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Forest Ecosystems 2024年第4期11卷 414-422页

作者： tzeng Yih lam Mark J.Ducey Department of Forest Resources Management Faculty of ForestryThe University of British Columbia2045-2424 Main MallVancouverBCV6T 1Z4 Canada Department of Natural Resources and the Environment University of New Hampshire114 James HallDurhamNH 03824USA

the inflection point is an important feature of sigmoidal height-diameter(H-D)*** is often cited as one of the properties favoring sigmoidal model ***,there are very few studies analyzing the inflection points of H-D *** goals of this study were to theoretically and empirically examine the behaviors of inflection points of six common H-D models with a regional *** six models were the Wykoff(WYK),Schumacher(SCH),Curtis(CUR),HossfeldⅣ(HOS),von Bertalanffy-Richards(VBR),and Gompertz(GPZ)*** models were first fitted in their base forms with tree species as random effects and were then expanded to include functional traits and spatial *** distributions of the estimated inflection points were similar between the two-parameter models WYK,SCH,and CUR,but were different between the threeparameter models HOS,VBR,and *** produced some of the largest inflection *** and VBR produced concave H-D curves without inflection points for 12.7%and 39.7%of the tree *** species or decreasing shade tolerance resulted in larger inflection *** trends in the estimated inflection points of HOS and VBR were entirely opposite across the ***,HOS could produce concave H-D curves for portions of the *** on the studied behaviors,the choice between two-parameter models may not *** recommend comparing seve ral three-parameter model forms for consistency in estimated inflection points before deciding on *** sigmoidal models to have inflection points does not necessarily mean that they will produce fitted curves with *** study highlights the need to integrate analysis of inflection points into modeling H-D relationships.

关键词： Concavity Forest inventory and analysis Generalized height-diameter models Growth functions Height-diameter functions Mixed-effects modeling Points of inflection Species-specific models

Epitranscriptomic Regulation of NMDA Receptors Rears its Ugly Head in Chemotherapy-Induced Neuropathic Pain

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Neuroscience Bulletin 2024年第8期40卷 1209-1211页

作者： Wing lam Yu Gerald W.Zamponi Department of Clinical Neurosciences Hotchkiss Brain InstituteAlberta Children's Hospital Research InstituteUniversity of CalgaryCalgaryAB T2N 4N1Canada

A number of different cancer chemotherapy agents such as cisplatin,oxaliplatin,and paclitaxel can lead to nerve damage,thereby giving rise to neuropathic pain states that present with mechanical and cold allodynia[1].Although these pain conditions often resolve after completion of the chemotherapy,a significant portion of patients exhibit longlasting pain that can persist longer than 12 months with a negative impact on the quality of life of affected individuals[1].

关键词： chemotherapy pain damage

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可持续城市发展:对城市承载力评估的综述

城市规划学刊 2015年第1期 125-126页

作者：干靓 WEI Y HUANG C lam P t I

城市承载力(UCC)是可持续城市发展的重要晴雨表和的准绳。本研究旨在通过广泛的文献综述,回顾党前的研究现状,比较了解评估模型的优势和劣势,总结认知差异,并提出规划师和城市管理者提升城市承载力的战略行动建议。研究首先回顾了生态... 详细信息

城市承载力(UCC)是可持续城市发展的重要晴雨表和的准绳。本研究旨在通过广泛的文献综述,回顾党前的研究现状,比较了解评估模型的优势和劣势,总结认知差异,并提出规划师和城市管理者提升城市承载力的战略行动建议。研究首先回顾了生态学上的承载力以及由此引申出的城市承载力概念,并界定了本文对于城市承载力更为精确和完整的定义:环境影响和自然资源、基础设施和城市服务、公众认知、机构设置以及社会支持能力对城市发展的限制,并指出城市承

关键词：可持续城市概念思维形式承载力评估管理人员管理者

Advances in discovery of novel investigational agents for functional cure of chronic hepatitis B:A comprehensive review of phases II and III therapeutic agents

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World Journal of Hepatology 2024年第3期16卷 331-343页

作者： Robert lam Joseph K Lim Section of Digestive Diseases Yale University School of MedicineNew HavenCT 06520United States

