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Side ionic-gated perovskite/graphene heterojunction synaptic transistor with bipolar photoresponse for neuromorphic computing

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Photonics Research 2024年第6期12卷 1167-1174页

作者： XIAOYING HE MINGHAO XU SHILIN LIU KUN WANG BOWEN CAO lan rao XIANGJUN XIN School of Electronic Engineering and Beijing Key Laboratory of Space-Ground Interconnection and Convergence Beijing University of Posts and TelecommunicationsBeijing 100876China Key Laboratory of Semiconductor Materials Science Beijing Key Laboratory of Low Dimensional Semiconductor Materials and DevicesInstitute of SemiconductorsChinese Academy of SciencesBeijing 100083China

By combining the good charge transport property of graphene and the excellent photo-carrier generation char-acteristic of perovskite nanocrystal,we propose and demonstrate an ionic-gated synaptic transistor based on CsPbBr_(3)∕graphene heterojunction for bipolar *** the potential barrier of the CsPbBr_(3)∕graphene heterojunction by the ionic-gate of the electrical double-layer effect can promote the sepa-ration of photogenerated carriers and effectively retard their *** the ionic-gate-tunable Fermi level of graphene and the pinning effect of perovskite nanocrystal,the bipolar photocurrent responses correspond-ing to the excitatory and inhibitory short-term and long-term plasticity are realized by adjusting the negative gate bias.A series of synaptic functions including logic operation,Morse coding,the optical memory and electrical erasure effect,and light-assisted re-learning have also been demonstrated in an optoelectronic collaborative ***,the excellent optical synaptic behaviors also contribute to the handwritten font recognition accuracy of-95%in artificial neural network *** results pave the way for the fabrication of bipolar photoelectric synaptic transistors and bolster new directions in the development of future integrated human ret-inotopic vision neuromorphic systems.

关键词： perovskite ionic Morse

前列腺素E1通过抑制内质网应激保护心肌梗死后大鼠的心脏

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中国病理生理杂志 2020年第6期36卷 1027-1033页

作者：饶兰兰马添翼中南大学湘雅医学院附属海口医院药学部海南海口570208 中南大学湘雅医学院附属海口医院心血管内科海南海口570208

目的:探讨前列腺素E1(PGE1)对心肌梗死(MI)后大鼠心脏的影响及相关分子机制。方法:将SPF级雄性SD大鼠分为假手术组、模型组和模型+PGE1组。通过结扎冠状动脉左前降支建立MI大鼠模型。通过超声心动图分析大鼠心功能变化;通过HE和Masson... 详细信息

目的:探讨前列腺素E1(PGE1)对心肌梗死(MI)后大鼠心脏的影响及相关分子机制。方法:将SPF级雄性SD大鼠分为假手术组、模型组和模型+PGE1组。通过结扎冠状动脉左前降支建立MI大鼠模型。通过超声心动图分析大鼠心功能变化;通过HE和Masson染色分析心肌组织形态学变化;通过TTC染色评估心肌梗死情况;通过TUNEL法检测心肌细胞死亡情况;通过免疫组化和Western blot检测内质网应激(ERS)相关因子葡萄糖调节蛋白78(GRP78)、C/EBP同源蛋白(CHOP)和caspase-12,以及凋亡相关因子Bcl-2、Bax和cleaved caspase-3的表达情况。结果:与假手术组比较,模型组大鼠心功能降低,心肌组织出现病理形态学改变,心肌梗死面积扩大,心肌细胞死亡增多,心肌组织中GRP78、CHOP、caspase-12、Bax和cleaved caspase-3的蛋白水平升高,Bcl-2表达降低(P<0. 01)。与模型组比较,模型+PGE1组大鼠心功能明显提高,心肌组织病理损伤明显减轻,心肌梗死的面积显著减小,心肌细胞死亡显著减少,心肌组织中GRP78、CHOP、caspase-12、Bax和cleaved caspase-3的蛋白水平降低,Bcl-2表达升高(P<0. 01)。结论:PGE1能通过降低ERS水平而减少胶原沉积、减轻炎症并提高心功能,从而保护心肌细胞免受MI的损伤。

关键词：前列腺素E1 心肌梗死内质网应激心室重构

Expression and clinical value of programmed cell death-ligand 1(PD-L1)in diffuse large B cell lymphoma:a retrospective study

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Chinese Journal of Cancer 2017年第12期36卷 767-777页

