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Retrospective review of tota. neoa.juva.t thera.y

World Journa. of Ga.trointestina. Oncology 2019年第10期11卷 857-865页

作者： laila Ba.a. Veli Ba.a.ov Stephen a.el Oba.d a.hra. Gene Gra.t Finley Moses S Ra. Kristina.Lundeen Dula.h K Monga.a.exa.der V Kirichenko Rodney E Wegner Depa.tment of Interna. Medicine Allegheny General HospitalPittsburghPA 15212United States Depa.tment of Ra.ia.ion Oncology Allegheny General HospitalPittsburghPA 15212United States Depa.tment of Medica. Oncology Allegheny General HospitalPittsburghPA 15212United States

Ba.KGROUND Neoa.juva.t chemora.iothera.y(nCRT)followed by resection a.d postopera.ive multi-a.ent chemothera.y(ma.hT)is the sta.da.d of ca.e for loca.ly a.va.ced recta. *** this a.proa.h,ma.hT a.ministra.ion ca. be dela.ed for severa. months,lea.ing to concern for dista.t *** countera.t this,a.novel trea.ment a.proa.h known a. tota. neoa.juva.t thera.y(TNT)ha. ga.ned popula.ity,in which pa.ients receive both ma.hT a.d nCRT prior to *** utilized the Na.iona. Ca.cer Da.a.a.e to exa.ine tempora. trends in TNT usa.e,a.d a.y potentia. effect on *** To study the tempora. trends in the usa.e of TNT a.d eva.ua.e its effica.y compa.ed to neoa.juva.t *** We queried the Na.iona. Ca.cer Da.a.a.e for pa.ients with loca.ly a.va.ced recta. ca.cer,Sta.e II-III,from 2004-2015 trea.ed with nCRT or *** wa. defined a. ma.hT initia.ed≥90 d prior to nCRT *** surviva. wa. ca.cula.ed from the da.e of dia.nosis to the da.e of la.t conta.t or dea.h using Ka.la.-Meier curves to present the cumula.ive proba.ility of surviva.,with logra.k sta.istics to a.sess *** cox regression wa. used to identify predictors of surviva. a.d propensity score a.a.ysis a.counted for *** We identified 9066 eligible pa.ients,with 8812 a.d 254 pa.ients receiving neoa.juva.t chemora.ia.ion followed by ma.hT a.d TNT,*** involvement,sta.e III disea.e,a.d trea.ment in recent yea.s were predictive of TNT *** wa. grea.er use of TNT with more a.va.ced sta.e,specifica.ly>1 node involved(odds ra.io[OR]=2.88,95%confidence interva.[CI]:2.11-3.93,Pa.d sta.e III disea.e(OR=2.88,95%CI:2.11-3.93,Pa.ed(OR=2.41,95%CI:1.27-4.56,Pa.grea.er increa.e from 2013 to 2015(OR=6.62,95%CI:3.57-12.25,Pa.d neoa.juva.t chemora.ia.ion a.ms ha. a.simila. 5-yea. surviva. a. 76%a.d 78%*** a.a.ysis with propensity score de

关键词： Tota. neoa.juva.t thera.y Neoa.juva.t chemora.ia.ion Multi-a.ent chemothera.y Loca.ly a.va.ced recta. ca.cer Na.iona. ca.cer da.a.a.e Colorecta. ca.cer Retrospective review Ga.trointestina. oncology Tempora. trends Surgica. excision

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a. a.sessment on the Coa.ta. Sea.a.er Qua.ity of the Gulf of Suez, Egypt

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Journa. of Environmenta. Protection 2020年第1期11卷 34-47页

作者： Ma.a. G. Ma.moud Ehsa. a.u El-Khir Ma.moud H. Ebeid laila a. Moha.ed Ma.douh a. Fa.my Kholoud S. Sha.a. Ma.ine Chemistry La.ora.ory National Institute of Oceanography and Fisheries Alexandria Egypt

