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Chinese Medical Journal 2020年第9期133卷 1099-1108页

作者： Le-Sang Shen Xiao-Yan Jin Xu-Meng Wang lai-zhen tou Jian Huang Department of Breast Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province HangzhouZhejiang 310009China Department of Surgical Oncology Zhejiang Taizhou Municipal HospitalTaizhouZhejiang 318000China Department of Surgical Oncology the First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China

Nearly 70%of breast cancer(BC)is hormone-receptor(HR)-positive,human epidermal growth factor receptor 2(HER2)-negative,and endocrine therapy is the mainstay of treatment for this ***,intrinsic or acquired endocrine resistance can occur during the endocrine *** on insights of endocrine resistance mechanisms,a number of targeted therapies have been and continue to be *** regard to HR-positive,HER2-negative advanced BC,aromatase inhibitor(AI)is superior to tamoxifen,and fulvestrant is a better option for patients previously exposed to endocrine *** drugs,such as cyclindependent kinases(CDK)4/6 inhibitors,mammalian target of rapamycin(mTOR)inhibitors,phosphoinositide-3-kinase(PI3K)inhibitors,and histone deacetylase(HDAC)inhibitors,play a significant role in the present and show a promising *** the application of CDK4/6 inhibitors becoming common,mechanisms of acquired resistance to them should also be taken into consideration.

关键词： Endocrine therapy Advanced breast cancer Endocrine resistance Targeted therapy

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao lai Xu zhen Gu Hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

Survey on surgical treatment of neonatal necrotizing enterocolitis in China 2022

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World Journal of Pediatric Surgery 2023年第4期6卷 231-237页

作者： Jiafang Gao Dengming lai Jinfa tou Department of Neonatal Surgery Children's HospitalZhejiang University School of MedicineHangzhouChina Neonatal Surgery Group of the Pediatric Surgery Branch Chinese Medical AssociationBeijingChina

Objective The aim of this study was to identify the state of surgical treatment of neonatal necrotizing enterocolitis(NEC)in *** A total of 246 delegates(88.0%senior surgeons)completed a survey sent by the Neonatal Surgery Group of the Pediatric Surgery Branch of the Chinese Medical Association in *** centers were eliminated due to lack of *** Generally,38.2% of surgeons work in centers where more than 20 cases of surgical NEC are treated per year.A total of 81.3% of surgeons reported the use of ultrasonography;the most used biomarkers were white blood cell count(95.9%),C-reactive protein(93.8%),and procalcitonin(76.3%).Most surgeons(80.9%)used a combination of two(67.2%)antibiotics or single(29.5%)antibiotic for a treatment period of 7-14 days,and most used antibiotics were carbapenems(73.9%),penicillin and cephalosporins(56.0%).Patients are issued the fasting order for 5-7 days by nearly half surgeons(49.8%)for conservative treatment.70.1% of surgeons deemed that the most difficult decision was to evaluate the optimal timing of *** surgeons(76.3%)performed diagnostic aspiration of peritoneal *** was performed for the diagnosis and/or treatment of NEC by 40.2% of surgeons.A total of 53.5% of surgeons reported being able to identify localized intestinal necrosis *** relied the most on pneumoperitoneum(94.2%)and failure of conservative treatment(88.8%)to evaluate the surgical *** laparotomy,surgical treatments vary according to NEC *** are fasted for 5–7 days by 55.2% of surgeons *** surgeons(91.7%)followed up with patients with NEC after discharge for up to 5 years(53.8%).Conclusions The most difficult aspect of surgical NEC is evaluating the timing of surgery,and surgeons in the children’s specialized hospitals are *** treatment of NEC totalis is controversial,and the indications for laparoscopy need to be further *** multicenter

关键词： Surgery treatment centers

Preparation and characterization of single(200)-oriented TiN thin films deposited by DC magnetron reactive sputtering

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Rare Metals 2022年第4期41卷 1380-1384页

作者： zhen-Dong Wang zhen-Quan lai Department of Physics Nanchang UniversityNanchang 330031China

Single(200)-oriented TiN thin films were deposited on quartz substrate by direct current(DC) magnetron reactive sputtering process at a wide range of substrate temperature from 200 to 600 ℃.The effects of sputtering pressure and substrate temperature on the crystalline nature,morphology,electrical and optical properties of the deposited thin films were analyzed by X-ray diffraction(XRD),atomic force microscopy(AFM),four-point resistivity test system and ultraviolet visible near-infrared(UV-Vis-NIR) spectroscopy,*** results show that single(200)-oriented TiN thin films can be obtained at a wide range of substrate temperature from 200 to 600 ℃ with the grain size increasing from 35.9 to 64.5 *** resistivity of the product is as low as95 μΩ·cm,and the value of the optical reflectance is above68 % in the near-infrared(NIR) range of 760-1500 nm.

关键词： TiN thin film DC magnetron reactive sputtering Crystal orientation Optical property

Biological effect and molecular mechanism study of biomaterials based on proteomic research

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Journal of Materials Science & Technology 2017年第7期33卷 607-615页

作者： zhen zhen Yufeng zheng Zigang Ge Chen lai Tingfei Xi Academy for Advanced lnterdisdplinary Studies Peking University Beijing 100871 China

Along with the role transformation of biomaterials from bioinert substitute to regenerative inducer, the biological effect and mechanism of material-organism interaction become more important. Since most of animal tests and cellular experiments stay on the phenomenon description instead of mechanism interpretation, the development of proteomics technologies provides a golden opportunity to uncover the molecular interaction mechanism between biomaterial-organism on whole scale. This review summarizes current application of proteomics in biological effect and mechanism study of biomaterials, and discusses the development and challenges for future studies.

