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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia qin Lingyan Liang Yichen Wei qingping Zhang Xiaocheng Li Haixia qin Yinqi lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

IL-10启动子多态性对慢性HBV感染者病情发展的关联性

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现代免疫学 2010年第4期30卷 342-345页

作者：王少扬孙顺来郑青马卫闽刘海周南京军区福州总医院感染科福州350003

为探讨IL-10启动子基因多态性对HBV感染者病情发展的影响,选择102例e抗原阳性的慢性乙型肝炎病毒感染者为观察对象,其中肝功能正常者50例(耐受期患者),肝功能异常患者52例(活动期患者)。采用限制性长片段多肽分析和直接测序的方法,检测I... 详细信息

为探讨IL-10启动子基因多态性对HBV感染者病情发展的影响,选择102例e抗原阳性的慢性乙型肝炎病毒感染者为观察对象,其中肝功能正常者50例(耐受期患者),肝功能异常患者52例(活动期患者)。采用限制性长片段多肽分析和直接测序的方法,检测IL-10启动子基因多态性,并与48例健康人群基因分布频率进行比较。结果从等位基因单基因分布频率分析比较,活动期患者-819C分布频率明显低于耐受期患者,而-592A分布频率明显高于耐受期患者。提示-592A与肝功能损害和激发免疫应答反应有一定相关性,相反-819C与免疫耐受相关。从基因型分析-592A/A基因型在活动期患者有较高的分布频率,而在耐受期患者分布频率低下,两组间比较有明显差异。-592A/C杂合子却相反,活动期患者频率低而耐受期患者频率高,分析-819基因组发现-819T/T活动期患者频率高于耐受期患者。从以上结果也看出,纯合子基因型在活动期患者中分布频率明显高于杂合子,而耐受期患者却相反。单倍体结果分析,(-1082/-819/-592)ATA活动期患者频率明显高于耐受期患者。表明IL-10启动子基因多态性影响HBV感染者病情发展。

关键词： IL-10 乙型肝炎启动子

Effect of anodic dissolution and passivation on X80 steel in NaHCO_(3) solution

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Petroleum Science 2021年第1期18卷 285-294页

作者： lai-shun Yang Chao Yang College of Civil Engineering and Architecture Shandong University of Science and TechnologyQingdao 266590ShandongChina Technology Inspection Center of Shengli Oilfield SINOPECDongying 257000ShandongChina China University of Petroleum(East China) Qingdao 266580ShandongChina

The effects of extreme stray current on the anodic dissolution and passivation of X80 steel in NaHCO3 solution were investigated using measurements of polarization curves and EIS,AFM and SEM *** the interference of anodic current(i=0~200 A/m2),main constituents of corrosion products of X80 steel were FeO(OH)and Fe3 O4.A double-layer film formed at i=00 A/m2,in which FeOOH was in outer and Fe3 O4 lied in *** formation mechanism of Fe3 O4 was confirmed and described by the electrochemical reaction in various regions on anodic potentiodynamic polarization curve.

关键词： Anodic current Passivation X80 steel Fe3O4 Near-neutral solution

Preparation and Luminescence Properties of the Na_(2)W_(2)O_(7) Crystal

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Chinese Physics Letters 2011年第11期28卷 246-248页

作者： WEI qin-Hua SHI Hong-Sheng CHAI Wen-Xiang qin lai-shun SHU Kang-Ying College of Materials Science and Engineering China Jiliang UniversityHangzhou 310018

We discuss the synthesis of Na2W2O7 polycrystalline materials based on the TG-DSC *** luminescence properties of the Na_(2)W_(2)O_(7) crystal are investigated using the Nd:YAG laser as the excitation *** is found that the maximum emission peak of the Na2W2O7 crystal is at 525 *** 525-nm luminescence decay has two *** has decay time 1.8s and the other 49.1μ*** comparing this results with that of the Na_(2)W_(4)O_(13) crystal,it is assumed that the 525-nm luminescence emission of the Na_(2)W_(2)O_(7) crystal originates from the WO^(6−)6 octahedral group.

关键词： experiment group crystal

Asymptotic Behavior of Positive Solutions of Semilinear Elliptic Equations in R^n, Ⅱ

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Acta Mathematica Sinica,English Series 2010年第9期26卷 1723-1738页

作者： Bai shun lai Shu qing ZHOU Institute of Contemporary Mathematics He 'nan University Kaifeng 475004 P. R. China School of Mathematics and Information Science He 'nan University Kaifeng 475004 P. R. China Department of Mathematics Hu'nan Normal University Changsha 410081 P. R. China

In this paper, we will analyze further to obtain a finer asymptotic behavior of positive solutions of semilinear elliptic equations in R^n by employing the Li＇s method of energy function.