作者： Li-Yang Hu Xiao-Lu Xu Hui-lan rao Jie Chen Ren-Chun Lai Hui-Qiang Huang Wen-Qi Jiang Tong-Yu Lin Zhong-Jun Xia Qing-Qing Cai State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Medical Oncology The Fifth Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 519000GuangdongP.R.China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology Guangzhou 510120GuangdongP.R.China Department of Radiotherapy Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityGuangzhou 510120GuangdongP.R.China Department of Anesthesiology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Hematology Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Background: The programmed cell death-1(PD-1)/programmed cell death-ligand 1(PD-L1) pathway inhibits the activation of T cells and plays a crucial role in the negative regulation of cellular and humoral immune *** large B-cell lymphoma(DLBCL) is the most common lymphoid malignancy in adults. In the present study, we aimed to detect the expression of PD-L1 in DLBCL and to analyze its relationship with ***: We reviewed medical records of 204 newly diagnosed DLBCL patients in Sun Yat-sen University Cancer Center between October 2005 and August 2012. The expression of PD-L1 in tumor tissues from these 204 patients was detected using immunohistochemical(IHC) assay. The expression of anaplastic lymphoma kinase(ALK), CD5,CD30, and C-Myc in tumor specimens from 109 patients was detected using IHC, and Epstein-Barr virus(EBV)-encoded RNAs(EBERs) were detected using fluorescence in situ hybridization. The Spearman method was used for correlation analysis. The Kaplan-Meier method with log-rank test was used for univariate analysis. Cox proportional hazards model was used for multivariate ***: Of the 204 patients, 100(49.0%) were PD-L1-positive in tumor cells and 44(21.6%) were PD-L1-positive in tumor microenvironment. PD-L1 expression in tumor cells and tumor microenvironment were more common in the non-germinal center B-cell-like(GCB) subtype than in the GCB subtype(P = 0.02 and P= 0.04). Patients with PD-L1 expression in tumor microenvironment were more likely to be resistant to first-line chemotherapy when compared with the patients without PD-L1 expression in tumor microenvironment(P = 0.03). PD-L1 expression in tumor microenvironment was negatively correlated with C-Myc expression(r =-0.20, P = 0.04). No correlations were detected between PD-L1 expression and the expression of ALK, CD5, and CD30 as well as EBERs. The 5-year overall survival(OS)rates were 50.0% and 67.3% in patients with and without PD-L1 expression in tumor cells(P

关键词： Programmed cell death-ligand 1 (PD-L1) Diffuse large B-cell lymphoma C-Myc Prognosis

BRD2 induces drug resistance through activation of the RasGRP1/Ras/ERK signaling pathway in adult T-cell lymphoblastic lymphoma

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Cancer Communications 2020年第6期40卷 245-259页

作者： Xiao-Peng Tian Jun Cai Shu-Yun Ma Yu Fang Hui-Qiang Huang Tong-Yu Lin Hui-lan rao Mei Li Zhong-Jun Xia Tie-Bang Kang Dan Xie Qing-Qing Cai State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Hematology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China

Background:Adult patients with T-cell lymphoblastic lymphoma(T-LBL)are treated with high-intensity chemotherapy regimens,but the response rate is still unsatisfactory because of frequent drug *** aimed to investigate the potential mechanisms of drug resistance in adults with ***:Gene expression microarray was used to identify differential mRNA expression profiles between chemotherapy-resistant and chemotherapy-sensitive adult T-LBL ***-time PCR and immunohistochemistry were performed to detect the expression of bromodomain-containing protein 2(BRD2)and c-Myc in fresh-frozen T-LBL tissues from 85 adult *** Ras pull-down assay was performed to monitor Ras *** immunoprecipitation assays were used to analyze the binding of E2F transcription factor 1(E2F1)/BRD2 to the RAS guanyl releasing protein 1(RasGRP1)promoter *** drug resistance effect and mechanism of BRD2 were determined by both in vivo and in vitro ***:A total of 86 chemotherapy resistance-related genes in adult T-LBL were identified by gene expression *** them,BRD2 was upregulated in chemotherapy-resistant adult T-LBL tissues and associated with worse progressionfree survival and overall survival of 85 adult T-LBL ***,BRD2 suppressed doxorubicin(Dox)-induced cell apoptosis both in vitro and in *** activation of RasGRP1/Ras/ERK signaling might contribute to the Dox resistance effect of ***,OTX015,a bromodomain and extra-terminal(BET)inhibitor,reversed the Dox resistance effect of ***-derived tumor xenograft demonstrated that the sequential use of OTX015 after Dox showed superior therapeutic ***:Our data showed that BRD2 promotes drug resistance in adult T-LBL through the RasGRP1/Ras/ERK signaling *** BRD2 may be a novel strategy to improve the therapeutic efficacy and prolong survival of adults with TLBL.

关键词： T-cell Lymphoblastic Lymphoma drug resistance BRD2 MEK ERK c-Myc RasGRP1 doxorubicin OTX015 sequential treatment simultaneous treatment

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玉树地震建筑震害启示

工业安全与环保 2011年第8期37卷 24-25页

作者：饶兰王磊开封大学土木建筑工程学院河南开封475004

近年在汶川、海地、智利、玉树、日本等地发生的大地震,无不说明当前全球正处于地震多发活跃期。中国处于太平洋与欧亚板块交界处,属于发生大地震频繁的区域。在汶川地震后,中国建筑抗震形势严峻。玉树地震再次凸显加强我国建筑抗震在... 详细信息

近年在汶川、海地、智利、玉树、日本等地发生的大地震,无不说明当前全球正处于地震多发活跃期。中国处于太平洋与欧亚板块交界处,属于发生大地震频繁的区域。在汶川地震后,中国建筑抗震形势严峻。玉树地震再次凸显加强我国建筑抗震在未来建筑发展中的重要性和必要性。

