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Belt and Road Initiative Tax Journal 2024年第1期 106-113页

作者： lala Babayeva Chingiz Musayev state Tax service Ministry of Economy the Republic of Azerbaijan

This article outlines the significance of the digital economy,highlighting the challenges to taxation,and introducing the focus of the article on Azerbaijan's *** recent decades,the digital revolution has transformed the global economy,reshaping industries,business models,and consumer behavior at an unprecedented *** transformation,commonly referred to as the digital economy,encompasses a broad spectrum of activities ranging from e-commerce and digital services to data analytics and cloud *** the digital economy continues to expand its influence,traditional tax systems face significant challenges in adapting to this new *** has ignited discussions worldwide across various legal and regulatory domains,and international taxation is no *** tax consequences are extensive,impacting both direct and indirect taxation,broader tax policy matters,and tax administration.

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Targeting the chromatin structural changes of antitumor immunity

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Journal of Pharmaceutical Analysis 2024年第4期14卷 460-482页

作者： nian-nian Li Deng-xing Lun ningning Gong Gang Meng Xin-ying Du He Wang Xiangxiang Bao Xin-yang Li Ji-wu song Kewei Hu lala Li si-ying Li Wenbo Liu Wanping Zhu Yunlong Zhang Jikai Li Ting Yao Leming Mou Xiaoqing Han Furong Hao Yongcheng Hu Lin Liu Hongguang Zhu Yuyun Wu Bin Liu Weifang People's Hospital WeifangShandong261000China school of Life sciences Nankai UniversityTianjin300071China Weifang Traditional Chinese Medicine Hospital WeifangShandong261000China shaanxi Key Laboratory of sericulture Ankang UniversityAnkangShaanxi725000China Guizhou Education University Guiyang550018China Guizhou normal University Guiyang550025China school of Medical Imaging Weifang Medical UniversityWeifangShandong261053China Department of Bone and soft Tissue Oncology Tianjin HospitalTianjin300299China Xinqiao Hospital of Army Military Medical University Chongqing400038China Teda Institute of Biological sciences&Biotechnology Nankai UniversityTianjin300457China

Epigenomic imbalance drives abnormal transcriptional processes,promoting the onset and progression of *** defective gene regulation generally affects carcinogenesis and tumor suppression networks,tumor immunogenicity and immune cells involved in antitumor responses may also be affected by epigenomic changes,which may have significant implications for the development and application of epigenetic therapy,cancer immunotherapy,and their ***,we focus on the impact of epigenetic regulation on tumor immune cell function and the role of key abnormal epigenetic processes,DnA methylation,histone post-translational modification,and chromatin structure in tumor immunogenicity,and introduce these epigenetic research *** emphasize the value of small-molecule inhibitors of epigenetic modulators in enhancing antitumor immune responses and discuss the challenges of developing treatment plans that combine epigenetic therapy and immuno-therapy through the complex interaction between cancer epigenetics and cancer immunology.

关键词： Antitumor immunity Chromatin structural Cancer epigenetics DnA methylation Histone modification Chemotherapy

集束-延续护理模式结合改良式袋鼠式护理对早产儿生长发育及母亲积极感受的影响

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临床医学研究与实践 2024年第14期9卷 181-185页

作者：王腊腊王艳神木市医院门诊部陕西神木719300 神木市医院骨科陕西神木719300

目的研究集束-延续护理模式结合改良式袋鼠式护理对早产儿生长发育及母亲积极感受的影响。方法选取2020年5月至2021年5月本院收治的90例早产儿为研究对象,以随机数字表法将其分为对照组与观察组,各45例。对照组采用常规护理干预,观察组... 详细信息

目的研究集束-延续护理模式结合改良式袋鼠式护理对早产儿生长发育及母亲积极感受的影响。方法选取2020年5月至2021年5月本院收治的90例早产儿为研究对象,以随机数字表法将其分为对照组与观察组,各45例。对照组采用常规护理干预,观察组在对照组基础上加施集束-延续护理模式结合改良式袋鼠式护理。比较两组的干预效果。结果干预后,观察组早产儿的头围、身长、体质量均优于对照组(Ps)各维度评分低于对照组(P<0.05)。干预后,观察组早产儿的智力发育指数(MDI)、精神运动发育指数(PDI)评分均高于对照组(P<0.05)。干预后,观察组早产儿的神经功能评估量表各维度评分高于对照组(P<0.05)。结论集束-延续护理模式结合改良式袋鼠式护理不仅能够促进早产儿生长发育,提高母亲积极感受及减少其不确定感,还能有效提升早产儿智能及神经功能发育,值得推广。

