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Development of novel therapies for Huntington's disease:hope and challenge

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Acta Pharmacologica Sinica 2005年第2期26卷 129-142页

作者： Zheng-hong QIN~(2,3,5),Jin WANG~4,Zhen-lun GU~2~2department of Pharmacology,Soochow University school of Medicine,Suzhou 215007,China ~3laboratory of cellular neurobiology,massachusetts general hospital and harvard medical school,Charlestown,ma 02129,usa ~4Molecular Neurogenetics Unit,Center forHuman Genetics Research,massachusetts general hospital and harvard medical school,Charlestown,ma 02129,usa departmentofPharmacology SoochowUniversitySchoolofMedicineSuzhou215007China

Huntington's disease(HD)is an autosomal dominant neurological *** is afatal neurological disorder affecting 5-10 out of 10000 *** there areintensive research efforts focusing on uncovering molecular mechanisms of thepathogenesis of HD,a number of studies have begun to look for effective thera-pies for *** is a large body of encouraging news on novel *** present paper reviews drugs used for symptomatic treatmentof HD and experimental therapies targeting HD molecular pathology.

关键词： Huntington disease huntingtin aggregates caspases nerve growth factors cell transplantation coenzyme Q10

Advances in measurement of knee kinematics during gait:application of a new imaging technique

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医用生物力学 2010年第S1期25卷 58-59页

作者： Guoan Li(Bioengineering Lab,department of Orthopaedic Surgery massachusetts general hospital and harvard medical school,Boston,ma 02114,usa)

Introduction Most of our knowledge of knee kinematics during gait is based on studies measuring knee motion using external skin markers. While these studies have dramatically improved our knowledge of human gait it re... 详细信息

关键词： Advances in measurement of knee kinematics during gait

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Advances in measurement of knee kinematics during gait:application of a new imaging technique

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Advances in measurement of knee kinematics during gait:appli...

High frequency and error-prone DNA recombination in ataxia telangiectasia cell lines

第四届中美生物医学工程暨海内外生物力学学术研讨会

作者： Guoan Li(Bioengineering Lab department of Orthopaedic Surgerymassachusetts general hospital and harvard medical school Boston ma 02114 usa

＜正＞Introduction Most of our knowledge of knee kinematics during gait is based on studies measuring knee motion using external skin *** these studies have dramatically improved our knowledge of human gait it remains a challenge to accurately determine the underlying bony motion and cartilage behavior ***,we validated the use of the dualfluoroscopic imaging system（DFIS） for measuring knee kinematics and cartilage contact mechanics during dynamic motion such as *** study presents the application of this method for measuring knee kinematics during treadmill gait in six degrees of freedom（6DOF）.

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广东医科大学学报 1998年第Z1期 175-176页

作者： Luo Chenmei *,Tang Wei,Mekeel L Kristin,et al (department of Radiation Oncology, massachusetts general hospital,harvard medical school,Boston, ma 02114 usa,and *department of Microbiology and Immunology,Guangdong medical C

High frequency and error-prone DNA recombination in ataxia telangiectasia cell lines... 详细信息

High frequency and error-prone DNA recombination in ataxia telangiectasia cell lines...

关键词： DNA cell

Spontaneous metastasis,proliferation characteristics and radiation sensitivity of fractionated irradiation recurrent and unirradiated human xenograft

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广东医科大学学报 1998年第Z1期 173-174页

作者： Huang Peigen *,Taghian Alphonse,Hsu W Dora,et al (department of Radiation Oncology,massachusetts general hospital,harvard medical school,Boston, ma 02114,usa and * department of Pathology,Guangdong medical College,Zhanji

Spontaneous metastasis,proliferation characteristics and radiation sensitivity of fractionated irradiation recurrent and unirradiated human xenograft... 详细信息

Spontaneous metastasis,proliferation characteristics and radiation sensitivity of fractionated irradiation recurrent and unirradiated human xenograft...

关键词： Spontaneous and

The effect of the overall treatment time of fractionated irradiation on the tumor control probability of a human soft tissue sarcoma xenograft in nude mice

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广东医科大学学报 1998年第Z1期 174-175页

作者： Allam Ayman,Perez A Luis,Huang Peigen *,et al (department of Radiation Oncology,massachusetts general hospital,harvard medical school,Boston, ma 02114,usa and * department of Pathology,Guangdong medical College,Zhanjiang,5

The effect of the overall treatment time of fractionated irradiation on the tumor control probability of a human soft tissue sarcoma xenograft in nude mice... 详细信息

The effect of the overall treatment time of fractionated irradiation on the tumor control probability of a human soft tissue sarcoma xenograft in nude mice...

关键词： time irradiation

Prediction of muscle forces in human musculoskeletal system-application of classic mechanics methods in biomechanics

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Prediction of muscle forces in human musculoskeletal system-...

Intrinsic control of axon regeneration

作者： Li Guo’an (Bioengineering laboratory,Dept.of Orthopaedic Surgery,massachusetts general hospital,harvard medical school,Boston,ma)

1 Introduction Quantitative data of in-vivo muscle forces,joint reaction forces and moments are critical for understanding physiological musculoskeletal function and injury *** data are also important for improvement ...

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The Journal of Biomedical Research 2010年第1期24卷 2-5页

作者： Zhigang He F.M. Kirby neurobiology Center, Children’s hospital, and department of neurology, harvard medical school, 300 Longwood Avenue, Boston, ma 02115, usa. [a] F.M. Kirby neurobiology Center Children's hospital and department of neurology harvard medical school 300 Longwood Avenue Boston ma 02115 usa

Spinal cord injury disrupts the connections between the brain and spinal cord, often resulting in the loss of sensory and motor function below the lesion site. The most important reason for such permanent functional deficits is the failure of injured axons to regenerate after injury. In principle, the functional recovery could be achieved by two forms of axonal regrowth： the regeneration of lesioned axons which will reconnect with their original targets and the sprouting of spared axons that form new circuits and compensate for the lost function. Our recent studies reveal the activity of the mammalian target of rapamycin （mTOR） pathway, a major regulator of new protein synthesis, as a critical determinant of axon regrowth in the adult retinal ganglion neurons. In this review, I summarize current understanding of the cellular and molecular mechanisms that control the intrinsic regenerative ability of mature neurons.

关键词：表单脊髓抗菌药理解力脑神经元西罗莫司轴突成年人人类

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针灸研究的复杂性与挑战性(英文)

针刺研究 2016年第5期41卷 389-395页

作者： Jian Kong Kristen Jorgenson department of Psychiatry Massachusetts General Hospital and Harvard Medical School Charlestown MA USA

With the growing popularity of acupuncture in western society in recent decades,many acupuncture researches and clinical studies have been *** studies have significantly enhanced our understanding of acupuncture;nevertheless,very few findings obtained from acupuncture research have been transferred to acupuncture clinical practice,which has significantly hampered the development of acupuncture *** addition,some crucial information,such as correct dosage of acupuncture,remains unknown,which further limits the interpretation of clinical trials testing the efficacy of acupuncture *** acupuncture research should try to fill these gaps and explore new ways to increase the clinical effectiveness of acupuncture treatment.

关键词：针灸针灸研究预期数安慰剂

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