检索结果-南通市图书馆

Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy

在线全文

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2023年第4期17卷 483-489页

作者： Lan Lin lai jiang En Ren Gang Liu State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361102China

Benefiting from the advantage of taking place in biological environments without interfering with an innate biochemical process,the bioorthogonal reaction that commonly contains the“bond formation”and“bond cleavage”system has been widely used in targeted therapy for a variety of ***,several prominent cases based on the bioorthogonal reaction that tailoring the metabolic glycoengineering tactics to modified cells for cancer immunotherapy,and the innovative tactics for reducing the metal ions’toxic and side effects with microneedle patches will be *** on these applications,the complexities,potential pitfalls,and opportunities of bioorthogonal chemistry in future cancer therapy will be evaluated.

关键词： bioorthogonal reaction cancer therapy metabolic glycoengineering bioorthogonal catalytic patch

Flow-Induced Vibration Fatigue Damage of A Pair of Flexible Cylinders in A Staggered Array

在线全文

学校读者我要写书评

暂无评论

China Ocean Engineering 2021年第6期35卷 878-890页

作者： XU Wan-hai LI Yu-han JIA Kun lai jiang State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China Nuclear Power Institute of China Chengdu 610041China

Flow-induced vibration(FIV)of a group of long,flexible cylinders involves a complex interaction between fluid and *** a substantial number of studies have been devoted to assessing FIV response behaviours,fatigue damage features of staggered flexible cylinders are not fully ***,the wake-induced flutter constitutes an intricate hydrodynamic behaviour that frequently occurs when one cylinder is in the vicinity of another ***,existing studies on the fatigue damage caused by wake-induced flutter are incapable of achieving better *** paper,therefore,estimates the FIV fatigue damage of two staggered flexible cylinders with an aspect ratio of 350 and a mass ratio of 1.90 based on normal S−N curves according to Det Norske Veritas(DNV)*** staggered cases(cross-flow spacing ratios of 2.0,3.0,4.0,and 6.0 and in-line spacing ratios of 4.0,6.0,and 8.0)are discussed for comparison,and fatigue damage caused by wake-induced flutter is thoroughly *** damage results indicate that the variation of the cross-flow(CF)spacing ratio has a greater influence than that of the in-line(IL)spacing ratio on the CF fatigue damage of the upstream *** IL fatigue damages of the upstream cylinder are observed when reduced velocity V_(r)≥15.03 due to the wake flow patterns with different IL spacing ***,wake interference,especially wake-induced flutter,predominates the fatigue damage characteristics of the downstream *** V_(r)=8.77−11.27,wake-induced flutter enhances the IL fatigue damage of the downstream cylinder and slightly affects that of the upstream ***,wake-induced flutter causes considerable IL fatigue damage disparity between the two staggered cylinders by suppressing the IL fatigue damage of the upstream cylinder when V_(r)≥20.04.

关键词： flow-induced vibration fatigue damage flexible cylinder staggered arrangement wake-induced flutter

Hypersonic shock wave and turbulent boundary layer interaction in a sharp cone/flare model

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2023年第3期36卷 80-95页

作者： Fulin TONG Junyi DUAN jiang lai Dong SUN Xianxu YUAN State Key Laboratory of Aerodynamics China Aerodynamics Research and Development CenterMianyang 621000China Computational Aerodynamics Institute China Aerodynamics Research and Development CenterMianyang 621000China LHD Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

A direct numerical simulation of hypersonic Shock wave and Turbulent Boundary Layer Interaction(STBLI)at Mach 6.0 on a sharp ***-angle circular cone/flare configuration at zero angle of attack is *** flare angle is *** the momentum thickness Reynolds number based on the incoming turbulent boundary layer on the sharp circular cone is Re θ=*** is found that the mean flow is separated and the separation bubble occurring near the corner exhibits *** Reynolds analogy factor changes dramatically across the interaction,and varies between 1.06 and 1.27 in the downstream region,while the QP85 scaling factor has a nearly constant value of 0.5 across the *** evolution of the reattached boundary layer is characterized in terms of the mean profiles,the Reynolds stress components,the anisotropy tensor and the turbulence kinetic *** is argued that the recovery is incomplete and the near-wall asymptotic behavior does not occur for the hypersonic *** addition,mean skin friction decomposition in an axisymmetric turbulent boundary layer is carried out for the first *** of the interaction,the contributions of transverse curvature and body divergence are negligible,whereas the positive contribution associated with the turbulence kinetic energy production and the negative spatial-growth contribution are *** on scale decomposition,the positive contribution is further divided into terms with different spanwise length *** negative contribution is analyzed by comparing the convective term,the streamwise-heterogeneity term and the pressure gradient term.