The present study focused on wa.er qua.ity a.sessment of 14 hotspot loca.ions in the Gulf of Suez by mea.uring the physicochemica. pa.a.eters sea.ona.ly during 2016. The results of investiga.ed a.ea.revea.ed tha., the a.nua. mea. ra.ge of wa.er wa.: tempera.ure (21.91°C - 29.22°C), pH (7.64 - 7.78), sa.inity (38.71‰ - 42.74‰), dissolved oxygen (6.09 - 8.78 mgO2/l,) oxidiza.le orga.ic ma.ter (1.4 - 5.4 mg/l), biologica. oxygen dema.d (1.14 - 3.94 mgO2/l), tota. suspended solids (18.56 - 37.69 mg/l), a.monia.(13.51 - 494.41 μg/l), nitrite (1.261 - 151.76 μg/l), nitra.e (7.11 - 487.85), dissolved inorga.ic phospha.e (2.22 - 53.26) a.d silica.e (19.83 - 347.61 μg/l). The N:P ra.io fluctua.ed between 4.21 a.d 1214.61 with the ma.n va.ue of 81.16 indica.ing tha. the different sites in the northern pa.t of the Gulf of Suez a.e P-limited. Ba.ed on the Principa. Component a.a.ysis Da.a. the sta.ions loca.ing in the Northern a.d Southern side of the Gulf of Suez a.e rela.ively good wa.er qua.ity;mea.while, wa.er qua.ity of the other sta.ions loca.ing in the northern side of the Gulf of Suez is found slightly polluted to a.different degree co-incided with a. increa.e in the huma. a.tivities in ea.h of these loca.ions.

关键词： The Gulf of Suez Sea.a.er Hydro-Chemica. Pa.a.eter Nutrients Wa.er Qua.ity Index (WQI)

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Bioetha.ol Production from Rice Stra. Enzyma.ica.ly Sa.cha.ified by Funga. Isola.es, Trichoderma.viride F94 a.d a.pergillus terreus F98

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Soft 2014年第2期3卷 19-29页

作者： Merva.e a. a.o-Sta.e a.med M. E. Ra.a. Nour Sh. EL-Gendy laila a. Fa.a.a. Hekma. R. Ma.ia. Egyptia. Petroleum Resea.ch Institute (EPRI) Cairo Egypt Fa.ulty of Science (Girls Bra.ch) Al-Azhar University Cairo Egypt Na.iona. Center for Ra.ia.ion Resea.ch a.d Technology (NCRRT) Cairo Egypt

Egypt fa.es a.high popula.ion growth ra.e nowa.a.s, which dema.ds for a. increa.e in a.ricultura. production efficiency. Consequently, a.ricultura. field residues will increa.e. Rice stra. is one of the ma.n a.riculture residues in Egypt. So this study wa. performed on rice stra. a. a.resource for production of bioetha.ol. Eight microbia. isola.es, five yea.ts a.d three fungi were isola.ed from rice stra.. Yea.t isola.es were selected for their a.ility to utilize different suga.s a.d cellulose. Chipped a.d grinded rice stra. wa. subjected to different pretrea.ment methods physica.ly through stea. trea.ment by a.tocla.ing a.d different doses of ga.ma.γ irra.ia.ion (50 a.d 70 Mra.). a.tocla.ed pretrea.ed rice stra. wa. further enzyma.ica.ly trea.ed throughout solid sta.e fermenta.ion process by different funga. isola.es;F68, F94 a.d F98 producing ma.imum tota. reducing suga.s of 12.62, 13.58, 17.00 g/L, respectively. Bioetha.ol production by sepa.a.e microbia. hydrolysis a.d fermenta.ion (SHF) process of rice stra. hydrolysa.e wa. performed by the two selected funga. isola.es;Trichoderma.viride F94 a.d a.pergillus terreus F98 a.d two yea.t isola.es (Y26 a.d Y39). The two yea.t isola.es ha.e been identified by 18S, RNa.a. Ca.dida.tropica.is Y26 a.d Sa.cha.omyces cerevisia. Y39. SHF processes by F94 a.d Y26 produced 45 ga.lon/ton rice stra. while tha. of F98 a.d Y39 produced 50 ga.lon/ton rice stra..

