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Journal of Intensive Medicine 2022年第3期2卷 197-198页

作者： Thinh N.Bui Hoang-Anh Ngo Nhat M.Huynh Nguyen-Huy Do-Tran lac duy le Thu-Anh Nguyen COVID-19 Intensive Care Unit 2 Thu Duc City HospitalThu Duc CityHo Chi Minh CityTam Phu 721400Vietnam Woolcock Institute of Medical Research 298 Kim MaBa DinhHanoi 118000Vietnam Usher Institute Old Medical SchoolUniversity of EdinburghEdinburgh EH89AGUnited Kingdom School of Medicine Vietnam National UniversityDong HoaHo Chi Minh CityDi AnBinh Duong 590000Vietnam Sydney School of Medicine The Faculty of Medicine and HealthThe University of SydneyCamperdownNSW 2050Australia

To the Editor:Recent randomized controlled trials,as well as high-quality systematic reviews and meta-analyses,strongly support the use of corticosteroids in patients with coronavirus disease 2019(COVID-19)who require oxygen support.[1]The use of pulse cor-ticosteroid therapy has been reported in case series and studies,showing significant improvement in patients and a reduction in mortality rate.[2]In this letter,we report the mortality rate among patients with severe COVID-19 receiving pulse corticos-teroids with methylprednisolone(500 mg/day)for≥3 days and≥24 h before intubation(median duration of therapy:3 days)compared with standard of care.

关键词： patients mortality therapy

Development of Air Vehicle with Active Flapping and Twisting of Wing

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Journal of Bionic Engineering 2011年第1期8卷 1-9页

作者： Sangyol Yoon lac-Hyong Kang Sungho Jo Department of Computer Science Korea Advanced Institute of Science and Technology Daejeon 305-701 Korea Department of Aerospace Engineering Korea Advanced Institute of Science and Technology Daejeon 305-701 Korea

This paper addresses mechanisms for active flapping and twisting of robotic wings and assesses flying effectiveness as a function of twist angle. Unlike the flapping motion of bird wings, insects generally make a twisting motion at the root of their wings while flapping, which makes it possible for them to hover in midair. This work includes the development of a Voice Coil Motor （VCM） because a flapping-wing air vehicle should be assembled with a compact actuator to decrease size and weight. A linkage mechanism is proposed to transform the linear motion of the VCM into the flapping and twisting motions of wings. The assembled flapping-wing air vehicle, whose weight is 2.86 g, produces an average positive vertical force proportional to the twist angle. The force saturates because the twist angle is mechanically limited. This work demonstrates the possibility of developing a flapping-wing air vehicle that can hover in midair using a mechanism that actively twists the roots of wings during flapping.

关键词： biomimetic flapping-wing air vehicle flapping twisting voice coil motor linkage mechanism

Exploring the utility of organo-polyoxometalate hybrids to inhibit SOX transcription factors

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Cell Regeneration 2014年第1期3卷 69-75页

作者： Kamesh Narasimhan Kevin Micoine Emmanuel lacôte Serge Thorimbert Edwin Cheung Bernold Hasenknopf Ralf Jauch Donnelly Centre for Cellular and Biomolecular Research University of TorontoToronto M5S 3E1Canada Genome Institute of Singapore 60 Biopolis StreetBuona Vista 138672Singapore Sorbonne Universités UPMC Univ Paris 06Institut Parisien de Chimie MoléculaireUMR 82324 Place Jussieu75005 ParisFrance CNRS Institut Parisien de Chimie MoléculaireUMR 82324 Place Jussieu75005 ParisFrance Faculty of Health Sciences University of MacaoAv.Padre Tomas PereiraTaipaMacaoChina Genome Regulation Laboratory Drug Development PipelineGuangzhou Institutes of Biomedicine190 Kai Yuan AvenueScience Park510530 GuangzhouChina

