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Application of Cameriere’s method for dental age estimation in children in South China

Forensic Sciences Research 2022年第2期7卷 106-114页

作者： Zedeng Yang Dan Wen Jiao Xiao Qianying Liu Shule Sun Aliye Kureshi Yunfeng Chang lagabaiyila zha Department of Forensic Science School of Basic Medical SciencesCentral South UniversityChangshaChina Xinjiang Medical University UrumqiChina

The aim of this study was to evaluate the applicability of Cameriere’s European formula for age estimation in children in South China and to adapt the formula to establish a more suitable formula for these children.Moreover,the performance of dental age estimation based on Cameriere’s method combining the developmental information of permanent teeth(PT)and third molar(TM)was also analysed.Orthopantomographs of 720 healthy children in Group A,and orthopantomographs of 320 children and 280 subadults in Group B were assessed.The samples of Group A were divided into training dataset 1 and test dataset 1,and the samples of Group B were also divided into training dataset 2 and test dataset 2.A South China-specific formula was established based on the training dataset 1,and the comparison of accuracy between the Cameriere’s European formula and the South China-specific formula was conducted with the test dataset 1.Additionally,a PT regression model,a TM regression model,and a combined regression model(PTþTM)were established based on the training dataset 2,and the performance of these three models were validated on the test dataset 2.The Cameriere’s European formula underestimated chronological age with a mean difference(ME)of-0.47±1.11 years in males and-0.69±1.19 years in females.However,the South China-specific formula underestimated chronological age,with a mean difference(ME)of-0.02±0.71 years in males and-0.14±0.73 years in females.Compared with PT model and TM model,the PT and TM combined model obtained the smallest root mean square error(RMSE)of 1.29 years in males and 0.93 years in females.In conclusion,the South China-specific formula was more suitable for assessing the dental age of children in South China,and the PT and TM combined model can improve the accuracy of dental age estimation in children.

关键词： Forensic sciences dental age estimation Cameriere’s method SouthChina linear regression

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Comparing the accuracy of Demirjian and Nolla methods and establishing a new method for dental age estimation in northeastern Chinese children

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Forensic Sciences Research 2022年第4期7卷 685-693页

作者： Dan Wen Zhiyu Ding Zhikai Tian Wenshuang Wu Weifeng Qu Wei He Chudong Wang Jienan Li lagabaiyila zha Ying Liu Department of Forensic Medicine School of Basic Medical SciencesCentral South UniversityChangshaChina Department of Orthopaedics The Third Xiangya Hospital of Central South UniversityChangshaChina Department of Oral Implantology Xiangya Stomatological HospitalCentral South UniversityChangshaChina Clinical Laboratory of Xiangya Stomatological Hospital Central South UniversityChangshaChina

Dental age estimation plays an important role in the field of clinic medicine and forensic medicine.The Demirjian and Nolla methods are common scoring methods for dental age estimation but there was no research about the comparison of accuracy of these two methods in northeastern Chinese children.Hence,in this study,we compared the accuracy of these two methods to explore more suitable method for our studied population.We collected 535 orthopantomograms from northern Chinese children aged from 6 to 15 years and divided them into training dataset and testing dataset according to the ratio of 7:3.The dental age of training dataset were estimated using Demirjian and Nolla methods,respectively.The results suggested that the mean differences of these two methods were 0.24 and−0.40 years,and mean absolute difference were 0.65 and 0.59 years.Then to further improve the accuracy of dental age assessment,the new improved formulas and dental age conversion tables were established after analyzing the relationship between the sum scores based on Nolla method and chronology age in training dataset.According to the new method used in testing dataset,the minimum value of mean difference(0.00)and mean absolute difference(0.49)were obtained,which are largely smaller than that of Demirjian and Nolla methods.The new developed method and dental age conversion scales may be more suitable dental age estimation method for northeastern Chinese children.

关键词： Forensic science forensic odontology dental age estimation Demirjian method Nolla method northeastern Chinese children

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Collagen1α1 promoter drives the expression of Cre recombinase in osteoblasts of transgenic mice

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Journal of Genetics and Genomics 2008年第9期35卷 525-530页

作者： lagabaiyila zha Ning Hou Jian Wang Guan Yang Yuanrong Gao Lin Chen Xiao Yang State Key Laboratory of Proteomics Genetic Laboratory of Development and Diseases Institute ofBiotechnology Beijing 100071 China Laboratory of Trauma Center Daping Hospital The Third Military Medical University Chongqing 400042 China

Osteoblasts participate in bone formation, bone mineralization, osteoclast differentiation and many pathological processes. To study the function of genes in osteoblasts using Cre-LoxP system, we generated a mouse line expressing the Cre recombinase under the control of the rat Collagenlcd （Collα1） promoter （Collα1-Cre）. Two founders were identified by genomic PCR from 16 offsprings, and the integration efficiency is 12.5%. In order to determine the tissue distribution and the activity of Cre recombinase in the transgenic mice, the Coll αl-Cre transgenic mice were bred with the ROSA26 reporter strain and a mouse strain that carries Smad4 conditional alleles （Smad4^Co/Co）. Multiple tissue PCR of Collα1-Cre;Smad4^Co/＋ mice revealed the restricted Cre activity in bone tissues containing osteoblasts and tendon. LacZ staining in the Collα1-Cre;ROSA26 double transgenic mice revealed that the Cre recombinase began to express in the osteoblasts of calvaria at E14.5. Cre activity was observed in the osteoblasts and osteocytes of P10 double transgenic mice. All these data indicated that the Collα1-Cre transgenic mice could serve as a valuable tool for osteoblast lineage analysis and conditional gene knockout in osteoblasts.

