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Traveling Wave Solution for Two Kinds of Reaction-Diffusion Equations

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Advances in Manufacturing 2000年第2期4卷 108-111页

作者： Jian-lan Hu Han-lin Zhang Beijing Polytechnical University Beijing China

The generialized Kuramoto Sivashinski equation and Fisher equation in chemical reaction diffusion was studied in this paper. By introducing a new method, the anthors obtained the exact traveling wave solution for th... 详细信息

关键词： traveling wave solution reaction diffusion equation Kuramoto Sivashinski equation Fisher equation

Genome-wide analysis of OVATE family proteins in cucumber(Cucumis sativus L.)

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Journal of Integrative Agriculture 2022年第5期21卷 1321-1331页

作者： HAN Li-jie SONG Xiao-fei WANG Zhong-yi LIU Xiao-feng YAN Li-ying HAN De-guo ZHOU Zhao-yang ZHANG Xiao-lan State Key Laboratories of Agrobiotechnology/Beijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops/MOE Joint Laboratory for International Cooperation in Crop Molecular Breeding/China Agricultural University Beijing 100193P.R.China Analysis and Testing Centre Hebei Normal University of Science&TechnologyQinhuangdao 066004P.R.China College of Horticulture Science and Technology Hebei Normal University of Science&TechnologyQinhuangdao 066004P.R.China Key Laboratory of Biology and Genetic Improvement of Horticultural Crops of Northeast Region Ministry of Agriculture and Rural Affairs/College of Horticulture&Landscape ArchitectureNortheast Agricultural UniversityHarbin 150030P.R.China

OVATE family proteins(OFPs)are plant-specific proteins with a conserved OVATE domain that regulate plant growth and *** OFPs have been studied in several species,their biological functions remain largely unknown in cucumber(Cucumis sativus L.).This study identified 19 Cs OFPs distributed on seven chromosomes in *** Cs OFP genes were expressed in reproductive organs,but with different expression *** expression of Cs OFP12-16c in Arabidopsis resulted in shorter and blunt *** overall results indicated that Cs OFP12-16c regulates silique development in Arabidopsis and may have a similar function in cucumber.

关键词： cucumber OVATE family proteins expression pattern Cs OFP12-16c fruit development

Effects of nitrogen application rate and hill density on rice yield and nitrogen utilization in sodic saline–alkaline paddy fields

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Journal of Integrative Agriculture 2021年第2期20卷 540-553页

作者： GUO Xiao-hong lan Yu-chen XU Ling-qi YIN Da-wei LI Hong-yu QIAN Yong-de ZHENG Gui-ping LU Yan-dong Heilongjiang Provincial Key Laboratory of Modern Agricultural Cultivation and Crop Germplasm Improvement/Daqing Key Laboratory of Saline-alkaline land Utilization and Improvement/College of Agriculture Heilongjiang Bayi Agricultural UniversityDaqing 163319P.R.China

Soil salinity and alkalinity can inhibit crop growth and reduce yield,and this has become a global environmental *** changes in nitrogen (N) application and hill density can improve rice yields in sodic saline–alkaline paddy fields and protect the *** investigated the interactive effects of N application rate and hill density on rice yield and N accumulation,translocation and utilization in two field experiments during 2018 and 2019 in sodic saline–alkaline paddy *** N application rates (0 (control),90,120,150,and 180 kg N ha^(-1) (N0–N4),respectively) and three hill densities(achieved by altering the distance between hills,in rows spaced 30 cm apart:16.5 cm (D1),13.3 cm (D2) and 10 cm (D3))were utilized in a split-plot design with three *** application rate and hill density significantly affected grain *** mathematical model of quadratic saturated D-optimal design showed that with an N application rate in the range of 0–180 kg N ha^(-1),the highest yield was obtained at 142.61 kg N ha^(-1) which matched with a planting density of 33.3×10^(4) ha^(-1).Higher grain yield was mainly attributed to the increase in panicles m^(–2).Nitrogen application rate and hill density significantly affected N accumulation in the aboveground parts of rice plants and showed a highly significant positive correlation with grain yield at *** full heading to maturity,the average N loss rate of the aboveground parts of rice plants in N4 was 70.21% higher than that of *** is one of the reasons why the yield of N4 treatment is lower than that of the N3 *** accumulation rates in the aboveground parts under treatment N3 (150 kg N ha^(-1)) were 81.68 and 106.07% higher in 2018 and 2019,respectively,than those in the *** N translocation and N translocation contribution rates increased with the increase in the N application rate and hill density,whereas N productivity of dry matter and grain first increased

关键词： rice yield saline–alkaline soil nitrogen accumulation paddy field Songnen Plain

Histone deacetylase inhibitor pracinostat suppresses colorectal cancer by inducing CDK5-Drp1 signaling-mediated peripheral mitofission

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Journal of Pharmaceutical Analysis 2023年第10期13卷 1168-1182页

