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Rice science 2014年第6期21卷 305-311页

作者： WANG Wei-xia lai Feng-xiang LI Kai-long fu Qiang State Key Laboratory of Rice Biology China National Rice Research Institute

The brown planthopper Nilaparvata lugens Stal （Homoptera： Delphacidae） can cause hopperburn by feeding on rice and also can transmit the grassy stunt disease. Resistant rice varieties have been developed, but several N. lugens strains can recover their virulence to these resistant rice varieties. In the present study, reference genes with stable expression levels in N. lugens populations showed different levels of virulence to susceptible and resistant rice varieties. The expression of six candidate reference genes in N. lugens feeding on susceptible and resistant rice varieties was analyzed. These genes were evaluated for their potential use in the analysis of differential gene expression. Polymerase chain reaction data was generated from N. lugens, including two different treatments （resistant or susceptible rice） and three virulent N. lugens populations. Three software programs （BestKeeper, Normfinder and geNorm） were used to assess the candidate reference genes. Both geNorm and Normfinder identified the genes 18S, E-ACT, E-TUB and a-TUB as the most stable reference genes. BestKeeper identified ETIF1 as the optimal reference gene with the least overall variation, whereas 18S and a-TUB were the second and third most stably expressed genes, respectively. Therefore, we concluded that the genes 18S and a-TUB were the most suitable reference genes in N. lugens. These results will facilitate future transcript profiling studies on N. lugens populations that show variation in virulence levels on different rice varieties.

关键词： reference gene Nilaparvata lugens quantitative real-time PCR gene expression rice

Urea-assisted mixed gas treatment on Li-Rich layered oxide with enhanced electrochemical performance

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Journal of Energy Chemistry 2022年第3期31卷 123-132,I0005页

作者： Liying Bao Lei Wei Nuoting fu Jinyang Dong lai Chen Yuefeng Su Ning Li Yun Lu Yongjian Li Shi Chen Feng Wu School of Materials Science and Engineering Beijing Institute of TechnologyBeijing Key Laboratory of Environmental Science and EngineeringBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China School of Automation Beijing Institute of TechnologyBeijing 100081China

Lithium-rich manganese-based oxides(LRMOs)have been considered as one of the most promising cathode materials owing to their superior specific capacity and high operating ***,their largescale commercial applications are limited due to problems such as structural instability,voltage decay,and poor cycle ***,pre-generated oxygen vacancies and oxygen-deficient phase were introduced to Li_(1.2)Mn_(0.6)Ni_(0.2)O_(2)(LMNO)using a facile urea-assisted mixed gas treatment(UMGT)method for facilitating electronic and ionic conductivity,reducing the surface oxygen partial pressure,and suppressing the release of lattice *** with the pristine LMNO material,the UMGT sample modified at 200℃exhibited enhanced discharge capacity,capacity retention,and rate *** addition,the Li+diffusion coefficient significantly improved by 50%than that of the reference *** importantly,the voltage decay was effectively suppressed,with average potential decreasing from 0.53 V(LMNO)to 0.39 V(UMGT-200)after 200 cycles at 1 *** proposed UMGT method provides an effective strategy to alleviate the phase transition and improve the electrochemical performance for lithium-rich materials,and identifies a promising research direction to inhibit the voltage decay of layered anion redox cathode materials.

关键词： Lithium-rich oxides Pre-generated oxygen vacancies Oxygen-deficient Voltage decay

A cytotoxic pyrrolidinoindoline diketopiperazine dimer from the algal fungus Eurotium herbariorum HT-2

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Chinese Chemical Letters 2013年第12期24卷 1049-1052页

作者： Ye Li Kun-lai Sun Yi Wang Peng fu Pei-Pei Liu Chen Wang Wei-Ming Zhu Key Laboratory of Marine Drugs Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of China

A new cytotoxic pyrrolidinoindoline diketopiperazine dimer, cristatumin E （1）, was isolated from the fermentation broth of the algal fungus Eurotium herbariorum HT-2 associated with the marine algae, Enteromorpha prolifera. The structure was determined by spectroscopic analyses and Marfey＇s amino acid analysis. Cristatumin E （1） showed cytotoxicity against K562 tumor cell line and antibacterial activity against Enterobacter aerogenes and Escherichia coli with IC50 and MIC values of 8.3, 44.0 and 44.0 μmol/L, respectively.

