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Cardioprotective Potential of Cymbopogon citratus Essential Oil against Isoproterenol-induced Cardiomyocyte Hypertrophy:Possible Involvement of NLRP3 Inflammasome and Oxidative Phosphorylation Complex Subunits

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Current Medical Science 2024年第2期44卷 450-461页

作者： Xiao-yun DING Hao ZHANG Yu-mei QIU Meng-die XIE Hu WANG Zheng-yu XIONG Ting-ting LI Chun-ni HE Wei dong Xi-lan TANG School of Pharmacy Jiangxi Science&Technology Normal UniversityNanchang 330013China Key Laboratory of Modern Preparation of Chinese Medicine Ministry of EducationJiangxi University of Chinese MedicineNanchang 330004China Jiangxi Provincial Key Laboratory of Drug Design and Evaluation Nanchang 330013China

Objective:Cymbopogon citratus(DC.)Stapf is a medicinal and edible herb that is widely used for the treatment of gastric,nervous and hypertensive *** this study,we investigated the cardioprotective effects and mechanisms of the essential oil,the main active ingredient of Cymbopogon citratus,on isoproterenol(ISO)-induced cardiomyocyte ***:The compositions of Cymbopogon citratus essential oil(CCEO)were determined by gas chromatography-mass *** were pretreated with 16.9µg/L CCEO for 1 h followed by 10µmol/L ISO for 24 *** hypertrophy-related indicators and NLRP3 inflammasome expression were ***,transcriptome sequencing(RNA-seq)and target verification were used to further explore the underlying ***:Our results showed that the CCEO mainly included citronellal(45.66%),geraniol(23.32%),and citronellol(10.37%).CCEO inhibited ISO-induced increases in cell surface area and protein content,as well as the upregulation of fetal gene ***,CCEO inhibited ISO-induced NLRP3 inflammasome expression,as evidenced by decreased lactate dehydrogenase content and downregulated mRNA levels of NLRP3,ASC,CASP1,GSDMD,and IL-1β,as well as reduced protein levels of NLRP3,ASC,pro-caspase-1,caspase-1(p20),GSDMD-FL,GSDMD-N,and pro-IL-1β.The RNA-seq results showed that CCEO inhibited the increase in the mRNA levels of 26 oxidative phosphorylation complex subunits in ISO-treated *** further experiments confirmed that CCEO suppressed ISO-induced upregulation of mt-Nd1,Sdhd,mt-Cytb,Uqcrq,and mt-Atp6 but had no obvious effects on mt-Col ***:CCEO inhibits ISO-induced cardiomyocyte hypertrophy through the suppression of NLRP3 inflammasome expression and the regulation of several oxidative phosphorylation complex subunits.

关键词： Cymbopogon citratus essential oil cardiac hypertrophy NLRP3 inflammasome oxidative phosphorylation complex subunits

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乡村景观与城市想象--基于我国村落影像话语叙事的考察

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编辑之友 2022年第8期 68-75页

作者：兰东兴郑媛之贵州民族大学传媒学院贵州贵阳550025

影像设备普及、互联网发展、城镇化、传统文化保护、消费主义盛行等因素互相激荡,催生出形态各异和数量巨大的村落影像。影像构建的乡村景观看似个性鲜明、内容丰富,实际上没有消除刻板印象。碎片化的景观不仅聚合为乡村社会图景,也折... 详细信息

影像设备普及、互联网发展、城镇化、传统文化保护、消费主义盛行等因素互相激荡,催生出形态各异和数量巨大的村落影像。影像构建的乡村景观看似个性鲜明、内容丰富,实际上没有消除刻板印象。碎片化的景观不仅聚合为乡村社会图景,也折射出记录者的愿景和消费文化背景下的观众心境。不同的村落影像在本质上都是城市人的想象,在影像记录时对现实有遮蔽,同时也通过遮蔽而实现情感表达。