关键词： Semilinear elliptic equation positive solutions asymptotic behavior

DEFORMATION OF COPOLYMER MICELLES INDUCED BY AMPHIPHILIC DIMER PARTICLES

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Chinese Journal of Polymer Science 2012年第2期30卷 164-172页

作者： Xiao-chun qin Chun-lai Ren National Laboratory of Solid State Microstructures Nanjing UniversityNanjing 210093China

Combining self-consistent-field theory and density-functional theory, we systematically study the deformation of copolymer micelles induced by the presence of amphiphilic dimer particles. Due to the amphiphilic nature, dimer particles tend to accumulate onto the interface of the copolymer micelle. With increasing concentration of the symmetric dimer particles, which are made of two identical spherical particles, the micelle deforms from the initial sphere to ellipse, dumbbell, and finally separates into two micelles. Furthermore, asymmetric dimer particles, composed by two particles with different sizes, are considered to investigate the influence of geometry of dimer particles on the deformation of the micelle. It is found that the micelle inclines to deform into dumbbell due to the additional curvature originating in the gathering of asymmetric dimer particles onto the interface of the micelle. The present study on the deformation of micelles is useful to understand the possible shape variation in the course of cell division/fusion.

关键词： Dimer particle Copolymer micelle Deformation Self consistent field theory Density function theory.

Paleozoic Tectonic Switch in the North qinling Orogenic Belt:Constraints from the Paleozoic Granites from the Northern qinling Migmatite Terrane

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Acta Geologica Sinica(English Edition) 2023年第3期97卷 695-706页

作者： qin Jiangfeng lai Shaocong LONG Xiaoping State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi'an 710069China

The variations in source rocks and melting conditions of granites can provide essential clues for the crustal magmatic response in orogenic *** on geochronology,whole-rock and mineral chemistry,this paper reveals two different granites in the Northern qinling migmatite complex,which reveal obvious differences in source region and melting *** older granodiorite(402±0.8 Ma)displays typical Na-rich adakite affinity,i.e.,high Na_(2)O/K_(2)O(2.04 to 2.64)and Sr/Y(96 to 117)ratios,they have relative evolved isotopic compositions(ε_(Nd)(t)=-0.52 to-0.04;zirconε_(Hf)(t)=-0.06 to+7.78).The younger leucogranite(371±2 Ma)displays higher SiO_(2)(72.32 to 73.45 wt%),lower(TFeO+MgO+CaO+TiO_(2))contents(qinling,indicating a scissor collision process between the South qinling and North China Craton(NCC)in Devonian era.

关键词： qinling zircon Paleozoic

Research advances in the treatment of Alzheimer＇s disease with polysaccharides from traditional Chinese medicine

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Chinese Journal of Natural Medicines 2017年第9期15卷 641-652页

作者： LIU qin WANG shun-Chun DING Kan Institute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine Shanghai 201203 China Glycochemistry and Glycobiology Lab Shanghai Institute ofMateria Medica Chinese Academy of Sciences Shanghai 201203China University of Chinese Academy of Sciences Beijing 100049 China Key Laboratory of Receptor Research Shanghai Institute ofMateria Medica Chinese Academy of Sciences Shanghai 201203China

Alzheimer's disease(AD) is a neurodegenerative disorder characterized by the loss of patients' memory and their cognitive abilities and the mechanism is not completely clear. Although a variety of drugs have been approved for the AD treatment, substances which can prevent and cure AD are still in great need. The effect of polysaccharides from traditional Chinese medicine(TCM) on anti-AD has gained great progress and attained more and more attention in recent years. In this review, research advances in TCM-polysaccharides on AD made in this decade are summarized.

关键词： Alzheimer’s disease Polysaccharides Traditional Chinese medicine

A Corrugated 2D Mn(Ⅱ) Network:[Mn_3(μ-oxalate)_3(μ-4,4'-bpy)_2(4,4'-bpy)_2]_n

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Chinese Journal of Structural Chemistry 2006年第7期25卷 873-877页

作者： YANG E WANG Xiao-qin CHEN shun-Yu College of Chemistry ＆ Materials Science Fujian Normal University Fuzhou 350007 China Fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China

The title complex, [Mn3（μ-oxalate）3（μ-4,4′-bpy）2（4,4′-bpy）2]n, was synthesized and structurally characterized by X-ray crystallography. It crystallizes in the monoclinic, space group P2 1/c with a = 16.3222（6）, b = 16.2594（5）, c = 16.4885（5） A, β = 94.9900（10）°, V= 4359.3（2） A^3, Z = 4, Mn3C46N8O12H32, Mr = 1053.62, Dc = 1.605 g/cm^3, F（000） = 2140 and μ（MoKa） = 0.932 mm^-1. The structure was refined to R = 0.0578 and wR = 0.1061 for 4795 observed reflections （I 〉 2σ（I））. The oxalate anions behave as the bridging ligand and link two manganese atoms repeatedly to form infinite one-dimensional chains which further extend into a two-dimensional network by bridging 4,4′-bpy ligands.

关键词： crystal structure one-dimensional chain two-dimensional layer bridging 4,4′-bpy ligands terminal 4,4′-bp)- ligands