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Gut microbiota interactions with anti-diabetic medications and pathogenesis of type 2 diabetes mellitus

World Journal of Methodology 2022年第4期12卷 246-257页

作者： Ravi Kant lakshya chandra Vipin Verma Priyanshu Nain Diego Bello Siddharth Patel Subash Ala Rashmi chandra Mc Anto Antony Department of Endocrinology Diabetes and MetabolismMedical University of South CarolinaAndersonSC 29621United States Department of Endocrinology Diabetes and MetabolismAnMed HealthAndersonSC 29621United States Department of Internal Medicine St Francis HospitalGreenvilleSC 29601United States Department of Internal Medicine Medical University of South CarolinaAndersonSC 29621United States Department of Internal Medicine AnMed HealthAndersonSC 29621United States Department of Graduate Medical Education Maulana Azad Medical CollegeDelhi 110002India Department of Surgery AnMed HealthAndersonSC 29621United States Department of Internal Medicine Decatur Morgan HospitalDecaturAL 35601United States

Microorganisms including bacteria,viruses,protozoa,and fungi living in the gastrointestinal tract are collectively known as the gut *** is the imbalance in microbial composition on or inside the body relative to healthy *** Firmicutes to Bacteroidetes ratio and decreased abundance of Akkermansia muciniphila are the predominant gut dysbiosis associated with the pathogenesis of type 2 diabetes mellitus(T2DM)and metabolic *** mechanisms linking gut dysbiosis,and metabolic diseases and their complications include altered metabolism of short-chain fatty acids and bile acids,interaction with gut hormones,increased gut microbial metabolite trimethylamine-N-oxide,bacterial translocation/Leaky gut syndrome,and endotoxin production such as *** association between the gut microbiota and glycemic agents,however,is much less understood and is the growing focus of research and *** studies suggest that the gut microbiota and anti-diabetic medications are interdependent on each other,meaning that while anti-diabetic medications alter the gut microbiota,the gut microbiota also alters the efficacy of anti-diabetic *** increasing evidence regarding the significance of gut microbiota,it is imperative to review the role of gut microbiota in the pathogenesis of *** review also discusses the interaction between gut microbiota and the various medications used in the treatment of T2DM.

关键词： Metabolic disease Gut microbiota Cardiovascular disease Short chain fatty acid Dysbiosis Trimethylamine-N-oxide

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Case of COVID-19 presenting with gastrointestinal symptoms

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World Journal of Virology 2020年第1期9卷 1-4页

作者： Ravi Kant lakshya chandra Mc Anto Antony Vipin Verma Division of Endocrinology Diabetes and MetabolismMedical University of South Carolina/AnMed CampusAndersonSC 29621United States Department of Medicine Bon Secours Saint Francis Health SystemGreenvilleSouth CarolinaSC 29601United States Department of Medicine Medical University of South Carolina/AnMed CampusAndersonSC 29621United States

Patients with coronavirus disease 2019(COVID-19)predominantly present with the pulmonary symptoms such as fever,cough,and shortness of *** present a case of an 83 years old patient with COVID-19 who presented with only gastrointestinal symptoms without respiratory *** case raises the concern regarding our current lack of understanding of extrapulmonary manifestations of *** genetic homology between 2019 severe acute respiratory syndrome coronavirus(SARS-CoV)2 and SARS-CoV,our case underscores the urgent need for further studies to understand the role of the gastrointestinal system in 2019 SARS-CoV-2 transmission and COVID-19 pathogenesis.

关键词： COVID-19 SARS-CoV-2 Coronavirus Gastrointestinal Diarrhea Pandemic

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