关键词： Bioetha.ol Rice Stra. Different Pretrea.ments Sa.cha.omyces cerevisia. Ca.dida tropica.is Sepa.a.e Hydrolysis a.d Fermenta.ion (SHF)

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The Importa.ce of Bringing the Fa.ily Together. Exploring the Experience a.d Mea.ing of Fa.ily Hea.th Conversa.ions in Dementia.Ca.e

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Open Journa. of Nursing 2019年第11期9卷 1153-1172页

作者： laila Mohrsen Busted Dorthe S. Nielsen Regner Birkelund The Depa.tment of Regiona. Hea.th Resea.ch Faculty of Health Sciences University of Southern Denmark Odense Denmark The Hea.th Sciences Resea.ch Center UCL University College Odense Denmark Migra.t Hea.th Clinic Odense University Hospital Center for Global Health University of Southern Denmark Odense Denmark

a.m: The a.m of this study wa. to investiga.e fa.ily members’ experience of enga.ing in the “Fa.ily Hea.th Conversa.ions” intervention. Methods: a.qua.ita.ive study wa. conducted with 15 fa.ily members who enga.ed in the intervention. The study used semi-structured interviews a.d da.a.were a.a.ysed using reflexive thema.ic a.a.ysis. Findings: Through a.a.ysis a.d interpreta.ion of the da.a. three themes were identified: 1) Support for na.iga.ing in unknown wa.ers;2) Bringing pea.e a.d relief to the fa.ily;3) Involving the rela.ive with dementia.in Fa.ily Hea.th Conversa.ions. Fa.ily Hea.th Conversa.ions showed were beneficia. to the fa.ilies of persons with dementia.a.d of grea. importa.ce to both individua. fa.ily members a.d the fa.ily. Involving the person with dementia.in the Fa.ily Hea.th Conversa.ions wa. not a.wa.s beneficia. for the fa.ily. Conclusion: Deciding when to involve the person with dementia.in Fa.ily Hea.th Conversa.ions requires thorough knowledge of the fa.ily a. well a. the person with dementia. to a.oid excluding them. The intervention supports reta.ning selfhood a.d a.tonomy for the person with dementia. even when the individua. did not pa.ticipa.e in the conversa.ion.

关键词： Fa.ily Hea.th Conversa.ions Dementia Ca.e Fa.ily Members

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Role of Urokina.e-Type Pla.minogen a.tiva.or Receptors a. a. Ea.ly Detector for Trea.ment Outcome in a.ult a.ute Myeloid Leukemia.in Egyptia. Pa.ients

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Journa. of Ca.cer Thera.y 2015年第11期6卷 963-970页

作者： Ha.a. R. Na.sa. Ema. Z. Ka.deel laila a. E. Hega.y a.a.y M. Hela. Ta.ek Da.wish Soa. a. Eltokhy Medica. Oncology NCI Cairo Egypt Clinica. Pa.hology NCI Cairo Egypt Clinica. Pa.hology Faculty of Medicine Cairo University Cairo Egypt

Ba.kground: The urokina.e-type pla.minogen a.tiva.or system which consists of a.proteina.e (the urokina.e-type pla.minogen a.tiva.or, uPa., a.receptor (the urokina.e-type pla.minogen a.tiva.or receptor uPa. or CD87) a.d inhibitors (Pa.1) is enriched in severa. types of tumors a.d involved in proteolysis, cell migra.ion a.d inva.ion. High expression of uPa.a.d uPa. is a.socia.ed with a. increa.ed rela.se ra.e a.d shorter surviva. in brea.t ca.cer a.d colorecta. ca.cinoma.. a.ms: This study shed light on the expression of uPa. in a.ult a.ute myeloid leukemia.(a.L) a.d its prognostic releva.ce. Methods: Periphera. blood a.d bone ma.row sa.ples a.e obta.ned from 54 newly dia.nosed a.L a.ult pa.ients, 20 hea.thy controls sta.ned with a.ti CD87 a.d estima.ed on flow cytometry. Results: CD87 expression wa. heterogeneous in different Fa. subtypes of a.L with high expression in monocytic leukemia.(M4/M5) (P va.ue 0.001). High expression of CD87 wa. a.socia.ed with shorter surviva. a.d poor response to thera.y (P = 0.028, 0.002 respectively). The most discrimina.ing cut off va.ue of CD87 expression wa. 20%, pa.ients with less tha. 20% expression ha. 4.6 times better trea.ment outcome tha. those with more tha. or equa. to 20%. On the multiva.ia.e a.a.ysis, CD87 wa. the most significa.t single va.ia.le tha. a.fect trea.ment outcome compa.ed to tota. leucocytic count, hemoglobin level, pla.elets count, cytogenetic a.d FLT expression. Summa.y/Conclusion: High CD87 expression is a. independent prognostic pa.a.eter a.socia.ed with poor response a.d shorter overa.l surviva. in a.ult a.L pa.ients.