关键词：玉树地震建筑震害防震

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一种针对新闻话题的多文档文摘技术

中文信息学报 2012年第6期26卷 79-84页

作者：岳大鹏饶岚王挺国防科技大学计算机学院湖南长沙410073 国防科技大学人文与社会科学院湖南长沙410073

多文档文摘技术能帮助用户减少不必要的阅读时间,有广阔的应用前景。该文以新闻报道为处理对象,以MMR(Maximal Marginal Relevance)文摘提取算法为基础,针对目前新闻报道往往以专题形式组织展现的特点,提出了一种基于话题的多文档文摘... 详细信息

多文档文摘技术能帮助用户减少不必要的阅读时间,有广阔的应用前景。该文以新闻报道为处理对象,以MMR(Maximal Marginal Relevance)文摘提取算法为基础,针对目前新闻报道往往以专题形式组织展现的特点,提出了一种基于话题的多文档文摘方法。这种方法以话题关键字为打分依据,同时考虑句子位置特征等信息对句子的重要性进行评分。该文利用TDT4的新闻报道语料对上述文摘方法进行了试验评价,将基于话题的文摘系统和两个Baseline文摘系统进行比较,取得了较好的实验结果,尤其在5%的压缩比例下有明显优势。

关键词：自动文摘话题自然语言处理新闻

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奥运场馆的建筑防水

涂料工业 2009年第2期39卷 70-72页

作者：曾佳王磊饶兰开封大学土木建筑工程学院河南开封475000

分析了2008北京奥运场馆建筑防水工程的有关技术,总结了奥运场馆防水工程建设的特点。

关键词：奥运场馆建筑防水

竹炭基固体磺酸催化剂的制备及其催化合成癸二酸二丁酯性能研究

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石油炼制与化工 2014年第5期45卷 66-71页

作者：饶兰杨琴蒋文伟四川大学化工学院成都610065 成都惠恩精细化工有限责任公司

以竹材为原料、氯磺酸为磺化剂,通过炭化-磺化法制备竹炭基固体磺酸催化剂,采用傅里叶红外光谱(FT-IR)、X射线衍射(XRD)、扫描电子显微镜仪(SEM)及热失重分析(TGA)等手段对催化剂进行表征,并将其用于催化癸二酸与正丁醇的酯化反应,考察... 详细信息

以竹材为原料、氯磺酸为磺化剂,通过炭化-磺化法制备竹炭基固体磺酸催化剂,采用傅里叶红外光谱(FT-IR)、X射线衍射(XRD)、扫描电子显微镜仪(SEM)及热失重分析(TGA)等手段对催化剂进行表征,并将其用于催化癸二酸与正丁醇的酯化反应,考察制备条件对催化剂活性的影响。结果表明:竹炭基固体磺酸催化剂具有无定形炭结构,其热稳定性良好;合成催化剂的最佳条件为炭化温度325℃、炭化时间1h、氯磺酸与竹炭配比2.5mL/g、室温下磺化2h,在此条件下制得的催化剂含酸量可达到1.77mmol/g;在正丁醇与癸二酸摩尔比为3.0、反应时间为100min、竹炭基固体磺酸催化剂用量为癸二酸质量的2.0%、环己烷用量为3mL的条件下,癸二酸转化率达99.14%,重复使用4次后,癸二酸转化率仍可保持在80%以上,说明催化剂性能稳定,具有良好的循环使用性能。

关键词：竹炭炭基固体磺酸催化剂癸二酸正丁醇酯化反应

饱和吸收体恢复时间对正交偏振耗散孤子的影响

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中国光学（中英文） 2024年第3期17卷 714-723页

作者：何晓颖张川张银东饶岚北京邮电大学电子工程学院天地互联与融合北京市重点实验室北京100876

偏振在脉冲锁模时,对其塑形和稳定起着至关重要的作用。本研究开发了一种用于产生正交偏振耗散孤子的被动锁模石墨烯光纤激光器的正交偏振数值模拟。重点是分析由偏振依赖的石墨烯微光纤饱和吸收体引起的净正常色散双折射腔对正交偏振... 详细信息

偏振在脉冲锁模时,对其塑形和稳定起着至关重要的作用。本研究开发了一种用于产生正交偏振耗散孤子的被动锁模石墨烯光纤激光器的正交偏振数值模拟。重点是分析由偏振依赖的石墨烯微光纤饱和吸收体引起的净正常色散双折射腔对正交偏振孤子的影响。研究结果表明,这种饱和吸收体的恢复时间显著影响正交偏振耗散脉冲的特性,如能量、脉宽、时间带宽乘积和啁啾。结果显示,其恢复时间为120飞秒时最佳,产生两个具有大啁啾的正交偏振的窄耗散孤子脉冲,分别约为7.47 ps和8.06 ps。这对于开发紧凑、高功率、偏振耗散孤子光纤激光系统具有重要意义。

关键词：正交偏振光被动锁模净正常色散腔恢复时间

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