检索结果-南通市图书馆

Journal of Genetics and Genomics 2022年第4期49卷 380-383页

作者： Shijing Wu Sin Man lam Huajin Li Binhua Jiang Zixi Sun Tian Zhu Xing Wei Xuan Zou Guanghou Shui Ruifang Sui Department of Ophthalmology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Department of Ophthalmology The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350004China LipidALL Technologies Company Limited ChangzhouJiangsu 213022China

First reported by Bietti in 1937(Bietti,1937),Bietti crystalline corneoretinal dystrophy(BCD,OMIM 210370)is a rare,autosomal recessively inherited progressive retinal *** disease is more common in Asian populations,particularly in Chinese and Japanese(Li et al.,2004).The prevalence of BCD is estimated at 1 in 67,000,representing around only 21,000 individuals in China(Ng et al.,2016).CYP4V2 was identified as the disease-causing gene in *** encodes a member of the cytochrome P450 family 4.

关键词： representing rare

在线全文

学校读者我要写书评

暂无评论

Phase change memory

Science China(Information Sciences) 2011年第5期54卷 1061-1072页

作者： lam Chung IBM Research T.J. Watson Research Center Yorktown Heights New York 10598 USA

Phase change memory (PCM) is a non-volatile solid-state memory technology based on the large resistivity contrast between the amorphous and crystalline states in phase change materials. We present the physics behind this large resistivity contrast and describe how it is being exploited to create high density PCM. We address the challenges facing this technology, including the design of PCM cells, fabrication, device variability, thermal cross-talk and write disturb. We discuss the scalability, assess the performance, and examine the reliability of PCM including data retention, multi-bit storage and endurance.

关键词： solid state memory non-volatile DRAM flash phase change resistive memory data retention write endurance solid-state drive computer memory

NOD2 and TLR2 ligands trigger the activation of basophils and eosinophils by interacting with dermal fibroblasts in atopic dermatitis-like skin inflammation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2016年第4期13卷 535-550页

作者： Delong Jiao Chun-Kwok Wong Huai-Na Qiu Jie Dong Zhe Cai Man Chu Kam-Lun Hon Miranda Sin-Man Tsang Christopher Wai-Kei lam Department of Chemical Pathology The Chinese University of Hong Kong Prince of Wales Hospital Shatin NT Hong Kong China Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Hong Kong China Department of Paediatrics The Chinese University of Hong Kong Prince of Wales Hospital Shatin NT Hong Kong China State Key Laboratory of Quality Research in Chinese Medicine Macao institute for Applied Research in Medicine and Health Macao University of Science and Technology Taipa Macao People's Republic of China

The skin of patients with atopic dermatitis （AD） has a unique predisposition for colonization by Staphylococcus aureus （S. aureus）, which contributes to the inflammation and grim prognosis of AD. Although the mechanism underlying the S. aureus-induced exacerbation of AD remains unclear, recent studies have found a pivotal role for pattern recognition receptors in regulating the inflammatory responses in S. aureus infection. In the present study, we used a typical mouse model of AD-like skin inflammation and found that S. aureus-associated nucleotide-binding oligomerization domain-containing protein 2 （NOD2） and toll-like receptor 2 （TLR2） ligands exacerbated AD-like symptoms, which were further deteriorated by the in vivo expansion of basophils and eosinophils. Subsequent histological analyses revealed that dermal fibroblasts were pervasive in the AD-like skin lesions, Co-culture of human dermal fibroblasts with basophils and eosinophils resulted in a vigorous cytokine/chemokine response to the NOD2/TLR2 ligands and the enhanced expression of intercellular adhesion molecule-1 on the dermal fibroblasts. Basophils and eosinophils were primarily responsible for the AD-related cytokine/chemokine expression in the co-cultures. Direct intercellular contact was necessary for the crosstalk between basophils and dermal fibroblasts, while soluble mediators were sufficient to mediate the eosinophil-fibroblast interactions. Moreover, the intracellular p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and nuclear factor-kappa B signaling pathways were essential for NOD2/TLR2 ligand-mediated activation of basophils, eosinophils, and dermal fibroblasts in AD-related inflammation. This study provides the evidence of NOD2/TLR2-mediated exacerbation of AD through activation of innate immune cells and therefore sheds light on a novel mechanistic pathway bv which S. aureus contributes to the DathoDhvsiology of AD.

