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Coaxial radiography guided puncture technique for percutaneous transforaminal endoscopic lumbar discectomy:A randomized control trial

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World Journal of Clinical Cases 2023年第16期11卷 3802-3812页

作者： Li-Ping Chen Bin-Song Wen Heng Xu Zheng Lu lai-jun yan Han Deng Hong-Bo Fu Hong-Jie Yuan Pei-Pei Hu Department of Pain Management The Affiliated Hospital of Xuzhou Medical CollegeXuzhou 221000Jiangsu ProvinceChina Department of Pain Management Nantong Hospital of Traditional Chinese MedicineNantong 226000Jiangsu ProvinceChina Department of Neurosurgery Haian People's HospitalNantong 226001Jiangsu ProvinceChina

BACKGROUND The coaxial radiography-guided puncture technique(CR-PT)is a novel technique for endoscopic lumbar *** the X-ray beam and the puncturing needle are maintained in a parallel and coaxial direction,the X-ray beam can be used to guide the trajectory angle,facilitating the choice of the puncture site and providing real-time *** puncture technique offers numerous advantages over the conventional anterior-posterior and lateral radiography-guided puncture technique(AP-PT),especially in cases of herniated lumbar discs with a hypertrophied transverse process or articular process,high iliac crest,and narrowed intervertebral *** To confirm whether CR-PT is a superior approach to percutaneous transforaminal endoscopic lumbar discectomy compared to *** In this parallel,controlled,randomized clinical trial,herniated lumbar disc patients appointed to receive percutaneous endoscopic lumbar discectomy treatment were recruited from the Pain Management Department of the Affiliated Hospital of Xuzhou Medical University and Nantong Hospital of Traditional Chinese ***-five participants were enrolled and divided into either a CR-PT group or an AP-PT *** CR-PT group underwent CR-PT,and the AP-PT group underwent *** number of fluoroscopies during puncturing,puncture duration(min),surgery duration(min),VAS score during puncturing,and puncture success rate were *** Sixty-five participants were included,with 31 participants in the CR-PT group and 34 in the AP-PT *** participant in the AP-PT group dropped out due to unsuccessful *** number of fluoroscopies[median(P25,P75)]was 12(11,14)in the CR-PT group vs 16(12,23)in the AP-PT group,while the puncture duration(mean±SD)was 20.42±5.78 vs 25.06±5.46,*** VAS score was 3(2,4)in the CR-PT group vs 3(3,4)in the AP-PT *** subgroup analysis was performed,considering only the participants with L5/S1 segment herniation:9 patients un

关键词： Herniated lumbar disc Coaxial Puncture Anterior-posterior L5/S1

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao lai Xu Zhen Gu Hua yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi lai Yian Lu yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao jun Liu Jianrong yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin yan You Zheng Gong yangping Zhuang Jiali Wu Yu Wang Hanlin Huang jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

全面预算管理在公立医院高质量发展中的实施路径

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现代医院管理 2020年第5期18卷 21-24页

作者：谢钢赖妍君刘涛宜宾市第一人民医院四川省宜宾市644000 四川大学文学与新闻学院成都市610064 四川轻化工大学管理学院四川省宜宾市643000

随着医疗改革的持续深入,公立医院的管理理念和运行方式也相应变化,推动公立医院向高质量发展方式转变。在此背景下,公立医院不仅要提高自身的业务能力,提升人民群众看病就医的获得感,还强调加强内部管理,合理安排资金,有效降低和控制... 详细信息

随着医疗改革的持续深入,公立医院的管理理念和运行方式也相应变化,推动公立医院向高质量发展方式转变。在此背景下,公立医院不仅要提高自身的业务能力,提升人民群众看病就医的获得感,还强调加强内部管理,合理安排资金,有效降低和控制成本。因此,本文通过研究公立医院全面预算管理的实施路径,帮助公立医院科学配置资源、挖掘隐藏潜力,提高核心竞争力,助推公立医院高质量发展和实现战略目标。

关键词：公立医院全面预算管理高质量发展

全面预算管理推进公立医院高质量发展的实践探索

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现代医院管理 2021年第3期19卷 67-71页

作者：谢钢赖妍君刘涛宜宾市第一人民医院四川省宜宾市644000 四川大学文学与新闻学院成都市610064 四川轻化工大学管理学院四川省宜宾市643000

随着国家医药卫生体制改革的持续深化,充分利用有限的医疗资源为人民群众提供全方位全周期健康服务成为现阶段公立医院高质量发展的重要任务。全面预算管理作为集规划、测算、分配、监督、考核、评价于一体的管理工具,在优化医疗资源配... 详细信息

