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Clinical characteristics of patients with early gastric prematurity cancer and analysis of complications by endoscopic resection

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3898-3904页

作者： Hong zhao Xiang-Yu Shi Li-Li Lv Yan-Zong lai Xiao-Xiao Bao Jian-Wen Hu Department of Gastroenterology Dongyang People’s HospitalDongyang 322100Zhejiang ProvinceChina Department of Gastroenterology Yiwu Tianxiang Medical East HospitalYiwu 322100Zhejiang ProvinceChina Department of Pathology Dongyang People’s HospitalDongyang 322100Zhejiang ProvinceChina

BACKGROUND Gastric cancer,a prevalent malignancy,poses a severe threat to the health of residents in *** intervention in early stages can extend patients’*** To analyze clinical characteristics of patients with early gastric cancer and efficacy and risk of complications associated with endoscopic *** This study included 175 patients with early gastric cancer treated at our hospital,with no restrictions on sex or *** data,pathological information,and endoscopic biopsy results were *** clinical characteristics of early gastric cancer were analyzed,and endoscopic resection was *** efficacy and incidence of complications were *** analysis was performed using SPSS 26.0 and GraphPad Prism 8.0 *** A total of 175 patients with early gastric cancer were included,with 75.43%(n=132)males and 24.57%(n=43)females.38.29%(n=67)and 35.43%(n=62)of patients had a history of smoking and alcohol consumption,*** included diabetes(8.57%,n=15),coronary heart disease(10.29%,n=18),and hypertension(43.43%,n=76),which was highly prevalent.A history of abdominal surgery and family history of digestive system cancer accounted for 21.14%and 17.14%,*** most common lesion location was the antral part of the stomach(52.00%,n=91),followed by the gastric angle,body,and *** pathological types were predominantly high-grade intraepithelial neoplasia(28.00%,n=49)and well-differentiated adenocarcinoma(26.86%,n=47),followed by moderately differentiated adenocarcinoma,high-moderately differentiated adenocarcinoma,and moderate-lowly differentiated adenocarcinoma.89.14%of the patients had intestinal metaplasia and 85.14%had *** endoscopic resection,re-examination revealed that 13 patients had cancer cells at the tissue margin,with a positive margin rate of 7.43%.Postoperative complications included no cases of gastrointestinal obstruction,but incisional infec

关键词： Early gastric cancer Clinical characteristics Endoscopic resection Complications

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Metal-N_(4)model single‐atom catalyst with electroneutral quadri‐pyridine macrocyclic ligand for CO_(2)electroreduction

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Carbon Energy 2024年第8期6卷 122-133页

作者： Jian‐zhao Peng Yin‐Long Li Yao‐Ti Cheng Fu‐Zhi Li Bo Cao Qing Wang Xian Yue Guo‐Tao lai Yang‐Gang Wang Jun Gu Department of Chemistry Southern University of Science and TechnologyShenzhenGuangdongChina Institute for Catalysis Hokkaido UniversitySapporoJapan

Metal–N–C single‐atom catalysts,mostly prepared from pyrolysis of metalorganic precursors,are widely used in heterogeneous *** metal sites with diverse local structures coexist in this type of material and it is challenging to characterize the local structure,a reliable structure–property relationship is difficult to *** macrocyclic complexes adsorbed on carbon support are well‐defined models to mimic the singleatom ***–N_(4)site with four electroneutral pyridine‐type ligands embedded in a graphene layer is the most commonly proposed structure of the active site of single‐atom catalysts,but its molecular counterpart has not been *** this work,we synthesized the conjugated macrocyclic complexes with a metal center(Co,Fe,or Ni)coordinated with four electroneutral pyridinic ligands as model catalysts for CO_(2)*** comparison,the complexes with anionic quadri‐pyridine macrocyclic ligand were also *** Co complex with the electroneutral ligand expressed a turnover frequency of CO formation more than an order of magnitude higher than that of the Co complex with the anionic *** ab initio molecular dynamics simulations based on the well‐defined structures of the model catalysts indicate that the Co complex with the electroneutral ligand possesses a stronger ability to mediate electron transfer from carbon to CO_(2).

