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Diagnosis of primary squamous cell carcinoma of the pancreas using endoscopic ultrasound-guided core needle biopsy

Gastroenterology Report 2017年第1期5卷 72-74,I0003页

作者： Amir Kashani Melissa Kahn laith h.jamil Division of Gastroenterology Cedars-Sinai Medical CenterLos AngelesUSA Department of Pathology and Laboratory Medicine Cedars-Sinai Medical CenterLos AngelesUSA

Primary squamous cell carcinoma(SCC)of the pancreas is a particularly rare *** of this tumor is tentatively made after ruling out metastatic SCC from another primary site and adenosquamous carcinoma(ASC)of the *** we discuss the case of a 76-year-old woman who was found to have a solitary pancreatic lesion and multiple hepatic *** of computed tomography-guided biopsy of the liver lesions were consistent with a metastatic carcinoma displaying squamous differentiation;therefore,an endoscopic ultrasound(EUS)-guided core-needle biopsy(CNB)of the pancreatic mass was *** histopathological examination of the pancreatic specimen at multiple levels revealed moderately well-differentiated SCC with no glandular *** extensive metastatic work-up did not reveal an extra-pancreatic origin for this SCC;hence,a diagnosis of primary SCC of the pancreas was *** our knowledge,this is the first report of the diagnosis of a primary SCC of the pancreas using EUS-guided *** believe that CNB has a diagnostic yield equivalent to that of fine-needle aspiration for recognizing pancreatic adenocarcinoma;however,when cytological examinations reveal atypical squamous epithelial cells suggestive of malignancy,CNB may provide a better tissue specimen,from which to determine the presence of a glandular *** an assessment will differentiate pancreatic SCC from ASC.

关键词： squamous cell carcinoma pancreatic neoplasms endoscopic ultrasonography core needle biopsy

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Liver metastasis from hepatoid adenocarcinoma of the esophagus mimicking hepatocellular carcinoma

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Gastroenterology Report 2017年第1期5卷 67-71,I0003页

作者： Amir Kashani Jonathan C.Ellis Melissa Kahn laith h.jamil Division of Gastroenterology Cedars-Sinai Medical CenterLos AngelesCAUSA Department of Pathology and Laboratory Medicine Cedars-Sinai Medical CenterLos AngelesCAUSA

Alpha-fetoprotein(AFP)-producing adenocarcinoma,histologically mimicking hepatocellular carcinoma(hCC),is a distinct entity known as hepatoid adenocarcinoma(hAC).Reported cases of hAC arising from the esophagus are extremely *** to common liver metastasis and elevated AFP levels in patients with esophageal hAC,differentiation of hAC with liver metastasis from hCC could be *** describe a case of esophageal hAC that presented with a liver mass showing hepatoid features and elevated serum AFP *** presentation was suspicious for *** further diagnostic work-up,the patient was diagnosed with esophageal hAC with liver *** distinction between these two entities is particularly important because hAC is more aggressive,and its therapeutic options are very limited.

关键词： hepatoid adenocarcinoma alpha-fetoproteins hepatocellular carcinoma

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