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Oral microbiota and host innate immune response in bisphosphonate-related osteonecrosis of the jaw

International Journal of Oral Science 2014年第4期6卷 219-226页

作者： Smruti Pushalkar Xin Li Zoya Kurago lalitha v ramanathapuram Satoko Matsumura Kenneth E Fleisher Robert Glickman Wenbo Yan Yihong Li Deepak Saxena Department of Basic Science and Craniofacial Biology New York University College of Dentistry Department of Oral and Maxillofacial Pathology Radiology and Medicine New York University College of Dentistry Department of Oral and Maxillofacial Surgery New York University College of Dentistry Department of Biology Nyack College

Bacterial biofilms have emerged as potential critical triggers in the pathogenesis of bisphosphonate（BP）-related osteonecrosis of the jaw（ONJ） or BRONJ. BRONJ lesions have shown to be heavily colonized by oral bacteria, most of these difficult to cultivate and presents many clinical challenges. The purpose of this study was to characterize the bacterial diversity in BRONJ lesions and to determine host immune response. We examined tissue specimens from three cohorts（n530）; patients with periodontal disease without a history of BP therapy（Control, n510）, patients with periodontal disease having history of BP therapy but without ONJ（BP, n55） and patients with BRONJ（BRONJ, n515）. Denaturing gradient gel electrophoresis of polymerase chain reaction（PCR）-amplified 16 S r RNA gene fragments revealed less bacterial diversity in BRONJ than BP and Control cohorts. Sequence analysis detected six phyla with predominant affiliation to Firmicutes in BRONJ（71.6%）, BP（70.3%） and Control（59.1%）. Significant differences（P,0.05） in genera were observed, between Control/BP, Control/BRONJ and BP/BRONJ cohorts. Enzyme-linked immunosorbent assay（ELISA）results indicated that the levels of myeloperoxidase were significantly lower, whereas interleukin-6 and tumor necrosis factor-alpha levels were moderately elevated in BRONJ patients as compared to Controls. PCR array showed significant changes in BRONJ patients with downregulation of host genes, such as nucleotide-binding oligomerization domain containing protein 2, and cathepsin G, the key modulators for antibacterial response and upregulation of secretory leukocyte protease inhibitor, proteinase 3 and conserved helix–loop–helix ubiquitous kinase. The results suggest that colonization of unique bacterial communities coupled with deficient innate immune response is likely to impact the pathogenesis of ONJ.

关键词： bisphosphonates denaturing gradient gel electrophoresis host response innate immunity oral microbiota osteonecrosis of the jaw

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Delineation of groundwater potential zones using remote sensing and Geographic Information Systems(GIS)in Kadaladi region,Southern India

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Journal of Groundwater Science and Engineering 2024年第2期12卷 147-160页

作者： Stephen Pitchaimani v Narayanan MSS Abishek RS Aswin SK Jerin Joe RJ PG and Research Department of Geology V.O.Chidambaram CollegeThoothukudi 628008India Research Scholar Manonmaniam Sundaranar UniversityTirunelveli 627012India

The primary objective of this research is to delineate potential groundwater recharge zones in the Kadaladi taluk of ramanathapuram,Tamil Nadu,India,using a combination of remote sensing and Geographic Information Systems(GIS)with the Analytical Hierarchical Process(AHP).various factors such as geology,geomorphology,soil,drainage,density,lineament density,slope,rainfall were analyzed at a specific *** layers were evaluated for quality and relevance using Saaty's scale,and then inte-grated using the weighted linear combination *** weights assigned to each layer and features were standardized using AHP and the Eigen vector technique,resulting in the final groundwater potential zone *** AHP method was used to normalize the scores following the assignment of weights to each criterion or factor based on Saaty's 9-point ***-wise matrix analysis was utilized to calculate the geometric mean and normalized weight for various *** groundwater recharge potential zone map was created by mathematically overlaying the normalized weighted *** layers indicating major elements influencing groundwater occurrence and recharge were derived from satellite images.2 Results indicate that approximately 21.8 km of the total area exhibits high potential for groundwater *** recharge is viable in areas with moderate slopes,particularly in the central and southeastern regions.

