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Evaluation of Abuse Drugs and Clinical Laboratory Tests Variations in Whole Blood ＆ Urine Samples of Abusers

Journal of Pharmacy and Pharmacology 2018年第1期6卷 69-76页

作者： Majid Rezaei Basiri Mojgan Behshid Alireza Najafi Saleh Alilou Haniyeh Mohebbi-Kamali: Fatemeh Hosseindoust Marziyeh Mokhtari Valiyollah Watani ladan aminzadeh Fatemeh Seyed Nejad Ashraf Razavi Ligha Saadat Department of Pharmacology and Toxicology School of Pharmacy Tabriz University of Medical Sciences Tabriz 51999 Iran Medical Education Research Center Tabriz University of Medical Sciences Tabriz 51999 Iran Department of Medical Surgical School of Nursing and Midwifery Tabriz University of Medical Sciences Tabriz 51999 Iran Forensic and Legal Medicine of Organization Tabriz 515 7733541 Iran Welfare Organization of East Azarbayjan Tabriz 5156935 761 Iran

In this study, five hundred urine samples and five hundred blood samples of abusers were examined for the presence of alkaloid substances and abuse drugs in urines and bloods. These numbers of blood and urine samples of addicts in clinics of welfare organization, during detoxification treatment or maintenance treatment were screened for abuse drugs presence. The all of samples were tested through as a view of clinical laboratory methods. Age ranges of female patients were 35 ~ 15 and age range of males patients were 45 ~ 15. All patients filled questionnaire and satisfy forms too. First, all fresh urine and blood samples were examined to confirm presence drugs abuses, depend on their addiction and treatment, so all samples were confirmed by two tests. Then they were examined to other clinical laboratory tests. All data were analyzed by t-test and were Anova one way and two ways of Anova Turkey, and p 〈 0.05 was considered significant. The p-value of this study was p = 0.0001. The results of this study were showed that 4% of abusers had mild increase in hematocrite level and 2% of narcotic drugs abusers had mild lower level of blood sugars than normal range and 4% of participants had increase liver enzymes such ALT （alanine transferase）, AST （aspartat transferase）, ALP （alkaline phosphatease） and 1% of them had renal failure. Although blood level BUN （blood urea nitrogen） and creatinin were examined to evaluation of their renal failure .The results in Tabriz/Iran undrevision of welfare organization clinics were approximately showed that positive results of addiction are in each of urine and blood samples. Because some of abusers directly consumed full long time agonist or partial agonists＇ drugs such as methadone and buprenorphine for their maintenance therapy in clinics. Also doing test on blood samples has high importance in distinguishing and confirmation of drugs abuse in samples. Also in this study we conclude that among all drug analytical methods the cheapest

关键词： Abusers urine and whole blood samples strip test thin-layer chromatography abuse drugs clinical laboratory tests.

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