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弱函数代数与函数代数的插补集

厦门大学学报（自然科学版） 1989年第2期28卷 138-141页

作者：赖春晖厦门大学数学系

证明当X为有限离散拓扑空间时,只要A是X上的弱函数代数就有A=C(X);给出了第一可数、紧T_2空间X上的所有弱的数代数的公共插补集;同时就紧T_2空间X上的函数代数A,讨论了与A=C(X)等价的三个命题。

关键词：弱函数代数函数代数插补集

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调动青年医务人员工作积极性的探索

现代医院 2008年第11期8卷 113-114页

作者：赖春晖东莞市桥头医院广东东莞523520

我院是一家青年医务人员比例较高的医院，占全院医务人员的71．2％。几年来，我们结合医院青年医务人员的特点，就如何调动青年医务工作者的工作积极性进行了积极探索，并取得了一定的实效：

关键词：青年医务人员极性青年医务工作者员工医院

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Anti-tumor Immune Response of Folate-Conjugated Chitosan Nanoparticles Containing the IP-10 Gene in Mice with Hepatocellular Carcinoma

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Anti-tumor Immune Response of Folate-Conjugated Chitosan Nan...

第十六届中国科协年会——分13感染、免疫和疫苗论坛

作者： chunhui lai Xia YU Yuan XIE Jian HE Yi PENG Sufang ZHOU Xiaoxun XIE Guorong LUO Nuo ZHOU Yongxiang ZHAO Xiaoling LU National Center for International Research of Biological Targeting Diagnosis and Therapy Guangxi Medical University Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research Guangxi Medical University Department of Oral and Maxillofacial Surgery the Affiliated Hospital of Stomatology Guangxi Medical University The Department of Immunology Guangxi Medical University

Folate-chitosan nanoparticles(FA-CS)were loaded with mouse interferon-inducible protein-10(IP-10)plasmid DNA to generate FA-CS-IP-10,which was used for immunotherapy in hepatocellular carcinoma(HCC).H22 tumor-bearing mice were treated with FA-CS-IP-10 and tumor targeting was observed by in vivo *** cytometry was used to detect the number of myeloid-derived suppressor cells(MDSCs)in tumor and CD4+CD25+FoxP3+T-regulatory cells(CD4+CD25+FoxP3+Tregs)in *** enzyme-linked immunospot assay was used to quantify the FA-CS-IP-10-induced tumor-specific cytotoxic T lymphocytes(CTLs)and secretory IFN-γ.IP-10expression,tumor vessel density,cell proliferation and apoptosis were evaluated by ***-CS-IP-10 significantly inhibited tumor growth,suppressed angiogenesis,increased apoptosis of cancer cells,and prolonged the survival time of H22 tumor-bearing *** tissue from FA-CS-IP-10-treated mice had significantly higher IP-10 expression,a lower proportion of Tregs in spleen and higher proportion of MDSCs in tumor and up-regulation of IFN-γsecretion in CTLs compared to the other experimental ***-CS-IP-10 is a promising immunotherapeutic agent for HCC.

关键词： immunotherapy,FA-CS-IP-10,hepatocellular carcinoma,IP-10

Folate-Modified Chitosan Nanoparticles Coating the Human IP-10 Gene Promote pMAGE-A1278-286 Specific CTL Responses to Hepatocellular Carcinoma in Mice

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Folate-Modified Chitosan Nanoparticles Coating the Human IP-...

第十六届中国科协年会——分13感染、免疫和疫苗论坛

作者： Khoune Sodaly Mong Nuo ZHOU Jian HE Siliang DUAN Sufang ZHOU chunhui lai Xia YU Yi PENG Xiaoxun XIE Guorong LUO Yuan XIE Yongxiang ZHAO Xiaoling LU National Center for International Research of Biological Targeting Diagnosis and Therapy Guangxi Medical University Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research Guangxi Medical University Department of Oral and Maxillofacial Surgery the Affiliated Hospital of Stomatology Guangxi Medical University The Department of Immunology Guangxi Medical University

