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Neutrophils in cancer—unresolved questions

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Science China(Life Sciences) 2021年第11期64卷 1829-1841页

作者： Melissa S.F.ng Leonard Tan Quanbo Wang Charles R.Mackay lai guan ng Singapore Immunology Network(SIgN) A*STAR(Agency for ScienceTechnology and Research)Biopolis 138648Singapore School of Pharmaceutical Sciences Shandong Analysis and Test CenterQilu University of Technology(Shandong Academy of Sciences)Jinan 250014China State Key Laboratory of Experimental Hematology Institute of HematologyChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China

There is growing recognition that neutrophils play an important role in cancer initiation, progression and metastasis. Although they are typically characterized as short-lived effector cells, neutrophils have been shown to acquire immunosuppressive and pro-tumorigenic functions that promote tumor progression and escape. As such, inhibition of their function or depletion of neutrophils are being explored as potential cancer therapies. However, growing evidence of neutrophil diversification in cancer and their potential anti-tumor roles raise many unresolved questions. Here, we review recent advances that address the definition,origin and function of neutrophils in cancer, and elaborate on obstacles that make the study of neutrophils challenging. We envision that this review will provide the groundwork for focused design of therapeutics that will specifically target "tumorreprogrammed" neutrophils while sparing normal neutrophils to improve patient outcomes.

关键词： neutrophils cancer myeloid-derived suppressor cells(MDSCs) immunotherapy

Immunological modulation in health and disease

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Cellular & Molecular Immunology 2023年第9期20卷 981-982页

作者： Bing Su lai guan ng Shanghai Institute of Immunology Department of Immunology and Microbiologyand the Ministry of Education Key Laboratory of Cell Death and DifferentiationShanghai Jiao Tong University School of Medicine200025 ShanghaiChina Center for Immune-Related Diseases at Shanghai Institute of Immunology and Department of Gastroenterology at Shanghai Jiao Tong University School of Medicine affiliated Ruijin Hospital 200025 ShanghaiChina Shanghai Immune Therapy Institute Shanghai Jiao Tong University School of Medicine affiliated Renji Hospital200127 ShanghaiChina

The immune system is a complex network of cells,tissues,and organs that protect the body from pathogens and *** consists of two interconnected branches:the innate immune response and the adaptive immune *** innate immune response is the body’s first line of defense against pathogens and acts promptly upon encountering *** consists of physical barriers such as skin and mucous membranes and innate immune cells such as neutrophils,macrophages,and natural killer *** cells recognize pathogen-associated molecular patterns shared by pathogens and initiate an immune response to eliminate them[1].

关键词： organs killer eliminate

Myeloid cell diversity:From fundamental biology to disease states

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hLife 2024年第12期2卷 658-660页

作者： Iván Ballesteros lai guan ng Daniela F.Quail Andrés Hidalgo Department of Neuroscience and Biomedical Sciences Universidad Carlos III de MadridMadridSpain Shanghai Immune Therapy Institute Renji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Rosalind and Morris Goodman Cancer Institute Department of PhysiologyMcGill UniversityQuebecCanada Vascular Biology and Therapeutics Program and Department of Immunobiology Yale University School of MedicineConnecticutUSA

The Keystone Symposia conference on Myeloid Cell Diversity(A324),held from January 29th to February 1st,2024,at the Fairmont Banff Springs in Canada,focused on advancing our understanding of myeloid cell behavior in homeostasis and *** by *** Hidalgo(Yale University,USA),Daniela ***(McGill University,Canada),and lai guan ng(Shanghai Immune Therapy Institute,China).

