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Design and development of novel bioadhesive niosomal formulation for the transcorneal delivery of anti-infective agent:In-vitro and ex-vivo investigations

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Asian Journal of Pharmaceutical Sciences 2015年第4期10卷 322-330页

作者： Yahaya Zubairu lalit mohan Negi Zeenat Iqbal Sushama Talegaonkar Department of Pharmaceutics Faculty of PharmacyJamia HamdardNew Delhi 110062India

Gatifloxacin eye drops are frequently used in eye *** such formulations have a major drawback *** duration of action and usually require 4e6 times installations daily.A chitosan coated niosomal formulation of gatifloxain was purposed to show a longer retention time on eyes and subsequent reduction in dosing *** were prepared by solvent injection method using cholesterol and *** extensive optimization of formulation was done using different ratios of cholesterol,Span-60 and drug,revealed NS60-5(cholesterol:span-6050:50 and drug content of 20 mg)to be the optimized niosome ***60-5 had shown a highest entrapment efficiency of 64.9±0.66%with particle size 213.2±1.5 nm and zeta potential34.7±2.2 *** niosomes were also coated with different concentrations of chitosan and *** studies had revealed that optimized niosomes(86.77±1.31%)had increased the transcorneal permeation of Gatifloxacin more than two fold than simple drug solution(37.19±1.1%).Longer retention potential of the coated niosomes was further verified by fluorescence *** revealed that simple dye solution got easily washed out with in 6 *** uncoated niosomes(NS60-5)showed a longer retention(more than 6 h),which was further enhanced in case of coated niosomes ***60-1(more than 12 h).Antimicrobial studies had shown the better efficacy of CNS60-1(zone of inhibition)when compared to marketed *** final chitosan formulation was found to have shown better ocular tolerability as demonstrated by corneal hydration test histopathology investigations.

关键词： Ocular Niosomes Bioadhesive Chitosan Fluorescence Gatifloxacin

Status of carbohydrate,protein and lipid profile in the mosquito larvae treated with certain phytoextracts

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Asian Pacific Journal of Tropical Medicine 2011年第4期4卷 301-304页

作者： Preeti Sharma lalit mohan Kamal Kumar Dua Chand Narayan Srivastava Applied Entomology & Vector Control Laboratory Department of ZoologyFaculty of ScienceDayalbagh Educational Institute Deemed University

Objective:To investigate the impact of the most potent petroleum ether extract of Artemisia annua(***) and Azadirachta indica(***) on total carbohydrate,lipid and protein level of Anopheles stephensi and Culex quinquefasciatus ***:Mosquito larvae were exposed to the extracts selected as per standard WHO ***(glucose),total lipid and protein were estimated by the methods as Nelson,Bragdon and Lowry described, ***:The glucose levels were increased to 27.87%and 46.8%,respectively in anopheline larval tissues after treatment with petroleum ether extract of *** and methanolic extract of *** culicine larvae,glucose levels were reduced to 58.96%and 24.65%, *** treatment with *** extract,lipid contents in anopheline and culicine larvae decreased by 28.57%and 25.0%,respectively and increased by 14.29%and 50.00%in the Anopheles and Culex larvae,respectively after treatment with methanolic extract of Az. *** protein levels were reduced to 63.13%and 92.62%in anopheline and to 32.39%and 48.12%in culicine larvae after treatment with *** and *** extracts,respectively. Conclusions:Two extracts produce significant alterations in the biochemical pr of iles of anopheline and culicine ***,the impacting factors of extracts on carbohydrate,lipid and protein contents of larvae are species and specific *** indicates the disturbed metabolic activity of the larvae.

关键词： Anopheles Culex Artemisia Azadirachta Biochemical profile Phytoextract

Swarm-LSTM: Condition Monitoring of Gearbox Fault Diagnosis Based on Hybrid LSTM Deep Neural Network Optimized by Swarm Intelligence Algorithms

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Computers, Materials & Continua 2021年第2期66卷 2041-2059页

作者： Gopi Krishna Durbhaka Barani Selvaraj Mamta Mittal Tanzila Saba Amjad Rehman lalit mohan Goyal School of Electrical and Electronics Sathyabama Institute of Science and TechnologyChennai600119India Department of Computer Science and Engineering G.B.Pant Government Engineering CollegeNew Delhi110020India Artificial Intelligence and Data Analytics(AIDA)Laboratory CCISPrince Sultan UniversityRiyadh11586Saudi Arabia Department of Computer Engineering J.C.Bose University of Science and TechnologyFaridabad121006India

Nowadays,renewable energy has been emerging as the major source of energy and is driven by its aggressive expansion and falling *** of the renewable energy sources involve turbines and their operation and maintenance are vital and a difficult *** monitoring and fault diagnosis have seen remarkable and revolutionary up-gradation in approaches,practices and technology during the last *** mostly do use a rotating type of machinery and analysis of those signals has been challenging to localize the *** paper proposes a new hybrid model wherein multiple swarm intelligence models have been evaluated to optimize the conventional Long Short-Term Memory(LSTM)model in classifying the faults from the vibration signals data acquired from the *** helps to analyze the performance and behavioral patterns of the system more effectively and efficiently which helps to suggest for replacement of the unit with higher *** results have demonstrated that the proposed hybrid modeling approach is effective in classifying the faults of the gearbox from the time series data and achieve higher diagnostic accuracy in comparison to the conventional LSTM methods.