关键词： atopic dermatitis basophils, eosinophils NOD2 TLR2

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

澳大利亚悉尼华人民间信仰

艺术与民俗 2024年第1期 54-61页

作者： [马来西亚]蓝姵錂北京大学社会学系

19世纪中叶华南移民以劳工身份前往澳大利亚,陌生与艰辛的异乡环境促使他们通过结社团结同乡和互相帮助。同乡会与庙宇因此诞生,并以解决移民的生老病死作为使命。悉尼的四邑关圣帝庙、要明洪圣宫、天后宫与护国观音庙的历史跨越一个世... 详细信息

19世纪中叶华南移民以劳工身份前往澳大利亚,陌生与艰辛的异乡环境促使他们通过结社团结同乡和互相帮助。同乡会与庙宇因此诞生,并以解决移民的生老病死作为使命。悉尼的四邑关圣帝庙、要明洪圣宫、天后宫与护国观音庙的历史跨越一个世纪,分别见证华人移民群体在不同时代的日常生活和信仰实践。它们皆由同乡会创建,既是移民社交联谊和实践信仰的场所,也发挥着弘扬中华文化的作用。另外,这些庙宇在维系移民群体与其祖籍地联系的同时,也具有推动移民群体与当地社区融合的功能。

关键词：澳大利亚华人移民民间信仰同乡会华人庙宇

Conditional Coverage Estimation for High-Quality Prediction Intervals

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science and Systems Engineering 2023年第3期32卷 289-319页

作者： Ziyi Huang Henry lam Haofeng Zhang School of Engineering and Applied Science Columbia UniversityNew YorkNY 10027USA

Deep learning has been recently studied to generate high-quality prediction intervals(PIs)for uncertainty quantification in regression tasks,including recent applications in simulation *** high-quality criterion requires PIs to be as narrow as possible,whilst maintaining a pre-specified level of data(marginal)***,most existing works for high-quality PIs lack accurate information on conditional coverage,which may cause unreliable predictions if it is significantly smaller than the marginal *** address this problem,we propose an end-to-end framework which could output high-quality PIs and simultaneously provide their conditional coverage *** doing so,we design a new loss function that is both easy-to-implement and theoretically justified via an exponential concentration *** evaluation on real-world benchmark datasets and synthetic examples shows that our approach not only achieves competitive results on high-quality PIs in terms of average PI width,but also accurately estimates conditional coverage information that is useful in assessing model uncertainty.

关键词： Uncertainty quantification prediction intervals conditional coverage neural networks calibrationerror

Theoretical study of substituent effect on the charge mobility of 2,5-bis(trialkylsilylethynyl)-1,1,3,4-tetraphenylsiloles

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2010年第11期53卷 2311-2317页

作者： lam Jacky Wing Yip Department of Chemistry The Hong Kong University of Science & Technology

The theoretical calculation of the charge mobility of 2,5-bis(trialkylsilylethynyl)-1,1,3,4-tetraphenylsiloles is presented.B3LYP/6-31* calculations demonstrated that these silole molecules possessed large coupling matrix elements and reorganization energies for electron and hole transfers and high electron *** bulkiness of the trialkyl substituents influenced the charge mobility of the silole molecules,with the smaller trimethyl group imparting higher charge mobility than triethyl and triisopropyl substituents.

关键词： silole theoretical calculation substitution effect electronic structure charge mobility

Role of Leptin in Immunity

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2007年第1期4卷 1-13页

作者： Queenie Lai Kwan lam Department of Pathology and Center of Infection and Immunology The University of Hong Kong

Leptin, a protein hormone produced by the adipocytes, has long been recognized to regulate metabolism, neuroendorine and other physiological functions. Early findings of increased leptin production during infection and inflammation and dysregulated immune response in leptin signaling-deficient mice provide strong evidence for the involvement of leptin in the immune responses. Recent data have established the regulatory function for leptin in immunity similar to the function of a pro-inflammatory cytokine, while gene-targeting studies also demonstrated an essential role of leptin in regulating hematopoiesis and lymphopoiesis. Moreover, there has been increasing evidence that leptin is involved in the pathogenesis of various autoimmune diseases. This review discusses recent advances in understanding the role of leptin in immunity and leptin-signaling pathways involved in modulating immune homeostasis and autoimmune pathogenesis. Cellular ＆ Molecular Immunology. 2007;4（1）：1-13.

关键词： leptin leptin signaling pro-inflammatory cytokine immune response autoimmune disease

Environmental threats to the Three Gorges Reservoir Region:Are mutagenic and genotoxic substances important?

