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Triple three-dimensional MS/MS spectrum facilitates quantitative ginsenosides-targeted sub-metabolome characterization in notoginseng

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4045-4058页

作者： Ke Zhang Jinru Jia Ting Li Wenjing Liu Pengfei Tu Jian-bo Wan Jun Li Yuelin song Modern Research Center for Traditional Chinese Medicine Beijing Research Institute of Chinese MedicineBeijing University of Chinese MedicineBeijing 100029China SCIEX China Beijing 100015China School of Pharmacy Henan University of Chinese MedicineZhengzhou 450046China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaip1Macao 999078China

Although serving as the workhorse,MS/MS cannot fully satisfy the analytical requirements of quantitative sub-metabolome *** more information intrinsically correlates to more structural and concentration clues,here,efforts were devoted to comprehensively tracing and deciphering MS/MS behaviors through constructing triple three-dimensional(33D)-MS/MS ***-targeted metabolomics of notoginseng,one of the most famous edible medicinal plants,was employed as a *** authentic ginsenosides were deployed to build the correlations between 33D-MS/MS spectra and structure/concentration *** assaying ginsenosides with progressive concentrations using QTOF-MS to configure 1st 3D spectrum,the generations of MS1 spectral signals,particularly multi-charged multimer anions,e.g.,[2Me2H]2e and[2Mt2HCOO]2e ions,relied on both concentration and the amount of sugar *** programming progressive collision energies to the front collision cell of Qtrap-MS device to gain 2nd 3D spectrum,optimal collision energy(OCE)corresponding to the glycosidic bond fission was primarily correlated with the masses of precursor and fragment ions and partially governed by the glycosidation *** quantitative relationships between OCEs and masses of precursor and fragment ions were utilized to build large-scale quantitative program for *** applying progressive exciting energies to the back collision chamber to build 3rd 3D spectrum,the fragment ion and the decomposition product anion exhibited identical dissociation trajectories when they shared the same molecular *** ginsenosides-focused quantitative metabolomics,significant differences occurred for sub-metabolome amongst different parts of *** differential ginsenosides were confirmatively identified by applying the correlations between 33D-MS/MS spectra and ***,33D-MS/MS spectrum covers all MS/MS behaviors and dramatically faci

关键词： Quantitative submetabolome characterization Ginsenosides Structural identification Notoginseng Full exciting energy ramp-MS3 spectrum

Multiple Matching Attenuation Based on Curvelet Domain Extended Filtering

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Journal of Ocean University of China 2024年第4期23卷 924-932页

作者： HUA Qingfeng CHEN Zhang HE Huili TAN Jun CHEN Haifeng LI Guanbao song Peng ZHAO bo JIANG Xiuping Key Laboratory of Marine Geology and Metallogeny First Institute of OceanographyMinistry of Natural ResourcesQingdao 266061China Laboratory for Marine Mineral Resources Qingdao Marine Science and Technology CenterQingdao 266237China College of Marine Geoscience Ocean University of ChinaQingdao 266100China BGP Inc. China National Petroleum CorporationZhuozhou 072750China Key Laboratory of Submarine Geosciences and Prospecting Techniques Ministry of EducationQingdao 266100China

The paper develops a multiple matching attenuation method based on extended filtering in the curvelet domain,which combines the traditional Wiener filtering method with the matching attenuation method in curvelet ***,the method uses the predicted multiple data to generate the Hilbert transform records,time derivative records and time derivative records of Hilbert ***,the above records are transformed into the curvelet domain and multiple matching attenuation based on least squares extended filtering is ***,the attenuation results are transformed back into the time-space *** on the model data and field data show that the method proposed in the paper effectively suppress the multiples while preserving the primaries ***,it has higher accuracy in eliminating multiple reflections,which is more suitable for the multiple attenuation tasks in the areas with complex structures compared to the time-space domain extended filtering method and the conventional curvelet transform method.

