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Pharmacodynamic evaluation for antiplasmodial activity of Holarrhena antidysentrica(Kutaja) and Azadirachta indica(Neemb) in Plasmodium berghei infected mice model

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Asian Pacific Journal of Tropical Medicine 2013年第7期6卷 520-524页

作者： Jadhav Priyanka lal hingorani Kshirsagar Nilima University Department of Infectious Diseases and University Department of Interpathy Research and Technology.Maharashtra University of Health Sciences.Mumbai India Pharmanza Herbals Pvt.Ltd. MumbaiIndia Office of National Chair(Clinical Pharmacology).Indian Council of Medical Research(ICMR).Government of India Dean ESI-PGIMSR MGM HospitalGovt.of India.MumbaiIndia

Objective:To investigate in-vivo anti-plasmodial activity of aqueous extracts of plants selected based on the symptomology mentioned in ***:The aqueous extracts of Holarrhena antidysentrica(***)(Kutaja) and Azadirachta indica(***)(Neemb) for their antiplasmodial potential in Plasmodium berghei(***) infected mice was assessed using Peters four day suppressive *** the extracts were administered at 2 dose levels,full dose(1 000 mg/d) and minimized dose(200 mg/d).10~6 *** infected RBCs were injected on day ’0’ and treated from day ’0’ till day ’3’ post-infection,Tail blood smears were collected, giemsa stained and *** mice were observed for survival and parasitemia was assessed till 50%of mice in control ***:It was observed that the percentage of parasitemia increased gradually in all the groups,with maximum in control group(Day 3-35,Day 9-46.98) and minimum in Chloroquine arm(Day *** 9-19.92).The percentage of parasitemia was compared using Mann-Whitney U test depicting that all test groups exhibited reduction in parasitemia as compared to control(P-value<0.002 for all groups).These groups showed similar percentage of survival as ***:The present investigation demonstrated the anti-plasmodial effects of *** and *** are two most commonly used medicinal plants in Ayurved for treatment of fever.

关键词： Holarrhena antidysentrica Azadirachta indica Plasmodium berghei Malaria Peter’s 4 day test Ayurved Parasitemia

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Rapid metabolic fingerprinting with the aid of chemometric models to identify authenticity of natural medicines: Turmeric, Ocimum, and Withania somnifera study

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Journal of Pharmaceutical Analysis 2023年第9期13卷 1041-1057页

作者： Samreen Khan Abhishek Kumar Rai Anjali Singh Saudan Singh Basant Kumar Dubey Raj Kishori lal Arvind Singh Negi Nicholas Birse Prabodh Kumar Trivedi Christopher T.Elliott Ratnasekhar Ch Metabolomics Lab Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Department of Crop Production&Protection Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Academy of Council of Scientific and Industrial Research(ACSIR) Ghaziabad201002India Department of Biotechnology Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Genetics and Plant Breeding Department Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Department of Phytochemistry Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India School of Biological Sciences Queen's UniversityBelfastBT95DLUK

Herbal medicines are popular natural medicines that have been used for *** use of alternative medicines continues to expand rapidly across the *** World Health Organization suggests that quality assessment of natural medicines is essential for any therapeutic or health care applications,as their therapeutic potential varies between different geographic origins,plant species,and *** of herbal medicines based on a limited number of secondary metabolites is not an ideal *** quality should be considered based on a complete metabolic profile,as their pharmacological activity is not due to a few specific secondary metabolites but rather a larger group of bioactive compounds.A holistic and integrative approach using rapid and nondestructive analytical strategies for the screening of herbal medicines is required for robust *** this study,a rapid and effective quality assessment system for geographical traceability,species,and variety-specific authenticity of the widely used natural medicines turmeric,Ocimum,and Withania somnifera was investigated using Fourier transform near-infrared(FT-NIR)spectroscopy-based metabolic *** different geographical origins of turmeric,five different Ocimum species,and three different varieties of roots and leaves of Withania somnifera were studied with the aid of machine learning *** good discrimination(R^(2)>0.98,Q^(2)>0.97,and accuracy=1.0)with sensitivity and specificity of 100%was achieved using this metabolic fingerprinting *** study demonstrated that FT-NIR-based rapid metabolic fingerprinting can be used as a robust analytical method to authenticate several important medicinal herbs.

关键词： Rapid metabolic fingerprinting Natural medicines FT-NIR Chemometric models

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