Background:SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer ***,rationally engineering specific inhibitors that interfere with transcription factor DNA interfaces continues to be a monumental challenge in the field of transcription factor chemical ***(POMs)are inorganic compounds that were previously shown to target the high-mobility group(HMG)of SOX proteins at nanomolar *** continuation of this work,we carried out an assessment of the selectivity of a panel of newly synthesized organo-polyoxometalate hybrids in targeting different transcription factor families to enable the usage of polyoxometalates as specific SOX transcription factor ***:The residual DNA-binding activities of 15 different transcription factors were measured after treatment with a panel of diverse *** belonging to the Dawson structural class were found to be more potent inhibitors than the Keggin ***,organically modified Dawson polyoxometalates were found to be the most potent in inhibiting transcription factor DNA binding *** size of the polyoxometalates and its derivitization were found to be the key determinants of their ***:Polyoxometalates are highly potent,nanomolar range inhibitors of the DNA binding activity of the Sox-HMG ***,binding assays involving a limited subset of structurally diverse polyoxometalates revealed a low selectivity profile against different transcription factor *** progress in achieving selectivity and deciphering structure-activity relationship of POMs require the identification of POM binding sites on transcription factors using elaborate approaches like X-ray crystallography and multidimensional *** summary,our report reaffirms that transcription factors are challenging molecular architec

关键词： architectures attractive rational

Enhancing compressive strength and durability of self-compacting concrete modified with controlled-burnt sugarcane bagasse ash-blended cements

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Frontiers of Structural and Civil Engineering 2022年第2期16卷 161-174页

作者： Duc-Hien le Yeong-Nain SHEEN Khanh-Hung NGUYEN Sustainable Developments in Civil Engineering Research Group Faculty of Civil EngineeringTon Duc Thang UniversityHo Chi Minh City700000Vietnam Department of Civil Engineering Kaohsiung University of Science and TechnologyKaohsiung80778China Department of Civil Engineering Lac Hong UniversityBien Hoa810000Vietnam

In sugar industries,the growing amount of sugarcane bagasse ash(SBA),a byproduct released after burning bagasse for producing electricity,is currently causing environmental *** residual ash displays a pozzolanic potential;and hence,it has potential as a cement *** study focuses on enhancing suitability of SBA through incorporating ground blast furnace slag(BFS)in manufacturing self-compacting concretes(SCCs).For this purpose,SBA was processed by burning at 700°C for 1 h,before being ground to the cement fineness of 4010 cm2/*** mixtures were prepared by changing the proportions of SBA and BFS(i.e.,10%,20%,and 30%)in blended systems;and their performance was *** results showed that the presence of amorphous silica was detected for the processed SBA,revealing that the strength activity index was above 80%.The compressive strength of SCC containing SBA(without BFS)could reach 98%–127%of that of the control;combination of SBA and 30%BFS gets a similar strength to the control after 28 *** durability,the 10%SBA+30%BFS mix exhibited the lowest risk of ***,the joint use of SBA and BFS enhanced significantly the SCC’s sulfate ***,a hyperbolic formula for interpolating the compressive strength of the SBA-based SCC was proposed and validated with error range estimated within±10%.

关键词： sugarcane bagasse ash self-compacting concrete compressive strength sulfate resistance water absorption strength formula

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改性蒙脱石固定化漆酶脱除剂的制备及脱除黄曲霉毒素B_(1)研究

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河南工业大学学报（自然科学版） 2024年第4期45卷 64-74页

作者：邬有胜王乐张孟月梁赢王金水河南工业大学生物工程学院河南郑州450001

为了提升脱除剂的吸附水平和可重复利用能力,并用于脱除黄曲霉毒素B_(1)(AFB_(1)),利用十六烷基三甲基溴化铵(CTAB)改性处理蒙脱石(MMT-CTAB),结合固定化漆酶(laccase)制得改性蒙脱石固定化漆酶(MMT-CTAB-lac),利用方程拟合考察脱除剂... 详细信息