关键词： multiple matching attenuation curvelet domain extended filtering

Proteomic study of vitreous in proliferative diabetic retinopathy patients after treatment with aflibercept:a quantitative analysis based on 4D label-free technique

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 676-685页

作者： Ting-Ting Feng Xiang Gao An-Ran Liang bo-Wen Zhao Guang-Hui He song Chen Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300070China Tianjin Key Laboratory of Ophthalmology and Visual Science Tianjin Eye InstituteTianjin Eye HospitalTianjin 300020China Key Laboratory of Ophthalmology Anyang Eye HospitalAnyang 455000Henan ProvinceChina Department of Ophthalmology Jining No.1 People’s HospitalJining 272011Shandong ProvinceChina

AIM:To identify different metabolites,proteins and related pathways to elucidate the causes of proliferative diabetic retinopathy(PDR)and resistance to anti-vascular endothelial growth factor(VEGF)drugs,and to provide biomarkers for the diagnosis and treatment of ***:Vitreous specimens from patients with diabetic retinopathy were collected and analyzed by Liquid Chromatography-Mass Spectrometry(LC-MS/MS)analyses based on 4D label-free *** differentially expressed proteins(DEPs),Gene Ontology(GO),Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway representation and protein interactions were ***:A total of 12 samples were *** proteomics results showed that a total of 58 proteins were identified as DEPs,of which 47 proteins were up-regulated and 11 proteins were *** found that C1q and tumor necrosis factor related protein 5(C1QTNF5),Clusterin(CLU),tissue inhibitor of metal protease 1(TIMP1)and signal regulatory protein alpha(SIRPα)can all be specifically regulated after aflibercept *** functional analysis showed that some DEPs are related to changes in inflammatory regulatory pathways caused by *** addition,protein-protein interaction(PPI)network evaluation revealed that TIMP1 plays a central role in neural *** addition,CD47/SIRPαmay become a key target to resolve anti-VEGF drug resistance in ***:Proteomic analysis is an approach of choice to explore the molecular mechanisms of *** data show that multiple proteins are differentially changed in PDR patients after intravitreal injection of aflibercept,among which C1QTNF5,CLU,TIMP1 and SIRPαmay become targets for future treatment of PDR and resolution of anti-VEGF resistance.

关键词： vitreous proliferative diabetic retinopathy proteome 4D label-free

Improving corrosion resistance of additively manufactured WE43 magnesium alloy by high temperature oxidation for biodegradable applications

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Journal of Magnesium and Alloys 2024年第3期12卷 940-953页

作者： Jinge Liu Bangzhao Yin Fei song Bingchuan Liu bo Peng Peng Wen Yun Tian Yufeng Zheng Xiaolin Ma Caimei Wang State Key Laboratory of Tribology in Advanced Equipment Beijing100084China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Department of Orthopaedics Beijing Tsinghua Changgung HospitalInstitute for Precision MedicineTsinghua UniversityBeijing102218China Department of Orthopaedics Peking University Third HospitalBeijing 100191China Engineering Research Center of bone and Joint Precision Medicine Ministry of EducationBeijing 100191China School of Materials Science and Engineering Peking UniversityBeijing 100871China Beijing AKEC Medical Co. Ltd.Beijing 102200China

Laser powder bed fusion(L-PBF)has been employed to additively manufacture WE43 magnesium(Mg)alloy biodegradable implants,but WE43 L-PBF samples exhibit excessively rapid *** this work,dense WE43 L-PBF samples were built with the relativity density reaching 99.9%.High temperature oxidation was performed on the L-PBF samples in circulating air via various heating temperatures and holding *** oxidation and diffusion at the elevated temperature generated a gradient structure composed of an oxide layer at the surface,a transition layer in the middle and the *** oxide layer consisted of rare earth(RE)oxides,and became dense and thick with increasing the holding *** matrix was composed ofα-Mg,RE oxides and Mg_(24)RE_(5) *** precipitates almost disappeared in the transition *** passivation effect was observed in the samples treated by a suitable high temperature *** original L-PBF samples lost 40%weight after 3-day immersion in Hank’s solution,and broke into fragments after 7-day *** casted and solution treated samples lost roughly half of the weight after 28-day *** high temperature oxidation samples,which were heated at 525℃ for 8 h,kept the structural integrity,and lost only 6.88%weight after 28-day *** substantially improved corrosion resistance was contributed to the gradient structure at the *** one hand,the outmost dense layer of RE oxides isolated the corrosive medium;on the other hand,the transition layer considerably inhibited the corrosion owing to the lack of ***,high temperature oxidation provides an efficient,economic and safe approach to inhibit the corrosion of WE43 L-PBF samples,and has promising prospects for future clinical applications.

