检索结果-南通市图书馆

Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection

Nano Research 2023年第7期16卷 9752-9759页

作者： Yuxing Jiang Hongtao Rong Yifan Wang Shange Liu Peng Xu Zhen Luo lamei guo Tao Zhu(✉) Hongpan Rong Dingsheng Wang Jiatao Zhang Yu Yi Hao Wang Tianjin Medical University General Hospital Tianjin 300052China CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and TechnologyBeijing 100190China Beijing Key Laboratory of Construction-Tailorable Advanced Functional Materials and Green Applications Key Laboratory of Medical Molecule Science and Pharmaceutics EngineeringMinistry of Industry and Information TechnologySchool of Materials Science&EngineeringSchool of Chemistry and Chemical EngineeringInstitute of Engineering MedicineBeijing Institute of TechnologyBeijing 100081China Department of Chemistry Tsinghua UniversityBeijing 100084China University of Chinese Academy of Sciences Beijing 100049China

Oxidative stress and inflammation are central pathophysiological processes in a traumatic spinal cord injury(SCI).Antioxidant therapies that reduce the reactive oxygen and nitrogen species(RONS)overgeneration and inflammation are proved promising for improving the outcomes.However,efficient and long-lasting antioxidant therapy to eliminate multiple RONS with effective neuroprotection remains challenging.Here,a single-atom cobalt nanozyme(Co-SAzyme)with a hollow structure was reported to reduce the RONS and inflammation in the secondary injury of SCI.Among SAzymes featuring different single metal-N sites(e.g.,Mn,Fe,Co,Ni,and Cu),this Co-SAzyme showed a versatile property to eliminate hydrogen peroxide(H_(2)O_(2)),superoxide anion(O_(2)·^(-)),hydroxyl radical(·OH),nitric oxide(·NO),and peroxynitrite(ONOO^(-))that overexpressed in the early stage of SCI.The porous hollow structure also allowed the encapsulation and sustained release of minocycline for neuroprotection in synergy.In vitro results showed that the Co-SAzyme reduced the apoptosis and pro-inflammatory cytokine levels of microglial cells under oxidative stress.In addition,the Co-SAzyme combined with minocycline achieved remarkable improved functional recovery and neural repairs in the SCI-rat model.

关键词： single-atom catalysis spinal cord injury reactive oxygen and nitrogen species anti-inflammation neuroprotection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frequency reconfigurable antenna actuated by inflated triangular structure:Design and analysis

引用

Chinese Journal of Aeronautics 2023年第5期36卷 280-285页

作者： Jiaming guo Xinghan QIU Jiawei ZHANG lamei ZHANG Changguo WANG School of Astronautics Harbin Institute of TechnologyHarbin 150001China National Key Laboratory of Science and Technology on Advanced Composites in Special Environments Harbin 150001China School of Electronics and Information Engineering Harbin Institute of TechnologyHarbin 150001China

This paper proposes a frequency reconfigurable triangular antenna actuated by an inflated triangular structure.The open path antenna is transformed from an open type to a closed structure by inflating.Inflatable structures are easy to manufacture by fusing 2 inextensible membranes together along a defined pattern of lines.However,the prediction of their deployed shape remains a challenge.To solve the pattern changed problem,guided by geometric analyses and local buckle characteristics,the inflated triangular structure has been designed and verified by experiment and simulation.In the process of transformation of the antenna,the resonant frequency of the antenna is changed because this frequency is determined by the conformational change.The resonant frequency changes from GHz to kHz when the design of initial structure sizes is from millimeter to meter.The measured peak gains,the frequency,and the radiation direction are also reconfigurable by the initial size.Finally,the reconfigurable resonator array is presented,which is coupled to electric fields to absorb all incident radiation.In this work,the changed pattern design by inflating is applied to the antenna design,and its frequency reconfigurability is achieved.Through the electricity performance analysis of the reconfigurable antenna,precise manufacturing will be possible and provide guidance for manufacturing frequency reconfigurable antennas.

关键词： Free kink design Frequency Reconfigurable Antenna(FRA) Inflated Return losses Thin film

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

产毒和非产毒拟柱孢藻的磷吸收转运通路基因比较及对低磷的响应表达特征分析

引用

植物生理学报 2024年第4期60卷 673-684页

作者：赖淑燕陈志江刘威陈子寒雷腊梅郭佳暨南大学生态学系广州510000

拥有完整的磷吸收转运通路基因(Pho调节子)是蓝藻适应环境磷波动的分子基础,目前对这些基因在拟柱孢藻(Cylindrospermopsis raciborskii)中的响应表达特征还知之甚少。本研究在拟柱孢藻非产毒株N8前期工作的基础上,分析产拟柱孢藻毒素(c... 详细信息