关键词： ab initio molecular dynamics CO_(2)reduction electrocatalysis model catalyst single‐atom catalyst

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危险化学品运输风险分析

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系统工程理论与实践 2007年第12期27卷 117-122,132页

作者：张江华赵来军复旦大学管理学院上海200433

文章从事故率估计和事故后果模拟分析两个维度来分析危险化学品运输风险.应用信息扩散理论估计了危险化学品运输事故率,并基于GIS技术模拟分析了危险化学品运输事故后果,前者弥补了样本信息不足的缺陷,而后者利用详尽的地理信息克服了... 详细信息

文章从事故率估计和事故后果模拟分析两个维度来分析危险化学品运输风险.应用信息扩散理论估计了危险化学品运输事故率,并基于GIS技术模拟分析了危险化学品运输事故后果,前者弥补了样本信息不足的缺陷,而后者利用详尽的地理信息克服了以往后果分析中准确度低的不足,完善了危险化学品运输风险分析,从而为更好的决策以减少事故、保护人民群众的生命和财产安全提供了保障.

关键词：危险化学品运输风险分析信息扩散模拟

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用于实时皮肤创面愈合的超强工程化蛋白凝聚体黏合剂

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Engineering 2023年第12期31卷 76-85页

作者： Ming Li Baimei Liu Wei Xu lai zhao Zili Wang Haonan He Jingjing Li Fan Wang Chao Ma Kai Liu Hongjie Zhang State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Department of Orthopedics Tongren HospitalShanghai Jiao Tong University School of MedicineShanghai 200336China Engineering Research Center of Advanced Rare Earth Materials Department of ChemistryTsinghua UniversityBeijing 100084China Xiangfu Laboratory Jiaxing 314102China

Adhesives have attracted a great deal of attention as an advanced modality in biomedical engineering because of their unique wound management ***,it is a grand challenge for current adhesive systems to achieve robust adhesion due to their tenuous interfacial bonding ***,the absence of dynamic adaptability in conventional chemical adhesives restricts neoblasts around the wound from migrating to the site,resulting in an inferior tissue-regeneration ***,an extracellular matrix-derived biocomposite adhesive with robust adhesion and a real-time skin healing effect is ***–liquid phase separation is well-harnessed to drive the assembly of the biocomposite adhesive,with the active involvement of supramolecular interactions between chimeric protein and natural DNA,leading to a robustly reinforced adhesion *** bioadhesive exhibits outstanding adhesion and sealing behaviors,with a sheared adhesion strength of approximately 18 MPa,outperforming its reported ***,the engineered bioderived components endow this adhesive material with biocompatibility and exceptional biological functions including the promotion of cell proliferation and migration,such that the use of this material eventually yields real-time in situ skin *** work opens up novel avenues for functionalized bioadhesive engineering and biomedical translations.

关键词： Biocomposite adhesive Protein DNA Coacervates Skin healing

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Effect of radiofrequency ablation combined with transcatheter arterial chemoembolization on inflammatory factors, oxidative stress response factors and tumor activity factors in patients with primary liver cancer

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Journal of Hainan Medical University 2017年第4期23卷 112-116页

作者： Kun Yang Xue-Wen Wang zhao lai Gui-Gang Qiu Sen Yang Department of Hepatobiliary Surgery the Forth People's Hospital of Zicong CitySichuan 643000 China

Objective:To investigate the effects of radiofrequency ablation (RFA) combined with transcatheter arterial chemoembolization (TACE) on inflammatory factors, oxidative stress response factors and tumor activity factors in primary hepatocellular carcinoma (HCC) ***:A total of 100 cases of primary liver cancer patients from January 2014 to June 2016 were selected and randomly divided into observation group and control group with 50 cases in each group, the observation group was treated with RFA combined with TACE treatment, the control group was given TACE treatment, compared two groups before treatment (T0), 1 weeks of treatment (T1), 2 weeks (T2) inflammation factor, oxidative stress factor and tumor activity ***:(1) The hs-CRP, IL-6 and TNF-α levels of T1 in two groups were significantly increased, T2 decreased significantly, T1>T1>T2, but the observation group hs-CRP, IL-6, TNF-α levels of T1 were higher than the control group and the difference was statistically significant, hs-CRP, IL-6, TNF-α levels of T2 had no statistically significant;(2) The ROS level of T1 in the observation group was higher than the control group, while the SOD and T-AOC levels were lower than the control group, the ROS level of T2 in the observation group was lower than the control group, SOD and T-AOC were higher than the control group, there was significant difference. (3) Serum AFP, CA199 and MMP levels in T1 and T2 of the observation group were lower than the control group, the difference was statistically ***:RFA treatment of HCC may lead to inflammation and increased oxidative stress in the early stage . However, TACE combined with TACE can improve the micro inflammatory state, especially enhance the antioxidant function and decrease the level of tumor active factor.

