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WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling

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International Journal of Oral Science 2024年第1期16卷 85-96页

作者： Qingling huang Yi Xiao Ting lan Youguang Lu Li huang Dali Zheng Department of Biochemistry and Molecular Biology School of Basic Medical SciencesFujian Medical UniversityFuzhouChina Fujian Key Laboratory of Oral Diseases School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Preventive Dentistry School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Dentistry The First Affiliated Hospital of Fujian Medical UniversityFuzhouChina

Wnt signaling are critical pathway involved in organ development, tumorigenesis, and cancer progression. WNT7A, a member of the Wnt family, remains poorly understood in terms of its role and the underlying molecular mechanisms it entails in head and neck squamous cell carcinoma (HNSCC). According to the Cancer Genome Atlas (TCGA), transcriptome sequencing data of HNSCC, the expression level of WNT7A in tumors was found to be higher than in adjacent normal tissues, which was validated using Real-time RT-PCR and immunohistochemistry. Unexpectedly, overexpression of WNT7A did not activate the canonical Wnt-β-catenin pathway in HNSCC. Instead, our findings suggested that WNT7A potentially activated the FZD7/JAK1/STAT3 signaling pathway, leading to enhanced cell proliferation, self-renewal, and resistance to apoptosis. Furthermore, in a patient-derived xenograft (PDX) tumor model, high expression of WNT7A and phosphorylated STAT3 was observed, which positively correlated with tumor *** findings underscore the significance of WNT7A in HNSCC progression and propose the targeting of key molecules within the FZD7/JAK1/STAT3 pathway as a promising strategy for precise treatment of HNSCC.

关键词： WNT squamous tumorigenesis

rtcisE2F promotes the self-renewal and metastasis of liver tumorinitiating cells via N^(6)-methyladenosine-dependent E2F3/E2F6 mRNA stability

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Science China(Life Sciences) 2022年第9期65卷 1840-1854页

作者： Zhenzhen Chen lan huang Kaili Wang Lulu Zhang Xiang Zhong Zhongyi Yan Benyu Liu Pingping Zhu School of Life Sciences Zhengzhou UniversityZhengzhou 450001China Biotherapy Center the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China School of Basic Medical Sciences Henan UniversityKaifeng 475004China Research Center of Basic Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China State Key Laboratory of Esophageal Cancer Prevention&Treatment Zhengzhou UniversityZhengzhou 450052China

Liver cancer is highly heterogeneous,and the tumor tissue harbors a variety of cell *** tumor initiating cells(TICs)well contribute to tumor heterogeneity and account for tumor initiation and metastasis,but the molecular mechanisms of liver TIC self-renewal are ***,we identified a functional read-through rt-circRNA,termed rtcisE2F,that is highly expressed in liver cancer and liver ***2F plays essential roles in the self-renewal and activities of liver ***2F targets E2F6 and E2F3 mRNAs,attenuates mRNA turnover,and increases E2F6/E2F3 ***,rtcisE2F functions as a scaffold of N^(6)-methyladenosine(m^(6)A)reader IGF2BP2 and E2F6/E2F3 ***2F promotes the association of E2F6/E2F3 mRNAs with IGF2BP2,and inhibits their association with another m^(6)A reader,***2BP2 inhibits E2F6/E2F3 mRNA decay,whereas YTHDF2 promotes E2F6/E2F3 mRNA *** switching m^(6)A readers,rtcisE2F enhances E2F6/E2F3 mRNA stability.E2F6 and E2F3 are both required for liver TIC self-renewal and Wnt/β-catenin activation,and inhibition of these pathways is a potential strategy for preventing liver tumorigenesis and *** conclusion,the rtcisE2F-IGF2BP2/YTHDF2-E2F6/E2F3-Wnt/β-catenin axis drives liver TIC self-renewal and initiates liver tumorigenesis and metastasis,and may provide a strategy to eliminate liver TICs.

