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Journal of Environmental Sciences 2024年第4期138卷 288-300页

作者： Shanshan Chen Wenqi Chen Zhiping Li Jianwei Yue Ken Kin lam Yung Ruijin Li Institute of Environmental Science Shanxi UniversityTaiyuan 030006China Institute of Judicial Identification Techniques for Environmental Damage Shanxi University and Shanxi Unisdom Testing Technology Co.Ltd.Taiyuan 030006China Department of Biology Hong Kong Baptist UniversityHong KongChina Shanxi Yellow River Laboratory Taiyuan 030006China

Fine particulate matter(pm_(2.5))exposure is associated with cardiovascular disease(CVD)morbidity and *** are sensitive targets of pm_(2.5),and mitochondrial dysfunction is closely related to the occurrence of *** epigenetic mechanism of pm_(2.5)-triggered mitochondrial injury of cardiomyocytes is *** study focused on the mi R-421/SIRT3 signaling pathway to investigate the regulatory mechanism in cardiac mitochondrial dynamics imbalance in rat H9c2 cells induced by pm_(2.5).Results illustrated that pm_(2.5)impaired mitochondrial function and caused dynamics homeostasis ***,pm_(2.5)up-regulated mi R-421 and down-regulated SIRT3 gene expression,along with decreasing p-FOXO3a(SIRT3 downstream target gene)and p-Parkin expression and triggering abnormal expression of fusion gene OPA1 and fission gene ***,mi R-421 inhibitor(mi R-421i)and resveratrol significantly elevated the SIRT3 levels in H9c2 cells after pm_(2.5)exposure and mediated the expression of SOD2,OPA1 and Drp1,restoring the mitochondrial morphology and *** suggests that mi R-421/SIRT3 pathway plays an epigenetic regulatory role in mitochondrial damage induced by pm_(2.5)and that mi R-421i and resveratrol exert protective effects against pm_(2.5)-incurred cardiotoxicity.

关键词： Fine particulate matter Rat H9c2 cells Mitochondrial damage MiR-421 SIRT3 Resveratrol

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静脉内平滑肌瘤病伴细胞不典型

疑难病杂志 2005年第1期4卷 39-39页

作者： lam pm Lo KW YuMY WongWS 中国香港特别行政区威尔斯亲王医院妇产科

1 病史摘要患者,女性,54岁,中国籍,因急性左下肢水肿就诊.既往有子宫肌瘤史2年.腹部及盆腔CT显示左髂总静脉血栓及子宫左下部肌瘤(直径6 cm).考虑静脉血栓系肌瘤压迫髂静脉所致,予抗凝治疗,为缩小子宫体积以减轻其对髂静脉的压力,皮下... 详细信息

1 病史摘要患者,女性,54岁,中国籍,因急性左下肢水肿就诊.既往有子宫肌瘤史2年.腹部及盆腔CT显示左髂总静脉血栓及子宫左下部肌瘤(直径6 cm).考虑静脉血栓系肌瘤压迫髂静脉所致,予抗凝治疗,为缩小子宫体积以减轻其对髂静脉的压力,皮下注射促性腺激素释放激素类似物(GnRHa)3个月.患者对GnRHa治疗无不良反应,治疗后闭经.4月后复查腹部及盆腔CT显示子宫明显缩小,但静脉血栓已扩展至下腔静脉,达左肾静脉水平.尽管已用抗凝剂并减轻了外来压力,但静脉血栓却迅速发展,结合患者有子宫肌瘤史,拟诊为静脉内平滑肌瘤病(intravenous leiomyomatosis,IVL),遂行全子宫及双附件切除术,并经腔静脉切开切除静脉内肿瘤.