Adoptive therapy is a promising approach for the treatment of *** adoptive therapy,antigen-presenting cells(APCs)loaded with tumor specific antigens stimulate the proliferation of peripheral blood mononuclear cells(PBMCs)to produce tumor antigen-specific CTLs that are transferred back to patients to kill cancer ***,tumor antigen-specific CTLs are difficult to get to tumor tissues,due to immune suppression in ***-inducible protein-10(IP-10),a powerful chemokine,attracts CTLs to tumor tissues and improves their anti-tumor *** this study,we developed folate-modified chitosan nanoparticles coating the human IP-10 gene(FA-CS-hIP-10),which bound to the folate receptors on hepatoma cells and promoted the expression of IP-10 to improve the activity of pMAGE-A1278-286 specific *** combination of FA-CS-hIP-10 and pMAGEA1278-286 specific CD8+CTLs increased the secretion of IFN-γ,inhibited tumor growth and extended the survival of nude mice with subcutaneously transplanted human hepatocellular *** results demonstrated that the mechanism of this novel therapy approach was involved in the inhibition of angiogenesis,inhibition of proliferation,and promotion of apoptosis of tumor *** study provided a potentially novel approach for the treatment of human hepatocellular carcinoma by improving the activity of tumor antigen-specific CTLs.

关键词： cytotoxic T lymphocytes,chitosan,interferon-inducible protein-10,nanoparticles,folate receptor

Folate-modified Chitosan Nanoparticles Containing the IP-10 Gene Enhance Melanoma-specific Cytotoxic CD8+CD28+ T Lymphocyte Responses

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Folate-modified Chitosan Nanoparticles Containing the IP-10 ...

第十二届全国免疫学学术大会

作者： He Jian Duan Siliang Yu Xia Qian Zhiyong Zhou Sufang Zhang Zhiyong Huang Xianing Huang Yong Su Jing lai chunhui Meng Jinyu Zhou Nuo Lu Xiaoling Zhao Yongxiang National Center for International Research of Biological Targeting Diagnosis and Therapy Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy ResearchCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Medical University State Key Laboratory for Biotherapy and Cancer Center West China HospitalSichuan University Department of Surgery Robert-Wood-Johnson Medical School University HospitalRutgers University Biomedical Polymers Laboratory Soochow University The Department of Immunology Guangxi Medical University

Background:Adoptive immunotherapy with cytotoxic T lymphocytes(CTLs) has great potential for the treatment of some malignant ***,augmenting the responses of tumor-specific CTLs is significant for the adoptive immunotherapy of *** study aimed to investigate the anti-tumor response of a combination therapy employing folate-modified chitosan nanoparticles containing IP-10(interferon-γ-inducible protein-10) plus melanoma TRP2-specific CD8+CD28+ T ***:We prepared folate-modified chitosan nanoparticles containing the mouse IP-10 gene(FA-CS-mIP-10),and induced melanoma TRP2-specific CD8+CD28+ T cells by co-culturing them with artificial antigen-presenting cells.B16-bearing mice were treated with FA-CS-mIP-10,melanoma TRP2-specific CD8+CD28+ T cells,a combination of both,and the saline *** volumes and the survival time of mice were *** proportion of myeloid-derived suppressor cells(MDSCs) infiltrating the tumor microenvironment and regulatory T cells(Tregs) in the spleen was analyzed by flow *** also detected the proliferation and angiogenesis of tumors by immunohistochemistry and apoptosis by ***:The combination therapy inhibited the progression of melanoma in *** with other treatments,it more efficiently inhibited tumor growth and increased the survival time of *** treatment with combination therapy,the proportion of MDSCs and Tregs decreased,while the percentage of CXCR3+CD8+ T cells ***,combination therapy inhibited proliferation and promoted apoptosis of tumor cells and significantly inhibited tumor angiogenesis in ***:We describe a novel strategy for improving the anti-tumor response of CD8+CD28+ CTLs by combining them with FA-CS-mIP-10 nanoparticles.