Chronic hepatitis B virus(HBV)infection affects over 295 million people globally and an estimated 1.6 million people in the United *** is associated with significant morbidity and mortality due to cirrhosis,liver failure,and liver *** therapy with oral nucleos(t)ide analogues is associated with high rates of virologic suppression,which in turn has been associated with a decreased risk of liver ***,current antiviral regimens are limited by concerns with adverse effects,adherence,resistance,long-term treatment,and ongoing risk for liver *** investigational agents are currently in development and are targeted at achieving functional cure with sustained hepatitis B surface antigen(HBsAg)loss and suppression of HBV *** we review key evidence from phases II and III trials defining the efficacy and safety profiles for key investigational agents for functional cure of chronic hepatitis B,including core/capsid inhibitors,entry inhibitors,RNA interference(siRNA/ASO),HBsAg inhibitors,toll-like receptor agonists,checkpoint inhibitors,and therapeutic vaccines.

关键词： Hepatitis B virus treatment Clinical trials RNA interference Entry inhibitors Core inhibitors Immunomodulators

Characteristics of Optic Nerve Damage Induced by Chronic Intraocular Hypertension in Rat

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Eye Science 2004年第1期20卷 25-29页

作者： JiantaoWang JianGe A.A.Sadun t.t.lam ZhongshanOphthalmicCenter SunYat-senUniversityGuangzhou51006China DohenyEyeCenter UniversityofSouthernCaliforniaUSA

Purpose:to set up the Sharma’s chronic intraocular hypertension model and investigate the intraocular pressure (IOP) as well as the optic nerve damage of this model in rat. Methods:the operations of the chronic intraocular hypertension model were performed as described by Sharma in 60 male Lewis albino rats. IOP was measured using the tono-Pen XL immediately after surgery and then at 5 day, 2 week or 4 week intervals. Cresyl violet staining of whole-mounted retinas was used to label retinal ganglion cells (RGCs), then RGCs were counted. Paraphenylenediamine (PPD) staining was performed in the semi-thin cross sections of optic nerve of rat, in order to know whether the axons of optic nerve were degenerated or not. Results:there were 47 rats with higher IOP after the episcleral veins cauterized in 60 rats. the ratio of elevated IOP was 78.3%. the IOPs were stable in 4 weeks. After cresyl violet staining, the RGCs loss was 11.0% and 11.3% was found in the central and peripheral retina respectively after 2 weeks of increased IOP. After 4 weeks of increased IOP, the loss of RGCs was 17% for the central retina and 24.6% for the peripheral retina. In the retinas without higher IOP, there was no loss of RGCs. PPD staining showed that optic nerve of rat with about 5.3% damage of axons located at the superior temporal region. Region of affected optic nerve 1 mm posterior to the globe by light microscope showed evidence of damaged axons with axonal swelling and myelin debris. Conclusion:Sharma’s chronic intraocular hypertension model is a reproducible and effective glaucoma model, which mimics human glaucoma with chronically elevation IOP and induced RGCs loss and damage of optic nerve. Eye Science 2004;20:25-29.

关键词：眼神经损害慢性眼内高压老鼠 RGCs 动物模型视网膜神经节

孕期非故意伤害住院治疗与婴儿的不良出生结局:出生前受伤对出生结局是否有影响?（英文）

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伤害医学（电子版） 2012年第1期1卷 16-24页

作者： Lawrence t lam Mary K lam 澳大利亚圣母大学悉尼医学院悉尼大学健康科学学院悉尼医学院儿科与儿童健康学科

目的探讨孕期受伤对婴儿出生结局的影响,调查伤害发生的时间对不良出生结局风险的作用.方法在澳大利亚新南威尔士州选择2003年内生育一胎的妇女作为研究对象,应用数据连接技术对二手数据进行Logistic多因素回归分析.在ICD-10-AM诊断... 详细信息

