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Protective effect of Ocimum sanctum Linn. leaf extract on ethanol withdrawal syndrome in Wistar rats

Asian Pacific Journal of Tropical Medicine 2018年第8期11卷 467-472页

作者： lalit sharma Aditi sharma G.L.Gupta Gopal Singh Bisht Department of Pharmacy Jaypee University of Information Technology School of Pharmaceutical Sciences Sholini University Department of Pharmacology SPPSPTM SVKM'S NMIMS University Department of BT and BI Jaypee University of Information Technology

Objective: To evaluate the effects of Oscimum sanctum L(O. sanctum), an important medicinal herb, on alcohol withdrawal syndrome in Wistar rats. Methods: Liquid diet with 7.2%, v/v ethanol was administered to the rats for 21 d. Control group animals received sucrose as an isocaloric liquid diet. After alcohol withdrawal, rats were examined at 6 th and 24 th hour for major withdrawal signs that included anxiety and hyper locomotor activity. Ethanol withdrawal anxiety was tested using elevated plus maze, light and dark model; the hyper locomotor activity using actophotometer. O. sanctum leaf extract(100, 200 and 300 mg/kg, oral) and diazepam(2 mg/kg, i.p) were administered to the treatment group animals 30 min before alcohol withdrawal estimation. Drug treatment was also given 30 min before the second observation at 24 th hour. On the last day of the protocol, rats were sacrificed by cervical dislocation liver, kidney and brain were isolated and preserved in formalin for further histopathological examination. Results: Findings from the present study revealed that O. Sanctum leaf extract treatment at doses 100, 200 and 300 mg/kg, oral had a significant protective effect on signs and symptoms of ethanol withdrawal in alcohol-dependent rats. However, no remarkable pathological and microscopic alterations were observed in histopathological examination. Conclusions: O. sanctum seems to be an active drug for the treatment of alcohol abstinence syndrome.

关键词： Oscimum sanctum Ethanol withdrawal syndrome Anxiety Hyperlocomotor activity Histopathology

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Innovation for Making Potable Water Available in Saline Groundwater Areas

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Journal of Water Resource and Protection 2014年第14期6卷 1284-1289页

作者： lalit Mohan sharma S M Sehgal Foundation Gurgaon India

Groundwater salinity is a widespread problem around the world with adverse consequences on health, soil quality and overall eco-systems. With the rapidly growing demands of groundwater, its exploitation is also accelerating. It is also changing the flow of the groundwater, which in turn causes ingress of sea water or intrusion of other saline groundwater or polluted water from the surrounding areas. The major consequences are scarcity of water even for domestic use and rise in the level and spread of groundwater salinity. An innovative technique of creating a pool of fresh groundwater within a saline aquifer is developed, which can address the issue. Technique is about recharging the saline aquifer with harvested rain water in such a way that recharged rain water does not get mixed with the existing saline groundwater rather it forms pool of fresh water in the saline aquifer. Water from this pool can be extracted without getting it mixed with saline groundwater. This innovation also eliminates the need of cost intensive provision of water storage structures to store rain water for fulfilling the domestic water needs. Thus, the saline aquifer unsuitable or otherwise useless for groundwater development can be used.

关键词： Rain Water Harvesting Hydro-Static Pressure Saline Groundwater Pool of Fresh Water

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Closed reduction and percutaneous pinning of displaced supracondylar fractures of humerus in children with delayed presentation

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Chinese Journal of Traumatology 2011年第1期14卷 14-19页

作者： Aman Dua Krishna Kiran Eachempati Rajesh Malhotra lalit sharma Mallinath Gidaganti Department of Orthopedics Punjab Institute of Medical Sciences Jalandhar India Krishna Institute of Medical Sciences Hyderabad India Department of Orthopedics All India Institute of Medical Sciences New Delhi India Department of Orthopedics Narayan HrudayalayaJaipur India Global Hospital Bangalore India