关键词： Gearbox long short term memory fault classification swarm intelligence optimization condition monitoring

MCBC-SMOTE:A Majority Clustering Model for Classification of Imbalanced Data

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Computers, Materials & Continua 2022年第12期73卷 4801-4817页

作者： Jyoti Arora Meena Tushir Keshav Sharma lalit mohan Aman Singh Abdullah Alharbi Wael Alosaimi Department of Information Technology MSITGGSIPUNew Delhi110058India Department of Electrical and Electronic Engineering MSITGGSIPUNew Delhi110058India School of Computer Science and Engineering Lovely Professional University144411PunjabIndia Department of Information Technology College of Computers and Information TechnologyTaif University11099Taif 21944Saudi Arabia

Datasets with the imbalanced class distribution are difficult to handle with the standard classification *** supervised learning,dealing with the problem of class imbalance is still considered to be a challenging research *** machine learning techniques are designed to operate on balanced datasets;therefore,the state of the art,different undersampling,over-sampling and hybrid strategies have been proposed to deal with the problem of imbalanced datasets,but highly skewed datasets still pose the problem of generalization and noise generation during *** overcome these problems,this paper proposes amajority clusteringmodel for classification of imbalanced datasets known as MCBC-SMOTE(Majority Clustering for balanced Classification-SMOTE).The model provides a method to convert the problem of binary classification into a multi-class *** the proposed algorithm,the number of clusters for themajority class is calculated using the elbow method and the minority class is over-sampled as an average of clustered majority classes to generate a symmetrical class *** proposed technique is cost-effective,reduces the problem of noise generation and successfully disables the imbalances present in between and within *** results of the evaluations on diverse real datasets proved to provide better classification results as compared to state of the art existing methodologies based on several performance metrics.

关键词： Imbalance class problem classification SMOTE k-means clustering sampling

Innovation for Making Potable Water Available in Saline Groundwater Areas

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Journal of Water Resource and Protection 2014年第14期6卷 1284-1289页

作者： lalit mohan Sharma S M Sehgal Foundation Gurgaon India

Groundwater salinity is a widespread problem around the world with adverse consequences on health, soil quality and overall eco-systems. With the rapidly growing demands of groundwater, its exploitation is also accelerating. It is also changing the flow of the groundwater, which in turn causes ingress of sea water or intrusion of other saline groundwater or polluted water from the surrounding areas. The major consequences are scarcity of water even for domestic use and rise in the level and spread of groundwater salinity. An innovative technique of creating a pool of fresh groundwater within a saline aquifer is developed, which can address the issue. Technique is about recharging the saline aquifer with harvested rain water in such a way that recharged rain water does not get mixed with the existing saline groundwater rather it forms pool of fresh water in the saline aquifer. Water from this pool can be extracted without getting it mixed with saline groundwater. This innovation also eliminates the need of cost intensive provision of water storage structures to store rain water for fulfilling the domestic water needs. Thus, the saline aquifer unsuitable or otherwise useless for groundwater development can be used.

关键词： Rain Water Harvesting Hydro-Static Pressure Saline Groundwater Pool of Fresh Water

A New Species of Fossil <i>Mus</i>(Muridae, Mammalia) from the Late Quaternary Deposits of Narmada Valley, Central India

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Open Journal of Geology 2011年第3期1卷 37-44页

作者： Bahadur Singh Kotlia Moulishree Joshi lalit mohan Joshi 不详

A new species of fossil Mus (Muridae, Rodentia) is described from the Pleistocene fluviatile deposits of the Narmada valley (Central India). The species, Mus narmadaensis sp. Nov., has a comparatively smaller lower molar which is characterized by a narrow molar with well connected cusps, small anterior expansion of lingual anteroconid, protoconid and metaconid, reduced posterior cingulum in addition to hypoconid and entoconid nearly at the same level. The large M3 has centrally placed bulbous hypoconid. Among the extant species, the present one is closest to M. shortridgei in having similarly placed protoconid and metaconid in M1 and a well developed hypoconid in M3.

