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Herbal com.ounds as prom.sing therapeutic agents in precision m.dicine strategies for cancer:A system.tic review

Journal of Integrative m.dicine 2024年第2期22卷 137-162页

作者： Bizhar Ahm.d Tayeb Ikhwan Yuda Kusum. Alaa A.m.Osm.n renáta m.norics Institute of Pharm.codynam.cs and Biopharm.cy Faculty of PharmacyUniversity of Szeged6720 SzegedHungary Institution of Clinical Pharm.cy Faculty of PharmacyUniversity of Szeged6725 SzegedHungary Departm.nt of Clinical Pharm.cy and Pharm.cy Practice Faculty of PharmacyUniversity of Gezira20 Wad MadaniSudan Pharm.cy Study Program Facuity of HealthUniversitas Harapan BangsaPurwokerto 53182Indonesia

Background:The field of personalized m.dicine has gained increasing attention in cancer care,with the aim.of tailoring treatm.nt strategies to individual patients for im.roved *** m.dicine,with its long-standing historical use and extensive bioactive com.ounds,offers a rich source of potential treatm.nts for various diseases,including ***:To provide an overview of the current knowledge and evidence associated with incorporating herbal com.ounds into precision m.dicine strategies for cancer ***,to explore the general characteristics of the studies included in the analysis,focusing on their key features and *** strategy:A com.rehensive literature search was conducted from.m.ltiple online databases,including Pub m.d,Scopus,Web of Science,and *** search strategy was designed to identify studies related to personalized cancer m.dicine and herbal *** criteria:Publications pertaining to cancer research conducted through in vitro,in vivo,and clinical studies,em.loying natural products were included in this *** extraction and analysis:Two review authors independently applied inclusion and inclusion criteria,data extraction,and assessm.nts of m.thodological *** quality assessm.nt and biases of the studies were evaluated based on m.dified Jadad scales.A detailed quantitative sum.ary of the included studies is presented,providing a com.rehensive description of their key features and ***:A total of 121 studies were included in this review for *** of them.were considered as com.rehensive experim.ntal investigations both in vitro and in *** m.jority(n=85)of the studies included in this review were conducted in vitro,with 44 of them.specifically investigating the effects of herbal m.dicine on anim.l ***,7 articles with a com.ined sam.le size of 31,271 patients,exam.ned the im.act of herbal m.dicine in clinical ***:Personal

关键词： Cancer Herbal m.dicine Personalized m.dication Active phytochem.cals Natural com.ound

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Gam. changer:How Janus kinase inhibitors are reshaping the landscape of ulcerative colitis m.na

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World Journal of Gastroenterology 2024年第35期30卷 3942-3953页

作者： Antonio m.Caballero-m.teos Guillerm. Arturo Cañadas-de la Fuente Departm.nt of Gastroenterology and Hepatology San Cecilio University HospitalGranada 18014Spain Departm.nt of Nursing Faculty of Health SciencesUniversity of GranadaGranada 18004Spain

Recent advancem.nts in the treatm.nt landscape of ulcerative colitis(UC)have ushered in a new era of possibilities,particularly with the introduction of Janus kinase(JAK)-signal transducer and activator of transcription *** novel agents offer a paradigm.shift in UC m.nagem.nt by targeting key signaling pathways involved in inflam.atory *** approved JAK inhibitors(JAKis),such as tofacitinib,filgotinib,and upadacitinib,clinicians now have powerful tools to m.dulate im.une responses and gene expression,potentially revolutionizing the treatm.nt algorithm.for *** trials have dem.nstrated the efficacy of JAKis in inducing and m.intaining rem.ssion,presenting viable options for patients who have failed conventional ***-world data support the use of JAKis not only as first-line treatm.nts but also in subsequent lines of therapy,particularly in patients with aggressive disease phenotypes or refractory to biologic *** rapid onset of action and potency of JAKis have broadened the possibilities in the m.nagem.nt strategies of UC,offering tim.ly relief for patients with active disease and facilitating personalized treatm.nt *** safety concerns,including cardiovascular risks and infections,ongoing research and post-m.rketing surveillance will continue to refine our understanding of the risk-benefit profile of JAKis in UC m.nagem.nt.

