检索结果-南通市图书馆

Design and development of novel bioadhesive niosomal formulation for the transcorneal delivery of anti-infective agent:In-vitro and ex-vivo investigations

引用

Asian Journal of Pharmaceutical Sciences 2015年第4期10卷 322-330页

作者： Yahaya Zubairu lalit mohan negi Zeenat Iqbal Sushama Talegaonkar Department of Pharmaceutics Faculty of PharmacyJamia HamdardNew Delhi 110062India

Gatifloxacin eye drops are frequently used in eye *** such formulations have a major drawback *** duration of action and usually require 4e6 times installations daily.A chitosan coated niosomal formulation of gatifloxain was purposed to show a longer retention time on eyes and subsequent reduction in dosing *** were prepared by solvent injection method using cholesterol and *** extensive optimization of formulation was done using different ratios of cholesterol,Span-60 and drug,revealed NS60-5(cholesterol:span-6050:50 and drug content of 20 mg)to be the optimized niosome ***60-5 had shown a highest entrapment efficiency of 64.9±0.66%with particle size 213.2±1.5 nm and zeta potential34.7±2.2 *** niosomes were also coated with different concentrations of chitosan and *** studies had revealed that optimized niosomes(86.77±1.31%)had increased the transcorneal permeation of Gatifloxacin more than two fold than simple drug solution(37.19±1.1%).Longer retention potential of the coated niosomes was further verified by fluorescence *** revealed that simple dye solution got easily washed out with in 6 *** uncoated niosomes(NS60-5)showed a longer retention(more than 6 h),which was further enhanced in case of coated niosomes ***60-1(more than 12 h).Antimicrobial studies had shown the better efficacy of CNS60-1(zone of inhibition)when compared to marketed *** final chitosan formulation was found to have shown better ocular tolerability as demonstrated by corneal hydration test histopathology investigations.

关键词： Ocular Niosomes Bioadhesive Chitosan Fluorescence Gatifloxacin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Potential Contribution of Wildlife Sanctuary to Forest Conservation: A Case Study from Binsar Wildlife Sanctuary

引用

Journal of Mountain Science 2013年第5期10卷 854-865页

作者： Balwant RAWAT Vikram S.negi Janhvi MISHRA RAWAT lalit M.TEWARI Laxmi RAWAT G.B. Pant Institute of Himalayan Environment and Development Kosi-Katarmal Forest Research Institute DehradunMolecular TaxonomyBotany Division Department of Botany D.S.B. CampusKumaun University Forest Research Institute DehradunForest Ecology and Environment Division

Forest vegetation of a protected area （Binsar Wildlife Sanctuary） in Kumaun region （west Himalaya） was analysed for structure, composition and representativeness across three different altitudinal belts, lower （1,6oo-1,8oo m a.s.1.）, middle （1,900-2,100 m a.s.1.） and upper （2,200-2,400 m a.s.1.） during 2oo9-2011 using standard phytosociological methods. Four aspects （east, west, north and south） in each altitudinal belt were chosen for sampling to depict maximum representation of vegetation in the sanctuary. Population structure and regeneration behaviour was analysed seasonally for two years to show the establishment and growth of tree species. A total of 147 plant species were recorded from the entire region of which 27 tree species were selected for detailed study. Highest number was recorded at upper （18 species）, and lowest at lower altitudinal belt （15 species）. The relative proportion of species richness showed higher contribution of tree layer at each altitudinal belt. The population structure, based on the number of individuals, revealed a greater proportion of seedling layer at each altitudinal belt. The relative proportion of seedlings increases significantly along altitudinal belts （p〈0.05） while opposite trends were observed in sapling and tree layers. The density of sapling and seedling species varied non-significantly across seasons （p〉0.05）. The density values decreased in summer and increased during rainy season. As far as the regeneration status is concerned, middle and upper altitudinal belts showed maximum number of species with fair regeneration as compared to lower altitudinal belt. Overall density diameter distribution of tree species showed highest species density and richness in the smallest girth class and decreased in the succeeding girth classes. This study suggests that patterns of regeneration behaviour would determine future structural and compositional changes in the forest communities. It is suggested that the compositional changes v

关键词： Altitudinal gradient Populationstructure Regeneration status West Himalaya Wildlife Sanctuary.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：