关键词： Cristatumin E Pyrrolidinoindoline diketopiperazine dimer Eurotium herbariorum Algal fungus Cytotoxicity Enteromorpha prolifera Marine algae

Modulating Pd e_(g) orbital occupancy in Pd-Au metallic aerogels for efficient carbon dioxide reduction

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Journal of Energy Chemistry 2023年第12期87卷 98-104,I0004页

作者： Yao Chen Juan Wang Tingjie Mao Cun Chen Hanjun Li Honggang Huang Hui fu Feili lai Jiadong Chen Nan Zhang Tianxi Liu Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringInternational Joint Research Laboratory for Nano Energy CompositesJiangnan UniversityWuxi 214122JiangsuChina Key Laboratory of Leather of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035ZhejiangChina Department of Chemistry KU LeuvenCelestijnenlaan 200FLeuven 3001Belgium

The electronic structure of electrocatalysts plays a critical role in energy conversion,whereas for an efficient catalyst,it is challenging to modulate the ***,we present a new strategy to modulate the e_(g) orbital occupancy of Pd by constructing composition-controllable Pd-Au metallic aerogels(MAs),optimizing the d-band center of Pd to achieve excellent performance for electrochemical carbon dioxide reduction reaction(CO_(2)RR).Specifically,Pd_(1)Au_(2) MAs achieve almost 100% Faraday efficiency(FE) of CO in the range of-0.40 to-0.80 V *** hydrogen electrode(RHE),as well as the long-term stability,being one of the best Pd-based materials for CO_(2)*** X-ray photoelectron spectroscopy(XPS) results and density functional theory(DFT) calculations demonstrate that the introduction of Au modulates the Pd e_(g) orbital occupancy,which significantly weakens *CO adsorption on Pd,reduces the CO_(2)RR energy barrier and consequently improves the electrocatalytic activity and stability for long-term *** work highlights a new strategy for designing efficient electrocatalysts for CO_(2)RR and beyond.

关键词： Pd Carbon dioxide reduction Alloy Aerogels Orbital occupancy

Synthesis of O-glycosylα-aryl nitrones

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Chinese Chemical Letters 2010年第9期21卷 1075-1078页

作者： Ying fu Huai Yuan Zhang Yan Hua Liu Xue Feng Li Dan Feng Huang Yu lai Hu Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education Key Laboratory of Polymer Material of Gansu Province College of Chemistry & Chemical Engineering Northwest Normal University Lanzhou 730070 China

α-Aryl nitrone are one of the most useful kinds of nitrones and have been extensively explored in recent ***,the sugar moieties have not been introduced into these molecules *** presented here an efficient synthesis ofα-aryl nitrone Oglycosides via condensation of N-substituted hydroxylamine and aryl aldehydes glycosides in benzene.

关键词： Nitrones Glycosides Aryl aldehyde Hydroxylamine Synthesis

Study on Modification of Polymer Properties by the Cold Drawing Process

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Soft 2015年第1期4卷 1-7页

作者： Wing-fu lai Department of Mechanical Engineering The University of Hong Kong Hong Kong China

Polymers have a wide diversity of applications, ranging from therapeutics delivery to tissue engineering. While advances in polymer chemistry have facilitated synthesis and development of new polymers, increasing efforts have also been directed to engineer properties of existing polymers. One of the common approaches to modify polymer properties is cold drawing, which can align polymer chains and orient the chains in a crystalline manner. Regarding the industrial significance of cold drawing in polymer engineering, this study used semi-crystalline high density polyethylene (HDPE) as a model to examine the effect of cold drawing on the anisotropic mechanical properties of polymers. During cold drawing, the yield strength of the polymer was shown to be in a positive relationship with the strain rate, and the hardness of the cold-drawn region was demonstrated to be significantly enhanced. Our results confirmed the feasibility of engineering the properties of polymers by applying tension for plastic deformation, and highlighted the importance of precise control of the strain rate in the treatment.

关键词： Cold Drawing Mechanical Deformation Polymers Strain Rate

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稀疏标签传播:一种鲁棒的领域适应学习方法

软件学报 2015年第5期26卷 977-1000页

作者：陶剑文 fu-lai CHUNG 王士同姚奇富浙江大学宁波理工学院信息科学与工程学院浙江宁波315100 香港理工大学电子计算学系江南大学数字媒体学院江苏无锡214122 浙江工商职业技术学院电子与信息工程学院浙江宁波315012

稀疏表示因其所具有的鲁棒性,在模式分类领域逐渐得到关注.研究了一种基于稀疏保留模型的新颖领域适应学习方法,并提出一种鲁棒的稀疏标签传播领域适应学习(sparse label propagation domain adaptation learning,简称SLPDAL)算法.SLPDA... 详细信息

稀疏表示因其所具有的鲁棒性,在模式分类领域逐渐得到关注.研究了一种基于稀疏保留模型的新颖领域适应学习方法,并提出一种鲁棒的稀疏标签传播领域适应学习(sparse label propagation domain adaptation learning,简称SLPDAL)算法.SLPDAL通过将目标领域数据进行稀疏重构,以实现源领域数据标签向目标领域平滑传播.具体来讲,SLPDAL算法分为3步:首先,基于领域间数据分布均值差最小化准则寻求一个优化的核空间,并将领域数据嵌入到该核空间;然后,在该嵌入核空间,基于l1-范最小化准则计算各领域数据的核稀疏重构系数;最后,通过保留领域数据间核稀疏重构系数约束,实现源领域数据标签向目标领域的传播.最后,将SLPDAL算法推广到多核学习框架,提出一个SLPDAL多核学习模型.在鲁棒人脸识别、视频概念检测和文本分类等领域适应学习任务上进行比较实验,所提出的方法取得了优于或可比较的学习性能.