关键词：不典型盆腔静脉内平滑肌瘤髂静脉静脉血栓腹部患者直径

An integrative analysis of miRNA and mRNA expression in the brains of Alzheimer's disease transgenic mice after real-world pm_(2.5)exposure

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Journal of Environmental Sciences 2022年第12期34卷 25-40页

作者： Pengfei Fu Yufei Zhao Chuan Dong Zongwei Cai Ruijin Li Ken Kin lam Yung Department of Biology Hong Kong Baptist UniversityHong Kong SARChina Golden Meditech Center for NeuroRegeneration Sciences Hong Kong Baptist UniversityHong Kong SARChina Institute of Environmental Science Shanxi UniversityTaiyuan 237016China State Key Laboratory of Environmental and Biological Analysis Hong Kong Baptist UniversityHong Kong SARChina

Fine particulate matter(pm_(2.5))is associated with increased risks of Alzheimer's disease(AD),yet the toxicological mechanisms of pm_(2.5)promoting AD remain *** this study,wildtype and APP/PS1 transgenic mice(AD mice)were exposed to either filtered air(FA)or pm_(2.5)for eight weeks with a real-world exposure system in Taiyuan,China(mean pm_(2.5)concentration in the cage was 61μg/m~3).We found that pm_(2.5)exposure could remarkably aggravate AD mice's ethological and brain ultrastructural damage,along with the elevation of the pro-inflammatory cytokines(IL-6 and TNF-α),Aβ-42 and ACh E levels and the decline of Ch AT levels in the *** on high-throughput sequencing results,some differentially expressed(DE)m RNAs and DE mi RNAs in the brains of AD mice after pm_(2.5)exposure were *** RT-q PCR,seven DE mi RNAs(mmu-mi R-193b-5p,122b-5p,466h-3p,10b-5p,1895,384–5p,and 6412)and six genes(Pcdhgb8,Unc13b,Robo3,Prph,Pter,and Tbata)were evidenced the and *** mi RNA-target gene pairs(mi R-125b-Pcdhgb8 pair and mi R-466h-3p-IL-17Rα/TGF-βR2/Aβ-42/ACh E pairs)were demonstrated that they were more related to pm_(2.5)-induced brain *** of Gene Ontology(GO)pathways and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways predicted that synaptic and postsynaptic regulation,axon guidance,Wnt,MAPK,and m TOR pathways might be the possible regulatory mechanisms associated with pathological *** revealed that pm_(2.5)-elevated pro-inflammatory cytokine levels and pm_(2.5)-altered neurotransmitter levels in AD mice could be the important causes of brain damage and proposed the promising mi RNA and m RNA biomarkers and potential mi RNA-m RNA interaction networks of pm_(2.5)-promoted AD.

关键词： Fine particulate matter mRNAs miRNAs Brain Alzheimer’s disease APP/PS1 transgenic mice

Field assessment of straw pellet combustion in improved heating stoves in rural Northeast China

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Journal of Environmental Sciences 2023年第5期127卷 295-307页

作者： Yafei Liu Zhimin Li Emily Floess You Zhang Nicholas lam Sylvester K.Mawusi Prabin Shrestha Xinghua Li Chunyu Xue Guangqing Liu Biomass Energy and Environmental Engineering Research Center College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 100875China Department of Civil Constructionand Environmental EngineeringNorth Carolina State UniversityRaleighNC 27695-7103USA Schatz Energy Research Center Humboldt State UniversityArcataCA 95521USA School of Space and Environment Beihang UniversityBeijing 100191China