关键词： Radiofrequency ablation Transcatheter arterial chemoembolization Primary liver cancer Inflammatory cytokines Oxidative stress Tumor activity factor

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Effect of surgical resection combined with transcatheter arterial chemoembolization on postoperative serum tumor marker levels and stem cell characteristics during tumor recurrence

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Journal of Hainan Medical University 2017年第9期23卷 97-100页

作者： Sen Yang zhao lai Xue-Wen Wang Jie Chen Teng-Gang Deng Department of Hepatobiliary Surgery Zigong Fourth People's Hospital in Sichuan ProvinceZigong 643000China

Objective:To study the effect of surgical resection combined with transcatheter arterial chemoembolization (TACE) on postoperative serum tumor marker levels and stem cell characteristics during tumor ***:A total of 98 patients with liver cancer who received radical resection in our hospital between May 2013 and July 2015 were reviewed and divided into TACE group and control group according to whether they received TACE within two months after surgical resection. Serum levels of tumor markers were detected 4 weeks after operation;the tumor recurrence was followed up within 3 years after operation, and the expression of stem cell marker molecules and cell proliferation molecules in recurrent lesions were ***: 4 weeks after radical hepatectomy, serum AFP, AFP-L3, GP73 and GPC3 levels in TACE group were significantly lower than those in control group;Nanog, CD133, EpCAM, PICK1, CyclinD1, C-myc and Survivin expression in surgically removed lesions of TACE group were not different from those of control group while Nanog, CD133, EpCAM, PICK1, CyclinD1, C-myc and Survivin expression in recurrent lesions were significantly lower than those of control ***: Surgical resection combined with TACE can more effectively remove liver cancer lesions, reduce the tumor marker levels and inhibit the tumor stem cell characteristics and cell proliferation activity in recurrent lesions.

关键词： Liver cancer Transcatheter arterial chemoembolization Tumor stem cell Proliferation

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Preparation of Fe-As alloys by mechanical alloying and vacuum hot-pressed sintering:microstructure evolution,mechanical properties,and mechanisms

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Rare Metals 2024年第8期43卷 3876-3892页

作者： Fei Chai Fei-Ping zhao Zhan Hu Shi-Yi Wen Ben-Hammouda Samia Ze-Lin Fu Xin-Ting lai Yan-Jie Liang Xiao-Bo Min Li-Yuan Chai School of Metallurgy and Environment Central South UniversityChangsha 410083China Chinese National Engineering Research Center for Control&Treatment of Heavy Metal Pollution Institute of Environmental EngineeringCentral South UniversityChangsha 410083HunanChin State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Department of Building Civiland Environmental EngineeringConcordia UniversityMontreal H3G 1M8Canada

Arsenic materials have attracted great attention due to their unique ***,research concerning iron-arsenic(Fe-As) alloys is very scarce due to the volatility of As at low temperature and the high melting point of ***,a new Fe-As alloy was obtained by mechanical alloying(MA) followed by vacuum hot-pressed sintering(VHPS).Moreover,a systematic study was carried out on the microstructural evolution,phase composition,leaching toxicity of As,and physical and mechanical properties of Fe-As alloys with varying weight fractions of As(20%,25%,30%,35%,45%,55%,65%,and 75%).The results showed that pre-alloyed metallic powders(PAMPs) have a fine grain size and specific supersaturated solid solution after MA,which could effectively improve the mechanical properties of Fe-As alloys by VHPS.A high density(> 7.350 g·cm^(-3)),low toxicity,and excellent mechanical properties could be obtained for FeAs alloys sintered via VHPS by adding an appropriate amount of As,which is more valuable than commercial Fe-As *** Fe-25% As alloy with low toxicity and a relatively high density(7.635 g·cm^(-3)) provides an ultra-high compressive strength(1989.19 MPa),while the Fe-65% As alloy owns the maximum Vickers hardness(HVo.5 899.41).After leaching by the toxicity characteristic leaching procedure(TCLP),these alloys could still maintain good mechanical performance,and the strengthening mechanisms of Fe-As alloys before and after leaching were *** in the grain size,micro structure,and phase distribution induced significant differences in the compressive strength and hardness.