关键词：集束-延续护理模式改良式袋鼠式护理早产儿生长发育母亲积极感受

Evaluation of Antibiotic Prescribing in the Pediatric Department of Gabriel TouréTeaching Hospital, Bamako, Mali

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Open Journal of Pediatrics 2024年第3期14卷 645-656页

作者： Pierre Togo Hawa Konaré Mariam Maïga Karamoko sacko Djénéba Konaté Abdoul Karim Doumbia Adama Dembélé Oumar Coulibaly Aminata sangaré Mohamed Elmouloud Cissé Fousseyni Traoré Belco Maïga Ibrahim Ahamadou Aminata Doumbia lala n’Drany sidibé Amadou Touré Yacouba Aba Coulibaly Kalirou Traoré Tati simaga souleymane sagara Leyla Bagna Maïga Bory Traoré Abdoul Aziz Diakité Fatoumata Dicko Mariam sylla sounkalo Dao Boubacar Togo Paediatric Department Gabriel Tour&#233 Teaching Hospital Bamako Mali Pediatric Department Distric VI Reference Health Center Bamako Mali Infectious Diseases Department Point G Teaching Hospital Bamako Mali

Objectives: The main objective was to evaluate antibiotic prescribing in the Department of Pediatrics at Gabriel Touré teaching hospital. Methods: This was a prospective descriptive study conducted from september 1 to november 31, 2018, in the Department of Pediatrics at Gabriel Touré teaching hospital. All children aged 0 to 15 years hospitalized for any pathology during the study period and having received at least one antibiotic had been included. Results: We collected 445 children’s records out of 1032 admissions during the study period, representing a hospital frequency of 43.1%. The sex ratio was 1.3%. The 2 - 5 age group accounted for 48.1%. Fever was the reason for consultation in 45.6% of cases. Patients’ general condition was altered in 60% of cases. The fathers were blue-collar workers in 65.4% and the mothers housewives in 85%, and had no education in 42.9% and 64.5% respectively. Hepatomegaly was present in 18.2%, splenomegaly in 9.6% and peripheral adenopathy in 3.1%. The site of infection was pulmonary in 37.6% and EnT in 9.2%. Bacterial infection was assumed on admission in 54% of cases, and meningitis in 57.7%. The discharge diagnosis was malaria in 54.6%, severe acute malnutrition in 18.6% and meningitis in 6.7%. The death rate was 3.8%. neutrophilic leukocytosis was present in 47.3% of patients. CRP was positive in 85% of patients. Blood cultures taken in 27.6% of patients were positive in 5. CsF analysis in 30% of patients showed elevated leukocytes in 6.5%. no cultures were positive. Antibiotic prescription was justified by infectious hypotheses in 43.1% of patients. β-lactam antibiotics were prescribed in 98.6%. Antibiotic therapy was not adapted to national/international recommendations in 68.3% of cases, and was not justified in 16.3% of cases on D5 of hospitalization. Conclusion: Antibiotic use was justified in more than half of patients, but remained inadequate in almost two-thirds of cases, in line with national and international recommend

关键词： Antibiotic Prescription Hospitalization Child

Interplanetary consequences and geoeffectiveness of CME associated with major solar flare from nOAA AR 12673

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Research in Astronomy and Astrophysics 2020年第2期20卷 85-93页

作者： shirsh Lata soni Radhe shyam Gupta Pyare lala Verma Department of Physics Govt.P.G.CollegeSatnaMP 485001India Department of Physics Govt.P.G.College MaiharSatnaMPIndia

In this reported work,we study a major X-class flare(X9.3) that arose from nOAA Active Region(AR) 12673 on 2017 september 6,from 11:53 UT to 12:10 UT in multi-wavelength *** event also produced a fast coronal mass ejection(CME).nOAA AR 12673 emerged at s09 W30 on 2017 september6 and grew rapidly to a large *** 2017 september 9,the maximum area of this AR was 1060 millionth of the solar *** group of sunspots disappeared over the west limb of the sun(s09 W83) on september *** was a fast emerging flux *** group of sunspots showed magnetic configuration category *** identified their earliest signatures of eruption in AIA 94A images with initialization and successive rapid growth from low coronal heights of hot channeled *** the other hand,the CME associated with this flare event triggered the intense Dst at 1 AU(–142 nT).We have acquired observations and analyze the reported event from the sun’s surface,corona(source AR),interplanetary space and in-situ measurement near *** addition,here we analyze the complex processes of CMECME interaction that have contributed a significant role to make the reported event so geoeffective.