拥有完整的磷吸收转运通路基因(Pho调节子)是蓝藻适应环境磷波动的分子基础,目前对这些基因在拟柱孢藻(Cylindrospermopsis raciborskii)中的响应表达特征还知之甚少。本研究在拟柱孢藻非产毒株N8前期工作的基础上,分析产拟柱孢藻毒素(cylindrospermopsin, CYN)藻株QDH7中Pho调节子基因的组成,并比较两藻株在高磷和低磷下的生长、碱性磷酸酶(alkaline phosphatase, ALP)活性及8个Pho调节子基因的时序表达。结果表明, QDH7和N8的Pho调节子基因均很完整,主要在排列和少数基因的拷贝数上存在差异。低磷下两藻株的生长都受到明显抑制, ALP活性在第14~18天显著升高,而产毒和非产毒藻株在相同磷浓度下的生长趋势基本一致。基因的时序表达分析表明,低磷下两藻株的双组份系统基因phoB和phoR在第4~6天和第14~16天有显著的表达升高,而2个高亲和力无机磷结合蛋白基因中仅pstS1的表达显著升高, 2个ALP基因中phoA1的表达与酶活性的增加基本同步,表明pstS1和phoA1基因在对低磷的响应中起主要作用;低亲和力无机磷转运系统pit在低磷处理第16~18天的表达上调可能是QDH7和N8极度缺磷状态的指示。我们发现低磷下产毒株QDH7有6个基因的最高相对表达量高于非产毒株N8,这种差异在磷不足的环境中可能会影响共存于自然水体中的2种基因型藻株对磷的竞争和相对优势的形成。

关键词：拟柱孢藻产毒和非产毒株磷吸收转运通路基因碱性磷酸酶基因表达

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ultrastretchable and wearable conductive multifilament enabled by buckled polypyrrole structure in parallel

引用

npj Flexible Electronics 2022年第1期6卷 419-429页

作者： Yimeng Li Yaya Gao Lizhen Lan Qian Zhang Leqian Wei Mengqi Shan lamei guo Fujun Wang Jifu Mao Ze Zhang Lu Wang Key Laboratory of Textile Science&Technology of Ministry of Education and College of Textiles Donghua UniversityShanghai 201620China Key Laboratory of Textile Industry for Biomedical Textile Materials and Technology Donghua UniversityShanghai 201620China Département de chirurgie Facultéde médecineUniversitéLavalAxe médecine régénératriceCentre de recherche du CHU de Québec-UniversitéLavalQuébec(QC)G1V 0A6Canada

Stretchable conductive fibers have attracted much attention due to their potential use in wearable electronics.However,the ultrahigh strain insensitive conductivity is hindered by mechanical mismatch in Young’s modulus and failure of stretchable structures under large deformation.This challenge is addressed with a conductive and elastic multifilament made of the polyurethane monofilaments that are surface-coated with buckled polypyrrole(PPy)of which flexibility is improved by sodium sulfosalicylate.Such parallel conductive monofilaments with PPy buckling on surface reduce the influence of cracks in the conductive coating on the overall conductivity,displaying an ultra-high strain insensitive behavior(quality factor Q=10.9).Remarkably,various complex forms of wearable electronic textiles made by this conductive multifilament maintain the strain-insensitive behavior of the original multifilament,even upon the large deformation of human joint.This multifilament with wrinkled PPy has attractive advantages in the application of super-stretched wearable electronic devices.

关键词： conductive polypyrrole conductivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

长期不同施肥模式对大麦–双季稻田根际土壤有机氮组分的影响

引用

土壤 2024年第2期56卷 273-280页

作者：郭勇文丽石丽红张腊梅程凯凯李超郑华斌唐海明湖南农业大学农学院长沙410128 湖南省土壤肥料研究所长沙410125 宁乡市农业农村局湖南宁乡410600

根际土壤有机氮组分在土壤养分和作物氮素营养中具有重要作用。本研究依托长期(37年)定位施肥试验田,设置4个施肥处理:不施肥对照(CK)、单独施用化肥(CF)、秸秆还田+化肥(RF)和30%有机肥+70%化肥(OM),于晚稻成熟期测定大麦–双季稻田根... 详细信息