关键词： circular RNA tumor-initiating cells self-renewal metastasis N^(6)-methyladenosine

Microwave Through Wall Imaging via An Induced Current Learning Method

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Journal of Beijing Institute of Technology 2024年第3期33卷 248-254页

作者： Pengjin lan Jianguo huang Tianyi Zhou Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingbo 315211China

In this paper,an induced current learning method(ICLM)for microwave through wall imaging(TWI),named as TWI-ICLM,is *** the inversion of induced current,the unknown object along with the enclosed walls are treated as a combination of ***,a non-iterative method called distorted-Born backpropagation(DB-BP)is utilized to generate the initial *** the training stage,several convolutional neural networks(CNNs)are cascaded to improve the estimated induced *** addition,a hybrid loss function consisting of the induced current error and the permittivity error is used to optimize the network ***,the relative permittivity images are conducted analytically using the predicted current based on *** the numerical and experimental TWI tests prove that,the proposed method can achieve better imaging accuracy compared to traditional distorted-Born iterative method(DBIM).

关键词： through wall imaging inverse scattering problem convolutional neural network(CNN)

SPP-extractor:Automatic phenotype extraction for densely grown soybean plants

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作物学报:英文版 2023年第5期11卷 1569-1578页

作者： Wan Zhou Yijie Chen Weihao Li Cong Zhang Yajun Xiong Wei Zhan lan huang Jun Wang Lijuan Qiu College of Computer Science Yangtze UniversityJingzhou 434023HubeiChina College of Agriculture Yangtze UniversityJingzhou 434025HubeiChina National Key Facility for Gene Resources and Genetic Improvement/Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China MARA Key Laboratory of Sustainable Crop Production in the Middle Reaches of the Yangtze River(Co-construction by Ministry and Province) College of AgricultureYangtze UniversityJingzhou 434025HubeiChina

Automatic collecting of phenotypic information from plants has become a trend in breeding and smart *** mature soybean plants at the harvesting stage,which are dense and overlapping,we have proposed the SPP-extractor(soybean plant phenotype extractor)algorithm to acquire phenotypic ***,to address the mutual occultation of pods,we augmented the standard YOLOv5s model for target detection with an additional attention *** resulting model could accurately identify pods and stems and could count the entire pod set of a plant in a single ***,considering that mature branches are usually bent and covered with pods,we designed a branch recognition and measurement module combining image processing,target detection,semantic segmentation,and heuristic *** results on real plants showed that SPP-extractor achieved respective R^(2) scores of 0.93–0.99 for four phenotypic traits,based on regression on manual measurements.

关键词： Soybean phenotype Branch length Computer vision A*algorithm Phenotype acquisition

Quantifying Solid Solution Strengthening in Nickel-Based Superalloys via High-Throughput Experiment and Machine Learning

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Computer Modeling in Engineering & Sciences 2023年第5期135卷 1521-1538页

作者： Zihang Li Zexin Wang Zi Wang Zijun Qin Feng Liu Liming Tan Xiaochao Jin Xueling Fan lan huang State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083China AECC Commercial Aircraft Engine Co. Ltd.Shanghai200241China State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi’an710049China

Solid solution strengthening(SSS)is one of the main contributions to the desired tensile properties of nickel-based superalloys for turbine blades and *** value of SSS can be calculated by using Fleischer’s and Labusch’s theories,while the model parameters are incorporated without fitting to experimental data of complex *** thiswork,four diffusionmultiples consisting of multicomponent alloys and pure Niare prepared and *** composition and microhardness of singleγphase regions in samples are used to quantify the ***,Fleischer’s and Labusch’s theories are examined based on high-throughput experiments,*** fitted solid solution coefficients are obtained based on Labusch’s theory and experimental data,indicating higher ***,six machine learning algorithms are established,providing a more accurate prediction compared with traditional physical models and fitted physical *** results show that the coupling of highthroughput experiments and machine learning has great potential in the field of performance prediction and alloy design.

关键词： Multicomponent diffusion multiples solid solution strengthening strengthening models machine learning

Prof. Huan-Yong Chen： a leading botanist and taxonomist, one of the pioneers and founders of modern plant taxonomy in China

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Protein & Cell 2016年第11期7卷 773-776页

作者： Rui-lan huang South China Botanical Garden Chinese Academy of Sciences Guangzhou 510650 China

Prof. Huan-Yong Chen （Woon-Young Chun, 陈焕镛, 1890- 1971）, a leading botanist and taxonomist （Fig. 1）, who started a new era for the modern plant science in China and made a great contribution to the plant taxonomy, botany and horticulture of China, especially in Southern China. He was one of the first academicians of the Chinese Academy of Sciences （CAS）, a member of the first, second and third China＇s National People＇s Congress （NPC）, one of the first editors of Flora of Republicae Popularis Sinicae （FRPS,