关键词： Proteomics Biomaterials Biological effect Molecular mechanism

Gravity-induced geometric spin Hall effect of freely falling quantum particle

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Communications in Theoretical Physics 2022年第10期74卷 76-82页

作者： zhen-lai Wang Xiang-Song Chen School of Mathematics and Physics Hubei Polytechnic UniversityHuangshi 435003China School of Physics and MOE Key Laboratory of Fundamental Quantities Measurement Huazhong University of Science and TechnologyWuhan 430074China

We discuss a new gravitational effect that the wave packet of a free-fall quantum particle undergoes a spin-dependent transverse shift in Earth’s gravitational *** effect is similar to the geometric spin Hall effect(GSHE)(Aiello 2009 et al ***.103100401),and can be called gravity-induced *** effect suggests that the free-fall wave packets of opposite spin-polarized quantum particles can be split in the direction perpendicular to spin and gravity.

关键词： gravity-induced geometric spin Hall effect quantum particle universality of free fall

Discrepancy between non-invasive prenatal testing result and fetal karyotype caused by rare confined placental mosaicism: A case report

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World Journal of Clinical Cases 2022年第24期10卷 8641-8647页

作者： zhen Li Guang-Rui lai Department of Obstetrics and Gynecology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Clinical Genetics Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

BACKGROUND Confined placental mosaicism(CPM)is one of the major reasons for discrepancies between the results of non-invasive prenatal testing(NIPT)and fetal karyotype *** SUMMARY We encountered a primiparous singleton pregnant woman with a rare CPM consisting of 47,XY,+21;47,XXY;and 46,XY,who obtained a false-positive result on NIPT with a high risk for trisomy ***-number variation sequencing on amniotic fluid cells,fetal tissue,and placental biopsies showed that the fetal karyotype was 47,XXY,while the placenta was a rare mosaic of 47,XY,+21;47,XXY;and 46,*** The patient had a rare CPM consisting of 47,XY,+21;47,XXY;and 46,XY,which caused a discrepancy between the result of NIPT and the actual fetal *** is important to remember that NIPT is a screening test,not a diagnostic *** positive result should be confirmed with invasive testing,and routine ultrasound examination is still necessary after a negative result.

关键词： Non-invasive prenatal testing Confined placental mosaicism Copy-number variation sequencing Karyotype analysis Case report

A separation form of unified convergence theorem

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Applied Mathematics(A Journal of Chinese Universities) 2008年第1期23卷 79-82页

作者： LUO lai-zhen LI Rong-lu Dept. of Math. Harbin Inst. of Tech. Harbin 150006 China.

In this paper, by introducing isometrically Pc0 property a separation form of convergence theorem is presented and the results generalize and unify several interesting conclusions in recent years.

关键词： quasi-normed group infinite matrix Antosik-Mikusinski theorem.

Experiments on self-excited oscillation in a thin-walled collapsible tube

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Acta Mechanica Sinica 2015年第6期31卷 817-826页

作者： Hai-Jun Wu lai-Bing Jia Xie-zhen Yin Department of Modern Mechanics University of Science and Technology of China Department of Naval Architecture and Marine Engineering University of Strathclyde

Self-excited oscillation in a collapsible tube is an important phenomenon in physiology. An experimental approach on self-excited oscillation in a thin-walled collapsi- ble tube is developed by using a high transmittance and low Young＇s modulus silicone rubber tube. The elastic tube is manufactured by the method of centrifugal casting in our laboratory. An optical method for recording the evolution of the cross-sectional areas at a certain position along the longitudinal direction of the tube is developed based on the technology of refractive index matching. With the transparent tube, the tube law is measured under the static no-flow condition. The cross section at the middle position of the tube transfers from a quasi-circular configuration to an ellipse, and then to a dumbell-shape as the chamber pressure is increased. During the self-excited oscillation, two periodic self-excited oscillating states and one transitional oscillating state are identified. They all belong to the LU mode. These different oscillating states are related to the initial cross-sectional shape of the tube caused by the difference of the downstream transmural pressure.

关键词： Collapsible tube Refractive index matching ·Cross-sectional area measurement· Self-excited oscillatingstates LU mode

Conjugated microporous polymer membranes for chemical separations

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Chinese Journal of Chemical Engineering 2022年第5期35卷 1-14页

作者： Zongyao Zhou zhen Li Lubna M.Rehman Zhiping lai Division of Physical Science and Engineering King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia

Conjugated microporous polymers(CMPs) are a unique class of porous organic materials, which are constructed with π-conjugation structures leading to intrinsic micropores. The CMPs properties such as high surface area, intrinsic and rich micropores, interlocking and rigid structure, extensive π-conjugation and tunable band-gap, chemical and thermal stability, together with tailored functionalities, contribute to its abundant potential for application in fields such as photocatalysis, optoelectronics, energy storage, and chemical sensors. Recently, CMPs have gained importance in the field of membranes for chemical separation. In this review, we briefly discuss the historical development of CMPs, followed by a detailed description of the progress in state-of-the-art design, preparation, and application of CMPs in membranes. Additionally, we provide inference on the future prospects of CMPs as membranes.

关键词： Conjugated microporous polymer Membrane Separation Electropolymerization Film