关键词：领域适应学习稀疏表示标签传播最大均值差多核学习

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稀疏近似最近特征空间嵌入标签传播

软件学报 2014年第6期25卷 1239-1254页

针对现有的基于图的半监督学习(graph-based semi-supervised learning,简称GSSL)方法存在模型参数敏感和数据空间判别信息不充分等问题,受最近特征空间嵌入和数据稀疏表示思想的启发,提出一种稀疏近似最近特征空间嵌入标签传播算法SANF... 详细信息

针对现有的基于图的半监督学习(graph-based semi-supervised learning,简称GSSL)方法存在模型参数敏感和数据空间判别信息不充分等问题,受最近特征空间嵌入和数据稀疏表示思想的启发,提出一种稀疏近似最近特征空间嵌入标签传播算法SANFSP(sparse approximated nearest feature space embedding label propagation).SANFSP首先利用特征空间嵌入投影点来稀疏表示原始数据;然后,度量原始数据和稀疏近似最近特征空间嵌入投影间的相似性;进而提出稀疏近似最近特征空间嵌入正则化项;最后,基于传统GSSL方法的标签传播算法,实现数据标签的平滑传播.同时,还将SANFSP算法简单拓展到out-of-sample学习.SANFSP算法在人造和实际数据集(如人脸识别、可视物件识别以及手写数字分类等)上取得了有效的实验结果.

关键词：半监督学习稀疏表示标签传播最近特征空间嵌入

S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1110-1127页

作者： Mengyao Hao Rong fu Jun Tai Zhenhuan Tian Xia Yuan yang Chen Mingjin Wang Huimin Jiang Ming Ji Fangfang lai Nina Xue Liping Bai Yizhun Zhu Xiaoxi Lv Xiaoguang Chen Jing Jin State Key Laboratory of Bioactive Substances and functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100050China Department of Otolaryngology Head and Neck SurgeryChildren's Hospital Capital Institute of PediatricsBeijing 100020China Department of Thoracic Surgery Peking Union Medical College HospitalPeking Union Medical CollegeDong Cheng DistrictBeijing 100730China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Pharmacology School of PharmaceuticalGuangzhou University of Chinese MedicineGuangzhou 510000China State Key Laboratory of Quality Research in Chinese Medicine Macao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyTaipaMacao SAR 999078China

Idiopathic pulmonary fibrosis(IPF)is a progressive lung disease with unclear etiology and limited treatment *** median survival time for IPF patients is approximately 2–3 years and there is no effective intervention to treat IPF other than lung *** important components of lung tissue,endothelial cells(ECs)are associated with pulmonary ***,the role of endothelial dysfunction in pulmonary fibrosis(PF)is incompletely ***-1-phosphate receptor 1(S1PR1)is a G protein-coupled receptor highly expressed in lung *** expression is markedly reduced in patients with ***,we generated an endothelial-conditional S1pr1 knockout mouse model which exhibited inflammation and fibrosis with or without bleomycin(BLM)*** activation of S1PR1 with an S1PR1 agonist,IMMH002,exerted a potent therapeutic effect in mice with bleomycin-induced fibrosis by protecting the integrity of the endothelial *** results suggest that S1PR1 might be a promising drug target for IPF therapy.

关键词： Idiopathic pulmonary fibrosis Endothelial barrier Tight junction Sphingosine-1-phosphate receptor 1 Sphingosine-1-phosphate receptor 1 agonist FTY720 IMMH002 Protein stability

Double-heavy tetraquarks with strangeness in the chiral quark model

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Chinese Physics C 2023年第2期47卷 29-40页

作者：陈晓云王福来谭悦杨友昌 College of Science Jinling Institute of TechnologyNanjing 211169China School of Physical Science and Technology Lanzhou UniversityLanzhou 730000China Research Center for Hadron and CSR Physics Lanzhou UniversityLanzhou 730000China Institute of Modern Physics of CAS Lanzhou 730000China Department of Physics Yancheng Institute of TechnologyYancheng 224000China Guizhou University of Engineering Science Bijie 551700China Zunyi Normal University Zunyi 563000China

Recently,some progress has been made in the experiments on double-heavy tetraquarks,such as T_(cc)reported by the LHCb Collaboration and Xccssreported by the Belle *** on the heels of our previous work about T_(cc) and T_(bb), we present a study on the bound and resonance states of their companions,QQqs(Q=c,b;q=u,s) tetraquarks with strange flavor in the chiral quark *** pictures,meson-meson and diquark-antidiquark ones,and their couplings were considered in our *** violation was neglected *** numerical analysis indicated that the states ccus with 1/2(1^(+)) ald bbus with 1/2(1^(+)) are the most promising stable states against strong ***,we found several resonance states for the double-heavy strange tetraquarks with the real scaling method.

关键词： quark model tetraquarks resonance states