Straw pellets are widely promoted and expected to be a cleaner alternative fuel to unprocessed crop residues and rawcoal in rural ***,the effectiveness of these dissemination programs is not well *** this field study,emission characteristics of burning strawpellets,rawcoal,and unprocessed corn cobs in heating stoveswere investigated in a pilot village in Northeast *** measurements covering the whole combustion cycle(ignition,flaming,and smoldering phases)shows the promotion of improved heating stoves and straw pellets could reduce pollutant emissions(e.g.,SO_(2) and CO),but increase NO_(X) and pm_(2.5) emissions compared to the initial stove-fuel use pattern in the studied *** is a significant variance in emission characteristics between different combustion *** normalized emission concentrations of the different stove-fuel combinations were higher than the limits in the Chinese national standard for heating stoves,indicating that the standard is not met for real-world *** consumption was lower than official *** surveys were conducted to identify the barriers to fuel and stove access associated with existing promotion strategies,management,and *** pilot program was of the typical“subsidy-and-policy-dependence”pattern and was unlikely to be implemented on a large *** innovation,operational optimization,and proper policies considering the local socioeconomic factors are needed to sustain the promotion of biomass straw pellets and stoves.

关键词： Northeast China Straw pellet Improved heating stove Emission factors

Chemical characteristics of aerosols at coastal station in Hong Kong.Ⅱ. Environmental behavior of trace elements during the April 1995 to April 1996

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Journal of Environmental Sciences 2004年第2期16卷 212-221页

作者： K.S.lam Z.L.Cheng S.C.Kot C.W.Tsang Department of Civil and Structural Engineering the Hong Kong Polytechnic UniversityResearch Center for Eco-Environmental Sciences Chinese Academy of SciencesDepartment of Mechanical Engineering The Hong Kong University of Science & Technology Clear Water BayDepartment of Applied Biology and Chemical Technology the Hong Kong Polytechnic University Hung Hom Hong Kong ChinaBeijing 100085 ChinaHong Kong ChinaHung Hom Hong Kong China

An one-year of sampling aerosol program was carried out during the period of April 1995 to April 1996 at coastal region, Cape D′Aguilar, in Hong Kong. The trace element composition of aerosol particles(TSP and pm 10 ) were measured and analyzed by using the Instrumental Neutron Activation Analysis(INAA) and Inductive Couple Plasma-Mass Spectrometry(ICP-MS) techniques. The results showed that the polluted elements such as: V, Zn, As, Pb, Cd, Sb, I, Se, Bi, with high enrichment factor(E.F) values, are derived from anthropogenic sources, while Sc, Al, Fe, Mn, Sm, La, Sr are less than 10 in E.F, these elements are related the crust and soil. The concentration of the trace elements are present seasonal variation i.e. summer low and winter high, whereas the V or noncrustal V(V *) present summer high and winter low, this phenomenon might be explained by local or regional oil combustion sources. Use three type of elemental ratio, e.g. La/Sm, Mn */V * and Bi/Al indicate that both TSP and pm 10 of La/Sm ratios are mainly related to soil and dust, Mn */V * are probably represent fossil combustion and Bi/Al are possibly associated with refuse incineration, ferromanganese alloys and aluminum production. The varimax rotation factor analysis for trace elements was performed. By means of the absolute principal component analysis(APCA) and multiple regression, the contribution of trace elements to possible sources and overall means of trace elements were estimated. The results showed that the present station is impacted by the anthropogenic species, although the quantities are different during the summertime and wintertime.

关键词： TSP pm 10 trace elements enhancement factor element ratios seasonal variation factor analysis

Underestimation of adolescent exposure to second-hand smoke at urban homes in Hong Kong

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Underestimation of adolescent exposure to second-hand smoke ...

Prediction of Ambient pm10 Concentration with Artificial Neural Network

第16届全国控制吸烟暨第6届青少年控烟经验学术交流会

作者： Leung LT Ho SY Wang MP Lo WS lam TH School of Public Health The University of Hong Kong

＜正＞Background Adolescent exposure to secondhand smoke（SHS）at home typically refers to smoking that occurs inside home（*** Youth Tobacco Survey）.This ignores SHS from neighbourhood sources that has been detected in smokefree homes as pm 2.5,an environmental marker of *** densely populated Hong Kong,where most people live in small multi-storey housing units and

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Prediction of Ambient PM10 Concentration with Artificial Neu...

