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Composition of Essential Oils from &lt.i>Litsea acutivena</i>Hayata

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American Journal of Plant Sciences 2019年第4期10卷 615-621页

作者： Do N. Dai Nguyen t. t. lam Nguyen A. Dung Le t. Huong Dao t. M. Chau isiaka A. Ogunwande Graduate University of Science and technology Vietnam Academy of Science and Technology Hanoi Vietnam Faculty of Agriculture Forestry and Fishery Nghean College of Economics Vinh Vietnam School of Natural Science Education Vinh University Vinh Vietnam 7 University Drive Aleku Area Osogbo Nigeria

the chemical components of the leaf oil of Litsea acutivena Hayata collected from Pù Huong Natural Reserve, Nghe An Province, Vietnam, were identified by co-chromatography with authentic samples, gas chromatography/mass spectrometry (GC/MS) and linear retention indices. the significant compounds of L. acutivena were α-phellandrene (30.4%) and α-pinene (14.2%). the constituents of essential oil of L. acutivena from Vietnam are being reported for the first time.

关键词： Litsea acutivena Essential Oil terpenes

Presence of extensive intraductal component.in patients undergoing breast conservative surgery predicts presence of residual disease in subsequent completion mastectomy

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Chinese Medical Journal 2009年第8期122卷 900-905页

作者： Christopher C. E Yiu Wings t. Y. Loo C. K. lam Louis W. C. Chow UNiMED Medical institute Comprehensive Centre for Breast Diseases Hong Kong China Clinical t.ial Centre Li Ka Shing Faculty of Medicine University of Hong Kong China

Background Local recurrence remains a serious problem among patients undergoing breast conservative surgery. t.is study aimed at.identifying risk factors for residual disease after breast conservative surgery. Methods t.is retrospective study was based on patients with invasive breast cancer who have received breast conservative surgery and subsequent completion mastectomy. All patients had a clear resection margin in the initial operation. We analyzed the association between the presence of residual disease during completion mastectomy and the following risk factors： t staging, young age, and presence of extensive intraductal component （EiC）, a close margin, lymphovascular permeation （LVP）, positivity of estrogen receptor, progesterone receptor, and c-erbB-2. Results Residual disease was encountered in 21 （45.7%） of 46 patients; EiC was present.in 28 patients （60.9%）, of whom 17 had residual disease. Presence of EiC during breast conservation surgery was associated with a higher risk of residual disease during completion mastectomy （P=0.011）. Other variables were not statistically significant risk factors for presence of residual disease. No local recurrence was recorded in our cohort, and the disease-free survival and overall survival after completion mastectomy were similar for patients who had residual disease and those who had not. Conclusions the presence of EiC is a significant risk factor for residual disease in patients after breast conservative surgery. Our findings may suggest the indicated value of completion mastectomy in patients with EiC during initial breast conservative surgery to decrease the risk of subsequent local failure.

关键词： extensive intraductal component breast conservative surgery residual disease completion mastectomy

taming Reactive Oxygen Species:Mitochondria-targeting Aggregation-induced Emission Luminogen for Neuron Protection via Photosensitization-t.iggered Autophagy

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CCS Chemistry 2022年第7期4卷 2249-2257页

作者： Chao Chen Ruoyao Zhang Jianyu Zhang Yufan Zhang Haoke Zhang Zaiyu Wang Xiaolin Huang Sijie Chen Ryan t.K.Kwok Jacky W.Y.lam Dan Ding Ben Zhong tang Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced StudyState Key Laboratory of Molecular NanoscienceDivision of Life ScienceDepartment of Chemical and Biological EngineeringThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong 999077 State Key Laboratory ofMedicinal Chemical Biology Key Laboratory of Bioactive MaterialsMinistry of EducationCollege of Life SciencesNankai UniversityTianjin 300071 Ming Wai Lau Centre for Reparative Medicine Karolinska InstitutetHong Kong 999077 Center for Aggregation-induced Emission SCUT-HKUST Joint Research InstituteState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640 Shenzhen institute of Aggregate Science and technology School of Science and EngineeringThe Chinese University of Hong KongShenzhen 518172 AiE institute Guangzhou Development DistrictHuangpuGuangzhou 510530

Oxidative damage to cells leads to accumulated harmful wastes,which in turn aggravate the imbalance of reactive oxygen species(ROS)and related ***,provoking the cellular defense system against severe oxidation and maint.ining ROS homeostasis are ***,we designed and synthesized a powerful mitochondria-targeting aggregation-induced emission photosensitizer(named DtCSPY)by maximal rest.iction of heat *** is demonstrated that taming ROS generation wit.in mitochondria through photosensitization-t.iggered autophagy via DtCSPY achieved a better neuroprotective effect against oxidative damages than Nacety-L-cyst.ine and vitamin *** work not only provides a new way to design high-performance photosensitizers by regulating the photophysical property,but also verifies the concept that taming ROS can be used for cell protection against destructive oxidation,thereby displaying broad prospects for alleviating oxidation-related diseases and promoting cell-based therapy.