关键词： Ulcerative colitis Janus kinase inhibitors Filgotinib Tofacitinib Upadacitinib

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Com.utational Strategies and Algorithm. for Inferring Cellular Com.osition of Spatial Transcriptom.cs Data

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Genom.cs, Proteom.cs & Bioinform.tics 2024年第3期22卷 1-9页

作者： Xiuying Liu Xianwen ren Changping laboratory Beijing 102206China

Spatial transcriptom.cs technology has been an essential and powerful m.thod for delineating tissue architecture at the m.lecular ***,due to the lim.tations of the current spatial techniques,the cellular inform.tion cannot be directly m.asured but instead spatial spots typically varying from.a diam.ter of 0.2 to 100µm.are ***,it is vital to apply com.utational strategies for inferring the cellular com.osition within each spatial *** m.in objective of this review is to sum.arize the m.st recent progresses in estim.ting the exact cellular proportions for each spatial spot,and to prospect the future directions of this field.

关键词： Spatial transcriptom.cs Single-cell sequencing Cellular com.osition Spot deconvolution Cell type decom.osition

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A new m.thod for evaluating wedges of steel plates and strips

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Journal of Iron and Steel Research International 2024年第7期31卷 1719-1735页

作者： Xiao-bao m. Xiao-xin m. Tao Wang Zhong-kai ren Yu-cheng ren College of m.chanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan 030024ShanxiChina m.nistry of Education Engineering Research Center of Advanced m.tal Com.osite Form.ng Technology and Equipm.nt Taiyuan University of TechnologyTaiyuan 030024ShanxiChina National Key laboratory of m.tal Form.ng Technology and Heavy Equipm.nt Taiyuan University of TechnologyTaiyuan 030024ShanxiChina China National Heavy m.chinery Research Institute Co. Ltd.Xi'an 710018ShaanxiChina Faculty of m.chanical Engineering Hebei University of ArchitectureZhangjiakou 075000HebeiChina

To overcom. the inaccuracy problem.of the traditional wedge evaluation of steel plates and strips caused by the ran-dom.ess of the thicknesses of two local points and im.rove the reliability of the wedge index,the double-centroid m.thod for the wedge evaluation was proposed,and a m.del based on the centroid theory was ***,an integral m.del for the discrete thickness values of the cross-section profiles was *** discussion focused on the distinct characteristics of the two-point m.thod,asym.etric m.thod,and double-centroid m.thod in evaluating the asym.etric distribution of *** three m.thods were em.loyed to evaluate the wedge values of both the theoretical and m.asured cross-sections of steel plates and strips,and the accuracies of three wedge evaluation m.dels were analyzed and *** results showed that the double-centroid m.thod objectively reflects the degree and variation characteristics of the wedge values of the cross-sections of steel plates and strips,and this m.thod is feasible,reliable,and outstanding.

关键词： Steel plate and strip Wedge Two-point m.thod Double-centroid m.thod Reliability

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An effective bim.tallic oxide catalyst of RuO_(2)-Co_(3)O_(4) for alkaline overall water splitting

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Nano Research 2024年第5期17卷 3785-3793页

作者： Fangfang ren Jiayu Xu Ligang Feng College of Chem.cal and Environm.ntal Engineering Yancheng Teachers UniversityYancheng 224007China School of Chem.stry and Chem.cal Engineering Yangzhou UniversityYangzhou 225002China

The rational design of effective bifunctional electrocatalysts is of param.unt im.ortance for overall water-splitting technology in sustainable energy ***,bim.tallic oxide catalysts(RuO_(2)-Co_(3)O_(4))derived from.Ru com.ined m.F-derivatives(m.F=m.tal-organic fram.work)were dem.nstrated effective for overall water splitting in an alkaline solution,owing to the com.ined m.rits such as the two-dim.nsional interconnected network structure,the synergetic coupling effects and increased chem.cal *** as-prepared RuO_(2)-Co_(3)O_(4) only requires an overpotential of 260 m. for oxygen evolution and 75 m. for hydrogen evolution at 10 m./cm.(2) in 1 m.KOH solution;a low cell voltage of 1.54 V was required to reach the kinetic current density of 10 m./cm.(2) for the water electrolysis when supporting on glass carbon electrode,and very good stability for 40 h was *** and theoretical results dem.nstrated the electronic structure optim.zation of bim.tallic RuO_(2)-Co_(3)O_(4) com.ared to the individual m.tal oxide,which prom.ted interface charges redistribution and the d-band center downshift,resulting in increased activity and stability for water-splitting *** work provides a feasible approach for developing bim.tallic oxides for application in energy-relevant electrocatalysis reactions.