为了提升脱除剂的吸附水平和可重复利用能力,并用于脱除黄曲霉毒素B_(1)(AFB_(1)),利用十六烷基三甲基溴化铵(CTAB)改性处理蒙脱石(MMT-CTAB),结合固定化漆酶(laccase)制得改性蒙脱石固定化漆酶(MMT-CTAB-lac),利用方程拟合考察脱除剂的吸附动力学,优化MMT-CTAB-lac脱除AFB1最适条件,并利用LC-MS和T.E.S.T软件探究AFB1降解途径及其降解产物毒性。改性处理后的脱除剂具有更大层间距和孔容、更小颗粒粒径,吸附AFB_(1)的比表面积增大;吸附于脱除剂中的AFB_(1)被固定化漆酶降解,有效阻止了AFB_(1)在脱除剂上的聚集,显著增大了MMT-CTAB-lac吸附容量;化学吸附是AFB1吸附过程中限速步骤,MMT-CTAB-lac对AFB_(1)的吸附量为44.5 mg·g^(-1),高于MMT-CTAB的吸附量;MMT-CTAB-lac对AFB_(1)脱除率为67%,且在弱酸及中性条件下均具有良好催化降解效果。进一步鉴定了MMT-CTAB-lac降解AFB1的产物,并提出了其降解AFB1的两种可能途径:第1种可能降解途径(内酯环结构被破坏),降解产物为C17H14O7和C16H12O5;第2种可能降解途径(呋喃环结构被破坏),降解产物为C17H14O7、C16H12O7和C14H10O4。并通过T.E.S.T软件的毒性预测,得出降解产物毒性有所降低。本研究开发的MMT-CTAB-lac为粮油食品中AFB_(1)的安全、高效脱除奠定了重要基础。

关键词：改性蒙脱石漆酶脱除黄曲霉毒素B_(1) 吸附动力学降解机理

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法国TGV2N双层客车

智慧轨道交通 1992年第3期 20-24页

作者： Francois lac te 李亚斌

本文系统阐述了法国铁路第三代高速客车——TGV2N双层客车的开发研制情况。文章介绍了这种新型双客的开发目标、设计特点以及为提高舒适度、实现17t轴重、轻量化、降低噪声、减振和样车试验所采取的措施。

关键词：双层客车高速列车法国

EXISTENCE　AND　UNIQUENESS　OF　THE　ENTROPY　SOLUTION　TO　A　NONLINEAR　HYPERBOLIC　EQUATION

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Chinese Annals of Mathematics,Series B 1995年第1期16卷 1-14页

作者： R.EYMARD T.Gallouёt R.Herbin LaboratoireCentraldesPontsetChaussees 58bdLefebvre75015PariaandUniverPariaNordFrance. E.N.S.Lyon 46alleed＇Italie69364lYONFrance. UniversitedeSavoie 73376LeBourgetduLacFrance.

This work is concerned with the proof of the existence and uniqueness of the entropy weak solution to the following nonlinear hyperbolic equation: at +div(vf(u)) = 0 inIR￣N × [0, T], with initial data u(., 0) = uo(.) inIR￣N ) where uo ∈ L∞(IR￣N ) is a given function, v is a divergence-free bounded functioll of class C1 from IR￣× x [0, T] to IR￣N, and f is a function of class C1 from IR toIR. It also gives a result of convergence of a numerical scheme for the discretization of this equation. The authors first show the existence of a 'process' solution (which generalizes the concept of entropy weak solutions, and can be obtained by passing to the limit of solutions of the numerical scheme). The uniqueness of this entropy process solution is then proven; it is also proven that the entropy process solution is in fact an entropy weak solution. Hence the existence and uniqueness of the entropy weak solution are proven.

关键词： Nonlinear hyperbolic equation Process solution Existence and uniqueness Convergence of finite volume scheme.