关键词： aggregation-induced emission mitochondrial targeting photosensitizer reactive oxygen species neuron protection

横向产业的空间集聚研究——以香港工业北移为例

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亚太经济 2007年第3期 98-103页

作者：杜曙光林民盾曲阜师范大学经济学院福建师范大学

基于新生产要素对传统生产要素主导地位的替代,以商品形成过程的三个元素为逻辑起点,我们建构了一个基本的横向产业模型。在该模型的基础上,本文进一步分析、探讨了横向产业空间选择、集聚的基本动因和内在机理,并结合香港工业北移现象... 详细信息

基于新生产要素对传统生产要素主导地位的替代,以商品形成过程的三个元素为逻辑起点,我们建构了一个基本的横向产业模型。在该模型的基础上,本文进一步分析、探讨了横向产业空间选择、集聚的基本动因和内在机理,并结合香港工业北移现象对横向产业的空间集聚进行了初步研究,归纳出横向产业空间集聚的两种模式。根据研究结论,现代企业应结合自身的核心优势元素,寻找优势空间,做好商品形成过程的其中一个模块;区域或国家则应细分商品形成元素、细分生产要素,去劣取优,发展核心优势产业,并持续为横向产业元素的空间集聚提供相应的支持。

关键词：横向产业空间集聚新生产要素工业北移

Uptake of prostate cancer screening and associated factors among Chinese men aged 50 or more: a population-based survey

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Cancer Biology & Medicine 2014年第1期11卷 56-63页

作者： Winnie K.W.So Kai Chow Choi Winnie P.Y.tang Paul C.W.Lee Ann t.Y.Shiu Simone S.M.Ho Helen Y.L.Chan Wendy W.t.lam William B.Goggins Carmen W.H.Chan the Nethersole School of Nursing The Chinese University of Hong Kong Department of Community Medicine The University of Hong Kong the Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong

Objective: to investigate the uptake rate of prostate specific antigen(PSA) testing among Hong Kong Chinese males aged 50 or above, and identify factors associated with the likelihood of undergoing a PSA ***: A population-based telephone survey was conducted in Hong Kong in 2007. the survey covered demographic information, perceived health status, use of complementary therapy, cancer screening behavior, perceived susceptibility to cancer and family history of cancer. Descriptive statistics, percentages and logistic regression analysis were used for data ***: A total of 1,002 men aged 50 or above took part.in the study(response rate =67%), and the uptake rate of PSA testing was found to be 10%. Employment status, use of complementary therapy, perceiving regular visits to a doctor as good for health and the recommendations of health professionals were significant factors associated with PSA ***: the uptake rate of PSA testing in the study population was very low. Among all the factors identified, recommendations from health professionals had the strongest association with the uptake of PSA testing, and they should therefore take an active role in educating t.is population about cancer prevention and detection.

关键词： Prostatic neoplasms early detection of cancer prostate-specific antigen (PSA) population-based survey

irving Kaplansky（1917--2006）

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数学译林 2008年第2期27卷 166-171,131页

作者： Hyman Bass t.Y.lam 马守全(译) 高燕芳(校) 陆柱家(校)

我喜欢以代数的方式看事物，当代数方法应用到无限多的实体时，我会更加为之着迷．

关键词：代数数学方程模理论

Uncompromised NK cell activation is essential for virus-specific CtL activity during acute influenza virus infection

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Cellular & Molecular immunology 2018年第9期15卷 827-837页

作者： Yuan Liu Jian Zheng Yinping Liu Liyan Wen Lei Huang Zheng Xiang Kwok-t.i lam Aizhen Lv Huawei Mao Yu-Lung Lau Wenwei tu Department of Pediat.ics and Adolescent Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Medical Genetic Center Guangdong Women and Children HospitalGuangzhou 511400China Department of Radiology Georgia Regents UniversityAugustaGA 30912USA GRU Cancer Center Georgia Regents UniversityAugustaGA 30912USA Department of Pediat.ics The University of Hong Kong—Shenzhen HospitalShenzhen 518053China