Objective： Supracondylar fractures of the humerus account for 60% of all the fractures around the pediatric elbow and even in developed countries 18% of patients undergo surgery 48 hours or longer following presentation in the hospital. Management guidelines are not clear yet for these patients who present late. The aim of this prospective study was to evaluate the clinical, radiological and functional outcome following closed reduction and percutaneous pinning of widely displaced supracondylar fractures of the humerus presenting 12 hours or more after ***： We reviewed the functional and radiological results of closed reduction and percutaneous pinning using crossed K-wires in 40 patients with displaced extension type supracondylar fracture of the humerus （Gartland type Ⅲ） with a delay of more than 12 hours in presentation. The average age of patients was 4.5 years and the mean delay in presentation was 17.55 ***： Closed reduction and percutaneous pinning was successful in 90% of patients. The mean follow up period was 15 months. The Baumann＇s angle was restored within 4 degrees of the unaffected side in all patients. Use of a small medial incision in patients with severe swelling helped us avoid ulnar nerve injury. Using Flynn＇s criteria,38 patients （95%） had an excellent result. Two patients had mild myositis and both had a poor result. None of the patients developed cubitus ***： Closed reduction and crossed pinning of displaced supracondylar fractures of humerus in children is a safe and effective method even with delayed presentation.

关键词： Fractures,bone Humerus Pediatrics Fluoroscopy

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Extraarticular bony ankylosis in a child with supracondy- lar fracture of humerus

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Chinese Journal of Traumatology 2012年第5期15卷 300-302页

作者： Sameer Naranje Ramprasad Kancherla Arun Kannan Rajesh Malhotra lalit sharma Sukesh Rao Sankineani Department of Orthopaedics All India Institute of Medical SciencesNew Delhi 110029India Department of Orthopaedics Avenue HospitalMelbourneAustralia

Myositis ossificans is defined as formation of bone at the site of injured muscle. It is one of the rare complications of supracondylar fracture of humerus in children. Myositis mass usually develops on the anterior aspect in the brachialis muscle and produces restriction of range of motion, but complete ankylosis is rare. To the best of our knowledge, this is the first case to be reported in the literature as a consequence of myositis ossificans traumatica. In this case, a six-year-old child presented to the casualtydepartment with pain in the right elbow after a fail on outstretched hand during play. After surgical excision through the anterior approach, the child had no symptoms referable to the elbow and a residual flexion deformity of 15 degrees with further painless flexion up to l00 degrees at last followup of one year after surgery.

关键词： Humerus Fractures, Bone Myositis Ankylosis

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Status of carbohydrate,protein and lipid profile in the mosquito larvae treated with certain phytoextracts

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Asian Pacific Journal of Tropical Medicine 2011年第4期4卷 301-304页

作者： Preeti sharma lalit Mohan Kamal Kumar Dua Chand Narayan Srivastava Applied Entomology & Vector Control Laboratory Department of ZoologyFaculty of ScienceDayalbagh Educational Institute Deemed University

Objective:To investigate the impact of the most potent petroleum ether extract of Artemisia annua(***) and Azadirachta indica(***) on total carbohydrate,lipid and protein level of Anopheles stephensi and Culex quinquefasciatus ***:Mosquito larvae were exposed to the extracts selected as per standard WHO ***(glucose),total lipid and protein were estimated by the methods as Nelson,Bragdon and Lowry described, ***:The glucose levels were increased to 27.87%and 46.8%,respectively in anopheline larval tissues after treatment with petroleum ether extract of *** and methanolic extract of *** culicine larvae,glucose levels were reduced to 58.96%and 24.65%, *** treatment with *** extract,lipid contents in anopheline and culicine larvae decreased by 28.57%and 25.0%,respectively and increased by 14.29%and 50.00%in the Anopheles and Culex larvae,respectively after treatment with methanolic extract of Az. *** protein levels were reduced to 63.13%and 92.62%in anopheline and to 32.39%and 48.12%in culicine larvae after treatment with *** and *** extracts,respectively. Conclusions:Two extracts produce significant alterations in the biochemical pr of iles of anopheline and culicine ***,the impacting factors of extracts on carbohydrate,lipid and protein contents of larvae are species and specific *** indicates the disturbed metabolic activity of the larvae.