关键词： Groundwater Satellite image Remote sensing GIS techniques Analytical Hierarchy Process(AHP)

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In vitro antiplasmodial activity of methanolic extracts from seaweeds of South West Coast of India

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Asian Pacific Journal of Tropical Medicine 2011年第11期4卷 862-865页

作者： S Ravikumar G Ramanathan M Gnanadesigan A Ramu v vijayakumar School of Marine Sciences Department of Oceanography and Coastal Area StudiesAlagappa UniversityThondi CampusThondi - 623 409Ramanathapuram DistrictTamil NaduIndia Department of Microbiology V.H.S.N.College.Virudhunagar DistrictTamil NaduIndia School of Chemistry Department of Inorganic ChemistryMadurai Kamaraj UniversityMadurai DistrictTamil NaduIndia

Objective:To identify the in vitro antiplasmodial activity of seaweed plants against Plasmodium falciparum ***:A total of eight seaweeds were collecled from Kanvakumari district,Tainilnadu,*** in vitro antiplasmodial activity was performed in 96 well plates against Plasmodium falciparum,and preliminary phytochemcial analysis were performed for the ***:Of the selected plants Enteromorpha intestinalis(2.61%) showed maximum percentage of *** minimum concentration of inhibitory(IC_(50)) value was observed with Chaetomorpha antennina[(26.37±4.14)μg/ml.]further,the positive controls such as chloroquine and artemether showed antiplasmodial activities(IC_(50)) with(19.10±5.93) and(6.03±0.21)μg/mL concentrations,*** preliminary phytochemical analysis of the seaweed extracts showed a variety of phytochemical constituents such as carboxylic acids,phenols,protein, resins,steroids and ***:The antiplasmodial activity of the seaweed extract might due to the presence of sugars and phenolic *** the present findings,it is concluded that,the seaweed extract of Chaetomorpha antennina can be further used as a putative antiplasmodial drugs in near future.

关键词： Antiplasmodial activity IC_(50) Phytochemical Seaweeds Plasmodium falciparum

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Prevalence of various pathological conditions in female buffaloes (Bubalus bubalis)

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Asian pacific Journal of Reproduction 2017年第2期6卷 58-67页

作者： Perumal Ponraj Sukkum Chang Nakulan v Rajesh Muthusamy veeraselvam Kalpana Devi Rajesh ICAR-National Research Centre on Mithun MedziphemaNagaland-797 106India TANUvAS-veterinary University Training and Research Centre Ramanathapuram-623 503India TANUvAS-veterinary College and Research Institute OrathanaduThanjavur-614 625India A.v.v.M.Sri Pushpam College Thanjavur-613 503India

The present review article has described the prevalence of various pathological conditions of reproductive system of female buffaloes starting from ovary to vulva and vagina. various pathological conditions were analyzed and tabulated as the total number of animal examined, number of the animals showed pathological lesions, percentage of animal showed various pathological lesions and percentage of individual pathological lesion in different parts of reproductive system of female buffaloes. The incidence of disorders of female genital organs of buffaloes has been reported by various authors at various percentages in different countries. The incidence of pathological conditions was recorded in clinically infertile cows after slaughtering or from apparently healthy buffaloes slaughtered for human consumption and/or based on postmortem examination. This review is comprehensively covering pathological conditions of female buffalo hitherto which was not previously described at one place. This review will provide a comprehensive knowledge about the prevalence of different pathological condition of different parts of reproductive tract of female buffaloes. The review has six numbers of tables described about the various pathological conditions from ovary to vulva and vagina in female buffaloes. The present review article will be very useful to the buffalo farmers, buffalo breeders and researchers are working in buffalo reproduction & breeding and pathology.

关键词： Female buffaloes Reproductive system Pathological conditions Infertility Incidence/Percentage

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Biosynthesis of silver nanoparticles by using mangrove plant extract and their potential mosquito larvicidal property

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Asian Pacific Journal of Tropical Medicine 2011年第10期4卷 799-803页

作者： M Gnanadesigan M Anand S Ravikumar M Maruthupandy v vijayakumar S Selvam M Dhineshkumar AK Kumaraguru School of Energy Environmental and Natural ResourcesDepartment of Marine and Coastal StudiesMadurai Kamaraj UniversityMadurai-625021Tamil NaduIndia School of Marine Sciences Department of Oceanography and Coastal Area StudiesAlagappa UniversityThondi CampusThondi-623409Ramanathapuram DistrictTamil NaduIndia School of Chemistry Department of Inorganic ChemistryMadurai Kamaraj UniversityMadurai-625021Tamil NaduIndia School of Chemistry Department of Industrial ChemistryAlagappa UniversityKaraikudi-630003Tamil NaduIndia

Objective:To identify the larvicidal activities of silver nano particles synthesised with Rhizophora mucronata（***） leaf extract against the larvae of Aedes aegypti（***） and Culex quinquefasciatus（***）.Methods:In vitro larvicidal activities such as LC50 and LC90 were assessed for the *** and *** larval ***, characterisation such as Uv,XRD,FTIR and AFM analysis were carried out for the synthesised silver nano ***:The LC50 value of the synthesised silver nano particle was identified as 0.585 and 0.891 mgg/L for *** and *** larvae respectively. Further,the LG90 values are also identified as 2.615 and 6.291 mg/L for *** and Cx. quinquefasciatus species *** synthesised silver nanoparticles have maximum absorption at 420 nm with the average size of 60-95 *** XRD data showed 20 intense values with various degrees such as 37.10°,47.66°,63.97°and 70.01°.The FTIR data showed prominent peaks in（3 426.89,2 925.49,2 869.56,2 346.95,1 631.49,1 031.73,669.18 and 455.12） different ***:The biosynthesis of silver nanoparticles with leaf aqueous extract of R. mucronata provides potential source for the larvicidal activity against mosquito borne diseases.

