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Microtubule acetylation dyshomeostasis in Parkinson’s disease

Translational Neurodegeneration 2023年第1期12卷 576-600页

作者： Padmashri Naren khan Sabiya Samim kamatham Pushpa Tryphena lalitkumar k.vora Saurabh Srivastava Dharmendra kumar khatri Shashi Bala Singh Molecular and Cellular Neuroscience Lab Department of Pharmacology and ToxicologyNational Institute of Pharmaceutical Education and Research(NIPER)HyderabadTelangana 500037India School of Pharmacy Queen’s University Belfast97 Lisburn RoadBelfast BT97BLUK Department of Pharmaceutics National Institute of Pharmaceutical Education and Research(NIPER)HyderabadTelangana 500037India

The inter-neuronal communication occurring in extensively branched neuronal cells is achieved primarily through the microtubule(MT)-mediated axonal transport *** mechanistically regulated system delivers cargos(proteins,mRNAs and organelles such as mitochondria)back and forth from the soma to the *** proteins like kinesins and dynein mechanistically regulate polarized anterograde(from the soma to the synapse)and retrograde(from the synapse to the soma)commute of the cargos,*** axonal transport of such cargos is achieved by altering the microtubule stability via post-translational modifications(PTMs)ofα-andβ-tubulin heterodimers,core components constructing the *** within the lumen of MTs,k40 acetylation ofα-tubulin viaα-tubulin acetyl transferase and its subsequent deacetylation by HDAC6 and SIRT2 are widely scrutinized PTMs that make the MTs highly flexible,which in turn promotes their *** movement of various motor proteins,including kinesin-1(responsible for axonal mitochondrial commute),is enhanced by this PTM,and dyshomeostasis of neuronal MT acetylation has been observed in a variety of neurodegenerative conditions,including Alzheimer’s disease and Parkinson’s disease(PD).PD is the second most common neurodegenerative condition and is closely associated with impaired MT dynamics and deregulated tubulin acetylation *** the relationship between status of MT acetylation and progression of PD pathogenesis has become a chicken-and-egg question,our review aims to provide insights into the MT-mediated axonal commute of mitochondria and dyshomeostasis of MT acetylation in *** enzymatic regulators of MT acetylation along with their synthetic modulators have also been briefly *** towards a tubulin-based therapy that enhances MT acetylation could serve as a disease-modifying treatment in neurological conditions that lack it.

关键词： Parkinson’s disease Microtubule acetylation Tubulin PTMs Mitochondria Axonal transport HDAC6 SIRT2 inhibitors

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COVAX-19 ■Vaccine:Completely blocks virus transmission to non-immune individuals

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Clinical Complementary Medicine and Pharmacology 2021年第1期1卷 28-31页

作者： Vivek P.Chavda lalitkumar k.vora Disha R.Vihol Department of Pharmaceutics and Pharmaceutical Technology L M College of PharmacyAhmedabad-380009GujaratIndia School of Pharmacy Queen’s University Belfast97 Lisburn RoadBT97BLUK Pharmacy Section L.M.College of PharmacyAhmedabad-380058GujaratIndia

Various vaccine platforms are geared against COVID-19 vaccine development to produce immunogens in *** design a recombinant protein-based COVID-19 vaccine,Vaxine pty Ltd used computer models of the spike protein and its human receptor,ACE2,to identify how the virus infects human *** on this,the COVAX-19 ■vaccine is *** does reduce not only COVID-19 disease but also blocks virus shedding and *** are optimistic that this vaccine candidate could be clinically available soon with sufficient vaccine efficacy with a considerable amount of reduction in vaccination-related side effects.

关键词： COVAX-19■Vaccine SARS-CoV-2 Pandemic Advax^(TM) SpikoGen■etc

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The potential role of essential oils in boosting immunity and easing COVID-19 symptoms

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Clinical Traditional Medicine and Pharmacology 2024年第2期5卷 54-62页

作者： Vivek P Chavda Pankti C.Balar Gargi Jogi Swati Marwadi Aayushi Patel Avani Doshi Jinal Ajabiya lalitkumar vora Department of Pharmaceutics and Pharmaceutical Technology L.M.College of PharmacyAhmedabad 380009GujaratIndia Department of Biotechnology Savitribai Phule University of Pune411041MaharashtraIndia Pharmacy Section Long Island UniversityUniversity PlazaBrooklynNY 11201United States Department of Pharmaceutical Chemistry K B Raval College of PharmacyGandhinagar 382423India Department of Pharmaceutics Analysis National Institute of Pharmaceutical Education and Research(NIPER)Ahmedabad 380009GujaratIndia School of Pharmacy Queen’s University Belfast97 Lisburn RoadBT97BLUK

Background:Several trials have been conducted since the beginning of the COVID-19 pandemic to establish possible clinical treatments for the infected ***,many these approaches have failed to demonstrate positive results in human clinical *** the middle of this investigation,essential oils attracted interest due to their numerous benefits and possible role in management of *** oils have virucidal effects at nontoxic quantities due to their tiny molecular size,high lipophilicity,and quick commencement of ***,the pulmonary exhalation,lower respiratory stimulus,and deep lung transport properties of essential oils increase their potential medicinal ***:The present review aimd to evaluate the potential efficacy of essential oil in management of ***:Following the Preferred Reporting Items for Systematic Review and Meta-Analysis(PRISMA)guidelines,studies published in English up to January 2024 were searched in the PubMed,Scifinder,and Scopus database,using relevant keywords,such as“Essential oil and COVID-19”,“Essential Oil and Viral Infection”,*** non-English articles,abstracts,conference papers,book chapters,and reviews were ***:A total of 108 potentially relevant articles were included for full-text review,with the emphasis is on scrutinizing the probable antiviral action of essential oils to inhibit the replication of *** tried to provide an opinion based on different studies performed using the same concept in different corners of the ***:Various essential oils hold a great potential to work as an adjuvant therapy in management and prevention of COVID-19.

关键词： COVID-19 SARS-CoV-2 Sunlight UV radiation Essential oil

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