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Evidence for current diagnostic criteria of diabetes mellitus

World Journal of Diabetes 2016年第17期7卷 396-405页

作者： Ritesh Kumar lakshmana perumal nandhini Sadishkumar Kamalanathan Jayaprakash Sahoo Muthupillai Vivekanadan Department of Endocrinology and Metabolism Jawaharlal Institute of Postgraduate Medical Education and Research

Diabetes mellitus is a non-communicable metabolicderangement afflicting several millions of individuals globally. It is associated with several micro and macro-vascular complications and is also a leading cause of mortality. The unresolved issue is that of definition of the diagnostic threshold for diabetes. The World Health Organization and the American Diabetes Asso-ciation(ADA) have laid down several diagnostic criteria for diagnosing diabetes and prediabetes based on the accumulating body of *** review has attempted to analyse the scientific evidence supporting the justification of these differing criteria. The evidence for diagnosing diabetes is strong, and there is a concordance between the two professional bodies. The controversy arises when describing the normal lower limit of fasting plasma glucose(FPG) with little evidence favouring the reduction of the FPG by the ADA. Several studies have also shown the development of complications specific for diabetes in patients with prediabetes as defined by the current criteria though there is a significant overlap of such prevalence in individuals with normoglycemia. Large multinational longitudinal prospective studies involving subjects without diabetes and retinopathy at baseline will ideally help identify the threshold of glycemic measurements for future development of diabetes and its complications.

关键词： Diabetes Prediabetes Post glucose Microvascular complications Macrovascular complications

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Impact of X-radiation in the management of COVID-19 disease

引用

World Journal of Radiology 2022年第7期14卷 219-228页

作者： Aishwarya T A Divya K Mohan K nandhini Venkateswarlu Raavi Venkatachalam perumal Department of Human Genetics Sri Ramachandra Institute of Higher Education and Research(Deemed to be University)PorurChennai 600116Tamil NaduIndia Department of Cell Biology and Molecular Genetics Sri Devaraj Urs Academy of Higher Education and Research(Deemed to be University)TamakaKolar 563103KarnatakaIndia

Coronaviruses are a diverse group of viruses that infect both animals and *** though the existence of coronavirus and its infection to humans is not new,the 2019-novel coronavirus(nCoV)caused a major burden to individuals and society i.e.,anxiety,fear of infection,extreme competition for hospitalization,and more importantly financial *** nCoV infection/disease diagnosis was based on non-specific signs and symptoms,biochemical parameters,detection of the virus using reverse-transcription polymerase chain reaction(RTPCR),and X-ray-based *** review focuses on the consolidation of potentials of X-ray-based imaging modality[chest-X radiography(CXR)and chest computed tomography(CT)]and low-dose radiation therapy(LDRT)for screening,severity,and management of COVID-19 *** studies suggest that CXR contributed significantly toward initial rapid screening/diagnosis and CT-imaging to monitor the disease *** chest CT has high sensitivity up to 98%and low specificity for diagnosis and severity of COVID-19 disease compared to ***,LDRT compliments drug therapy in the early recovery/Less hospital stays by maintaining the physiological parameters better than the drug therapy *** the results undoubtedly demonstrated the evidence that X-ray-based technology continues to evolve and play a significant role in human health care even during the pandemic.

关键词： Corona virus COVID-19 infection COVID-19 disease X-rays Computed tomography Low dose radiotherapy

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