Environment Pollution and Human Health

The 10th EpmESC

作者： L. H. lam K. M. Mok Department of Civil and Environmental Engineering Faculty of Science and Technology University of Macau Macau SAR China Department of Civil and Environmental Engineering Faculty of Science and Technology University of Macau Macau SAR China

This paper presents the design of building economic and flexible artificial neural network (ANN) model for the prediction of pm10 concentration 24-hour-ahead. In stead of relying purely on historical

关键词： pm10 prediction criteria pollutants meteorological effect artificial neural network

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中国药理学与毒理学杂志 2006年第3期 174-177页

作者： Jia Gao Huan-Jun Tian Wei-Qun Shu Eun-Jung Park Kwangsik Park Paul Kwan-Sing lam T Prapamontol U Mevatee C Puaninta A Mangklabrucks N Udomvong T Kaewthummanukul S Sriboonruang S Nimsakul C Kingkeow Werawan Ruangyuttikarn

S5-1 Effects of persistent organic pollutants(POPs) in water on Chongqing population health CAO Jia, TIAN Huan-Jun, SHU Wei-Qun(Preventive Medicine College, the Third Military Medical University, Chongqing 400038, China)Abstract:Many organic pollutants occur in drinking water in considerable amounts, and mimic or interfere with reproductive development and function. Furthermore, it is not known whether multiple organic pollutants (MOP) from drinking water induce uterotrophic effects. In this study, we compared the effects of MOP on uterine wet weight by different exposure approaches (ip, sc, po) on prepubertal 21-d-old Wistar rats and Kunming mice. The multiple organic pollutants in drinking water were concentrated by solid-phase extraction (SPE), and dissolved in DMSO.

关键词： pm Environment Pollution and Human Health

白内障伴糖尿病性黄斑水肿的患者行超声乳化联合曲安西龙玻璃体腔注射:6个月的前瞻性先导研究

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世界核心医学期刊文摘（眼科学分册） 2005年第12期1卷 53-54页

作者： lam D.S.C Mohamed S 宋虎平 Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong Hong Kong Eye Hospital 147K Argyle Street Kowloon Hong Kong

Aims: To assess the safety and efficacy of phacoemulsification with intravitreal triamcinolone (ivTA) injection in diabetics with cataract and clinically significant macular oedema (CSMO). Methods: A total of 19 eyes of 15 consecutive diabetic patients with cataract and CSMO were prospectively recruited. Patients underwent phacoemulsification and intraocular lens implantation with 4 mg ivTA injection at completion of surgery. Patients were followed up on day 1, then weekly for 1 month, and thereafter monthly until 6 months postoperatively. Best corrected visual acuity (BCVA), central macular thickness (CMT) measured by optical coherence tomography, and adverse events were recorded. Results: In total, 17 eyes completed 6 months of follow-up. In all, 58.8% showed improvement in BCVA of ≥ 2 lines, with statistically significant improvement in mean Snellen BCVA of 2.4 lines at 6 months. The peak BCVA was achieved at 4 months. The mean CMT decreased from a baseline of 449 pm to a minimum of 321 ± 148 μ m (28.5% reduction) achieved at 2 months, with statistically significant reduction at all postoperative time intervals until 6 months. Of 17 eyes, 4 (23.5% ) developed transiently elevated intraocular pressure that normalised by 6 months in all but one patient. No injection or surgery-related complications were encountered. Conclusions: Phacoemulsification with concurrent 4 mg ivTA injection appears to be a safe option for managing diabetics with cataract and CSMO. However, large-scaled randomised controlled trials are necessary for delineating the relative contributions of cataract removal and CMT reduction to visual improvement. Moreover, the transient effect on CMT may warrant further studies to determine optimal timing and dosage of further ivTA injections.

关键词：超声乳化玻璃体腔注射曲安西龙黄斑水肿晶体植入矫正视力

空气污染对肝脏脂质代谢的影响及性别差异研究

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空气污染对肝脏脂质代谢的影响及性别差异研究