关键词：村落影像景观城市中心主义话语分析

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次边缘柱失效下预应力混凝土框架抗连续倒塌性能研究

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工程力学 2023年第10期40卷 58-70页

作者：兰冬璆邓小芳金浏钱凯北京工业大学城市减灾与防灾防护教育部重点实验室北京100124 桂林理工大学广西建筑新能源与节能重点实验室广西桂林541004

考虑到去柱后弯矩方向在去柱处出现反转并且可能与预应力筋布置形式相反,预应力混凝土结构具有较大的倒塌风险,该文通过拟静力试验和数值模拟研究了次边缘柱失效下无黏结预应力混凝土(PC)梁-柱子结构的抗连续倒塌性能。对2个具有不同预... 详细信息

考虑到去柱后弯矩方向在去柱处出现反转并且可能与预应力筋布置形式相反,预应力混凝土结构具有较大的倒塌风险,该文通过拟静力试验和数值模拟研究了次边缘柱失效下无黏结预应力混凝土(PC)梁-柱子结构的抗连续倒塌性能。对2个具有不同预应力筋布置形式(直线型和抛物线型)的1/2缩尺梁-柱子结构进行Pushdown加载,分析了试件的破坏模式、抗力机制演变和极限承载力。为量化预应力筋的影响,制作了一个具有相同几何尺寸和非预应力筋配筋率的钢筋混凝土试件作为参考。结果表明:预应力筋可以显著提高结构承载力,同时改变结构的破坏模式,降低结构变形能力。预应力筋产生的水平拉力加剧了边柱的挠曲P-δ效应,使边柱提早发生大偏心受压破坏。为进一步了解预应力混凝土框架抗倒塌性能,基于有限元软件LS-DYNA建立了精细化有限元模型开展系列参数分析。数值分析表明,预压应力可以增强压拱机制,预应力筋对于大变形阶段承载力的提高贡献显著。

关键词：预应力结构连续倒塌试验研究数值分析次边缘柱失效

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Experimental investigation of hollow-core photonic crystal fibers with five photonic band-gaps

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Optoelectronics Letters 2008年第4期4卷 253-256页

作者： YUAN Jin-hui HOU lan-tian WEI dong-bin WANG Hai-yun ZHOU Gui-yao Institute of Infrared Optical Fibers and Sensors College of Information Science and Engineering Yanshan UniversityQinhuangdao 066004 China

The hollow-core photonic crystal fibers(HC-PCFs) with integrity structure have been fabricated with an improved twice stack-and-draw *** transmission spectrum shows that five photonic band-gaps within 450-1100 nm have... 详细信息

关键词：中空光子晶体光纤光子带隙实验研究光学元件

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HEPS六极铁标定方案分析

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核技术 2024年第2期47卷 41-48页

作者：韩圆颖吴亚峰董岚王铜卢尚闫路平张露彦刘晓阳闫皓月马娜何振强柯志勇门玲鸰李波王小龙梁静中国科学院高能物理研究所北京100049 散裂中子源科学中心东莞523803

六极铁作为高能同步辐射光源(High Energy Photon Source,HEPS)储存环八铁单元的重要部件之一,其技术工艺较为复杂,对加工精度和中心引出精度要求都很高。本文对HEPS六极铁的机械中心引出标定方案进行了研究,利用极缝偏差角对常规标定... 详细信息

六极铁作为高能同步辐射光源(High Energy Photon Source,HEPS)储存环八铁单元的重要部件之一,其技术工艺较为复杂,对加工精度和中心引出精度要求都很高。本文对HEPS六极铁的机械中心引出标定方案进行了研究,利用极缝偏差角对常规标定坐标系进行旋转,使三个极缝面更接近理论位置,从而减小磁铁主场斜分量;对每块磁铁进行两次机械中心标定,极缝间距的实测值与设计值的标准偏差在0.015 mm,坐标系旋转前后的基准点偏差标准值为0.09 mm,旋转角最大可达0.6 mrad。这种考虑极缝偏差角的建系方法可以提高标定的精度,能为实际工作中同类型、准直精度有相同要求的设备标定提供参考,有利于加速器装置的顺利安装,对加速器准直测量具有十分重要的意义。