关键词： a.L Pla.minogen Surviva. uPa. CD87

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COVID-19 in Children: Experience from a.Tertia.y Ca.e Hospita. in Ba.gla.esh

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Open Journa. of Pedia.rics 2022年第5期12卷 749-766页

作者： Ka.rul laila Muja.mel Ha.ue Sutopa.Ha.der Supti Sha.a.a.a.hter Ra.ma. Depa.tment of Pedia.rics Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh

Ba.kground: Children a.e genera.ly a. low risk of infection a.d da.a.on COVID-19 in children a.e sca.ce. This study wa. underta.en to document da.a.from a.tertia.y ca.e hospita. in Ba.gla.esh on the incidence, presenta.ion a.d immedia.e outcome of COVID-19 in children. Methodology: It wa. a.cross-sectiona. study conducted in the fever clinic a.d the depa.tment of Pedia.rics, Ba.ga.a.dhu Sheikh Mujib Medica. University (BSMMU) over a.period of one yea. from July 2020 to June 2021. a.l the RT–PCR positive pedia.ric ca.es (1 month to 18 yea.s) were enrolled. Da.a.were collected by a.structured, predesigned a.d pre-tested questionna.re. Da.a.were a.a.yzed using Microsoft Excel sprea.sheet softwa.e 2010. Frequency, percenta.e a.d chi-squa.e tests were done for sta.istica. a.a.ysis. Result: a.ong 8203 suspected pedia.ric COVID-19 ca.es, 850 (10.36%) wa. RT PCR positive. The highest number of RT-PCR positive COVID-19 ca.es wa. found in a.ril 2021. More tha. 63% of ca.es were in the a.e group of 10 to 18 yea.s. Ma.e: fema.e ra.io wa. 0.97:1. Fever wa. the most common (75.9%) presenting fea.ure followed by brea.hing difficulty a.d chest pa.n in 9.6% a.d 7% of a. style="font-fa.ily: ">pa.ients respectively. Mild infection group wa. predomina.t (56.7%). a.ong the symptoma.ic ca.es, 16.7% were hospita.ized. Oxygen inha.a.ion a.d bronchodila.ors were needed in 75% of hospita.ized pa.ients. a.l the severe a.d critica. ca.es were ma.a.ed in the inpa.ient depa.tment a.d in pedia.ric PICU when indica.ed. Most of the pa.ients (99.4%) improved with or without a.y complica.ion. Four critica.ly ill pa.ients (0.75%) developed multi-orga. dysfunction a.d expired in PICU. Conclusion: a. style="font-fa.ily: ">The ma.ority of COVID-19 ca.es belonged to the older a.e group. More tha. 75% ca.es were symptoma.ic. History of conta.t wa. present in 78% ca.es. More tha. 99% children recovered with or without sequela. a.d 0.8% children with pre-existing co-morbidities expired.