根际土壤有机氮组分在土壤养分和作物氮素营养中具有重要作用。本研究依托长期(37年)定位施肥试验田,设置4个施肥处理:不施肥对照(CK)、单独施用化肥(CF)、秸秆还田+化肥(RF)和30%有机肥+70%化肥(OM),于晚稻成熟期测定大麦–双季稻田根际土壤基础理化性质、微生物生物量氮和有机氮组分(氨基酸态氮、氨基糖态氮、酸解氨态氮、酸解未知态氮、非酸解性氮)含量。研究表明:相对CK处理,RF和OM处理显著增加了稻田根际土壤有机碳、全氮、铵态氮和硝态氮的含量。RF和OM处理土壤微生物生物量氮含量分别比CK处理增加了19.8%和30.7%。酸解性氮作为根际土壤全氮的主体部分,占全氮的59.61%~72.06%;各处理根际土壤酸解性氮含量大小顺序表现为OM>RF>CF>CK。各施肥处理中,酸解有机氮中的氨基糖态氮、氨基酸态氮和酸解未知态氮含量均以OM处理最大,分别比CK处理增加139.3%、47.9%和110.0%;酸解氨态氮以RF处理最大,比CK处理增加69.9%。土壤有机碳、全氮、铵态氮、硝态氮与土壤氨基酸态氮、氨基糖态氮、酸解未知态氮以及微生物生物量氮均呈极显著(P<0.01)正相关。因此,秸秆、有机肥配施化肥均能有效提高大麦–双季稻田根际土壤的供氮能力,是改善稻田土壤肥力的有效手段。

关键词：长期施肥双季稻根际土壤有机氮组分酸解性氮

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

KRAS mutation:from undruggable to druggable in cancer

引用

Signal Transduction and Targeted Therapy 2021年第12期6卷 3466-3485页

作者： lamei Huang Zhixing guo Fang Wang Liwu Fu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteSun Yat-Sen University Cancer CenterGuangzhou 510060P.R.China

Cancer is the leading cause of death worldwide,and its treatment and outcomes have been dramatically revolutionised by targeted therapies.As the most frequently mutated oncogene,Kirsten rat sarcoma viral oncogene homologue(KRAS)has attracted substantial attention.The understanding of KRAS is constantly being updated by numerous studies on KRAS in the initiation and progression of cancer diseases.However,KRAS has been deemed a challenging therapeutic target,even“undruggable”,after drugtargeting efforts over the past four decades.Recently,there have been surprising advances in directly targeted drugs for KRAS,especially in KRAS(G12C)inhibitors,such as AMG510(sotorasib)and MRTX849(adagrasib),which have obtained encouraging results in clinical trials.Excitingly,AMG510 was the first drug-targeting KRAS(G12C)to be approved for clinical use this year.This review summarises the most recent understanding of fundamental aspects of KRAS,the relationship between the KRAS mutations and tumour immune evasion,and new progress in targeting KRAS,particularly KRAS(G12C).Moreover,the possible mechanisms of resistance to KRAS(G12C)inhibitors and possible combination therapies are summarised,with a view to providing the best regimen for individualised treatment with KRAS(G12C)inhibitors and achieving truly precise treatment.

关键词： KRAS precise truly

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomic insights into the origin, adaptive evolution, and herbicide resistance of Leptochloa chinensis, a devastating tetraploid weedy grass in rice fields

引用

Molecular Plant 2022年第6期15卷 1045-1058页

作者： Lifeng Wang Xuepeng Sun Yajun Peng Ke Chen Shan Wu Yanan guo Jingyuan Zhang Haona Yang Tao Jin lamei Wu Xiaomao Zhou Bin Liang Zhenghong Zhao Ducai Liu Zhangjun Fei Lianyang Bai State Key Laboratory of Hybrid Rice Hunan Academy of Agricultural SciencesChangsha 410125China Hunan Weed Science Key Laboratory Hunan Academy of Agricultural SciencesChangsha 410125China Boyce Thompson Institute Cornell UniversityIthacaNY 14853USA College of Horticulture Science Zhejiang A&F UniversityHangzhou 311300China Qingdao Kingagroot Compounds Co.Ltd Qingdao 266000China USDA-ARS Robert W.Holley Center for Agriculture and HealthIthacaNY 14853USA

Chinese sprangletop (Leptochloa chinensis), belonging to the grass subfamily Chloridoideae, is one of the most notorious weeds in rice ecosystems. Here, we report a chromosome-scale reference genome assembly and a genomic variation map of the tetraploid L. chinensis. The L. chinensis genome is derived from two diploid progenitors that diverged ∼10.9 million years ago, and its two subgenomes display neither fractionation bias nor overall gene expression dominance. Comparative genomic analyses reveal substantial genome rearrangements in L. chinensis after its divergence from the common ancestor of Chloridoideae and, together with transcriptome profiling, demonstrate the important contribution of tetraploidization to the gene sources for the herbicide resistance of L. chinensis. Population genomic analyses of 89 accessions from China reveal that L. chinensis accessions collected from southern/southwestern provinces have substantially higher nucleotide diversity than those from the middle and lower reaches of the Yangtze River, suggesting that L. chinensis spread in China from the southern/southwestern provinces to the middle and lower reaches of the Yangtze River. During this spread, L. chinensis developed significantly increased herbicide resistance, accompanied by the selection of numerous genes involved in herbicide resistance. Taken together, our study generated valuable genomic resources for future fundamental research and agricultural management of L. chinensis, and provides significant new insights into the herbicide resistance as well as the origin and adaptive evolution of L. chinensis.

