：钱淼岚劳兰珺复旦大学数学研究所上海200433 复旦大学管理学院上海200433

从随机过程的角度来看,连续时间风险理论中讨论的许多模型是L啨vy过程.以经典的复合Poisson风险模型为例,利用L啨vy过程的L啨vy测度,对破产时损失及破产时刻的联合分布进行再讨论.此方法不受模型具体形式的制约,可以用于除复合Poisson... 详细信息

从随机过程的角度来看,连续时间风险理论中讨论的许多模型是L啨vy过程.以经典的复合Poisson风险模型为例,利用L啨vy过程的L啨vy测度,对破产时损失及破产时刻的联合分布进行再讨论.此方法不受模型具体形式的制约,可以用于除复合Poisson模型以外更广泛的一类模型的研究.

关键词：风险过程破产时刻破产时损失 Lévy测度