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Neuroretinal dysfunction in patients affected by neurofibromatosis type 1

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International Journal of Ophthalmology(English edition) 2022年第5期15卷 773-779页

作者： Antonietta Moramarco Luca Lucchino Fabiana Mallone Michela Marcelli Ludovico Alisi Vincenzo Roberti Sandra Giustini Alessandro lambiase Marcella Nebbioso Department of Sense Organs Sapienza University of RomePoliclinico Umberto IRome 00161Italy Department of Dermatology and Venereology Sapienza University of RomePoliclinico Umberto IRome 00161Italy

AIM:To examine neuroretinal function by using the multifocal electroretinography(mf ERG)test in patients with neurofibromatosis type 1(NF1)without optic pathway gliomas(OPGs).METHODS:This study was conducted on 35 patients(35 eyes)with NF1 and 30 healthy subjects(30 eyes)for the control *** subject underwent a complete ophthalmological examination including spectral domainoptical coherence tomography(SD-OCT)and mf *** 1.5-Tesla magnetic resonance imaging(MRI)scan of the brain was performed in NF1 patients to assess the presence of *** participants were recruited having a best corrected visual acuity(BCVA)of no less than 20/20 in each *** amplitude and implicit time of the P1 wave(first-order Kernel component)were evaluated on mf *** analysis was carried out in the two central degrees and in the four quadrants from two to 25 degrees of visual ***:Statistically significant results were obtained for the P1 wave amplitudes in the 4 quadrants in NF1 patients compared to healthy controls,while the reduction was not significant in the 2 central degrees between the groups.A statistically significant difference was observed among the P1 wave amplitudes as recorded in the 4 quadrants within the NF1 group,with lower amplitudes detected in the nasal *** differences in the implicit times were recorded in the 2 central degrees and in the 4 quadrants as compared between NF1 patients and ***:Impaired neuroretinal function in NF1 patients is expressed in a decreased amplitude of the P1-wave between 2 and 25 central retinal degrees on mf *** intracellular signal transduction due to abnormal neurofibromin-mediated cyclic adenosine monophosphate(c AMP)generation,can be *** possible use of mf ERG as subclinical retinal damage indicator has a potential utility in clinical practice for the follow-up of NF1 patients.

关键词： neurofibromatosis type 1 multifocal electroretinography neuroretinal function optic pathway gliomas neurofibromin

Pharmacogenetics as a tool to tailor antiretroviral therapy: A review

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World Journal of Virology 2015年第3期4卷 198-208页

作者： Antonio Aceti Laura Gianserra Lara lambiase Alfredo Pennica Elisabetta Teti Clinical Infectious Diseases Sant’Andrea HospitalSapienza University of Rome

Highly active antiretroviral therapy(HAART) has substantially changed human immunodeficiency virus(HIV) infection from an inexorably fatal condition into a chronic disease with a longer life expectancy. This means that HIV patients should receive antiretroviral drugs lifelong, and the problems concerning with a chronic treatment(tolerability, side effects, adherence to treatment) have now become dominant. In this context, strategies for the treatment personalization have taken a central role in optimizing the therapeutic response and prevention of adverse drug reactions. In this setting, the study of pharmacogenetics features could be a very useful tool in clinical practice; moreover, nowadays the study of genetic profiles allows optimizations in the therapeutic management of People Living With HIV(PLWH) through the use of test introduced into clinical practice and approved by international guidelines for the adverse effects prevention such as the genetic test HLA-B*5701 to detect hypersensitivity to Abacavir. For other tests further studies are needed: CYP2B6 516 G > T testing may be able to identify patients at higher risk of Central Nervous System side effects following standard dosing of Efavirenz, UGT1A1*28 testing before initiation of antiretroviral therapy containing Atazanavir may aid in identifying individuals at risk of hyperbilirubinaemia. Pharmacogenetics represents a research area with great growth potential which may be useful to guide the rational use of antiretrovirals.

关键词： Pharmacogenetics Pharmacogenomics Single nucleotide polymorphism Pharmacokinetics Highly active antiretroviral therapy Polymorphism Phenotype Pharmacodynamic

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情迷新港

游艇业 2016年第3期 90-97页

作者： Cristina lambiase

世界帆船之都Newport 帆船的魅力吸引新港Newport被誉为“世界帆船之都（Sailing Capital of the World）”，距离波士顿（Boston）98公里，离纽约New York也非常近，绵延6英里的海岸线、宜人的气候和风力条件，使扬帆出海成为迷人享受。

关键词：帆船波士顿海岸线世界公里

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旅行的意义

游艇业 2016年第6期 110-115页

作者： Cristina lambiase

抓住那些让我们成为“更好的人”的小瞬间——康泰纳仕奢华旅游集市教给我的几件小事。

关键词：旅行个人生活方式旅游

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伦敦圣诞童话

游艇业 2016年第6期 104-109页

作者： Cristina lambiase

为什么要去伦敦过圣诞节？至少有10个理由。我说的理由，可不是英镑人民币率问题，也不是圣诞节伦敦各大百货公司的疯狂打折购物优惠。

关键词：伦敦童话百货公司圣诞节人民币购物

Monitoring Plan on PCDD/Fs and DL-PCBs Milk Contamination in Campania Region (Italy)

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International Journal of Analytical Mass Spectrometry and Chromatography 2015年第2期3卷 32-36页

作者： Francesco Paolo Serpe Alfredo Scaramuzzo Pasquale Maglio Sara lambiase Mauro Esposito Istituto Zooprofilattico Sperimentale del Mezzogiorno Portici Italy

During the carrying out of the monitoring plan as part of the Regional Law n. 3/2005 emerged, in 2008, the well known “buffalo milk crisis” that led to the enactment of other monitoring plans targeted to the research of dioxins in food. From the last monitoring plan on PCDD/Fs and DL-PCBs in Campania Region, named as “Surveillance plan 2011-2014”, all dairy products from N. 50 farms intended to the production of bovine, buffalo and ovine milk, resulted compliant to the maximum levels fixed by EU in Regulation 1259/2011, suggesting the effectiveness of the restrictive measures on farming practices applied after the sanitary emergency of 2008. On the other hand, the action limits reported in EU Recommendations 516/2011 and 711/2013 were exceeded in two sheep farms and two buffalo farms, to represent the critical issues that nowadays exist.

关键词： Dioxin Campania Region Italy Milk