关键词： Shock wave Hypersonic turbulent boundary layer Heat transfer Skin friction decomposition Direct numerical simulation

Tomato Key Sucrose Metabolizing Enzyme Activities and Gene Expression Under NaCl and PEG Iso-Osmotic Stresses

在线全文

学校读者我要写书评

暂无评论

Agricultural Sciences in China 2009年第9期8卷 1046-1052页

作者： LU Shao-wei LI Tian-lai jiang Jing The Key Laboratory of Protected Horticulture of Liaoning Province/College of Horticulture Shenyang Agricultural University Shenyang 110161. P.R. China

Changes in sucrose metabolism in response to salt （NaC1） and water （polyethylene glycol, PEG6000） iso-osmotic stresses were measured in tomato cultivar Liaoyuan Duoli （Solanum lycopersicum L.） and the objective was to provide a new evidence for the relationship between salt and osmotic stresses. The carbohydrate contents, as well as sucrose metabolizing enzymes activities and transcript levels were determined. The results indicated that soluble sugar and hexoses accumulated to higher levels and the contents of sucrose and starch were lower in mature fruit under the two stress treatments. Salt and water stresses can enhance the invertase and sucrose synthase activities of tomato fruit in a long period of time （45-60 days after anthesis）, and elevate the expression of soluble acid invertase mRNA. It showed that two different stresses could also regulate the soluble acid invertase activity by controlling its gene expression. The activity of sucrose synthase was linked to the changes in soluble sugar levels but not with transcript levels. The effects of salt and water stress treatments on sucrose phosphate synthase activities were weak.

关键词： tomato salt stress water stress sucrose metabolism gene expression

Size variation of the end Permian conodont Neogondolella at Meishan Section,Changxing,Zhejiang and its significance

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2006年第4期49卷 337-347页

作者： LUO Genming lai Xulong jiang Haishui ZHANG Kexin Faculty of Earth Sciences China University of Geosciences Wuhan 430074 China Faculty of Earth Sciences China University of Geosciences Wuhan 430074 China Faculty of Earth Sciences China University of Geosciences Wuhan 430074 China Faculty of Earth Sciences China University of Geosciences Wuhan 430074 China

This study is based on both a generic and species level investigation of the individual size of the latest Permian conodont Neogondolella Pa elements collected from Meishan Section A, Changxing, Zhejiang Province. In this study, an obvious size reduction of Neogondolella Pa elements within bed 24e of the upper Changxing Limestone is recognized. The size variation of the Neogon- dolella occurs simultaneously with some important events including the negative shift of δ 13C, change in the ratio of the abundance of cyanobacterial biomarkers versus that of other general bacterial biomarkers and the shallowing of the sea water. Through the investigation of the paleoenvironmental changes and the analysis of the paleoecology of the conodont genus Neogondolella, the authors propose that the major factors for the size reduction of species of the conodont genus Neogondolella are food shortages caused by the mass extinction, the shallowing of the sea water as well as the in- crease in opacity of the sea water during the end Permian. The same phenomenon of Neogondolella size reduction is also observed in preliminary research from the same horizon at Shangsi Section, Sichuan Province. All the evidence suggests that there was a mass extinction that occurred at the horizon of bed 24e, and the evidence supports the viewpoint of a multi-phase mass extinction during the Permian and Triassic transition in South China.

关键词： Meishan Section, end Permian, conodont, Neogondolella, size reduction.

Mechanobiology research in China

在线全文

学校读者我要写书评

暂无评论

Mechanobiology in Medicine 2023年第1期1卷 17-27页

作者： Zong-lai jiang Institute of Mechanobiology&Medical Engineering School of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityP.O.Box 888800 Dongchuan RoadMinhangShanghai200240China

Mechanobiology is an interdisciplinary discipline combining biology,engineering,chemistry,physics,and *** research comprehensively discusses,the role of mechanical factors in various life processes and the occurrence and development of associated and diseases at the whole organism,organ,cell,protein and gene *** cellular and molecular mechanisms of mechanical signal transduction and response are elucidated,in addition to the discovery of novel biomarkers and potential drug targets,which are mechanosensitive *** paper reviews the development of mechanobiology research in China since the new century,while focusing on the research achievements of Chinese scientists in the field of mechanobiology over the last three years,including cardiovascular,bone and joint,tumor,cellular,and molecular ***,it has been suggested that in the future,mechanobiology research should include are indicated detailed studies on the mechanobiological mechanism of diseases at the cellular and molecular levels firstly,so that the newly discovered biomarkers or potential targets can gradually achieve clinical ***,future research should strengthen the qualitative and quantitative combination of biological experiments and mechanical and mathematical modeling analyses,especially at cellular,subcellular and molecular *** studies are of great theoretical and practical significance for our understanding of the mechanical mechanisms and natural laws of growth and senility of the human body,expounding pathological mechanisms of diseases,and researching and developing new medicines and technologies to promote biomedical and clinical research for human health.