关键词： Anopheles Culex Artemisia Azadirachta Biochemical profile Phytoextract

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MOALG: A Metaheuristic Hybrid of Multi-Objective Ant Lion Optimizer and Genetic Algorithm for Solving Design Problems

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Computers, Materials & Continua 2024年第3期78卷 3489-3510页

作者： Rashmi sharma Ashok Pal Nitin Mittal lalit Kumar Sreypov Van Yunyoung Nam Mohamed Abouhawwash Department of Mathematics Chandigarh UniversityGharuanMohali140413India Deaprtment of Industry 4.0 Shri Vishwakarma Skill UniversityPalwal121102India Department of ICT Convergence Soonchunhyang UniversityAsan31538Korea Department of Computational Mathematics Science and Engineering(CMSE)College of EngineeringMichigan State UniversityEast LansingMI 48824USA Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt

This study proposes a hybridization of two efficient algorithm’s Multi-objective Ant Lion Optimizer Algorithm(MOALO)which is a multi-objective enhanced version of the Ant Lion Optimizer Algorithm(ALO)and the Genetic Algorithm(GA).MOALO version has been employed to address those problems containing many objectives and an archive has been employed for retaining the non-dominated *** uniqueness of the hybrid is that the operators like mutation and crossover of GA are employed in the archive to update the solutions and later those solutions go through the process of MOALO.A first-time hybrid of these algorithms is employed to solve multi-objective *** hybrid algorithm overcomes the limitation of ALO of getting caught in the local optimum and the requirement of more computational effort to converge *** evaluate the hybridized algorithm’s performance,a set of constrained,unconstrained test problems and engineering design problems were employed and compared with five well-known computational algorithms-MOALO,Multi-objective Crystal Structure Algorithm(MOCryStAl),Multi-objective Particle Swarm Optimization(MOPSO),Multi-objective Multiverse Optimization Algorithm(MOMVO),Multi-objective Salp Swarm Algorithm(MSSA).The outcomes of five performance metrics are statistically analyzed and the most efficient Pareto fronts comparison has been *** proposed hybrid surpasses MOALO based on the results of hypervolume(HV),Spread,and *** primary objective of developing this hybrid approach has been achieved *** proposed approach demonstrates superior performance on the test functions,showcasing robust convergence and comprehensive coverage that surpasses other existing algorithms.

关键词： Multi-objective optimization genetic algorithm ant lion optimizer metaheuristic

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MCBC-SMOTE:A Majority Clustering Model for Classification of Imbalanced Data

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Computers, Materials & Continua 2022年第12期73卷 4801-4817页

作者： Jyoti Arora Meena Tushir Keshav sharma lalit Mohan Aman Singh Abdullah Alharbi Wael Alosaimi Department of Information Technology MSITGGSIPUNew Delhi110058India Department of Electrical and Electronic Engineering MSITGGSIPUNew Delhi110058India School of Computer Science and Engineering Lovely Professional University144411PunjabIndia Department of Information Technology College of Computers and Information TechnologyTaif University11099Taif 21944Saudi Arabia

Datasets with the imbalanced class distribution are difficult to handle with the standard classification *** supervised learning,dealing with the problem of class imbalance is still considered to be a challenging research *** machine learning techniques are designed to operate on balanced datasets;therefore,the state of the art,different undersampling,over-sampling and hybrid strategies have been proposed to deal with the problem of imbalanced datasets,but highly skewed datasets still pose the problem of generalization and noise generation during *** overcome these problems,this paper proposes amajority clusteringmodel for classification of imbalanced datasets known as MCBC-SMOTE(Majority Clustering for balanced Classification-SMOTE).The model provides a method to convert the problem of binary classification into a multi-class *** the proposed algorithm,the number of clusters for themajority class is calculated using the elbow method and the minority class is over-sampled as an average of clustered majority classes to generate a symmetrical class *** proposed technique is cost-effective,reduces the problem of noise generation and successfully disables the imbalances present in between and within *** results of the evaluations on diverse real datasets proved to provide better classification results as compared to state of the art existing methodologies based on several performance metrics.