关键词： Laser powder bed fusion Biodegradable magnesium alloy High temperature oxidation Corrosion resistance WE43.

Insights into the electron transfer mechanisms of peroxydisulfate activation by modified metal-free acetylene black for degradation of sulfisoxazole

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Chinese Chemical Letters 2024年第8期35卷 349-356页

作者： Chunxiu Yu Zelin Wu Hongle Shi Lingyun Gu Kexin Chen Chuan-Shu He Yang Liu Heng Zhang Peng Zhou Zhaokun Xiong bo lai State Key Laboratory of Hydraulics and Mountain River Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China Sichuan Academy of Eco-Environmental Sciences Chengdu 610041China Sino-German Centre for Water and Health Research Sichuan UniversityChengdu 610065China

Herein,a modified metal-free acetylene black(MMF-AB)catalyst was synthesized by a simple solvothermal-calcination method and designed successfully to activate peroxodisulfate(PDS)for the degradation of sulfisoxazole(SIZ).Due to the doping of N,S and O metal-free elements,the modified catalyst showed excellent catalytic performance with 100%SIZ removal within 30 *** first-order reaction rate constants(evaluating catalytic efficiencies and activity)of MMF-AB(kobs=0.105 min^(−1))was 3 times higher than pure-AB(k_(obs)=0.029 min^(−1)).Interestingly,it was demonstrated that the reaction sys-tem is based on the transfer of electrons from SIZ to PDS to realize an electron-transfer-based mechanism by the evidence of premixing,electron paramagnetic resonance(EPR)spectroscopy,salt-bridge experi-ments and electrochemical *** introduction of recyclable filtration device solved the secondary pollution caused by the dispersion of the powdered catalyst in the treated water,which further proved the practicality and superiority of the MMF-AB catalyst.

关键词： Peroxydisulfate Sulfisoxazole Acetylene black Electrochemical Electron transfer

Radical involved reactive wetting and retarding mechanism of alumina refractory ceramic by molten slags under weak static magnetic field

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Journal of Iron and Steel Research International 2024年第6期31卷 1355-1366页

作者： Sheng-hao Li Ao Huang Fan-bo Zeng Hui Peng Hao-ran Wei Xue-chun Huang Sheng-qiang song Hua-zhi Gu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

High alumina slag will cause severe corrosion at the interface of alumina refractory,and the wetting behavior of slag is a key factor influencing the corrosion resistance of refractory *** static magnetic field is a promising solution for improvement in the slag resistance of *** wetting of alumina refractory ceramics with different basicities of high alumina slags under a weak static magnetic field was analyzed,given that a weak static magnetic field can affect the corrosion behavior of refractory *** slag S_(3) as an example,when there was an external static magnetic field of 1.0 mT at 1600 ℃,the thickness of calcium aluminate reaction layer at the interface decreased by 36.7%,the denting depth of interface decreased by 35.6%,and the apparent wetting angle increased by 20%.The living radicals and their formation path in oxide melts were verified by first-principles calculation combined with electron paramagnetic resonance spectroscopy *** influence of the flux density of a weak static magnetic field on the wetting behavior of slags was also *** contact angle of the slags increased owing to the inhibitory effect of magnetic field on the radicalinvolved reaction at the interface of the slag and the alumina refractory *** relationships between the magnetic flux density,diffusion coefficient,slag microstructure(hyperfine coupling constant),and contact angle were *** provides a theoretical basis for the field control of radical involved reactive wetting between inorganic oxide slags and solid oxide ceramics.

关键词： Alumina refractory ceramic Molten slag Weak magnetic field effect Reactive wetting Free radical

A Selective‑Response Hypersensitive Bio‑Inspired Strain Sensor Enabled by Hysteresis Effect and Parallel Through‑Slits Structures

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Nano-Micro Letters 2024年第2期16卷 139-153页

作者： Qun Wang Zhongwen Yao Changchao Zhang Honglie song Hanliang Ding bo Li Shichao Niu Xinguan Huang Chuanhai Chen Zhiwu Han Luquan Ren Key Laboratory of Bionic Engineering(Ministry of Education) Jilin UniversityChangchunJilin 130022People’s Republic of China Liaoning Academy of Materials LiaoningShenyang 110167People’s Republic of China Key Laboratory of CNC Equipment Reliability(Ministry of Education) Jilin UniversityChangchunJilin 130022People’s Republic of China