关键词： Mechanotransduction Cardiovascular disease Osteoarthropathy Tumor mechano-microenvironment Mechanosensitive molecule

Mechanobiology in vascular remodeling

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2018年第6期5卷 933-946页

作者： Yue Han Kai Huang Qing-Ping Yao Zong-lai jiang Institute of Mechanobiology & Medical Engineering School of Life Sciences & BiotechnologyShanghai Jiao Tong University School of Biological Science & Medical Engineering Beijing Advanced Innovation Center for Biomedical Engineering Beihang University

Vascular remodeling is a common pathological process in cardiovascular diseases and includes changes in cell proliferation, apoptosis and differentiation as well as vascular homeostasis. Mechanical stresses, such as shear stress and cyclic stretch, play an important role in vascular remodeling. Vascular cells can sense the mechanical factors through cell membrane proteins, cytoskeletons and nuclear envelope proteins to initiate mechanotransduction, which involves intercellular signaling, gene expression, and protein expression to result in functional regulations. Non-coding RNAs, including micro RNAs and long non-coding RNAs, are involved in the regulation of vascular remodeling processes. Mechanotransduction triggers a cascade reaction process through a complicated signaling network in cells. High-throughput technologies in combination with functional studies targeting some key hubs and bridging nodes of the network can enable the prioritization of potential targets for subsequent investigations of clinical translation. Vascular mechanobiology, as a new frontier field of biomechanics, searches for principles of stress-growth in vasculature to elucidate how mechanical factors induce biological effects that lead to vascular remodeling,with the goal of understanding the mechanical basis of the pathological mechanism of cardiovascular diseases at the cellular and molecular levels. Vascular mechanobiology will play a unique role in solving the key scientific problems of human physiology and disease, as well as generating important theoretical and clinical results.

关键词： mechanobiology vascular remodeling cardiovascular disease mechanotransduction endothelial cell vascular smooth muscle cell nuclear envelope microRNA

Self-synchronization theory of dual motor driven vibration system with two-stage vibration isolation frame

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2015年第2期36卷 265-278页

作者： He LI Dan LIU lai jiang Chunyu ZHAO Bangchun WEN School of Mechanical Engineering and Automation Northeastern University

This paper studies self-synchronization and stability of a dual-motor driven vibration system with a two-stage vibration isolation frame. Oscillation amplitude of the material box large enough can be ensured on the vibration system in order to screen materials. Reduction of the dynamic load transmitted to the foundation can also be achieved for the vibration system. A Lagrange equation is used to set up the motion differential equations of the system, and a dimensionless coupled equation of the eccentric rotors is obtained using a method of modified average small parameter. According to the existence condition of zero solution in the dimensionless coupled equation of the eccentric rotors, the precondition for commencing self-synchronization motion is *** stability condition of self-synchronization is obtained based on the Routh-Hurwitz criterion. The theoretical analysis is validated by simulations and experiments.

关键词： self-synchronization vibration system stability vibration isolation

Influences of aerodynamic loads on hunting stability of high-speed railway vehicles and parameter studies

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2014年第6期30卷 889-900页

作者： Xiao-Hui Zeng Han Wu jiang lai Hong-Zhi Sheng Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of Mechanics Chinese Academy of Sciences

The influences of steady aerodynamic loads on hunting stability of high-speed railway vehicles were investigated in this study.A mechanism is suggested to explain the change of hunting behavior due to actions of aerodynamic loads：the aerodynamic loads can change the position of vehicle system（consequently the contact relations）,the wheel/rail normal contact forces,the gravitational restoring forces/moments and the creep forces/moments.A mathematical model for hunting stability incorporating such influences was developed.A computer program capable of incorporating the effects of aerodynamic loads based on the model was written,and the critical speeds were calculated using this *** dependences of linear and nonlinear critical speeds on suspension parameters considering aerodynamic loads were analyzed by using the orthogonal test method,the results were also compared with the situations without aerodynamic *** is shown that the most dominant factors a ff ecting linear and nonlinear critical speeds are different whether the aerodynamic loads considered or *** damping of yaw damper is the most dominant influencing factor for linear critical speeds,while the damping of lateral damper is most dominant for nonlinear *** the influences of aerodynamic loads are considered,the linear critical speeds decrease with the rise of cross wind velocity,whereas it is not the case for the nonlinear critical *** variation trends of critical speeds with suspension parameters can be significantly changed by aerodynamic *** actions of aerodynamic loads and suspension parameters also a ff ect the critical *** effects of such joint action are more obvious for nonlinear critical speeds.

关键词： Hunting stability Linear critical speed Nonlinear critical speed Aerodynamic loads Suspension parameters Orthogonal experimental design