关键词： Canada inflammation. homeostasis

The convergence of hematology and immunology(November 13-15;Tianjin, China)

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Blood Science 2020年第2期2卷 41-43页

作者： Guoguang Zheng lai guan ng Tao Cheng State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesInstitute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China Singapore Immunology Network(SIgN) A∗STAR(Agency for ScienceTechnology and Research)Biopolis138648 Singapore

The Convergence of Hematology and Immunology(CHI),which was sponsored by State Key Laboratory of Experimental Hematology,Institute of Hematology and Blood Diseases Hospital,Chinese Academy of Medical Sciences(CAMS),was held in Tianjin,***-chaired by Tao Cheng of Institute of Hematology and Blood Diseases Hospital at CAMS(Tianjin,China),lai guan ng,and Florent Ginhoux of Singapore Immunology Network(Singapore),the two-day meeting invited 34 scientists from China,the United States,Singapore,Israel,Sweden,Switzerland,Japan,Italy,and Australia to present and share their latest views on the topics in hematology and immunology.

关键词： Blood Immunology CAMS

A chemotaxis model to explain WHIM neutrophil accumulation in the bone marrow of WHIM mouse model

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Blood Science 2019年第1期1卷 102-112页

作者： Ai Kia Yip Akhila Balachander Leonard DLTan Ka Hang Liong Rui Zhen Tan Karl Balabanian Francoise Bachelerie lai guan ng Keng-Hwee Chiam Bioinformatics Institute(BII) A∗STAR(Agency for ScienceTechnology and Research)Biopolis138671 Singapore Singapore Immunology Network(SIgN) A∗STAR(Agency for ScienceTechnology and Research)Biopolis138648 Singapore Singapore Institute of Technology Dover Drive138683 Singapore INSERM UMR-S996 Laboratory of Excellence in Research on Medication and Innovative TherapeuticsUniversitéParis-Sud92140 ClamartFrance State Key Laboratory of Experimental Hematology Institute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences288 Nanjing RoadTianjin 300020China

Neutrophils are essential immune cells that defend the host against pathogenic microbial *** are produced in the bone marrow and are retained there through CXCR4–CXCL12 ***,patients with the Warts,Hypogammaglobulinemia,Infections,and Myelokathexis(WHIM)syndrome are prone to infections due to increased accumulation of neutrophils in the bone marrow leading to low numbers of circulating *** neutrophils accumulate in the bone marrow in this condition is poorly *** better understand factors involved in neutrophil accumulation in the bone marrow,neutrophils from wildtype and WHIM mouse models were characterized in their response to CXCL12 *** neutrophils were found to exert stronger traction forces,formed significantly more lamellipodia-type protrusions and migrated with increased speed and displacement upon CXCL12 stimulation as compared to wildtype *** speed of WHIM neutrophils showed a larger initial increase upon CXCL12 stimulation,which decayed over a longer time period as compared to wildtype *** proposed a computational model based on the chemotactic behavior of neutrophils that indicated increased CXCL12 sensitivity and prolonged CXCR4 internalization adaptation time in WHIM neutrophils as being responsible for increased accumulation in the bone *** findings provide a mechanistic understanding of bone marrow neutrophil accumulation in WHIM condition and novel insights into restoring neutrophil regulation in WHIM patients.

关键词： Cell migration Cell traction force CXCL12 sensitivity CXCR4 internalization WHIM syndrome

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基于卷积神经网络的双阶段水下图像增强方法

北京航空航天大学学报 2025年第1期51卷 321-332页

作者：路斯棋管凤旭赖海涛杜雪哈尔滨工程大学智能科学与工程学院哈尔滨150001 哈尔滨工程大学教育部极端海洋环境波动场前沿科学中心哈尔滨150001

由于水体对光线不同粒子的吸收能力具有一定差异,水下采集到的图像往往存在严重的退化现象,严重影响水下机器人对环境的感知。传统的图像处理方法和基于退化模型的图像恢复算法受到水下环境的复杂性和物理参数不确定性的影响往往表现出... 详细信息