关键词： Fossil Mus Late Quaternary Narmada basin Central India

Science Letters:Demonstration of a new biosensing concept for immunodiagnostic applications based on change in surface conductance of antibodies after biomolecular interactions

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第9期7卷 683-685页

作者： VASHIST Sandeep Kumar KAUR Inderpreet BAJPAI Ram Prakash BHARADWAJ lalit mohan TEWARI Rupinder RAITERI Roberto Department of Biophysical and Electronic Engineering University of Genoa via Opera Pia 11A Genoa-16145 Italy Biomolecular Electronics and Nanotechnology Division Central Scientific Instruments Organization Sector 30 Chandigarh-160030 India Department of Biotechnology Panjab University Sector 14 Chandigarh-160014 India

We report an important observation that the surface conductivity of antibody layer immobilized on polylysine-coated glass substrate decreases upon the formation of complex with their specific antigens. This change in conductivity has been observed for both monoclonal and polyclonal antibodies. The conductance of monoclonal mouse 1gG immobilized on polylysine-coated glass substrate changed from 1.02×10^-8 Ω^-1 to 1.41×10^-11 Ω^-1 at 10 V when complex is formed due to the specific biomolecular interactions with rabbit anti-mouse 1gG F（ab′）2. Similar behavior was observed when the same set up was tested in two clinical assays：（1） anti-Leishmania antigen polyclonal antibodies taken from Kala Azar positive patient serum interacting with Leishmania promastigote antigen, and （2） anti-p21 polyclonal antibodies interacting with p21 antigen. The proposed concept can represent a new immunodiagnostic technique and may have wide ranging applications in biosensors and nanobiotechnology too.

关键词： Immunodiagnosis Antibodies Immune complex Conductance

Feasibility and efficacy of delayed pharmacoinvasive therapy for STelevation myocardial infarction

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World Journal of Cardiology 2023年第1期15卷 23-32页

作者： Rishi Sethi lalit mohan Pravesh Vishwakarma Abhishek Singh Swati Sharma Monika Bhandari Ayush Shukla Akhil Sharma Gaurav Chaudhary Akshyaya Pradhan Sharad Chandra Varun Shankar Narain Sudhanshu Kumar Dwivedi Department of Cardiology King George's Medical UniversityLucknow 226003Uttar PradeshIndia

BACKGROUND ST-elevation myocardial infarction(STEMI)refers to a clinical syndrome that features symptoms of myocardial ischemia with consequent ST-elevation on electrocardiography and an associated rise in cardiac *** restoration of brisk flow in the coronary vasculature is critical in reducing mortality and *** patients with STEMI who could not receive primary percutaneous coronary intervention(PCI)on time,pharmacoinvasive strategy(thrombolysis followed by timely PCI within 3-24 h of its initiation)is an effective *** To analyze the role of delayed pharmacoinvasive strategy in the window period of 24-72 h after *** This was a physician-initiated,single-center prospective registry between January 2017 and July 2017 which enrolled 337 acute STEMI patients with partially occluded coronary *** received routine pharmacoinvasive therapy(PCI within 3-24 h of thrombolysis)in one group and delayed pharmacoinvasive therapy(PCI within 24-72 h of thrombolysis)in another *** primary endpoint was major adverse cardiac and cerebrovascular events(MACCE)within 30 d of the *** secondary endpoints included major bleeding as defined by Bleeding Academic Research Consortium classification,angina,and dyspnea within 30 *** The mean age in the two groups was comparable(55.1±10.1 years vs 54.2±10.5 years,P=0.426).Diabetes was present among 20.2%and 22.1%of patients in the routine and delayed groups,*** rate was 54.6%and 55.8%in the routine and delayed groups,*** was initiated within 6 h of onset of symptoms in both groups(P=0.125).The mean time from thrombolysis to PCI in the routine and delayed groups was 16.9±5.3 h and 44.1±14.7 h,*** significant difference was found for the occurrence of measured clinical outcomes in the two groups within 30 d(8.7%vs 12.9%,P=0.152).Univariate analysis of demographic characteristics and risk factors for patients who reporte

关键词： Coronary artery disease ST-elevation myocardial infarction Primary percutaneous coronary intervention Pharmacoinvasive strategy Thrombolysis Atherosclerosis

Dt1-SWEET10a partner:Photoperiodic control of seed weight in soybean

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Molecular Plant 2024年第6期17卷 839-841页

作者： Li-Qing Chen lalit Dev Tiwari Department of Plant Biology University of Illinois at Urbana-ChampaignUrbanaIL 61801USA DOE Center for Advanced Bioenergy and Bioproducts Innovation University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Institute for Sustainability Energyand EnvironmentUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA

Seed weight and size are critical agronomic traits essential for determining yield and composition,receiving significant attention throughout domestication(Meyer et al.,2012).Seed weight serves as a reliable indicator of average seed size due to their positive *** of seed weight involves both developmental and environmental cues,affecting cell proliferation or expansion(Li et al.,2019).

关键词： soybean SWEET1 weight