关键词： solar wind Coronal Mass Ejection(CME) sun

Management and treatment of bizarre open globe trauma in three steps:a case report

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International Journal of Ophthalmology(English edition) 2011年第2期4卷 218-219页

作者： lala Ceklic slobodanka Latinovic Aljoscha s.neubauer Djoko Obucina Bobana Petrovic Clinical Center of Eastern sarajevo-Eye Clinic Kasindo Ludvig Maximillian Univeristy Eye Clinic

This is a case presentation of a very bizarre open globe trauma with anterior segment foreign body-fishing hook stuck in the cornea and iris. Complications due to this kind of eye trauma might be very hazardous and with serious impact on visual function. We are representing our approach and experience of three step management of this kind of eye injury: first-extract the foreign body, close and reconstruct the eyeball, second-fight inflammation, and third-restore the visual function by cataract surgery.

关键词： eye trauma anterior segment foreign body traumatic cataract

核动力厂最终安全分析报告维护管理的思考及建议

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核安全 2024年第4期23卷 91-95页

作者：邵辉杨腊腊陈秋炀杨煦苏州热工研究院有限公司苏州215004

核动力厂最终安全分析报告(Final safety Analysis Report,FsAR)作为核动力运行许可证的申请文件之一,是全面反映核动力厂设计和运行信息的文件,也是营运单位实施核动力厂修改、安全分析及事件评价的重要依据。鉴于FsAR的重要作用,营运... 详细信息

核动力厂最终安全分析报告(Final safety Analysis Report,FsAR)作为核动力运行许可证的申请文件之一,是全面反映核动力厂设计和运行信息的文件,也是营运单位实施核动力厂修改、安全分析及事件评价的重要依据。鉴于FsAR的重要作用,营运单位需要对其进行适当的维护和管理,以确保FsAR能够真实反映核动力厂实际配置。目前,我国核安全相关法规导则尚未提供FsAR维护和管理的具体指导方法,营运单位对FsAR维护和管理方法各有不同,FsAR内容与核动力厂实际配置不一致的矛盾也日渐突出。随着我国运行核动力厂数量的增多,监管单位的监管压力也明显增加。本文基于国内运行核动力厂FsAR的维护和管理现状,结合国外核动力厂的良好实践,提出了FsAR维护和管理的改进建议。

关键词：最终安全分析报告维护和管理改进建议插页修改定期升版

Using Capillary Pressure Derived Parameters for Improving Permeability Prediction

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International Journal of Geosciences 2013年第9期4卷 1313-1320页

作者： Amir Maher s. lala Geophysics Department Faculty of Science Ain Shams University Cairo Egypt

This paper presents the construction and verification of a new better semi-analytical, statistically derived universal model than that modified from Huet and Blasingame equation for estimating absolute permeability from mercury injection capillary pressure data. The foundation of my new model is the petrophysical relation between absolute permeability and capillary-pressure/wetting phase saturation properties. I also incorporate characteristics of capillary pressure behavior using the classic Brooks-Corey power-law model. The final form of my new proposed model allowed us to predict absolute permeability as a function of effective porosity, irreducible wetting phase saturation, displacement or threshold pressure corresponding pore throat radius, and basic pore size characteristics. I built my model using 189 sets of mercury—injection (Hg-air) capillary pressure data and measured permeability-including core samples from several reservoirs both carbonate and sandstone lithologies. I identified this correlation by quantifying its accuracy and precision based on regression analysis. I compared permeability estimates obtained from Huet and Blasingame mercury-injection capillary-pressure-based model and my new universal predicted permeability model to a set of laboratory measured permeability of my studied core sample and previously published data results respectively, where I quantified the method’s accuracy and precision based on error analysis. The measured permeability samples range is from 0.003 mD to 5341 mD. I review current employed models that are classified as belonging to Poiseuille model.