关键词：六极铁中心标定机械中心坐标系旋转准直精度

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Development characteristics and controlling factor analysis of the Neogene Minghuazhen Formation shallow water delta in Huanghekou area, Bohai offshore basin

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Journal of Palaeogeography 2019年第3期8卷 251-269页

作者： Li-Xin Tian Hao Liu Cheng-Min Niu Xiao-Feng Du Bo Yang Xiao-dong lan Dan-Lei Chen Shenzhen Branch of China National Offshore Oil Corporation Shenzhen People's Republic of China School of Ocean Sciences China University of Geosciences (Beijing) Beijing 100083 People's Republic of China Exploration & Exploitation Research Institute Tianjin Branch of China National Offshore Oil Corporation Tianjin People's Republic of China

Based on a combination of high resolution 3-D seismic, drilling and well logging and core data, this study focuses on describing the depositional features of the Neogene Minghuazhen Formation shallow water delta in Huanghekou area(HHKA), Bohai offshore basin and discussing the evolution and controlling factors of shallow water delta sandbody. An obvious meandering fluvial delta system developed in sequence 1(SQ1) of the Neogene in HHKA with thinner sandbody of distributary channels and poor development of mouth bar. The sequence texture obviously influences the vertical development and stacking pattern of sandbodies and controls the distribution of sandbodies in plain view as well. In shallow water lacustrine basins, relative topographic height difference leads to change of distribution of accommodation space, and sandbodies of distributary channels usually develop well in local low-lying areas where accommodation space increases. The delta is dominated by distributary channel sandbodies during the early period of base level rising. Sandbodies contact with each other in a lateral stacking pattern and are characterized by a fan shape in plain view. Distributary channels gradually narrow and tend to shift during the mid-late-period of base level rising, while the sandbodies are characterized by a net shape in plain view. During the period of base level slow falling, the multistory/multilateral channel sandbodies dominated the inner front of shallow-water delta and the delta sand dispersal distributes as a lobe shape.

关键词： The Neogene Minghuazhen Formation Huanghekou area Bohai offshore basin Shallow water delta Micro-palaeogeomorphology Base level Sandbody stacking pattern

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抑制型产业政策能缓解企业投融资期限结构错配吗?——基于去产能政策的经验分析

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产经评论 2023年第4期14卷 5-19页

作者：叶德珠董兰新暨南大学经济学院

在防范和化解重大风险背景下,企业投融资期限结构错配问题越来越受到学术界关注。基于国务院出台的去产能政策信息,以2010—2020年中国A股上市企业为研究样本,实证研究抑制型产业政策对企业投融资期限结构错配的影响和作用机制。结果显... 详细信息

在防范和化解重大风险背景下,企业投融资期限结构错配问题越来越受到学术界关注。基于国务院出台的去产能政策信息,以2010—2020年中国A股上市企业为研究样本,实证研究抑制型产业政策对企业投融资期限结构错配的影响和作用机制。结果显示:去产能政策缓解了产能过剩行业企业的投融资期限结构错配,即政策抑制了企业“短贷长投”行为。机制检验表明,去产能政策主要通过抑制企业固定资产投资和增加企业内源融资发挥缓解企业投融资期限结构错配的作用。异质性分析发现,相较于民营企业,去产能政策对国有企业投融资期限结构错配的缓解作用更强。对抑制型产业政策与企业投融资期限结构之间关系的认识能够为更好地推行产业政策、防范和化解金融风险提供重要启示。

关键词：抑制型产业政策去产能政策投融资期限结构错配固定资产投资内源融资

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TL1A Promotes Fibrogenesis in Colonic Fibroblasts via the TGF-β1/Smad3 Signaling Pathway

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Current Medical Science 2024年第3期44卷 519-528页

作者： Jia SONG dong-lei SUN Chen-yang LI Yu-xin LUO Qian LIU Yue YAO Hong ZHANG Ting-ting YANG Mei SONG Xin-li BAI Xiao-lan ZHANG Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesShijiazhuang050000China Department of Pediatrics The Second Hospital of Hebei Medical UniversityShijiazhuang050000China