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2015年第12期27卷 172-174页

作者： Paul K.S.lam State Key Laboratory in Marine Pollution Department of Biology and ChemistryCity University of Hong Kong

The Three Gorges Dam project（TGDP）,with a total static investment of 95.46 billion RMB（US$10.97 billion）based on the 1993 price level,commenced in 1994 and was completed in *** creation of the Three Gorges Reservoir following the completion of the TGDP had brought about significant changes to the Three Gorges Reservoir Region（TGRR）,stretching from the town of Sandouping in Hubei Province to the Jiangjin District of Chongqing *** TGDP has led to progressive urbanization and industrialization of the TGRR,accompanied by increased shipping activities,greater

关键词： Three Gorges Dam Persistent organic pollutants Yangtze River Sediment Water

Online hybrid test using a finite element program and an explicit integration scheme

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2015年第1期58卷 163-173页

作者： Alexandre lam PAN Peng DENG KaiLai Department of Civil Engineering Tsinghua University Key Laboratory of Civil Engineering Safety and Durability of China Education Ministry Department of Civil Engineering Tsinghua University

A new online hybrid test system combined with substructuring techniques and incorporating finite element methods is *** the proposed system,numerical substructure analysis is conducted by ABAQUS/*** ABAQUS user subroutine is used as the interface between the main control program and ABAQUS to impose the target displacements and determine the reaction *** iteration is needed in this system,making it suitable for physical *** the approach also avoids the need to modify source code,it will be appealing to a number of real engineering *** proposed system adopts a separated-model framework,operator-splitting integration scheme,and data exchange through a socket *** earthquake responses of a simple steel moment-resisting frame are simulated,and the results obtained from the new system are compared to those obtained from the conventional *** is found that the results obtained from the new system are accurate,demonstrating the applicability and efficiency of the proposed *** optimal test parameters are also studied to gain the most accurate results in the minimum time.

关键词： online hybrid test substructuring ABAQUS/Explicit separated-model framework operator-splitting method

社区居家老年人跌倒经历的体验:质性研究的meta整合

在线全文

学校读者我要写书评

暂无评论

International Journal of Nursing Sciences 2024年第2期11卷 276-285页

作者：江慧悯袁浩斌 Stephen TEE 林爱贞 Faculty of Health Sciences and Sports Macao Polytechnic UniversityMacaoChina Faculty of Health and Social Sciences Bournemouth UniversityBournemouthEnglandUK

目的系统评价和整合社区居家老年人跌倒经历的看法与体验,为后续发展跌倒预防及管理的干预提供信息,为健康照护实践提供建议。方法依据乔安娜布里格斯研究所(Joanna Briggs Institute,JBI)质性系统评价方法论进行质性研究meta整合,在Pub... 详细信息

目的系统评价和整合社区居家老年人跌倒经历的看法与体验,为后续发展跌倒预防及管理的干预提供信息,为健康照护实践提供建议。方法依据乔安娜布里格斯研究所(Joanna Briggs Institute,JBI)质性系统评价方法论进行质性研究meta整合,在PubMed、CINAHL、PsycInfo、Embase、Web of science等数据库进行检索,发表时间限定为2010年1月至2023年5月,仅纳入经同行评审的英文文献。使用JBI质性研究质量评价标准评价纳入文献的方法学质量,按照ConQual评分准则检验整合结果的信度。本综述方案已在PROSPERO注册(CRD 42023421789)。结果共纳入10项研究,方法学质量评价得分为60%至90%。提炼59个完好明确的结果,将相似结果归纳组合形成7个类别,并综合成3个整合结果,在ConQual评分上,综合结果2评为中等,综合结果1和3评为低等。整合结果1:跌倒后老年人经历了身体的损伤和疼痛、日常活动受限、社交受限、独立性降低或丧失、并有恐惧和无助感。整合结果2:经历跌倒后,老年人反思跌倒的原因,并识别、解释风险因素。整合结果3:老年人对跌倒原因和后果有正面和负面的看法,其采取的应对跌倒的措施包括使用辅助器具、纠正风险因素、寻求医疗帮助、关注身体和心理状况等。结论医疗卫生提供者应重视老年人跌倒后的感受、经历,以及对跌倒原因和影响的反思,进行特定的干预。今后还需要进行纵向研究,以检测跌倒对老年人的长期影响,深入了解他们的反思、感知、态度和预防行为随时间的改变情况。

关键词：老年人社区经历跌倒观点系统综述