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Protective effects of pyrroloquinoline quinone on glutamate induced neurotoxicity in cultured hippocampal neurons

Protective effects of pyrroloquinoline quinone on glutamate ...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Qi ZHANG Wen HU Yun GU Nan HU Xiao-Song GU Fei DING~* Jiangsu Key laboratory of Neurore generation Nantong University Nantong 226001

＜正＞Pyrroloquinoline quinone（PQQ）,a water-soluble anionic compound,was first identified in 1979 as a novel redox cofactor of bacterial dehydrogenases,which was involved in redox reactions by transporting electrons in the mitochondrial respirtatory *** is involved in many physiological and pharmacological effects,such as protecting isolated rabbit heart from reoxygenation injury,preventing rat liver damage by ethanol,increasing the level of nerve growth factor in mouse astroglial cells,inhibiting melanogenesis in murine B16-F10 melanoma,***,PQQ can promote the regeneration of rat sciatic nerve and can direct oxidize the redox site of N-methyl-D-aspartic acid（NMDA） receptors to protect cultured cortical neurons from injury against NMDA or ***,the molecular mechanisms involved in PQQ activity are not yet fully ***,we established a glutamate injury model in cultured hippocampal neurons to observe the effects of PQQ on neurons and the underlying *** hippocampal neurons were cultured from E18 SD rats and maintained for 7～8d until maturation in Neurobasal medium supplemented with 2%B27. First,different concentrations of PQQ（50,100,200μmol/L） were incubated with hippocampal neurons for 24h to observe whether PQQ had any effect on normal cultured *** results of MTT showed that there was little change of cell viability with PQQ treatment,indicating that PQQ did not affect the cell growth of normal cultured hippocampal neurons. Then,hippocampal neurons were exposed to 125μmol/L glutamate for 15min followed by treatment with different concentrations of PQQ for *** viability decreased significantly after exposure to glutamate and PQQ treatment could increase the cell viability,showing a protective effect against glutamate-induced *** 33342 and terminal deoxynucleotidyl transferase dUTP-mediated nicked end labeling（TUNEL） stainings indicated that apoptotic cell induced by glutamate were rescued wit

关键词： pyrroloquinoline quinone glutamate hippocampal neurons rat

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