Objective Intestinal fibrosis is a refractory complication of inflammatory bowel disease(IBD).Tumor necrosis factor ligand-related molecule-1A(TL1A)is important for IBD-related intestinal fibrosis in a dextran sodium sulfate(DSS)-induced experimental colitis *** study aimed to explore the effects of TL1A on human colonic *** A trinitrobenzene sulfonic acid(TNBS)-induced experimental colitis model of LCK-CD2-TL1A-GFP transgenic(Tg)or wild-type(WT)mice was established to determine the effect and mechanism of TL1A on intestinal *** human colonic fibroblast CCD-18Co cell line was treated concurrently with TL1A and human peripheral blood mononuclear cell(PBMC)*** proliferation and activation of CCD-18Co cells were detected by BrdU assays,flow cytometry,immunocytochemistry and Western *** metabolism was tested by Western blotting and real-time quantitative polymerase chain reaction(RT-qPCR).Results The level of collagen metabolism in the TNBS+ethyl alcohol(EtOH)/Tg group was greater than that in the TNBS+EtOH/WT *** growth factor-β1(TGF-β1)and p-Smad3 in the TNBS+EtOH/Tg group were upregulated as compared with those in the TNBS+EtOH/WT *** proliferation of CCD-18Co cells was promoted by the addition of human PBMC supernatant supplemented with 20 ng/mL TL1A,and the addition of human PBMC supernatant and TL1A increased CCD-18Co proliferation by 24.4%at 24 ***1A promoted cell activation and increased the levels of COL1A2,COL3A1,and TIMP-1 in CCD-18Co *** of CCD-18Co cells with TL1A increased the expression of TGF-β1 and *** TL1A promotes TGF-β1-mediated intestinal fibroblast activation,proliferation,and collagen deposition and is likely related to an increase in the TGF-β1/Smad3 signaling pathway.

关键词： tumor necrosis factor ligand-related molecule-1A fibrosis inflammatory bowel disease myofibroblasts transforming growth factor-β1

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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-dong Qian Qiao Gao Sheng-lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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New perspectives on the therapeutic potential of quercetin in non-communicable diseases:Targeting Nrf2 to counteract oxidative stress and inflammation

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Journal of Pharmaceutical Analysis 2024年第6期14卷 805-822页

作者： Li Zhang Li-Yue Xu Fei Tang dong Liu Xiao-lan Zhao Jing-Nan Zhang Jia Xia Jiao-Jiao Wu Yu Yang Cheng Peng Hui Ao State Key Laboratory of Southwestern Chinese Medicine Resources School of PharmacyChengdu University of Traditional Chinese MedicineChengdu611137China Innovative Institute of Chinese Medicine and Pharmacy Chengdu University of Traditional Chinese MedicineChengdu611137China

Non-communicable diseases(NCDs),including cardiovascular diseases,cancer,metabolic diseases,and skeletal diseases,pose significant challenges to public health *** complex pathogenesis of these diseases is closely linked to oxidative stress and inflammatory *** factor erythroid 2-related factor 2(Nrf2),a critical transcription factor,plays an important role in regulating antioxidant and anti-inflammatory responses to protect the cells from oxidative damage and inflammation-mediated ***,Nrf2-targeting therapies hold promise for preventing and treating ***(Que)is a widely available flavonoid that has significant antioxidant and anti-inflammatory *** modulates the Nrf2 signaling pathway to ameliorate oxidative stress and *** modulates mitochondrial function,apoptosis,autophagy,and cell damage biomarkers to regulate oxidative stress and inflammation,highlighting its efficacy as a therapeutic agent against ***,we discussed,for the first time,the close association between NCD pathogenesis and the Nrf2 signaling pathway,involved in neurodegenerative diseases(NDDs),cardiovascular disease,cancers,organ damage,and bone ***,we reviewed the availability,pharmacokinetics,pharmaceutics,and therapeutic applications of Que in treating *** addition,we focused on the challenges and prospects for its clinical *** represents a promising candidate for the treatment of NCDs due to its Nrf2-targeting properties.

关键词： Quercetin Nrf2 Non-communicable diseases Antioxidant Anti-inflammatory Availability

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