作者： Xiao-Ling Liang lan Ouyang Nan-Nan Yu Zheng-Hua Sun Zi-Kang Gui Yu-Long Niu Qing-Yu He Jing Zhang Yang Wang MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes Institute of Life and Health EngineeringCollege of Life Science and TechnologyJinan UniversityGuangzhou510632China Department of Radiology The First Affiliated Hospital of Jinan University and MOE Key Laboratory of Tumor Molecular BiologyJinan UniversityGuangzhou510632China

Divisions at the periphery and midzone of mitochondria are two fission signatures that determine the fate of mitochondria and *** induction of excessively asymmetric mitofissionassociated cell death(MFAD)by switching the scission position from the mitochondrial midzone to the periphery represents a promising strategy for anticancer *** screening a series of paninhibitors,we identified pracinostat,a pan-histone deacetylase(HDAC)inhibitor,as a novel MFAD inducer,that exhibited a significant anticancer effect on colorectal cancer(CRC)in vivo and in *** increased the expression of cyclin-dependent kinase 5(CDK5)and induced its acetylation at residue lysine 33,accelerating the formation of complex CDK5/CDK5 regulatory subunit 1 and dynaminrelated protein 1(Drp1)-mediated mitochondrial peripheral *** cells with high level of CDK5(CDK5-high)displayed midzone mitochondrial division that was associated with oncogenic phenotype,but treatment with pracinostat led to a lethal increase in the already-elevated level of CDK5 in the CRC ***,pracinostat switched the scission position from the mitochondrial midzone to the periphery by improving the binding of Drp1 from mitochondrial fission factor(MFF)to mitochondrial fission 1 protein(FIS1).Thus,our results revealed the anticancer mechanism of HDACi pracinostat in CRC via activating CDK5-Drp1 signaling to cause selective MFAD of those CDK5-high tumor cells,which implicates a new paradigm to develop potential therapeutic strategies for CRC treatment.

关键词： HDAC inhibitor Pracinostat CDK5 Mitochondrial fission Acetylation Drp1

A Small-Scale Medication of Leflunomide as a Treatment of COVID-19 in an Open-Label Blank-Controlled Clinical Trial

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Virologica Sinica 2020年第6期35卷 725-733页

作者： Ke Hu Mengmei Wang Yang Zhao Yunting Zhang Tao Wang Zhishui Zheng Xiaochen Li Shaolin Zeng Dong Zhao Honglin Li Ke Xu Ke lan Department of Respiratory and Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China Shanghai Key Laboratory of New Drug Design State Key Laboratory of Bioreactor EngineeringSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Virology College of Life SciencesWuhan UniversityWuhan 430072China Frontier Science Center for Immunology and Metabolism Wuhan UniversityWuhan 430072China

We recently reported that inhibitors against human dihydroorotate dehydrogenase(DHODH)have broad-spectrum antiviral activities including their inhibitory efficacies on SARS-CoV-2 replication in infected ***,there are limited data from clinical studies to prove the application of DHODH inhibitors in Coronavirus disease 2019(COVID-19)*** the present study,we evaluated Leflunomide,an approved DHODH inhibitor widely used as a modest immune regulator to treat autoimmune diseases,in treating COVID-19 disease with a small-scale of *** of 10 laboratory-confirmed COVID-19 patients of moderate type with obvious opacity in the lung were *** of the patients were treated with Leflunomide,and another five were treated as blank controls without a *** the patients accepted standard supportive treatment for *** patients given Leflunomide had a shorter viral shedding time(median of5 days)than the controls(median of 11 days,P=0.046).The patients given Leflunomide also showed a significant reduction in C-reactive protein levels,indicating that immunopathological inflammation was well *** obvious adverse effects were observed in Leflunomide-treated patients,and they all discharged from the hospital faster than *** preliminary study on a small-scale compassionate use of Leflunomide provides clues for further understanding of Leflunomide as a potential antiviral drug against COVID-19.

关键词： DHODH inhibitors Leflunomide Coronavirus disease 2019(COVID-19) Viral shedding time Inflammation

The impact of receptor-binding domain natural mutations on antibody recognition of SARS-CoV-2

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1116-1118页

作者： Cheng Li Xiaolong Tian Xiaodong Jia Jinkai Wan Lu Lu Shibo Jiang Fei lan Yinying Lu Yanling Wu Tianlei Ying MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology School of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghaiChina Department of Comprehensive Liver Cancer The Fifth Medical CenterChinese PLA General HospitalBeijingChina Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyInstitutes of Biomedical SciencesFudan UniversityShanghaiChina

Dear Editor,The ongoing COVID-19 pandemic has resulted in over 25.0 million confirmed cases and over 840,000 deaths *** the third severe respiratory disease outbreak caused by the coronavirus,COVID-19 has led to much larger infected populations and coverage of geographic areas than SARS and *** high prevalence of infection has raised significant concerns about the emergence and spread of escape variants,which may evade human immunity and eventually render candidate vaccines and antibody-based therapeutics ***,some naturally mutated SARS-CoV or MERS-CoV strains from the sequential outbreaks were reported to resist neutralization by the antibodies isolated during the first outbreak1,2.