目的探讨孕期受伤对婴儿出生结局的影响,调查伤害发生的时间对不良出生结局风险的作用.方法在澳大利亚新南威尔士州选择2003年内生育一胎的妇女作为研究对象,应用数据连接技术对二手数据进行Logistic多因素回归分析.在ICD-10-AM诊断为孕期受伤的患者中选取同时发生受伤与分娩的患者,通过日常记录资料,收集低出生体重、早产、出生后1分钟内低Apgar评分、有复苏需要、收入新生儿重症监护病房(NICU)或特殊托儿所(SCN)以及死亡率的信息.主要观察指标:应用ICD-10-AM的病历治疗获得孕期受伤的患者,从病历资料中选取同时发生受伤与分娩的患者,通过日常记录资料,收集低出生体重、早产、出生后1分钟内低Apgar评分、有复苏需要、收入新生儿重症监护病房(NICU)或特殊托育所(SCN)以及死亡率的信息.结果校正潜在的混杂因素后,母亲在孕期受伤的早产婴儿是对照组婴儿的1.36倍(OR=1.36,95％CI=1.01～1.83).母亲孕期受伤的低出生体重儿的几率比对照组增加了40％(OR=1.38,95％CI=1.00～1.90),被收治入SCN的几率增加了50％ (OR=1.50,95％CI=1.18～ 1.81).母亲因受伤入院治疗而出生的婴儿与母亲在产前曾受伤的婴儿,其出生结局之间没有统计学意义,出生结局包括低出生体重(OR=1.08,95％CI=0.62～1.93)与早产(OR=1.20,95％CI=0.57 ～2.55).结论孕期受伤,无论产前何时受伤都会增加婴儿不良出生结果的风险,尤其是低体重儿、早产儿和收治入特殊托育所者.

关键词：非故意伤害孕期出生结局基于人群数据连接

Statistical analyses for NANOGrav 5-year timing residuals

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Research in Astronomy and Astrophysics 2017年第2期17卷 63-76页

作者： Yan Wang James M. Cordes Fredrick A. Jenet Shami Chatterjee Paul B. Demorest timothy Dolch Justin A. Ellis Michael t. lam Dustin R. Madison Maura A. McLaughlin Delphine Perrodin Joanna Rankin Xavier Siemens Michele Vallisneri MOE Key Laboratory of Fundamental Physical Quantities Measurements School of Physics Huazhong University of Science and Technology Wuhan 430074 China Center for Advanced Radio Astronomy University of Texas at Brownsville 1 West University Boulevard Brownsville TX 78520 USA Department of Physics and Astronomy University of Texas at Brownsville 1 West University Boulevard Brownsville TX 78520 USA Department of Astronomy Cornell University Ithaca NY 14853 USA National Radio Astronomy Observatory 520 Edgemont Road Charlottesville VA 22903 USA Department of Physics Hillsdale College 33 E. College Street Hillsdale M149242 USA Jet Propulsion Laboratory California Institute of Technology 4800 Oak Grove Drive Pasadena CA 91106 USA Department of Physics West Virginia University EO. Box 6315 Morgantown WV 26505 USA INAF-Osservatorio Astronomico di Cagliari Via della Scienza 5 09047 Selargius (CA) Italy Department of Physics University of Vermont Burlington VT 05405 USA Center for Gravitation Cosmology and Astrophysics Department of Physics University of Wisconsin-Milwaukee P.O. Box 413 Milwaukee WI 53201 USA

In pulsar timing, timing residuals are the differences between the observed times of arrival and predictions from the timing model. A comprehensive timing model will produce featureless resid- uals, which are presumably composed of dominating noise and weak physical effects excluded from the timing model （e.g. gravitational waves）. In order to apply optimal statistical methods for detecting weak gravitational wave signals, we need to know the statistical properties of noise components in the residuals. In this paper we utilize a variety of non-parametric statistical tests to analyze the whiteness and Gaussianity of the North American Nanohertz Observatory for Gravitational Waves （NANOGrav） 5- year timing data, which are obtained from Arecibo Observatory and Green Bank telescope from 2005 to 2010. We find that most of the data are consistent with white noise; many data deviate from Gaussianity at different levels, nevertheless, removing outliers in some pulsars will mitigate the deviations.