关键词： Collagenl osteoblast Cre recombinase transgenic mouse

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Genetic polymorphism of 29 STR loci in the Hunan Han population from China

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Forensic Sciences Research 2019年第4期4卷 351-353页

作者： Yanfang Liu Ying Liu Juanjuan Guo Xiaoliang Fu Zhihui Wang Yujie Liu Jifeng Cai lagabaiyila zha Department of Forensic Science School of Basic Medical SciencesCentral South UniversityChangshaChina Department of Oral and Maxillofacial Surgery Xiangya Stomatological HospitalCentral South UniversityChangshaChina Department of Trade and Economic School of Economy and TradeHunan University of CommerceChangshaChina

Dear Editor,The Han population accounts for the majority of the Chinese population.Hunan is a large province located at 108470–114150 E and 30080–24380 N in Southern China,specifically in the area in the middle reaches of Yangtze River.The province has a total area of 218400 km2 and a population of 72 million.The Han population of the province is approximately 59.15 million[1].In this study,we evaluated the allele frequencies and forensic parameters of 29 short tandem repeat(STR)loci by using two commercial kits(GoldeneyeTM 20A kit and Investigator HDplex kit).

关键词： population Hunan Yangtze

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Cardiomyocyte Overexpression of miR-27b Induces Cardiac Hypertrophy and Dysfunction in Mice

Cardiomyocyte Overexpression of miR-27b Induces Cardiac Hype...

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中国遗传学会第二届“模式生物与人类健康”研讨会

作者：王剑 lagabaiyila zha 军事医学科学院生物工程研究所

Recent studies have begun to reveal critical roles of microRNAs(miRNAs) in the pathogenesis of cardiac hypertrophy and dysfunction.In this study,we tested whether a transforming growth factor-β(TGF-β)-regulated miRNA played a pivotal role in the development of cardiac hypertrophy and heart failure.We observed that miR-27b was

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Genetic Polymorphism of Nine Non-CODIS STR Loci in Hu- nan Province-based Chinese Han Population

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法医学杂志 2014年第6期30卷 441-445页

作者： GUO Juan-juan LIU Ying GUO Ya-dong YAN Jie CHANG Yun-feng CAI Ji-feng LUTing zha lagabaiyila Department of Forensic Medicine School of Basic Medicine Central South University Changsha 410013China Department of Oral and Maxillofacial Surgery Xiangya Stomatological Hospital Central SouthUniversity Changsha 410013 China

Objective To determine the allelic frequency distribution and genetic parameters of nine non-CODIS DNA index systems of the short tandem repeat (STR) loci (D2S1772, D6S1043, D7S3048, D8S1132, D11S2368, D12S391, D13S325, D18S1364, and GATA198B05). Methods A total of 353 blood samples were collected, extracted, amplified, and analyzed from unrelated healthy individuals of Han nationality in Hunan Province, China. Results One hundred and fourteen alleles were observed in the population with corresponding allelic frequencies ranged from 0.001 0 to 0.323 0. For all the nine non-CODIS STR loci, the observed genotypic data showed no significant deviations from the Hardy-Weinberg equilibrium. The Ho, He, PIC, DP, and PE of the studied non-CODIS STR loci ranged from 0.108 0 to0.195 0, 0.805 0 to 0.892 0, 0.770 0 to 0.860 0, 0.925 0 to 0.966 0 and 0.607 0 to 0.780 0, respectively. Conclusion Nine non-CODIS STR loci have high degrees of polymorphisms, which may be useful in individual forensic identification and parentage testing in forensic practice.

关键词： forensic genetics polym orphism,genetic short tandem repeats non-CODIS Han nationality Hunan

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表型信息SNPs在法医学中的研究进展

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中国法医学杂志 2013年第3期28卷 218-220页

作者：李忠华扎拉嘎白乙拉侯一平四川大学华西基础医学与法医学院四川成都610041

单核苷酸多态性(single nucleotide polymorphism,SNP),是指人群中正常个体基因组中单个碱基的变异,而能够提供个体表型信息的SNPs(phenotype informative SNPs,PISNPs)对法医学实践有重要意义。本文对PISNPs的基本概念、研究方法和其... 详细信息

单核苷酸多态性(single nucleotide polymorphism,SNP),是指人群中正常个体基因组中单个碱基的变异,而能够提供个体表型信息的SNPs(phenotype informative SNPs,PISNPs)对法医学实践有重要意义。本文对PISNPs的基本概念、研究方法和其在法医学中的应用进展进行综述,并对如何加强PISNPs在法医学方面的应用提出了几点看法。