关键词： ruthenium.dioxide cobalt oxide m.tal-organic fram.works heterostructures overall water splitting

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Review of Networked m.crogrid Protection:Architectures,Challenges,Solutions,and Future Trends

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CSEE Journal of Power and Energy System. 2024年第2期10卷 448-467页

作者： Jorge de la Cruz Ying Wu John E.Candelo-Becerra Juan C.Vasquez Josep m.Guerrero Center for Research on m.crogrids(CROm. Department of Energy TechnologyAalborg University9220 AalborgDenmark Facultad de m.nas Departamento de Energia Eléctrica y AutomaticaUniversidad Nacional de ColombiaSede MedellinCarrera 80 No.65-223RobledoMedellin 050041Colombia. Center for Research on m.crogrids at UPC(UPC CROm. Department of Electronic EngineeringTechnical University of Catalonia(UPC)08019 Barcelona Spain ICREA Pg.Lluis Companys 2308010 BarcelonaSpain Center for Research on m.crogrids at AAU(AAU CROm. AAU EnergyAalborg University(AAU)9220 Aalborg EastDenmark

Design and selection of advanced protection schem.s have becom. essential for reliable and secure operation of networked *** protection schem.s that allow correct operation of m.crogrids have been proposed for individual system. in different topologies and ***,protection schem.s for networked m.crogrids are still in devel-opm.nt,and further research is required to design and operate advanced protection in interconnected *** of these m.crogrids in different nodes with various intercon-nection technologies increases fault occurrence and com.licates protection *** paper aim. to point out challenges in developing protection for networked m.crogrids,potential solutions,and research areas that need to be addressed for their ***,this article presents a system.tic analysis of different m.crogrid clusters proposed since 2016,including several architectures of networked m.crogrids,operation m.des,com.onents,and utilization of renewable sources,which have not been widely explored in previous review ***,the paper presents a discussion on protection system. currently available for m.crogrid clusters,current challenges,and solutions that have been proposed for these ***,it discusses the trend of protection schem.s in networked m.crogrids and presents som. conclusions related to ***—Adaptive eprotection,m.crogrid cluster,m.crogrid,m.ltiple m.crogrid,networked m.crogrid,real-tim. sim.lation,sm.rt grid.

关键词： Adaptive eprotection m.crogrid cluster m.crogrid m.ltiple m.crogrid networked m.crogrid real-tim. sim.lation sm.rt grid

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Elucidating the structure-activity relationship of Cu-Ag bim.tallic catalysts for electrochem.cal CO_(2) reduction

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Journal of Energy Chem.stry 2024年第6期93卷 345-351,I0009页

作者： Qining Huang Lili Wan Qingxuan ren Jingshan Luo Institute of Photoelectronic Thin Film.Devices and Technology State Key Laboratory of Photovoltaic Materials and CellsKey Laboratory of Photoelectronic Thin Film Devices and Technology of TianjinMinistry of Education Engineering Research Center of Thin Film Photoelectronic TechnologyNankai UniversityTianjin 300350China Frontiers Science Center for New Organic m.tter Nankai UniversityTianjin 300071China Haihe laboratory of Sustainable Chem.cal Transform.tions Tianjin 300192China

Developing bim.tallic catalysts is an effective strategy for enhancing the activity and selectivity of electrochem.cal CO_(2) reduction reactions,where understanding the structure-activity relationship is essential for catalyst ***,we prepared two Cu-Ag bim.tallic catalysts with Ag nanoparticles attached to the top or the bottom.of Cu *** tested in a flow cell,the Cu-Ag catalyst with Ag nanoparticles on the bottom.achieved a faradaic efficiency of 54%for ethylene production,m.ch higher than the catalyst with Ag nanoparticles on the *** catalysts were further studied in the H-cell and zero-gap m.A *** was found that placing the two m.tals in the intensified reaction zone is crucial to triggering the tandem.reaction of bim.tallic *** work elucidates the structure-activity relationship of bim.tallic catalysts for CO_(2) reduction and dem.nstrates the im.ortance of considering both catalyst structures and cell characteristics to achieve high activity and selectivity.

关键词： Electrochem.cal CO_(2)reduction Bim.tallic catalyst Cu-Ag Structure-activity relationship

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Fault diagnosis of HVAC system.with im.alanced data using m.lti-scale convolution com.osite neural network

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Building Sim.lation 2024年第3期17卷 371-386页

作者： Rouhui Wu Yizhu ren m.ngying Tan Lei Nie School of m.chanical Engineering Hubei University of TechnologyWuhan430068China Industrial Research Institute of Xiangyang Hubei University of Technology Xiangyang441100China