关键词： pulsar timing array general -- statistical tests

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大鼠慢性高眼压诱导视神经损伤的研究

上海交通大学学报（医学版） 2008年第6期28卷 622-625页

作者：汪建涛许迅 Alfredo A.Sadun tim t.lam 葛坚上海交通大学第一人民医院眼科上海200080 南加州大学 Keck医学院Doheny眼科研究所洛杉矶90033 中山大学中山眼科中心广州510060

目的建立大鼠慢性高眼压模型,对其眼压、视网膜节细胞(RGCs)和视神经轴突损伤进行研究。方法对40只大鼠行慢性高眼压模型手术,分为4组:术后即刻、5 d、2周和4周,每组10只,分别测定眼压。采用全视网膜-RGCs Cresyl Violet染色,术后2周和... 详细信息

目的建立大鼠慢性高眼压模型,对其眼压、视网膜节细胞(RGCs)和视神经轴突损伤进行研究。方法对40只大鼠行慢性高眼压模型手术,分为4组:术后即刻、5 d、2周和4周,每组10只,分别测定眼压。采用全视网膜-RGCs Cresyl Violet染色,术后2周和4周对大鼠视网膜进行RGCs计数,并对视神经进行对位苯二胺(PPD)染色。对照组20只大鼠,分为2组,每组10只。结果31只大鼠眼压升高,眼压升高率为77.5%,且4周内眼压维持稳定。眼压升高2周时中心和周边RGCs分别减少11.0%和11.3%,眼压升高4周时中心和周边视网膜分别丢失RGCs达17%和24.6%,与正常对照组比较差异均有统计学意义(P0.05)。高眼压组大鼠视神经轴突在颞上方有大约5.3%损伤,球后1 mm的视神经在光镜下可以看到视神经轴突水肿和髓鞘碎屑。结论慢性高眼压动物模型是一种可以重复且有效的青光眼模型,它模拟了人类慢性眼压升高所导致的RGCs丢失和视神经的损伤。

关键词：高眼压动物模型视网膜节细胞视神经损伤

Hypoxic and temporal variation in the endocrine disrupting toxicity of perfluorobutanesulfonate in marine medaka(Oryzias melastigma)

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Journal of Environmental Sciences 2024年第2期136卷 279-291页

作者： Baili Sun Jing Li Yachen Bai Xiangzhen Zhou Paul K.S.lam Lianguo Chen State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China University of Chinese Academy of Sciences Beijing 100049China Office of the President Hong Kong Metropolitan University30 Good Shepherd StreetKowloonHong Kong SARChina

Perfluorobutanesulfonate(PFBS)is an emerging pollutant capable of potently disrupting the sex and thyroid endocrine systems of ***,the hypoxic and temporal variation in PFBS endocrine disrupting toxicity remain largely *** the present study,adult marine medaka were exposed to environmentally realistic concentrations of PFBS(0 and 10μg/L)under normoxia or hypoxia conditions for 7 days,aiming to explore the interactive behavior between PFBS and *** addition,PFBS singular exposure was extended till 21days under normoxia to elucidate the time-course progression in PFBS *** results showed that hypoxia inhibited the growth and caused the suspension of egg spawn regardless of PFBS *** regard to the sex endocrine system,7-day PFBS exposure led to an acute stimulation of transcriptional profiles in females,which,subsequently,recovered after the 21-day *** potency of hypoxia to disturb the sex hormones was much stronger than PFBS.A remarkable increase in estradiol concentration was noted in medaka blood after hypoxia *** in sex endocrinology of coexposed fish were largely determined by hypoxia,which drove the formation of an estrogenic *** further enhanced the endocrine disrupting effects of ***,the hepatic synthesis of vitellogenin and choriogenin,two commonly used sensitive biomarkers of estrogenic activity,failed to initiate in response to the estrogen *** to sex endocrine system,disturbances in thyroidal axis by PFBS or hypoxia were relatively ***,the present findings will advance our toxicological understanding about PFBS pollutant under the interference of hypoxia.

关键词： Perfluorobutanesulfonate(PFBS) Aquatic hypoxia temporal toxicity Combined exposure Endocrine disruption Marine medaka