关键词： Leptochloa weed sgenome polyploidization genome evolution genetic diversity adaptive selection herbicide resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Magnetization Reversal for Ni Nanowires Studied by Micromagnetic Simulations

引用

Journal of Materials Science & Technology 2009年第2期25卷 151-154页

作者： Nianmei Hen Guanghua guo lamei Zhang Guangfu Zhang Wenbin Song School of Physics Science and Technology Central South University Changsha 410083 China State Key Laboratory for Powder Metallurgy Central South University Changsha 410083 China

The magnetization reversal mechanisms for Ni nanowires with different diameters were investigated by micromagnetic simulations. The results show that the reversal mechanisms are significantly dependeht on the diameter of wire. For very thin wires, the reversal occurs by pseudo-coherent rotation. With increasing diameter, magnetization reversal takes place via different nucleation （the transverse domain wall and the vortex domain wall） and subsequent propagation. The reason of transition from the transverse domain wall to the vortex domain wall is given by analytical studies. With further increase of the diameter, the reversal nuclear domain wall becomes tundishoshaped form. As the diameter increases, the width of wall becomes larger.

关键词： Nanowire Micromagnetics Magnetization reversal mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genetic Analysis of FBXO2, FBXO6, FBXO12, and FBXO41 Variants in Han Chinese Patients with Sporadic Parkinson's Disease

引用

Neuroscience Bulletin 2017年第5期33卷 510-514页

作者： lamei Yuan Zhi Song Xiong Deng Zhijian Yang Yan Yang Yi guo Hongwei Lu Hao Deng Center for Experimental Medicine The Third Xiangya Hospital Central South University Changsha 410013 China Department of Neurology The Third Xiangya HospitalCentral South University Changsha 410013 China Department of Medical Information Information Security and Big Data Research Institute Central South UniversityChangsha 410013 China

Parkinson＇s disease （PD） is the second most common neurodegenerative disorder and has an elusive etiology. It is likely multifactorial, and genetic defects contribute to its pathogenesis. At least 25 genetic loci and 20 monogenic genes have been identified in monogenic PD. Recessive F-box protein 7 gene （FBX07） mutations reportedly cause hereditary parkinsonism. To explore the roles of four paralogs （FBX02, FBX06, FBX012, and FBX041） in PD development, their variants （rs9614, rs28924120, rs6442117, and rs61733550, respectively） were analyzed in 502 Han Chinese patients with PD and 556 age, gender, and ethnicity-matched normal participants in China's Mainland. Statistically significant differences in genotypic and allelic frequencies were detected only in the FBX02 variant rs9614 （P = 0.001 and 0.023, respectively; odds ratio 0.819, 95% confidence interval 0.690-0.973） between patients and controls. These results suggest that the FBX02 variant rs9614 C allele may decrease the PD risk in mainland Han Chinese and may be a biomarker for PD.

关键词： Parkinson＇s disease· FBX02 · FBX06.FBXO12 · FBX041· Variant

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fabrication of High Nano-ZnO Assembled Cotton Fabric with UV Blocking Property

引用

Journal of Wuhan University of Technology(Materials Science) 2018年第6期33卷 1376-1380页

作者：凌超郭腊梅 College of Textiles Donghua University Key Laboratory of Textile Science and Technology Ministry of Education Donghua University

In order to fabricate a novel ZnO/cotton composite, a high proportion of ZnO nanoparticles were assembled in cotton fibers, and the as-obtained cotton fabric can possess better UV blocking property compared with common ZnO/cotton composite. Firstly, the cotton fibers were pre-treated by hydrogen peroxide solution（H;O;） and sodium hydroxide（NaOH）, urea（CON;H;）. Secondly, the fabric was fabricated via in situ deposition. The effects of concentration of treatment liquid, ammonia-smoking time and curing temperature on the tensile property of the fabric, UV blocking property and water-washing durability test of as-obtained cotton fabrics were investigated. Thirdly, the as-obtained cotton sample was characterized by X-ray diffraction（XRD） and field emission scanning electron microscopy（FESEM）. It was shown that ZnO nanoparticles were assembled between cotton fibers, the surface and inside of the lumen and the mesopores of cotton fibers, while the content of nano-ZnO assembled in fabric can reach 15.63 wt%. It is proved that the finished fabric can obtain a very excellent UV blocking property, under the condition of zinc ion in concentration of 15 wt%, ammonia-smoking time for 10 min, curing temperature at 150 ℃ for 2 min.

关键词： high-assembled ZnO cotton fabric UV blocking washing durability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：