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SIGNAL TRANSDUCTION AND TARGETED THERAPY 2024年第1期9卷 1-19页

作者： Wang, Xiujian Tao, Xiao Chen, Pengjie Jiang, Penglei Li, Wenxiao Chang, Hefeng Wei, Cong lai, xinyi Zhang, Hao Pan, Yihan Ding, Lijuan Liang, Zuyu Cui, Jiazhen Shao, Mi Teng, xinyi Gu, Tianning Wei, Jieping Kong, Delin Si, Xiaohui Han, Yingli Fu, Huarui Lin, Yu Yu, Jian Li, Xia Wang, Dongrui Hu, Yongxian Qian, Pengxu Huang, He Zhejiang Univ Affiliated Hosp 1 Bone Marrow Transplantat Ctr Sch Med Hangzhou 310003 Peoples R China Zhejiang Univ Med Ctr Liangzhu Lab Liangzhu Lab 1369 West Wenyi Rd Hangzhou 311121 Peoples R China Zhejiang Univ Inst Hematol Hangzhou 310003 Peoples R China Zhejiang Prov Engn Lab Stem Cell & Immun Therapy Hangzhou 310003 Peoples R China Zhejiang Univ Ctr Stem Cell & Regenerat Med Sch Med Hangzhou 310058 Peoples R China Wenzhou Med Univ Affiliated Hosp 3 Dept Hematol Wenzhou 325200 Peoples R China

Clinical evidence supports the notion that T cell exhaustion and terminal differentiation pose challenges to the persistence and effectiveness of chimeric antigen receptor-T (CAR-T) cells. MEK1/2 inhibitors (MEKIs), widely used in cancer treatment due to their ability to inhibit aberrant MAPK signaling, have shown potential synergistic effects when combined with immunotherapy. However, the impact and mechanisms of MEKIs on CAR-T cells remain uncertain and controversial. To address this, we conducted a comprehensive investigation to determine whether MEKIs enhance or impair the efficacy of CAR-T cells. Our findings revealed that MEKIs attenuated CAR-T cell exhaustion and terminal differentiation induced by tonic signaling and antigen stimulation, thereby improving CAR-T cell efficacy against hematological and solid tumors. Remarkably, these effects were independent of the specific scFvs and costimulatory domains utilized in CARs. Mechanistically, analysis of bulk and single-cell transcriptional profiles demonstrates that the effect of MEK inhibition was related to diminish anabolic metabolism and downregulation of c-Fos and JunB. Additionally, the overexpression of c-Fos or JunB in CAR-T cells counteracted the effects of MEK inhibition. Furthermore, our Cut-and-Tag assay revealed that MEK inhibition downregulated the JunB-driven gene profiles associated with exhaustion, differentiation, anergy, glycolysis, and apoptosis. In summary, our research unveil the critical role of the MAPK-c-Fos-JunB axis in driving CAR-T cell exhaustion and terminal differentiation. These mechanistic insights significantly broaden the potential application of MEKIs to enhance the effectiveness of CAR-T therapy.

关键词： JunB metabolism stimulation

High-temperature-tolerant flexible supercapacitors: Gel polymer electrolytes and electrode materials

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Journal of Energy Chemistry 2025年第1期100卷 426-457页

作者： Chong Peng xinyi Huang Mingwei Zhao Shuling Liao Quanhong Yang Nianjun Yang Siyu Yu School of Chemistry & Chemical Engineering Southwest University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy Storage School of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Department of Chemistry & IMO-IMOMEC Hasselt University

The development of flexible supercapacitors(FSCs) capable of operating at high temperatures is crucial for expanding the application areas and operating conditions of supercapacitors. Gel polymer electrolytes and electrode materials stand as two key components that significantly impact the efficacy of hightemperature-tolerant FSCs(HT-FSCs). They should not only exhibit high electrochemical performance and excellent flexibility, but also withstand intense thermal stress. Considerable efforts have been devoted to enhancing their thermal stability while maintaining high electrochemical and mechanical performance. In this review, the fundamentals of HT-FSCs are outlined. A comprehensive overview of state-of-the-art progress and achievements in HT-FSCs, with a focus on thermally stable gel polymer electrolytes and electrode materials is provided. Finally, challenges and future perspectives regarding HT-FSCs are discussed, alongside strategies for elevating operational temperatures and *** review offers both theoretical foundations and practical guidelines for designing and manufacturing HT-FSCs, further promoting their widespread adoption across diverse fields.