Accurate fault diagnosis of heating,ventilation,and air conditioning(HVAC)system. is of significant im.ortance for m.intaining norm.l operation,reducing energy consum.tion,and m.nim.zing m.intenance ***,in practical applications,it is challenging to obtain sufficient fault data for HVAC system.,leading to im.alanced data,where the num.er of fault sam.les is m.ch sm.ller than that of norm.l ***,m.st existing HVAC system.fault diagnosis m.thods heavily rely on balanced training sets to achieve high fault diagnosis ***,to address this issue,a com.osite neural network fault diagnosis m.del is proposed,which com.ines Sm.TETom.k,m.lti-scale one-dim.nsional convolutional neural networks(m.DCNN),and support vector m.chine(SVm..This m.thod first utilizes Sm.TETom.k to augm.nt the m.nority class sam.les in the im.alanced dataset,achieving a balanced num.er of faulty and norm.l ***,it em.loys the m.DCNN m.del to extract feature inform.tion from.the augm.nted ***,it replaces the original Softm.x classifier with an SVm.classifier for classification,thus enhancing the fault diagnosis *** the Sm.TETom.k-m.DCNN-SVm.m.thod,we conducted fault diagnosis validation on both the ASHRAE RP-1043 dataset and experim.ntal dataset with an im.alance ratio of 1:*** results dem.nstrate the superiority of this approach,providing a novel and prom.sing solution for intelligent building m.nagem.nt,with accuracy and F1 scores of 98.45%and 100%for the RP-1043 dataset and experim.ntal dataset,respectively.

关键词： fault diagnosis chiller im.alanced data Sm.TETom.k m.lti-scale neural networks

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CFD investigation of structural effects of internal gas intake on powder conveying perform.nce in fuel supply system. for aerospace engines

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Particuology 2024年第9期92卷 140-154页

作者： Guanlong ren Haijun Sun Fangjun Chen Wen Shen Yunzhen Cai Yihua Xu Henrik Ström.Bilainu Oboirien Qingang Xiong School of Aircraft Engineering Nanchang Hangkong UniversityNanchang330063China Engineering Research Center of Aero-engine Technology for General Aviation Ministry of EducationNanchang330063China State Key laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhou510640China Departm.nt of m.chanics and m.ritim. Sciences Chalmers University of TechnologyGöteborg41296Sweden Departm.nt of Chem.cal Engineering University of JohannesburgJohannesburg17011South Africa

Optim.l design of gas intake in powder fuel supply system. is crucial for perform.nce of aerospace *** is little research on the im.act of intake structure on powder conveying *** novel internal intakes were proposed,which are spherical,cube-shaped,and *** validation,CFD sim.lations dem.nstrate that fluctuation of m.ss flow rate of powders in the dom.-shaped intake is reduced by about 73.3%com.ared with the annular external *** trends of phase velocities are sim.lar for the spherical and cube-shaped intakes,while those are sim.lar for the annular external and dom.-shaped internal *** of area of gas zone for the annular external and spherical internal intakes is larger than that for the cube-shaped and dom.-shaped internal *** and relative pressure drop in the fluidization cham.er have a stable stage,and fluctuation of relative pressure drop is sm.ll when dom.-shaped internal intake is used.

关键词： Powder supply system Intake structure Dense gas-solid flow Two-fluid m.del Powder fluidization Pressure drop

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Design,Testing and Control of a m.gnetorheological Dam.er for Knee Prostheses

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Journal of Bionic Engineering 2024年第4期21卷 1788-1800页

作者： Hounan Song Yu Cao Wei Chen Lei ren Yongxin m. Kunyang Wang Xu Wang Yao Zhang Luquan ren Key laboratory of Bionic Engineering Ministry of EducationJilin UniversityChangchun130022People’s Republic of China Departm.nt of m.chanical Aerospace and Civil EngineeringThe University of ManchesterManchesterM139PLUK

This study aim. to develop a m.gnetorheological(m.)dam.er for sem.-active knee prostheses to restore the walking ability of transfem.ral *** core dim.nsions of the m. dam.er were determ.ned via theoretical m.gnetic field calculations,and the theoretical relationship between current and joint torque was derived through electrom.gnetic ***,a physical prototype of the sem.-active prosthetic knee equipped with the m. dam.er was *** on the data obtained from.angle sensor,pressure sensor(loadcell),and inertial m.asurem.nt unit(Im.)on the prosthesis,a m.tching control algorithm.is *** joint torque of the m. dam.er can be adaptively adjusted according to the walking speed of the am.utee,allowing the am.utee to realize a natural *** effectiveness of the control program.was verified by the ADAm. and m.TlaB *** results of the test and sim.lation show that the m. dam.er can provide sufficient torque needed for norm.l hum.n activities.

关键词： Sem.-active knee prosthesis m.gnetorheological dam.er Theoretical analysis ADAm. and m.TlaB co-sim.lation

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