关键词： Biosynthesis Mangroves Larvicidal

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Antagonistic properties of seagrass associated Streptomyces ***-1:A source for anthraquinone rich compound

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Asian Pacific Journal of Tropical Medicine 2012年第11期5卷 887-890页

作者： S.Ravikumar M.Gnanadesigan A.Saravanan N.Monisha v.Brindha S.Muthumari School of Marine Sciences Department of Oceanography and Coastal Area StudiesAlagappa UniversityThondi campusThondi-623 409Ramanathapuram DistrictTamilnaduIndia Department of Microbiology Selvamm Arts and Science CollegeNamakkal-637 003TamilnaduIndia Department of Biotechnology AVS College of Arts and ScienceSalemTamilnaduIndia Department of Biotechnology Thassim Beevi Abdul Kader College for WomenKilakarai-623 517Ramanathapuram DistrictTamilnaduIndia Departemt of Biotechnology Meenakshi Ramasamy Arts and Science CollegeThathanur-621 804Ariyalur DistrictTamilnaduIndia

Objective:To identify the antibacterial potential of seagrass(Syringodium isoetifoliutn) associate microbes against bacterial ***:Eumeration of microbial associates were analyzed with leaf and root samples of Syringodium *** and MBC were calculated for bacterial pathogens with microbial *** and GC-MS analysis were calculated for Actinomycetes sp.(Act01) which was the most ***:Of the isolated microbial associates phosphatase producing bacterial isolates were identified as maximum [(26l.78±35.09) CFU×10~4/g]counts in root *** the selected microbial isolates Actinomycete sp(Act01) showed broad spectrum of antibacterial activity against antibiotic resistant and fish bacterial *** analysis of Act01 showed maximum identities(99%) with the Streptomyces sp.(GU5500072).The 16s rDNA secondary structure of Act01 showed the free energy values as -366.3 kkal/*** GC-MS analysis Act01 showed maximum retention value with 23.742 RT and the corresponding chemical class was identified as 1,4-dihydroxy-2-(3- hydroxybutyl)-9,10-anthraquinone 9,***:In conclusion,Streptomyces sp. (GU045544.1) from Syringodium isoetifolium could be used as potential antibacterial agent.

关键词： Actinomycetes sp. MIC MBC Phylogenetic analysis Syringodium isoetifolium

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High Security for De-Duplicated Big Data Using Optimal SIMON Cipher

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Computers, Materials & Continua 2021年第5期67卷 1863-1879页

作者： A.Muthumari J.Banumathi S.Rajasekaran P.vijayakarthik K.Shankar Irina v.Pustokhina Denis A.Pustokhin Department of Computer Science and Engineering University College of EngineeringRamanathapuram623513India Department of Information Technology University College of EngineeringNagercoil629004India Department of EEE PSN College of Engineering(Anna University)Tirunelveli627152India Department of Information Science and Engineering Sir M.Visvesvaraya Institute of TechnologyBangalore56215India Department of Computer Applications Alagappa UniversityKaraikudi63003India Department of Entrepreneurship and Logistics Plekhanov Russian University of EconomicsMoscow117997Russia Department of Logistics State University of ManagementMoscow109542Russia

Cloud computing offers internet location-based affordable,scalable,and independent *** computing is a promising and a cost-effective approach that supports big data analytics and advanced applications in the event of forced business continuity events,for instance,pandemic *** handle massive information,clusters of servers are required to assist the equipment which enables streamlining the widespread quantity of data,with elevated velocity and modified *** deduplication model enables cloud users to efficiently manage their cloud storage space by getting rid of redundant data stored in the *** deduplication also saves network *** this paper,a new cloud-based big data security technique utilizing dual encryption is *** clustering model is utilized to analyze the Deduplication process hash *** kernel Fuzzy C means(MKFCM)was used which helps cluster the data stored in cloud,on the basis of confidence data encryption *** confidence finest data is implemented in homomorphic encryption data wherein the Optimal SIMON Cipher(OSC)technique is *** security process involving dual encryption with the optimization model develops the productivity *** this paper,the excellence of the technique was confirmed by comparing the proposed technique with other encryption and clustering *** results proved that the proposed technique achieved maximum accuracy and minimum encryption time.