关键词： South China Botanical Garden (SCBG) Chinese Botanists Flora Republicae Popularis Sinicae Identifying Plant Specimens Honorary Vice-President

Financial Knowledge,Capability to Guard Against Risks,and Rural Households’Selection of Financial Assets:An Empirical Study Based on Rural Households in China

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Contemporary Social Sciences 2022年第2期7卷 1-24页

作者： Wang Yang huang lan School of Statistics Chengdu University of Information Technology

Based on rural household data collected in two rounds of the China Household Finance Survey(CHFS)in 2015 and 2017,respectively,this paper presents the likely impact of financial literacy and capability against risks on the breadth and depth of participation by rural households in risky financial *** instrumental variables are used to solve endogenous problems,we find that a good command of financial knowledge and a higher risk management level could significantly increase the probability and proportion of rural households investing in risky financial assets.A mechanism analysis further reveals that financial knowledge motivates rural households to engage in financial investments by helping them evaluate their capability to guard against *** multiple dimensions of indicators are employed to measure financial knowledge,the estimated results remain *** view of this,we have put forward some policy suggestions to increase the property income of rural households and promote the rural financial market.

关键词： rural households financial knowledge risk management financial assets

Radiomics in the diagnosis and treatment of hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 346-351页

作者： Chun Jiang Yi-Qi Cai Jia-Jia Yang Can-Yu Ma Jia-Xi Chen lan huang Ze Xiang Jian Wu Department of Clinical Laboratory The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China Zhejiang University School of Medicine Hangzhou 310030China Department of Infection Management The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China

Hepatocellular carcinoma(HCC)is a common malignant *** present,early diagnosis of HCC is dif-ficult and therapeutic methods are *** can achieve accurate quantitative evaluation of the lesions without invasion,and has important value in the diagnosis and treatment of *** fea-tures can predict the development of cancer in patients,serve as the basis for risk stratification of HCC patients,and help clinicians distinguish similar diseases,thus improving the diagnostic ***-more,the prediction of the treatment outcomes helps determine the treatment *** is also helpful in predicting the HCC recurrence,disease-free survival and overall *** review summa-rized the role of radiomics in the diagnosis,treatment and prognosis of HCC.

关键词： Hepatocellular carcinoma Radiomics Diagnosis Prognosis Treatment

Cyclic Pulsating Pressure Enhanced Segregating Structuration of Ultra-High Molecular Weight Polyethylene/Graphene Composites as High-performance Light-Weight EMI Shields

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Chinese Journal of Polymer Science 2024年第7期42卷 958-967,I0008页

作者： Yun-Zhi huang Xiao-Xiao Liu lan-Wei Li Guang-Ming huang Zhao-Xia huang Jin-Ping Qu National Engineering Research Center of Novel Equipment for Polymer Processing Key Laboratory of Polymer Processing EngineeringMinistry of EducationGuangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced ManufacturingSchool of Mechanical and Automotive EngineeringSouth China University of TechnologyGuangzhou 510641China School of Advanced Manufacturing Technology Guangdong Mechanical&Electrical PolytechnicGuangzhou 510550China

Currently,the enhancement in electromagnetic interference(EMI)performance of polymeric composite generally relies on either improving electrical conductivity(σ)for stronger electromagnetic(EM)reflections or tailoring structure for higher EM ***,we proposed a novel technique called cyclic pulsating pressure enhanced segregating structuration(CPP-SS),which can reinforce these two factors *** structural information was supplied by optical microscopy(OM)and scanning electron microscopy(SEM),both of which confirmed the formation and evolution of segregate structured ultra-high molecular weight polyethylene(UHMWPE)/graphene ***,the result showed that CPP-SS can significantly improve theσof ***,advanced specific EMI shielding efficiency of 31.1 d B/mm was achieved for UHMWPE/graphene composite at 1-mm thickness and a low graphene loading of 5 wt%.Meanwhile,it also confirmed that the intrinsic disadvantage of poor mechanical properties of conventional segregated structure composites can be *** work is believed to provide a fundamental understanding of the structural and performance evolutions of segregated structured composites prepared under CPPSS,and to bring us a simple and efficient approach for fabricating high-performance,strong and light-weight polymeric EMI shields.

关键词： Cyclic pulsating pressure Segregated structure Ultra-high molecular weight polyethylene Graphene Electromagnetic interface