关键词： COVID-19 Infection Severity a.e Group Co-Morbid Conditions

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a.sessment of Usua. Fruit, Vegeta.le a.d Vita.in C Inta.es in a.Sa.ple of Egyptia. Children: Pilot Study

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Food a.d Nutrition Sciences 2015年第10期6卷 923-934页

作者： laila Hussein Neha. Ha.sa. Ma.moud Moha.a. Sa.a. a.del a.iz Depa.tment of Nutrition National Research Center Giza Egypt

The objective wa. to crea.e a. Egyptia. da.a.a.e on the contributors of fruit a.d vegeta.les in the diets of preschool children a.d to estima.e the usua. da.ly inta.es of fruits, vegeta.les a.d vita.in C. a.tota. of 59 hea.thy boys a.d girls a.ed 2.5 - 6 yea.s a.tending da. ca.e centers in urba. Giza.governora.e completed the study by interviewing their mothers on 6x non-consecutive da.s using the 24 h dieta.y reca.l. Pa.ticipa.ts were cla.sified a.cording to a.e, gender a.d socioeconomic cla.s. Preva.ence of da.ly consumptions of fruits a.d vegeta.les a.ounted to 22% a.d 54%, respectively of the tota. children. The da.ly inta.es of fruits a.d vegeta.les a.era.ed 117.5 a.d 56.4 g, respectively. The consumption of different types of fruits a.d vegeta.les wa. unevenly distributed by different persona. a.d socia. va.ia.les. Estima.ed da.ly vita.in C supply from the diet wa. 38 mg per child, which sa.isfied the respective recommended nutrient inta.e (RNI) of 30 mg for the first six yea.s of life. However, the diet of 15% of the children covered less tha. 75% of RNI. Top fruits contributing to vita.in C were ora.ges, gua.a. wa.ermelon, pea.s a.d gra.es. Extra.foods such a. chipsy wa. consumed by 81% of the children, contributed 18% to da.ly vita.in C supply a.d a.so 58.6 mg sodium. a.multilevel intervention stra.egy is wa.ra.ted for promoting da.ly fruit a.d vegeta.le inta.e a.d hea.thy ea.ing in ea.ly childhood.

关键词： Children a.ed 2.5 - 6 Yea.s Fruit & Vegeta.le Inta.es Vita.in C Inta.e Hea.th Problems & Vit C Deficiency

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a.socia.ion between IL-37 a.d VEGF Gene Expression in Psoria.is Pa.hogenesis in Egyptia. Popula.ion

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Journa. of Biosciences a.d Medicines 2022年第5期10卷 136-149页

作者： Sherif M. El-Sherbini a.med Kh. S. Sa.a.a.laila a. Ra.hed Moha.ed H. Na.a.y Sa.ir a. M. El-Ma.ry Genetic Engineering a.d Biotechnology Resea.ch Institute Al-Sadat University Al-Sadat Egypt Fa.ulty of a.plied Medica. science Misr University for Science and Technology Giza Egypt Fa.ulty of Medicine Cairo University Cairo Egypt

Ba.kground: Psoria.is is considered a.common skin disea.e, ma.ked by the production a.d eleva.ion of infla.ma.ory pla.ues tha. regula.ly shed sca.es resulting from extensive skin epithelia. cell prolifera.ion. T lymphocytes, neutrophils, a.d other leukocytes enter the irrita.ed skin, resulting in epiderma. kera.inocyte hyperpla.ia. va.cula. hyperpla.ia. ecta.ia. a.d T lymphocyte, neutrophil other forms of leukocyte infiltra.ion. a.m of the Work: the study a.med to investiga.e the role of IL-37 a.d VEGF gene expression in the pa.hogenesis of psoria.is in Egyptia. pa.ients. Methodology: Polymera.e cha.n rea.tion techniques (PCR) were a.plied to detect VEGF in the skin homogena.es of psoria.is pa.ients. In a.dition, the ELIZa.technique wa. a.plied to investiga.e IL-37 in skin homogena.es. One hundred ca.es ha.e been divided into two groups: 50 hea.thy volunteers a. the group I hea.thy control;50 psoria.is pa.ients a. group II. PCR rea.-time technology wa. a.sessed through extra.ted DNa.sa.ples for VEGF a.plifica.ion in skin homogena.e. Result: Our results revea.ed tha. psoria.is pa.ients significa.tly ha. a.substa.tia. reduction in IL-37 compa.ed to the control group (p Conclusion: There is a.significa.t inverse a.socia.ion between IL-37 a.d VEGF in psoria.is pa.ients. Study findings revea.ed tha. IL-37 gene expression decrea.es while VEGF gene expression increa.es in psoria.ic individua.s. Such a.mea.urement ma. be beneficia. in determining the severity of the condition, a. well a. ta.ing into considera.ion of the disea.e’s dia.nosis.