关键词： Cloud security deduplication clustering optimization big data dual encryption

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An Intelligent Deep Learning Based Xception Model for Hyperspectral Image Analysis and Classification

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Computers, Materials & Continua 2021年第5期67卷 2393-2407页

作者： J.Banumathi A.Muthumari S.Dhanasekaran S.Rajasekaran Irina v.Pustokhina Denis A.Pustokhin K.Shankar Department of Information Technology University College of EngineeringNagercoil629004India Department of Computer Science and Engineering University College of EngineeringRamanathapuram623513India Department of Computer Science and Engineering Kalasalingam Academy of Research and EducationKrishnankoil626128India Department of Electrical Engineering PSN College of EngineeringTirunelveli627152India Department of Entrepreneurship and Logistics Plekhanov Russian University of EconomicsMoscow117997Russia Department of Logistics State University of ManagementMoscow109542Russia Department of Computer Applications Alagappa UniversityKaraikudi630001India

Due to the advancements in remote sensing technologies,the generation of hyperspectral imagery(HSI)gets significantly *** classification of HSI becomes a critical process in the domain of hyperspectral data *** massive availability of spectral and spatial details of HSI has offered a great opportunity to efficiently illustrate and recognize ground ***,deep learning(DL)models particularly,convolutional neural networks(CNNs)become useful for HSI classification owing to the effective feature representation and high *** this view,this paper introduces a new DL based Xception model for HSI analysis and classification,called Xcep-HSIC ***,the presented model utilizes a feature relation map learning(FRML)to identify the relationship among the hyperspectral features and explore many features for improved classifier ***,the DL based Xception model is applied as a feature extractor to derive a useful set of features from the FRML *** addition,kernel extreme learning machine(KELM)optimized by quantum-behaved particle swarm optimization(QPSO)is employed as a classification model,to identify the different set of class *** extensive set of simulations takes place on two benchmarks HSI dataset,namely Indian Pines and Pavia University *** obtained results ensured the effective performance of the XcepHSIC technique over the existing methods by attaining a maximum accuracy of 94.32%and 92.67%on the applied India Pines and Pavia University dataset respectively.

关键词： Hyperspectral imagery deep learning xception kernel extreme learning map parameter tuning

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Effect of temperature and strain rate on compressive response of extruded magnesium nano-composite

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Journal of Magnesium and Alloys 2015年第3期3卷 224-230页

作者： B.Selvam P.Marimuthu R.Narayanasamy v.Senthilkumar K.S.Tun M.Gupta Department of Mechanical Engineering Mookambigai College of EngineeringPudukkottaiTamilnadu 622502India Syed Ammal Engineering College RamanathapuramTamilnadu 623502India Department of Production Engineering National Institute of TechnologyTiruchirappalliTamilnadu 620015India Department of Mechanical Engineering National University of Singapore9 Engineering Drive 1Singapore 117576Singapore

The hot deformation behaviour of extruded magnesium-zinc oxide nano composite has been studied using hot compression *** test was conducted in the temperature range of 250-400℃ and in the strain rate range of 0.01 to 1.5 s^(−1).The processing map was obtained using the power dissipation efficiency with the functions of temperature and strain *** workability and instability domains were observed in the processing map for a nano *** optical microscopy(OM),scanning electron microscopy(SEM)and transmission electron microscopy(TEM)images were used to confirm the formation of dynamic recrystallization(DRX),dynamic recovery(DRY)and instability *** workability region of the composite was identified at a working temperature of 400℃ and the strain rate of 0.01 s^(−1) from the processing *** instability regions were observed at higher strain rates(>0.1 s^(−1))and temperatures(250-400℃).

关键词： Metal matrix composites Powder metallurgy Processing map Strain rate Instability Nano-composite

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Fuzzy Logic Recursive Gaussian Denoising of Color video Sequences via Shot Change Detection

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Circuits and Systems 2016年第8期7卷 1560-1568页

作者： v. Sasikala N. UmaMaheswari R. venkatesh Department of Computer Science and Engineering University College of Engineering Ramanathapuram Pullangudi Tamil Nadu India Department of Computer Science and Engineering PSNA College of Engineering and Technology Dindigul Tamil Nadu India Department of Information Technology PSNA College of Engineering and Technology Dindigul Tamil Nadu India

A new technique using fuzzy in a recursive fashion is presented to deal with the Gaussian noise. In this technique, the keyframes and between frames are identified initially and the keyframe is denoised efficiently. This frame is compared with the between frames to remove noise. To do so the frames are partitioned into blocks;the motion vector is calculated;also the difference is measured using the dissimilarity function. If the blocks have no motion vectors in the block, the block of value is copied to the between frames otherwise the difference between the blocks is calculated and this value is filtered with temporal filtering. The blocks are processed in overlapping manner to avoid the blocking effect and also to reduce the additional edges created while processing. The simulation results show that the peak signal to noise ratio of the new technique is improved up to 1 dB and also the execution time is greatly reduced.

关键词： Keyframe Restoration Between Frame Restoration Motion Detection

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