Flexible strain sensors are promising in sensing minuscule mechanical signals,and thereby widely used in various advanced ***,the effective integration of hypersensitivity and highly selective response into one flexible strain sensor remains a huge ***,inspired by the hysteresis strategy of the scorpion slit receptor,a bio-inspired flexible strain sensor(BFSS)with parallel through-slit arrays is designed and ***,BFSS consists of conductive monolayer graphene and viscoelastic styrene–isoprene–styrene block *** the synergistic effect of the bio-inspired slit structures and flexible viscoelastic materials,BFSS can achieve both hypersensitivity and highly selective frequency ***,the BFSS exhibits a high gage factor of 657.36,and a precise identification of vibration frequencies at a resolution of 0.2 Hz through undergoing different morphological changes to high-frequency vibration and low-frequency ***,the BFSS possesses a wide frequency detection range(103 Hz)and stable durability(1000 cycles).It can sense and recognize vibration signals with different characteristics,including the frequency,amplitude,and *** work,which turns the hysteresis effect into a"treasure,"can provide new design ideas for sensors for potential applications including human–computer interaction and health monitoring of mechanical equipment.

关键词： Bio-inspired strain sensors Hysteresis effect Hypersensitivity Selective frequency response Health monitoring applications

Upcycling of Poly(butylene adipate-co-terephthalate)into Dual Covalent Adaptable Networks through Chain Breaking-Crosslinking Strategy

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Chinese Journal of Polymer Science 2024年第10期42卷 1505-1513,I0011页

作者： Bin-bo Wang Rong Huang Xin Wang Tao Jiang Yi Wang Shuai Du Fa-Lin Li Jin Zhu song-Qi Ma Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi214122China Key Laboratory of Bio-based Polymeric Materials Technology and Application of Zhejiang Province Divisions of Polymers and CompositesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China University of Chinese Academy of Sciences Beijing100049China

Poly(butylene adipate-co-terephthalate)(PBAT),a widely studied biodegradable material,has not effectively addressed the problem of plastic *** into consideration the cost-effectiveness,upcycling PBAT should take precedence over direct composting *** present work adopts a chain breaking-crosslinking strategy,upcycling PBAT into dual covalent adaptable networks(CANs).During the chainbreaking stage,the ammonolysis between PBAT and polyethyleneimine(PEI)established the primary crosslinked ***,styrene maleic anhydride copolymer(SMA)reacted with the hydroxyl group,culminating in the formation of dual covalent adaptable *** contrast to PBAT,the PBAT-dual-CANs exhibited a notable Young's modulus of 239 MPa,alongside an inherent resistance to creep and *** to catalysis from neighboring carboxyl group and excess hydroxyl groups,the PBAT-dual-CANs exhibited fast stress ***,they could be recycled through extrusion and hot-press reprocessing,while retaining their *** straightforward strategy offers a solution for dealing with plastic waste.

关键词： Poly(butylene adipate-co-terephthalate) Dynamic crosslinked networks Chain breaking-crosslinking strategy Upcycle Recycle

Room-temperature phonon-coupled single-photon emission in hexagonal boron nitride

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 109-114页

作者： Jia-Min lai Qing-Hai Tan Feilong song Haonan Chang Yanpei Lv Xue-Lu Liu Jinghua Teng Weibo Gao Ping-Heng Tan Jun Zhang State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing100083China Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education&Research Institute of Materials Science Shanxi Normal UniversityTaiyuan 030000China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)Singapore 138634Singapore

Photon-lattice(phonon)coupling is fundamental to light-matter interaction,particularly when it reaches the quantum limit of the phonon-coupled single-photon emission,which holds great potential for quantum manipulation and quantum information ***,we report single defect state-phonon coupling in hexagonal boron nitride(h BN)at room *** ultrabroad spectrum of single-photon emissions can be achieved by selecting the excitation *** photoluminescence excitation spectroscopy,we observe single-phonon-assisted resonance-enhanced single-photon emission,along with multiple phonon replicas that herald the creation of phonon Fock *** also develop a transition model to gain insight into the physical process behind the single defect state-phonon *** work sets the stage for manipulating electron-phonon coupling state with single quantum-level precision at room temperature.

关键词： temperature phonon hexagonal