由于水体对光线不同粒子的吸收能力具有一定差异,水下采集到的图像往往存在严重的退化现象,严重影响水下机器人对环境的感知。传统的图像处理方法和基于退化模型的图像恢复算法受到水下环境的复杂性和物理参数不确定性的影响往往表现出较差的泛化能力。为提高水下图像的视觉效果,利用深度学习模型强大的学习能力,提出一种基于卷积神经网络的双阶段水下图像增强方法,通过图像损坏和图像恢复两个阶段的处理将退化的水下图像增强为视觉效果优秀的近空气图像。在Challenge60、U45、EUVP和RUIE数据集上的测试结果表明,提出的方法相比于已有水下图像复原、增强算法具有更好的增强效果,水下图像质量指标(UIQM)提升了5.18%,水下彩色图像质量评价(UCIQE)指标提升了6.64%。

关键词：卷积神经网络深度学习双阶段水下图像增强水下图像复原

Laboratory Experiment on Wave Induced Turbulence

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Journal of Ocean University of China 2018年第4期17卷 721-726页

作者： WEI lai guan Changlong TROITSKAYA Yuliya Physical Oceanography Laboratory Ocean University of China Institute of Applied Physics Russian Academy of Science

A laboratory experiment was conducted inside a wind wave tank to investigate the wave induced turbulence. In this experiment, the wave surface elevation and velocity beneath the water surface were measured simultaneously to investigate the relation between the wave status and wave induced turbulence. The profile of the turbulent dissipation rate and Reynolds stress were calculated using experimental data. The effect of the wave status on turbulence is investigated with regard to the wind wave, swell, and mixed wave conditions. It was depicted that the turbulence decreased with increasing depth from the water surface and that the turbulence that was induced by a wave with larger wavelength and wave height is much stronger for the same wave status. Finally, we observed that the wind wave is more effective in activating the wave induced turbulence.

关键词： wave induced turbulence turbulent dissipation rate wave-turbulence decomposition

微生物-碳化改性钢渣及其对水泥水化特性影响研究进展

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复合材料学报 2025年第1期42卷 119-132页

作者：邓威翟健梁赖淏陆福洋宗有杰熊锐关博文常明丰长安大学材料科学与工程学院诺丁汉大学土木工程学院

微生物诱导碳酸盐沉淀(MICP)是一种新型环保处理技术，其独特的矿化及生物酶催化机制在固废处理及利用方面展现出广阔前景。基于钢渣水化特性，本文探讨了碳化条件及生物酶特性对碳酸盐成核影响，分析并总结了MICP与碳化反应机制、生物... 详细信息

微生物诱导碳酸盐沉淀(MICP)是一种新型环保处理技术，其独特的矿化及生物酶催化机制在固废处理及利用方面展现出广阔前景。基于钢渣水化特性，本文探讨了碳化条件及生物酶特性对碳酸盐成核影响，分析并总结了MICP与碳化反应机制、生物-碳化改性中钢渣的物相演变规律、碳酸钙成核及晶体生长等研究进展，从力学性能、水化热及体积稳定性角度进一步综述了改性钢渣对水泥基胶凝材料水化特性影响机制，指出了现阶段微生物-碳化技术在钢渣改性研究中存在的不足，为实现钢渣低污染、高质化利用提供有益参考。

关键词：钢渣水化特性微生物催化酶碳酸盐沉淀碳化反应成核效应

Three-dimensional histology:new visual approaches to morphological changes during neural regeneration

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Neural Regeneration Research 2017年第1期12卷 53-55页

作者： Hei Ming lai Ho Man ng Wutian Wu School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina Research Center of Reproduction Development and GrowthLi Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina guangdong-Hong Kong-Macao Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Three-dimensional（3D） histology utilizes tissue clearing techniques to turn intact tissues transparent,allowing rapid interrogation of tissue architecture in three *** this article,we summarized the available tissue clearing methods and classified them according to their physicochemical principles of operation,which provided a framework for one to choose the best techniques for various research *** attempts in addressing various questions regarding the degenerating and regenerating nervous system have been promising with the use of 3D histological techniques.

关键词： three-dimensional histology tissue clearing neuronal morphology neuronal network