关键词： Polymer membrane electrodes

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纳米金属有机框架材料在药物递送领域的应用

化学进展 2019年第6期31卷 783-790页

作者：赖欣宜王志勇郑永太陈永明中山大学聚合物复合材料及功能材料教育部重点实验室材料科学与工程学院

金属有机框架材料(Metal-Organic Frameworks,MOFs)是一类由金属离子及有机配体自组装而成的多孔材料,具有孔隙率高、比表面积大和结构多样化等独特优点,广泛应用于气体储存、物质分离和催化等领域。纳米尺寸金属有机框架材料(Nanoscale... 详细信息

金属有机框架材料(Metal-Organic Frameworks,MOFs)是一类由金属离子及有机配体自组装而成的多孔材料,具有孔隙率高、比表面积大和结构多样化等独特优点,广泛应用于气体储存、物质分离和催化等领域。纳米尺寸金属有机框架材料(Nanoscale Metal-Organic Frameworks,NMOFs)既保持了传统MOFs的规整性,也具有纳米颗粒的特殊性质,在生物医药领域中是绝佳的药物载体。相比于传统纳米药物载体,NMOFs与药物的结合方式丰富,展现了多种药物装载模式,可以满足不同药物的制备需求,也可引入不同功能分子优化性能。最近,有越来越多的研究报道了多功能化NMOFs应用于药物递送领域,并实现刺激响应性的可控释放。本文将着重对NMOFs材料作为药物载体负载抗癌药物、光敏剂和核酸的应用进展进行综述。

关键词：金属有机框架材料纳米颗粒药物递送抗癌药物光敏剂核酸

艾滋病相关创伤后应激障碍症状患者的生活体验质性研究

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中国艾滋病性病 2024年第6期30卷 618-622页

作者：赖欣怡王红红唐楚蕾中南大学湘雅护理学院长沙410013 南京医科大学护理学院南京211166

目的探索艾滋病相关创伤后应激障碍症状患者的生活体验,为临床制订心理干预对策提供依据。方法采用诠释现象学研究方法,通过目的抽样在湖南省长沙市某医院艾滋病病房或门诊深度访谈16位患者,并应用诠释现象学分析法对访谈资料进行分... 详细信息

目的探索艾滋病相关创伤后应激障碍症状患者的生活体验,为临床制订心理干预对策提供依据。方法采用诠释现象学研究方法,通过目的抽样在湖南省长沙市某医院艾滋病病房或门诊深度访谈16位患者,并应用诠释现象学分析法对访谈资料进行分析。结果 16名访谈对象中男性9名,女性7名,其中经同性性传播6人,异性性传播10人。研究提炼出“HIV感染确诊与创伤后应激障碍的动态建构”(社会环境:遭受艾滋病污名化和歧视、心理变化:对未来治疗与结局的担忧与恐惧、个人认知:打破自我认知,难以接受事实)、“打破生活常态”(日常生活状态不佳、人际交往疏远、工作多方受阻)和“回归生活的障碍因素”(消极的认知评价、回归家庭受阻、医疗支持不足)三大主题。结论艾滋病相关创伤后应激障碍症状患者生活常态被打破,并面临回归生活受阻的困境。医护工作人员应关注艾滋病患者的创伤后应激障碍症状,帮助患者提高自我应对能力,加强社会支持,以缓解艾滋病相关创伤后应激障碍症状,促进其重返社会。

关键词：艾滋病创伤后应激障碍生活体验质性研究

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火力发电中的热能动力装置维护与检测分析

集成电路应用 2022年第10期39卷 309-311页

作者：赖新熠上海电力大学上海200090

阐述保持火力发电系统的稳定性,需要采取正确的措施检测并维护热能动力装置,保障热能动力装置运行安全。探讨遵循科学的原则养护热能动力装置,确保热能动力装置稳定运行。

关键词：发电系统热能动力装置稳定性检测分析

计及源荷互补特性的“源网荷储一体化项目”优化配置

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电力自动化设备 2024年第7期44卷 123-131页

作者：孟旭瑶付立军赖心怡孙亚璐杨昌海文福拴浙江大学电气工程学院浙江杭州310027 海军工程大学电磁能技术全国重点实验室湖北武汉430033 国网甘肃省电力公司经济技术研究院甘肃兰州730030

针对“源网荷储一体化项目”(后简称一体化项目)在风光消纳率、清洁用电率等方面的建设要求,提出了计及源荷互补特性的一体化项目优化配置方法。基于包含风光发电制氢负荷、可平移工业负荷、电动汽车快充站的一体化项目拓扑,建立了一体... 详细信息

针对“源网荷储一体化项目”(后简称一体化项目)在风光消纳率、清洁用电率等方面的建设要求,提出了计及源荷互补特性的一体化项目优化配置方法。基于包含风光发电制氢负荷、可平移工业负荷、电动汽车快充站的一体化项目拓扑,建立了一体化项目内部的多类型负荷用电功率模型。提出基于分时Copula函数生成时序一致的风光联合出力场景集的方法,进而提出分为风光额定功率配比优化、容量配置优化、负荷接入位置优化三阶段的一体化项目优化配置方法。通过算例分析对所提方法的可行性和有效性进行仿真验证。

关键词： “源网荷储一体化项目” 源荷互补特性不确定集优化配置负荷选址

Optimizing Fine-Tuning in Quantized Language Models:An In-Depth Analysis of Key Variables