关键词： Imbalance class problem classification SMOTE k-means clustering sampling

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Deep Learning and SVM-Based Approach for Indian Licence Plate Character Recognition

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Computers, Materials & Continua 2023年第1期74卷 881-895页

作者： Nitin sharma Mohd Anul Haq Pawan Kumar Dahiya B.R.Marwah Reema lalit Nitin Mittal Ismail Keshta Department of Electronics&Communication Engineering Chandigarh UniversityMohali140413India Department of Computer Science College of Computer and Information SciencesMajmaah University11952Al-MajmaahSaudi Arabia Department of Electronics&Communication Engineering DCRUST Murthal131039India Department of Transportation Engineering IITKanpur208016Uttar PradeshIndia Department of Computer Science Applications PIETSmalkha132102India Skill Faculty of Science and Technology Shri Vishwakarma Skill UniversityPalwal121102India Computer Science and Information Systems Department College of Applied SciencesAlMaarefa UniversityRiyadhSaudi Arabia

Every developing country relies on transportation,and there has been an exponential expansion in the development of various sorts of vehicles with various configurations,which is a major component strengthening the automobile *** is a developing country with increasing road traffic,which has resulted in challenges such as increased road accidents and traffic oversight *** the lack of a parametric technique for accurate vehicle recognition,which is a major worry in terms of reliability,high traffic density also leads to mayhem at checkpoints and toll plazas.A system that combines an intelligent domain approach with more sustainability indices is a better way to handle traffic density and transparency *** Automatic Licence Plate Recognition(ALPR)system is one of the components of the intelligent transportation system for traffic *** study is based on a comprehensive and detailed literature evaluation in the field of *** major goal of this study is to create an automatic pattern recognition system with various combinations and higher accuracy in order to increase the reliability and accuracy of identifying digits and alphabets on a car *** research is founded on the idea that image processing opens up a diverse environment with allied fields when employing distinct soft techniques for *** properties of characters are employed to recognise the Indian licence plate in this *** licence plate recognition,more than 200 images were analysed with various parameters and soft computing techniques were *** comparison to neural networks,a hybrid technique using a Convolution Neural Network(CNN)and a Support Vector Machine(SVM)classifier has a 98.45%efficiency.

关键词： Intelligent transportation system automatic license plate recognition system neural network random forest convolutional neural network support vector machine

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Feasibility and efficacy of delayed pharmacoinvasive therapy for STelevation myocardial infarction

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World Journal of Cardiology 2023年第1期15卷 23-32页

作者： Rishi Sethi lalit Mohan Pravesh Vishwakarma Abhishek Singh Swati sharma Monika Bhandari Ayush Shukla Akhil sharma Gaurav Chaudhary Akshyaya Pradhan Sharad Chandra Varun Shankar Narain Sudhanshu Kumar Dwivedi Department of Cardiology King George's Medical UniversityLucknow 226003Uttar PradeshIndia

BACKGROUND ST-elevation myocardial infarction(STEMI)refers to a clinical syndrome that features symptoms of myocardial ischemia with consequent ST-elevation on electrocardiography and an associated rise in cardiac *** restoration of brisk flow in the coronary vasculature is critical in reducing mortality and *** patients with STEMI who could not receive primary percutaneous coronary intervention(PCI)on time,pharmacoinvasive strategy(thrombolysis followed by timely PCI within 3-24 h of its initiation)is an effective *** To analyze the role of delayed pharmacoinvasive strategy in the window period of 24-72 h after *** This was a physician-initiated,single-center prospective registry between January 2017 and July 2017 which enrolled 337 acute STEMI patients with partially occluded coronary *** received routine pharmacoinvasive therapy(PCI within 3-24 h of thrombolysis)in one group and delayed pharmacoinvasive therapy(PCI within 24-72 h of thrombolysis)in another *** primary endpoint was major adverse cardiac and cerebrovascular events(MACCE)within 30 d of the *** secondary endpoints included major bleeding as defined by Bleeding Academic Research Consortium classification,angina,and dyspnea within 30 *** The mean age in the two groups was comparable(55.1±10.1 years vs 54.2±10.5 years,P=0.426).Diabetes was present among 20.2%and 22.1%of patients in the routine and delayed groups,*** rate was 54.6%and 55.8%in the routine and delayed groups,*** was initiated within 6 h of onset of symptoms in both groups(P=0.125).The mean time from thrombolysis to PCI in the routine and delayed groups was 16.9±5.3 h and 44.1±14.7 h,*** significant difference was found for the occurrence of measured clinical outcomes in the two groups within 30 d(8.7%vs 12.9%,P=0.152).Univariate analysis of demographic characteristics and risk factors for patients who reporte

关键词： Coronary artery disease ST-elevation myocardial infarction Primary percutaneous coronary intervention Pharmacoinvasive strategy Thrombolysis Atherosclerosis

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