随着国家医药卫生体制改革的持续深化,充分利用有限的医疗资源为人民群众提供全方位全周期健康服务成为现阶段公立医院高质量发展的重要任务。全面预算管理作为集规划、测算、分配、监督、考核、评价于一体的管理工具,在优化医疗资源配置,控制不合理成本,实现战略发展目标方面发挥了积极作用。笔者通过介绍Y医院全面预算管理的实施流程及其应用成效,期望能够起到以点带面的作用。

关键词：公立医院全面预算管理高质量发展

Liquid refractive index measurement method based on orthogonal polarization laser self-mixing interference

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Optoelectronics Letters 2025年

作者： ZHAO yan WANG Haipeng DU Shengzhi TONG Jigang KANG jun School of Electrical Engineering and Automation， Tianjin University of Technology Tianjin Key Laboratory for Control Theory and Applications in Complicated Systems Department of Electrical Engineering， Tshwane University of Technology

In this paper， a novel method combining orthogonal polarization laser self-mixing interference is proposed. The method utilizes a rotating cuvette to measure the refractive index of liquids at different concentrations. The cuvette is filled with the liquid to be measured and rotated by a certain angle. The change in the number of interference fringes， caused by comparing an empty cuvette with a liquid-filled cuvette， is used to calculate the refractive index of the liquid. A four-fold logic subdivision algorithm is then used to improve measurement resolution. The experimental results show that for pure water and different NaCl and glucose solutions concentrations， the average relative errors are 0.47%， 0.59%， and 2.17%， respectively， with the maximum relative error within ±2.54%. The standard deviation of all solutions is less than 3.4%.

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基于“行动导向”的《机械分析应用基础》课程教学研究

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教育现代化 2017年第7期4卷 120-122页

作者：吴晖辉曾宪荣赖燕君严健荣顺德职业技术学院

行动导向教学法是近年来流行于我国教育领域的一种新的方法,本文结合我校《机械分析应用基础》课程的教学实践,探讨在实施教学过程中运用行动导向教学法的方式方法达到能力目标和知识目标,论证行动导向教学法对提高学生的创新能力和学... 详细信息

行动导向教学法是近年来流行于我国教育领域的一种新的方法,本文结合我校《机械分析应用基础》课程的教学实践,探讨在实施教学过程中运用行动导向教学法的方式方法达到能力目标和知识目标,论证行动导向教学法对提高学生的创新能力和学习积极性的作用,也给出了课程中的反思和展望。

关键词：行动导向项目教学机械分析

平均血小板体积和红细胞分布宽度与系统性红斑狼疮活动指数评分的相关性

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医学临床研究 2021年第6期38卷 897-899页

作者：张默吟秦淑芳来艳君西安市第九医院检验科陕西西安710054

【目的】探讨平均血小板体积(MPV)和红细胞分布宽度(RDW)与系统性红斑狼疮(SLE)活动指数评分(SLEDAI评分)的相关性。【方法】在本院接受治疗的120例SLE患者,根据SLEDAI评分分为活动组和非活动组。选取同期体检的健康志愿者50例为对照组... 详细信息

【目的】探讨平均血小板体积(MPV)和红细胞分布宽度(RDW)与系统性红斑狼疮(SLE)活动指数评分(SLEDAI评分)的相关性。【方法】在本院接受治疗的120例SLE患者,根据SLEDAI评分分为活动组和非活动组。选取同期体检的健康志愿者50例为对照组。比较各组的相关资料,分析MPV和RDW与SLEDAI评分的相关性,采用ROC曲线评估MPV和RDW预测患者SLE活动度的价值。【结果】(1)活动组RDW、MPV、血沉(ESR)、C反应蛋白(CRP)及IgG明显高于非活动组和对照组(P<0.05);活动组血红蛋白浓度(HGB)、C3及C4水平明显低于非活动组和对照组(P<0.05)。非活动组RDW、MPV、ESR、CRP及IgG明显高于对照组(P<0.05);非活动组HGB、C3及C4水平明显低于对照组(P<0.05)。(2)Pearson相关性分析显示,SLEDAI评分与MPV、RDW均呈正相关(均P<0.05)。(3)MPV预测患者SLE活动度的曲线下面积(AUC)和95%CI分别为0.594和(0.468~0.697),截断点为12.98 fL时,灵敏度、特异度分别为56.9%和77.4%。RDW水平的预测患者SLE活动度的AUC和95%CI分别为0.687和(0.417~0.783),截断点为14.23%时,灵敏度、特异度分别为67.8%和86.7%。【结论】MPV和RDW具有潜在的评估SLE疾病活动度的临床价值。

关键词：红斑狼疮系统性/血液平均血小板体积红细胞指数