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Computers, Materials & Continua 2025年第1期82卷 307-325页

作者： Ao Shen Zhiquan lai Dongsheng Li Xiaoyu Hu National Key Laboratory of Parallel and Distributed Computing National University of Defense TechnologyChangsha410073China Strategic Assessments and Consultation Institute Academy of Military ScienceBeijing100091China

Large-scale Language Models(LLMs)have achieved significant breakthroughs in Natural Language Processing(NLP),driven by the pre-training and fine-tuning *** this approach allows models to specialize in specific tasks with reduced training costs,the substantial memory requirements during fine-tuning present a barrier to broader ***-Efficient Fine-Tuning(PEFT)techniques,such as Low-Rank Adaptation(LoRA),and parameter quantization methods have emerged as solutions to address these challenges by optimizing memory usage and computational *** these,QLoRA,which combines PEFT and quantization,has demonstrated notable success in reducing memory footprints during fine-tuning,prompting the development of various QLoRA *** these advancements,the quantitative impact of key variables on the fine-tuning performance of quantized LLMs remains *** study presents a comprehensive analysis of these key variables,focusing on their influence across different layer types and depths within LLM *** investigation uncovers several critical findings:(1)Larger layers,such as MLP layers,can maintain performance despite reductions in adapter rank,while smaller layers,like self-attention layers,aremore sensitive to such changes;(2)The effectiveness of balancing factors depends more on specific values rather than layer type or depth;(3)In quantization-aware fine-tuning,larger layers can effectively utilize smaller adapters,whereas smaller layers struggle to do *** insights suggest that layer type is a more significant determinant of fine-tuning success than layer depth when optimizing quantized ***,for the same discount of trainable parameters,reducing the trainable parameters in a larger layer is more effective in preserving fine-tuning accuracy than in a smaller *** study provides valuable guidance for more efficient fine-tuning strategies and opens avenues for further research into optimizing LLM

关键词： Large-scale Language Model Parameter-Efficient Fine-Tuning parameter quantization key variable trainable parameters experimental analysis

Low‑Temperature Fabrication of Stable Black‑Phase CsPbI_(3)Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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Nano-Micro Letters 2025年第3期17卷 232-245页

作者： Yingjie Zhao Yicheng Sun Chaoxin Pei Xing Yin xinyi Li Yi Hao Mengru Zhang Meng Yuan Jinglin Zhou Yu Chen Yanlin Song College of Chemistry and Pingyuan Laboratory Zhengzhou UniversityZhengzhou 450001People’s Republic of China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Key Laboratory of Bio‑Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049People’s Republic of China

Flexible wearable optoelectronic devices fabricated fromorganic–inorganic hybrid perovskites significantly accelerate the developmentof portable energy,biomedicine,and sensing fields,but their poor thermal stabilityhinders further ***,all-inorganic perovskites possessexcellent thermal stability,but black-phase all-inorganic perovskite filmusually requires high-temperature annealing steps,which increases energy consumptionand is not conducive to the fabrication of flexible wearable *** this work,an unprecedented low-temperature fabrication of stable blackphaseCsPbI3perovskite films is demonstrated by the in situ hydrolysis reactionof diphenylphosphinic chloride *** released diphenyl phosphateand chloride ions during the hydrolysis reaction significantly lower the phasetransition temperature and effectively passivate the defects in the perovskitefilms,yielding high-performance photodetectors with a responsivity of 42.1 AW−1 and a detectivity of 1.3×10^(14)***,high-fidelity imageand photoplethysmography sensors are demonstrated based on the fabricated flexible wearable *** work provides a newperspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

艺术赋能乡村建设——乡村振兴背景下祝店村现代化设计发展策略研究

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鞋类工艺与设计 2024年第21期4卷 166-168页

作者：来心怡陈梦溪河南工学院河南新乡453000

随着时代发展,我国已全面进入小康社会,农民物质生活水平逐步提升,农业农村产业结构不断调整完善。本文以乡村振兴背景下的新乡市封丘县祝店村为例,重点探讨了艺术设计在乡村现代化中的作用,涵盖特色乡村环境建设、艺术设计赋能产业结... 详细信息

随着时代发展,我国已全面进入小康社会,农民物质生活水平逐步提升,农业农村产业结构不断调整完善。本文以乡村振兴背景下的新乡市封丘县祝店村为例,重点探讨了艺术设计在乡村现代化中的作用,涵盖特色乡村环境建设、艺术设计赋能产业结构调整、设计人才振兴乡村以及文化资源优化利用等方面。特别是在保护传统文化、提升乡村环境美化、激发乡村内生活力等领域,通过分析如何整合自然资源与现代需求,提升乡村景观与生活质量,探讨了艺术设计在增强乡村文化吸引力和经济活力中的潜力,从而为推动乡村的可持续发展提供了可行的路径。

关键词：乡村振兴乡村建设艺术现代化设计