关键词： Mechanical alloying Vacuum hot-pressed sintering High-pressure Arsenic-iron alloys Mechanical properties

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The root-knot nematode effectorMi2G02 hijacks a host plant trihelix transcription factor to promote nematode parasitism

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Plant Communications 2024年第2期5卷 151-168页

作者： Jianlong zhao Kaiwei Huang Rui Liu Yuqing lai Pierre Abad Bruno Favery Heng Jian Jian Ling Yan Li Yuhong Yang Bingyan Xie Michael Quentin Zhenchuan Mao State Key Laboratory of Vegetable Biobreeding Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081China INRAE Universite´Cote d’AzurCNRSISA06903 Sophia AntipolisFrance Department of Plant Pathology and Key Laboratory of Pest Monitoring and Green Management of the Ministry of Agriculture China Agricultural UniversityBeijing 100193China

Root-knot nematodes(RKNs)cause huge agricultural losses every *** secrete a repertoire of effectors to facilitate parasitism through the induction of plant-derived giant feeding cells,which serve as their sole source of ***,the mode of action of these effectors and their targeted host pro-teins remain largely *** this study,we investigated the role of the effector Mi2G02 in Meloidogyne incognita ***-derived Mi2G02 RNA interference in Arabidopsis thaliana affected giant cell development,whereas ectopic expression of Mi2G02 promoted root growth and increased plant sus-ceptibility to *** used various combinations of approaches to study the specific interactions between Mi2G02 and *** GT-3a,a trihelix transcription ***-3a knockout in *** affected feeding-site development,resulting in production of fewer egg masses,whereas GT-3a overex-pression in *** increased susceptibility to *** and also root ***,we demon-strated that Mi2G02 plays a role in maintaining GT-3a protein stabilization by inhibiting the 26S proteasome-dependent pathway,leading to suppression of TOZ and RAD23C expression and thus promoting nematode *** work enhances our understanding of how a pathogen effector manipulates the role and regulation of a transcription factor by interfering with a proteolysis pathway to reprogram gene expression for development of nematode feeding cells.

关键词： Meloidogyne incognita effector giant cell Mi2G02 transcription factor interaction

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Manganese oxide and derivative-modified materials in advanced oxidation processes:A review of modification enhancement and activation mechanisms

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Chinese Chemical Letters 2024年第3期35卷 40-51页

作者： Si Sun Shuang Song Shuai Yang Yong-Li He Yang Shi Peng Zhou zhao-kun Xiong Yang Liu Heng Zhang Ye Du Chuan-Shu He Bo lai State Key Laboratory of Hydraulics and Mountain River Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China Sino-German Centre for Water and Health Research Sichuan UniversityChengdu 610065China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaSichuanChengdu 610054China

Manganese oxides(MNO_(x)),as low-toxicity and high-abundance catalysts,have been demonstrated to hold great promise for application in advanced oxidation processes(AOPs).However,further application of this material is restricted due to its unsatisfactory oxidant activation ***,recently remarkable research on deep activation mechanisms and modification of MNO_(x)have been undertaken to improve its ***,modification enhancement mechanisms of MNO_(x)to efficiently degrade various organic contaminants were discussed and highlighted,including metal doping,coupling with other metal oxides,composite with carbonaceous material,and compounding with other *** activation mechanisms of different MNO_(x)and derivative-modified material(such as doped MNO_(x),metal oxide-MNO_(x)hybrids,and MNO_(x)-carbonaceous material hybrids)were summarized in great details,which was specifically categorized into both radical and non-radical *** effects of pH,inorganic ions,and natural organic matter on degradation reactions are also ***,future research directions and perspectives are presented to provide a clear interpretation on the MNO_(x)initiated AOPs.

关键词： Manganese oxide Derivative-modified materials Modification enhancement mechanisms Advanced oxidation process Activation mechanism

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考虑传播率和移出率变化的谣言传播规律研究

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上海理工大学学报 2014年第4期36卷 345-350页

作者：赵来军吴盼上海交通大学中美物流研究院上海200030 上海交通大学安泰经济管理学院上海200052 上海大学管理学院上海200444

经典的谣言传播模型的研究中,谣言传播率和移出率通常被视为常数,根据实际情况提出传播率和移出率变化的谣言传播模型,在均匀网络和无标度网络中分别研究了传播率和移出率随时间变化的谣言传播模型,建立相应的平均场方程,并在Matlab中... 详细信息

经典的谣言传播模型的研究中,谣言传播率和移出率通常被视为常数,根据实际情况提出传播率和移出率变化的谣言传播模型,在均匀网络和无标度网络中分别研究了传播率和移出率随时间变化的谣言传播模型,建立相应的平均场方程,并在Matlab中进行数值分析.结果显示在传播率和移出率变化的谣言传播模型中,传播阈值依然存在,谣言最终的影响力较传播率和移出率不变的情况更为显著.此外,通过均匀网络与无标度网络谣言传播的对比分析发现,在传播率和移出率随时间变化的情况下,网络拓扑结构对谣言传播也有很大影响,并且均匀网络中谣言最终的影响力较无标度网络中谣言的最终影响力更为显著.

关键词：谣言传播模型均匀网络无标度网络传播率函数移出率函数

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