关键词：法医物证学 PISNPs 全基因组关联分析

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玻璃体液检测技术在法医学死亡时间推断中的研究进展

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法医学杂志 2018年第1期34卷 49-54,59页

作者：段伟成兰玲梅郭亚东扎拉嘎白乙拉闫杰丁艳君蔡继峰中南大学基础医学院法医系湖南长沙410013

死亡时间(PMI)的判定在法医学研究及检案工作中一直占据极其重要的地位。玻璃体液因其独特的解剖学位置,被认为能较好地用于PMI推断,且引起了学者的兴趣,并对此展开了较多研究。目前,针对玻璃体液的检测技术在不断发展完善,并已被逐渐... 详细信息

死亡时间(PMI)的判定在法医学研究及检案工作中一直占据极其重要的地位。玻璃体液因其独特的解剖学位置,被认为能较好地用于PMI推断,且引起了学者的兴趣,并对此展开了较多研究。目前,针对玻璃体液的检测技术在不断发展完善,并已被逐渐应用于法医学,同时利用玻璃体液进行PMI推断的研究也在不断深入。本文对目前已报道的不同玻璃体液检测技术、仪器,如离子选择性电极技术、毛细管离子分析技术、光谱法、色谱法、纳米传感技术、全自动生化分析仪、流式细胞仪等,以及近年基于此展开的PMI推断研究的相关进展进行了综述,同时分析其存在的问题,为学者们提供研究方向,以期使得玻璃体液分析在PMI推断中更加精确、实用。

关键词：法医病理学玻璃体液综述死亡时间色谱法,液相光谱法,荧光

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Demirjian和Cameriere法在8～16岁湖南汉族青少年牙龄推断中的应用

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法医学杂志 2019年第4期35卷 406-410页

作者：兰玲梅杨泽登孙淑乐文丹阿丽耶·库热什 Moutanou Modeste Judes ZEYE 扎拉嘎白乙拉李敏中南大学基础医学院法医学系湖南长沙410013 新疆医科大学基础医学院新疆乌鲁木齐830011 中南大学湘雅口腔医院牙周科湖南长沙410008

目的运用Demirjian法和Cameriere法测定湖南省汉族青少年的牙龄,并比较两者结果的准确性。方法 2016年1月-2017年7月,从中南大学湘雅口腔医院收集湖南省无特殊疾病、营养状况良好的8~16岁汉族青少年的口腔全景片480例,其中男性236例,女... 详细信息

目的运用Demirjian法和Cameriere法测定湖南省汉族青少年的牙龄,并比较两者结果的准确性。方法 2016年1月-2017年7月,从中南大学湘雅口腔医院收集湖南省无特殊疾病、营养状况良好的8~16岁汉族青少年的口腔全景片480例,其中男性236例,女性244例。分别依照Demirjian法和Cameriere法测定每个青少年的牙龄,利用SPSS 20.0软件对两种方法测得的牙龄与实际年龄进行配对t检验,比较推测牙龄与实际年龄的差异。结果男性样本的平均实际年龄为11.91岁,女性样本的平均实际年龄为11.88岁。Demirjian法测得的牙龄比实际年龄平均低估了0.11岁(男性)和0.15岁(女性)。Cameriere法测得的牙龄比实际年龄平均低估了0.83岁(男性)和0.72岁(女性)。结论 Demirjian法在推断湖南省汉族青少年牙龄时比Cameriere法准确,更适用于该地区青少年牙龄的测定。

关键词：法医牙科学年龄测定,牙齿 Demirjian法 Cameriere法青少年汉族湖南

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湖南汉族人群21个STR基因座的遗传多态性(英文)

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法医学杂志 2016年第5期32卷 356-362页

作者：邹鹰郭娟娟李情鹏左道宏刘金山郭亚东闫杰扎拉嘎白乙拉蔡继峰兰玲梅中南大学基础医学院法医学系湖南长沙410013 中南大学湘雅医学院湖南长沙410013 内蒙古民族大学附属医院内科内蒙古通辽028000

目的调查湖南地区汉族人群21个STR基因座（D3S1358、D13S317、D7S820、D16S539、Penta E、D2S441、TPOX、TH01、D2S1338、CSF1PO、Penta D、D10S1248、D19S433、v WA、D21S11、D18S51、D6S1043、D8S1179、D5S818、D12S391和FGA）的遗传多态性。方法共采集560例湖南汉族健康无关个体血液样本,使用Chelex-100法提取DNA,应用AGCU EX22试剂盒及9700 PCR扩增仪进行复合扩增,扩增产物使用310遗传分析仪进行分离分析。结果共发现248个等位基因,等位基因频率分布在0.001~0.518。除Penta E（P=0.023）外,其余基因座的基因型分布均符合Hardy-Weinberg平衡。21个基因座的累积个人识别率、累积非父排除率、累积匹配率分别为0.999 999 999 999 999 999 999 999 8、0.999 999 998和1.36×10^-25。结论 21个STR基因座在湖南汉族人群中呈高度多态性。本研究可为法医学个人识别及亲子鉴定提供有价值的数据及理论基础。

关键词：法医遗传学多态现象遗传短串联重复序列湖南汉族

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