Natural killer (NK) cells are indispensable components of both the innate and adaptive immune response. However,their precise roles in the cross-talk between innate and adaptive immunity during influenza virus infection remaincontroversial. By comparing NK cell dynamics and activity under a sub-lethal dose and high dose of influenza virusinfection, we showed that.influenza virus PR8 directly infected NK cells during natural infection, which wasconsistent with our previous findings obt.ined from an in vitro investigation of human NK cells. the impairments incytotoxicity and iFN-γ production by spleen NK cells following high-dose infection were accompanied by decreasedvirus-specific killing mediated by cytotoxic t lymphocytes (CtLs). importantly, the weakened CtL activity could bereversed by adoptive transfer of spleen NK cells harvested from low-dose-infected mice but not healthy *** together, our data provide direct evidence supporting the cont.ibution of NK cells to antiviral t-cellresponses. t.is study also indicates that a novel NK-targeted immune evasion strategy is used by influenza virusto shrink both innate and adaptive immune responses.

关键词： CtL influenza NK cell

Zr（Ⅳ） surface sites determine CH3OH formation rate on Cu/ZrO2/SiO2-CO2 hydrogenation catalysts

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Chinese Journal of Catalysis 2019年第11期40卷 1741-1748页

作者： Erwin lam Kim Larmier Shohei tada Pat.ick Wolf Olga V. Safonova Christophe Copéret EtH Zürich Department of Chemistry and Applied Biosciences Vladimir-Prelog-Weg 1-5 CH-8093 Zürich Switzerland Paul Scherrer institute CH-5232 Villigen Switzerland iFP Energies Nouvelles Rond-Point de l’échangeur de Solaize BP3 69360 Solaize France Department of Chemical System Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku 113-8656 Tokyo Japan

Cu/ZrO2/SiO2 are efficient catalysts for the selective hydrogenation of CO2 to CH3OH. in order to understand the role of ZrO2 in these mixed-oxides based catalysts, in situ X-ray absorption spectroscopy has been carried out on the Cu and Zr K-edge. Under reaction conditions, Cu remains metallic, while Zr is present.in three types of coordination environment associated with 1) bulk ZrO2, 2) coordinatively saturated and 3) unsaturated Zr(Ⅳ) surface sites. the amount of coordinatively unsaturated Zr surface sites can be quantified by linear combination fit of reference X-Ray absorption near edge structure (XANES) spectra and its amount correlates with CH3OH formation rates, thus indicating the importance of Zr(Ⅳ) Lewis acid surface sites in driving the selectivity toward CH3OH. t.is finding is consistent with the proposed mechanism, where CO2 is hydrogenated at the interface between the Cu nanoparticles that split H2 and Zr(Ⅳ) surface sites that stabilizes reaction intermediates.

关键词： CO2 hydrogenation ZrO2/SiO2 supported Cu nanoparticles Lewis acidic surface sites in situ X-ray absorption spectroscopy

Metabolomics through the lens of precision cardiovascular medicine

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Journal of Genetics and Genomics 2017年第3期44卷 127-138页

作者： Sin Man lam Yuan Wang Bowen Li Jie Du Guanghou Shui State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Beijing Anzhen Hospital Capital Medical UniversityThe Key Laboratory of Remodeling-Related Cardiovascular DiseasesMinistry of EducationBeijing Collaborative Innovation Center for Cardiovascular DisordersBeijing Institute of HeartLung&Blood Vessel DiseaseBeijing 100029China Lipidall technologies Company Limited Changzhou 213000China

Metabolomics, which targets at the extensive characterization and quantitation of global metabolites from both endogenous and exogenous sources, has emerged as a novel technological avenue to advance the field of precision medicine principally driven by genomics-oriented approaches. in particular,metabolomics has revealed the cardinal roles that the environment exerts in driving the progression of major diseases threatening public health. Herein, the existent and potential applications of metabolomics in two key areas of precision cardiovascular medicine will be critically discussed： 1） the use of metabolomics in unveiling novel disease biomarkers and pathological pathways; 2） the cont.ibution of metabolomics in cardiovascular drug development. Major issues concerning the statistical handling of big data generated by metabolomics, as well as its interpretation, will be briefly addressed. Finally, the need for integration of various omics branches and adopting a multi-omics approach to precision medicine will be discussed.

关键词： Metabolomics Precision medicine Cardiovascular diseases Lipidomics Multi-omics