关键词： Capillary Pressure Permeability Poiseuille Model

Comparison of sublingual microcirculatory parameters measured by sidestream darkfield videomicroscopy in anesthetized pigs and adult humans

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Animal Models and Experimental Medicine 2023年第5期6卷 499-503页

作者： Raushan lala Ryan Homes shaun Pratt Wendy Goodwin Mark Midwinter school of Biomedical sciences The University of QueenslandSt LuciaQldAustralia school of Veterinary sciences The University of QueenslandGattonQldAustralia Jamieson Trauma Institute Royal Brisbane and Women's HospitalHerstonQldAustralia Traumatic Injury sciences Group The University of QueenslandSt LuciaQldAustralia

Background:This study aimed to compare sublingual microcirculatory parameters between anesthetized pigs and conscious adult humans using sidestream darkfield *** overarching aim of the work was to validate the pig as an experimental model of changes in microcirculatory function following traumatic haemorrhagic shock and ***:Fourteen large white pigs and 14 humans were recruited for the *** sidestream darkfield videomicroscopy clips were captured in anesthetized pigs and conscious *** underwent manual analysis in Automated Vascular Analysis 3.2 *** total vessel density(TVD),perfused vessel density(PVD),proportion of perfused vessels(PPVs)and microvascular flow index(MFI)were *** independent samples t test was used for between species comparison of microcirculatory *** and Conclusions:Conscious humans had a significantly lower TVD,PVD and MFI than anesthetized *** significant difference in PPVs was observed between the *** of the microcirculation is a critical determinant of tissue metabolic function and *** it may not be surprising that some inter species differences in the sublingual microcirculatory anatomy were identified between pig and human subjects,it is interesting to report the insignificant difference in *** direct microcirculatory measure represents a relative change which should hold translatable value across *** therefore conclude the pig is a suitable model for microcirculatory research and may be a suitable species to investigate changes in microcirculatory perfusion following perturbations in cardiovascular homeostasis,for example during traumatic haemorrhagic shock and resuscitation.

关键词： comparative anatomy microcirculation sidestream darkfield videomicroscopy

Bioleaching of copper from pre and post thermally activated low grade chalcopyrite contained ball mill spillage

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Frontiers of Environmental science & Engineering 2013年第2期7卷 281-293页

作者： sandeep PAnDA nilotoala PRADHAn Umaballav MOHAPATRA sandeep K. PAnDA swagat s.RATH Danda s. RAO Bansi D. nAYAK lala B. sUKLA Barada K. MIsHRA CsIR-Institute of Minerals and Materials Technology Bhubaneswar 751013 India Department of Botany North Orissa University Baripada 757003 India Regional Center of Central Tuber Crops Research Institute Bhubaneswar 751019 India

Bioleaching of a low grade chalcopyrite （ball mill spillage material） was tested for copper recovery in shake flasks. The original samples （as received） were thermally activated （600℃, 30 min） to notice the change in physico-chemical and mineralogical characteristics of the host rock and subsequently its effect on copper recovery. A mixed culture of acidophilic chemolithotrophic bacterial consortium predominantly entailing Acidithiobacillus fer- rooxidans strain was used for bioleaching studies and optimization of process parameters of both original and thermally activated samples. Mineralogical characteriza- tion studies indicated the presence of chalcopyrite, pyrite in the silicate matrix of the granitic rock. Field emission scanning electron microscopy coupled with Energy dispersive spectroscopy （FEsEM-EDs） and X-ray Fluor- escence （XRF） analysis indicated mostly siO2. With pH 2, pulp density 10% w/v, inoculum 10% v/v, temperature 30~C, 150 ***-~, 49% copper could be recovered in 30 days from the finest particle size （- 1 ~ 0.75 mm） of the original spillage sample. Under similar conditions 95% copper could be recovered from the thermally activated sample with the same size fraction in 10 days. The study revealed that thermal activation leads to volume expansion in the rock with the development of cracks, micro and macro pores on its surface, thereby enabling bacterial solution to penetrate more easily into the body, facilitating enhanced copper dissolution.

关键词： ball mill spillage thermal activation bioleaching copper