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新型塑料薄膜电容器

塑料 1984年第2期 49-50页

作者： John Dale-lac 王培贤

二十多年来,塑料薄膜电容器的应用种类在不断增加。最初是用于代替浸渍纸类电容器,它的主要优点是干式结构,这就消除了泄漏浸渍料的问题,此外,也缩小了电容器的体积并提高了电气参数。目前,在电容器的国际市场上,塑料薄膜电容器已超过了... 详细信息

二十多年来,塑料薄膜电容器的应用种类在不断增加。最初是用于代替浸渍纸类电容器,它的主要优点是干式结构,这就消除了泄漏浸渍料的问题,此外,也缩小了电容器的体积并提高了电气参数。目前,在电容器的国际市场上,塑料薄膜电容器已超过了35%。

关键词：塑料薄膜电容器电子轻子聚碳酸醋电晕效应

Polymer Matrix Resin Improvement for Aerospace Applications

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Polymer Matrix Resin Improvement for Aerospace Applications

Screening of probiotics with efficient α-glucosidase inhibitory ability and study on the structure and function of its extracellular polysaccharide

第十三届国际复合材料会议

作者： Xiao-Su YINational Key Laboratory of Advanced Composites (lac) PO BOX 81-3 100095 BEIJING CHINA

＜正＞A promising thermoplastic modified epoxy system has been developed at lac to meet the aerospace specific requirements such as good impact and hot/wet behavior, and high damage tolerance as well. The thermoplastic modifier was PEK-C, a domestic product in China. The processing-stmcmre-property relations for the resin casts and carbon composites were studied in terms of composition, morphology, inter-phase reaction, and mechanical properties. To explore the organoclay also as a possible modifier for polymer matrix resins, intercalation and exfoliation behavior were studied by using XRD and DSC, respectively. Subsequently, exfoliated

关键词： thermoplastic toughed epoxy organoclay nanocomposites low viscosity BMI

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Food Bioscience 2022年第1期45卷 131-145页

作者： Jia-Bin Wang le-Yi Yu Xu Zeng Jun-Wei Zheng Bin Wang Li Pan School of Biology and Biological Engineering South China University of TechnologyGuangzhouChina Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering South China University of TechnologyGuangzhouChina

Inhibition ofα-glucosidase activity is an important strategy in lowering the concentration of blood *** this paper,using domestic and foreign characteristic food-derived substances as the sources of lactobacillus,the performance of them were evaluated by measuring the strains’α-glucosidase inhibitory ***,the cell-free extracellular supernatants(CFS)of lactobacillus rhamnosus LB1lac10 was determined to have the highest α-glucosidase inhibition *** on the Nanopore third-generation sequencing technology platform,the genome of LB1lac10 was sequenced and functional gene annotation was *** that,the biological activity and structural composition of the exopolysaccharide produced by *** LB1lac10 were *** purified exopolysaccharide EPS1-1 also showed efficientα-glucosidase inhibitory *** structure and conformation characteristics of EPS1-1 were further *** EPS1-1 from *** LB1lac10 had a molecular weight of 88,650 Da,and it was mainly composed of mannose,glucuronic acid,glucose,xylose,galactose,and *** the FT-IR and NMR analyses,EPS1-1 had functional groups of a typical polysaccharide structure and contained two types of glycosidic bonds with α-configuration *** main glycosidic bond corresponded to→4)-α-D-Glcp-(1→,which might be an important reason why EPS1-1 could inhibit α-*** studies showed that EPS1-1 had high heat resistance to meet the needs of food *** results suggested that *** LB1lac10 could be used as a potential probiotic to lower blood sugar,and the EPS1-1 has the potential to serve as a naturalα-glycosidase inhibitor to regulate the concentration of blood glucose.

关键词： lactobacillus rhamnosus α-glucosidase inhibitory activity Third-generation sequencing Extracellular polysaccharide Probiotic activity