关键词： cytotoxic T lymphocytes melanoma folate chitosan interferon-γ-inducible protein-10

早孕期唐氏综合征一站式临床风险评估的临床应用价值

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中华妇幼临床医学杂志（电子版） 2019年第5期15卷 590-595页

作者：蒙春华赖春慧李荣南宁市第二人民医院医学检验科

目的探讨早孕期唐氏综合征(DS)一站式临床风险评估(OSCAR)的临床应用价值。方法选取2016年3月至2017年12月,于南宁市第二人民医院产科门诊接受早孕期OSCAR筛查的4219例孕妇为研究对象。预产年龄为17.3~51.8岁,孕龄为11~13+6孕周。所... 详细信息

目的探讨早孕期唐氏综合征(DS)一站式临床风险评估(OSCAR)的临床应用价值。方法选取2016年3月至2017年12月,于南宁市第二人民医院产科门诊接受早孕期OSCAR筛查的4219例孕妇为研究对象。预产年龄为17.3~51.8岁,孕龄为11~13+6孕周。所有孕妇于孕龄为11~13+6孕周行胎儿颈项透明层(NT)测量。采用时间分辨免疫荧光分析法,检测孕妇血清妊娠相关蛋白(PAPP-A)和游离β-人绒毛膜促性腺激素(fβ-hCG)水平,将所测定的血清PAPP-A和fβ-hCG值输入产前筛查数据管理软件LifeCycle4.0,软件自动计算血清fβ-hCG和PAPP-A水平中位数倍数(MoM),并结合孕妇预产年龄、抽血当日体重、超声检查所提示孕龄、胎儿数等临床资料,计算胎儿罹患DS和18-三体综合征的风险。对于筛查结果高风险者建议进一步行羊水穿刺进行羊水细胞染色体核型分析;筛查结果为低风险者于中孕期再次行产前筛查。所有筛查高风险孕妇均跟踪随访至胎儿出生后42d。本研究遵循的程序符合南宁市第二人民医院医学伦理委员会所制定的伦理学标准,得到该委员会批准(批准文号:20190924)。所有孕妇接受早孕期OSCAR筛查或介入性产前诊断前,均签署知情同意书。结果 ①4219例早孕期接受OSCAR筛查的孕妇中,DS高风险率为2.5%(103/4219),18-三体综合征高风险率为0.3%(11/4219)。不同预产年龄段的DS和18-三体综合征高风险率比较,差异均有统计学意义(P<0.05)。进一步对DS高风险率进行比较结果显示,≥35岁孕妇DS高风险率均高于其他年龄段,并且差异亦均有统计学意义(P<0.05)。②NT值随孕龄增大呈逐渐增大的趋势,NT值MoM中位数也随着孕龄增大而增加。③孕妇血清PAPP-A水平中位数随孕龄增大而升高,血清fβ-hCG水平中位数随孕龄增大而降低。④4219例早孕期进行OSCAR的孕妇中,筛查结果高风险者为113例(2.7%),低风险者为4106例(97.3%)。113例高风险孕妇中,同意行羊水穿刺或者绒毛穿刺术诊断的孕妇为42例(37.2%,42/113),羊水细胞染色体核型分析诊断异常者为3例,其中,DS为2例(预产年龄分别为34岁和33岁),13-三体综合征为1例(预产年龄为22岁)。⑤113例筛查高风险孕妇中,1例孕妇尚未进行产前诊断即出现胎儿停止生长发育,随后引产。进一步追踪筛查低风险孕妇结果发现,2例孕妇出现死胎进而引产的情况,该2例孕妇在产前筛查时PAPP-AMoM值异常,分别为0.35和0.28(正常参考值范围为0.5~2.5)。⑥对113例筛查高风险孕妇进行随访结果显示,成功随访为106例(93.8%),失访7例(6.2%)。结论早孕期DSOSCAR简便、经济,具有高性价比。此外,PAPP-AMoM值异常可作为不良妊娠结局的参考指标。

关键词：唐氏综合征产前诊断妊娠初期妊娠相关血浆蛋白A 孕妇

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Folate-Modified Chitosan Nanoparticles Coated InterferonInducible Protein-10 Gene Enhance Cytotoxic T Lymphocytes' Responses to Hepatocellular Carcinoma

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第十一届全国免疫学学术大会

作者： Duan Siliang Song Mongkhoune He Jian Zhou Nuo Zhou Sufang Zhao Jing Fang Yuan Peng Yi Huang Xianing Luo Guorong lai chunhui Yu Xia Zhang Zhiyong Xie Yuan Zhao Yongxiang Lu Xiaoling National Center for International Research of Biological Targeting Diagnosis and Therapy Guangxi Medical University Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research Guangxi Medical University Department of Oral and Maxillofacial Surgery the Affiliated Hospital of Stomatology Guangxi Medical University Department of Surgery Robert-Wood-Johnson Medical School University Hospital Rutgers UniversityThe State University of New Jersey The Department of Immunology Guangxi Medical University