关键词： immunity eventually render

Goniodilactone and gomoheptenolactone,two novel cytotoxic styryllactones from the leaves of Goniothalamus cheliensis

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Chinese Chemical Letters 2012年第5期23卷 583-586页

作者： Jiu Xiang Zhu Dong Lei Yu Wen Hua Huang lan Sun Yang Lv Qi Tai Zheng Kuo Hsiung Lee Jing Guang Yu Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Division of Medicinal Chemistry and Natural Products School of PharmacyUniversity of North CarolinaUSA Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Two novel styryllactones,goniodilactone（1） and gonioheptenolactone（2）,were isolated from the leaves of Goniothalamus cheliensis *** structures were determined on the basis of spectroscopic data as well as X-ray crystallography analysis. Compounds 1 and 2 exhibited significant cytotoxicities in a panel of human cancer cells,including DU-145,PC-3,MCF-7,A-549, KB and KBvin,with GI_（50）S in the range of 1.29-4.56μg/mL.

关键词： Goniothalamus cheliensis Goniodilactone Gonioheptenolactone Cytotoxic activity Styryllactones

Development and validation of a risk prediction model for repeated indwelling urinary catheterization in patients with cervical cancer after surgery

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Clinical Research Communications 2023年第1期6卷 19-24页

作者： Fang Wang Xiao-Li Wang Shi-Qun Zhou lan-lan Lou Zhi-Min Wu Department of Gynecology and Obstetrics Third Military Medical University Southwest HospitalChongqing 404100China Department of Geriatrics The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 404100China

Objective:To study the factors influencing secondary indwelling catheterisation after cervical cancer surgery and to develop a predictive risk ***:A total of 260 patients in a tertiary hospital in Chongqing were selected from January 2020 to December 2021 via convenience *** information of patients was recorded,including age;body mass index;history of hypertension and diabetes,bladder dysfunction,postoperative urinary retention,and postoperative urinary tract infection;Histology;staging;surgical approach;Operation time;Time of first remove of catheter;indwelling catheter days;Hospitalization *** absolute shrinkage and selection operator was used to reduce dimensionality and select patient characteristics,and multivariate analysis was performed based on the selected *** on the outcome of analysis,a line chart model was developed for predicting the risk of secondary catheterization in patients with indwelling catheterization after radical cervical cancer *** coefficient of conformity index(C-index)and calibration curves were used to evaluate the accuracy and *** model was internally validated via bootstrapping(1000 random samples),and the clinical utility of the model was assessed via decision curve analysis(DCA).Results:Four characteristic variables were selected,including preoperative bladder function,postoperative urinary tract infection,surgical approach,and Time of first remove of *** are independent risk factors affecting urinary *** risk prediction model exhibited good discrimination performance with a C-index of 0.722(95%CI,0.661-0.783)and was well *** C-index was 0.708 in internal validation *** showed that the risk model was clinically useful for predicting secondary catheterization,and clinical benefits were observed at the decision threshold of≥11%.Conclusion:A novel model was developed to predict the risk of secondary *** model was based on preoperat

关键词： cervical cancer predictors nomogram indwelling catheter secondary catheterization

Genetic Characteristics of Lipooligosaccharide and Capsular Polysaccharide of Campylobacter jejuni from Different Sources in China

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Biomedical and Environmental Sciences 2022年第12期35卷 1106-1114页

作者： WANG Jia Qi CHEN Xiao Li ZHOU Gui lan WANG Hai Rui GU Yi Xin ZHANG Jian Zhong SHAO Zhu Jun ZHANG Mao Jun State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China National Institute of Environmental Health Chinese Center for Disease Control and PreventionBeijing 100021China

Objective To determine the distribution of two important virulence factors[lipooligosaccharide(LOS)and capsular polysaccharide(CPS)]in Campylobacter jejuni(***)isolated from different sources in China and to develop a rapid screening method for Guillain–Barrésyndrome(GBS)-associated *** Whole-genome sequencing was carried out for 494 *** *** Ortho MCL software was used to define the LOS/CPS gene *** genotyping was performed with serotype-specific sequence alignment using the BLAST ***-time Polymerase chain reaction(PCR)was developed with the unique sequences of specific CPS *** Nine novel and 29 previously confirmed LOS classes were *** classes A,B,and C were the most common(48.2%,238/494)among the 494 ***-six capsular types were identified in 448 ***2,HS4c,HS5/31,HS19,and HS8/17 were the most frequent CPS genotypes(58.7%,263/448).Strains of 17 CPS genotypes(strain number>5)had one or two prevalent LOS classes(Plance of GBS-associated strains in China.

关键词： Campylobacter jejuni Lipooligosaccharide Capsular polysaccharide Multiplex real-time PCR