关键词： IL-37 VEGF Gene Expression Psoria.is PCR

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Nutritiona. Epidemiologica. Study to Estima.e Usua. Inta.e a.d to Define Optimum Nutrient Profiling Choice in the Diet of Egyptia. Youths

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Food a.d Nutrition Sciences 2015年第15期6卷 1422-1436页

作者： Moushira.Za.i laila Hussein Mosta.a.Gouda.Ra.ia.Ba.suoni a.med Ha.sa.ein Depa.tment of Biologica. a.thropology National Research Centre Giza Egypt Depa.tment of Huma. Nutrition National Research Centre Giza Egypt Depa.tment Informa.ion a.d Systems National Research Centre Giza Egypt

Objectives: To define optimum food a.d nutrient profiling in gender-specific a.d a.e group-specific va.ia.t regression models. Setting: 481 subjects of both sexes (18.4 yea.s old) from Giza.urba. were set. Design: Dieta.y a.sessment used the 24-h dieta.y reca.l da.a.to ca.cula.e the estima.ed energy a.d (24) nutrients ea.en by ea.h individua.. Four indices—food va.iety diversity score, hea.thy ea.ing index (HEI), mea. proba.ility of nutrients a.equa.y (MPa. a.d nutrient rich food (NRF9.3) index score were used for a.sessing the profiling of the diet. Results: a.tota. of 163 individua. food items were consumed by the pa.ticipa.ts within the 24-h dieta.y reca.l with a. a.era.e da.ly inta.e of (6.6) different food va.ieties. Gra.ns were the top contributors of energy a.d 10 ma.ro a.d micro nutrients followed by the mea. group. Ba.ed on the MPa.da.a. the mea. a.cepta.le inta.e (a.) of dieta.y ca.cium (32.9%) a.d vita.in C (30%) were limiting in the diet. The diet profiling consumed by the teena.ers a.ed 14.8 yea.s wa. inferior compa.ed to tha. consumed by subjects a.ing 23.9 yea.s. Linea. regression a.a.yses were conducted between the 4 indices a. the dependent va.ia.le a.d a.l possible combina.ions of 16 nutrients of interest a. independent va.ia.les. NRF9.3 wa. the optimum nutrient index a.d correla.ed nega.ively with ma.kers of a.domina. obesity. Conclusion: Implementa.ion of nutrition intervention progra. wa. directed to youths to include a.e a.propria.e good hea.thy foods to decrea.e the risk of nutrient deficiencies.

关键词： Egyptia. Youths Hea.thy Ea.ing Index Mea. Proba.ility Nutrient a.equa.y Nutrient Rich Food Index a.thropometric Mea.ures of Hea.th Risk Correla.ions

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印度的中产阶级也在搞消费升级

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营销界 2019年第7期 55-60页

作者： laila 不详

班加罗尔的华人圈,一个故事流传甚广。因为中方管理者批评印度员工饮茶时间太久,后者愤而辞职。天塌下来,不能不喝Cha.(印地语里的茶)。印度年均消费十亿公斤茶叶,痴迷程度不输于中国的福建人和潮汕人。在尘土飞扬的马路边,印度人不管不... 详细信息

班加罗尔的华人圈,一个故事流传甚广。因为中方管理者批评印度员工饮茶时间太久,后者愤而辞职。天塌下来,不能不喝Cha.(印地语里的茶)。印度年均消费十亿公斤茶叶,痴迷程度不输于中国的福建人和潮汕人。在尘土飞扬的马路边,印度人不管不顾,啜饮土瓷碗中甜腻的Cha.。在班加罗尔,这是到处可见的景象。

关键词：中产阶级消费升级

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