Purpose:To improve the efficacy of adoptive immunotherapy,we aimed to develop a novel therapy approach to increase the concentration of tumor antigen-specific CTLs in tumor tissues and improve their anti-tumor ***:Chitosan nanoparticles were prepared using the ion template method,then folate and carbodiimide were then combined in a beaker and mixed in the dark using a magnetic stirrer for 1 *** diluted h IP-10 plasmid

关键词： Cytotoxic T Lymphocytes Chitosan Interferon-Inducible Protein-10 Nanoparticles Folate Receptor

Folate-Modified Chitosan Nanoparticles Coated Interferon-Inducible Protein-10 Gene Enhance Cytotoxic T Lymphocytes' Responses to Hepatocellular Carcinoma

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Folate-Modified Chitosan Nanoparticles Coated Interferon-Ind...

第十二届全国免疫学学术大会

作者： Duan Siliang Song Mongkhoune He Jian Zhou Nuo Zhou Sufang Zhao Jing Fang Yuan Peng Yi Huang Xianing Luo Guorong lai chunhui Yu Xia Zhang Zhiyong Xie Yuan Zhao Yongxiang Lu Xiaoling National Center for International Research of Biological Targeting Diagnosis and Therapy Guangxi Medical University Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research Guangxi Medical University Department of Oral and Maxillofacial Surgery the Affiliated Hospital of StomatologyGuangxi Medical University Department of Surgery Robert-Wood-Johnson Medical School University HospitalRutgers University The Department of Immunology Guangxi Medical University

Adoptive therapy using tumor antigen-specific cytotoxic T lymphocytes(CTLs) is a promising approach for treatment of human *** to immune suppression in cancer patients,it is difficult for tumor antigen-specific CTLs to arrive at tumor ***-inducible protein-10(IP-10) is a powerful chemokine that effectively attracts CTLs to tumor tissues and improves their anti-tumor *** over expression of IP-10 in tumor tissues can efficiently promote efficacy of adoptive ***-modified chitosan nanoparticles coating the human IP-10 gene(FA-CS-hIP-10) were therefore developed in this *** FA-CS-hIP-10 nanoparticles were specifically bound to folate receptors on hepatoma cells and promoted the expression of IP-10,to improve the activity of pMAGE-A1278-286 specific *** of the FA-CS-hIP-10 and pMAGE-A1278-286 specific CD8+ CTLs efficiently increased secretion of IFN-,inhibited tumor growth and extended survival of nude mice with subcutaneously transplanted human hepatocellular *** results demonstrated that the mechanism behind this novel therapeutic approach involved inhibition of angiogenesis and proliferation,and also promoted apoptosis of tumor *** study provides a potentially novel approach for treatment of human hepatocellular carcinoma by improving the activity of tumor antigen-specific CTLs.

关键词： Cytotoxic T Lymphocytes Chitosan Interferon-Inducible Protein-10 Nanoparticles Folate Receptor

全过程工程咨询模式下BIM技术在招投标阶段的应用实践与思考

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绿色建造与智能建筑 2024年第9期 35-38页

作者：宋志红郭建淼来春晖瑞和安惠项目管理集团有限公司石家庄050025

当今随着计算机软硬件和网络的高速发展,基于三维的设计和协同工作成为现实,建筑信息模型(BIM)技术作为辅助手段对项目管理可进行虚拟建造、可视化、方案模拟、目标控制等,并可将物理、建造、运维等信息动态集成和同步更新,贯穿于项目... 详细信息

当今随着计算机软硬件和网络的高速发展,基于三维的设计和协同工作成为现实,建筑信息模型(BIM)技术作为辅助手段对项目管理可进行虚拟建造、可视化、方案模拟、目标控制等,并可将物理、建造、运维等信息动态集成和同步更新,贯穿于项目全生命周期,实现节资、节时、高效的建设,为管理工作带来极大可视化的三维管控优势。招标工作作为全过程工程咨询的前期阶段尤为重要,运用BIM技术可辅助确定最优投标方案及为后续BIM应用奠定模型基础。本文依托某学校新校区工程的招标工作,重点阐述BIM技术在招投标阶段的应用实践与思考。

关键词： BIM 三维可视化招标实践

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