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Game changer:How Janus kinase inhibitors are reshaping the landscape of ulcerative colitis mana

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World Journal of Gastroenterology 2024年第35期30卷 3942-3953页

作者： Antonio M Caballero-Mateos Guillermo Arturo Cañadas-de la Fuente department of Gastroenterology and Hepatology San Cecilio University HospitalGranada 18014Spain department of Nursing Faculty of Health SciencesUniversity of GranadaGranada 18004Spain

Recent advancements in the treatment landscape of ulcerative colitis(UC)have ushered in a new era of possibilities,particularly with the introduction of Janus kinase(JAK)-signal transducer and activator of transcription *** novel agents offer a paradigm shift in UC management by targeting key signaling pathways involved in inflammatory *** approved JAK inhibitors(JAKis),such as tofacitinib,filgotinib,and upadacitinib,clinicians now have powerful tools to modulate immune responses and gene expression,potentially revolutionizing the treatment algorithm for *** trials have demonstrated the efficacy of JAKis in inducing and maintaining remission,presenting viable options for patients who have failed conventional ***-world data support the use of JAKis not only as first-line treatments but also in subsequent lines of therapy,particularly in patients with aggressive disease phenotypes or refractory to biologic *** rapid onset of action and potency of JAKis have broadened the possibilities in the management strategies of UC,offering timely relief for patients with active disease and facilitating personalized treatment *** safety concerns,including cardiovascular risks and infections,ongoing research and post-marketing surveillance will continue to refine our understanding of the risk-benefit profile of JAKis in UC management.

关键词： Ulcerative colitis Janus kinase inhibitors Filgotinib Tofacitinib Upadacitinib

Mechanical properties of the A356 aluminum alloy modified with la/Ce

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Journal of rare Earths 2013年第8期31卷 811-816页

作者： E. Aguirre-de la.torre R. Pérez-Bustamante J. Camarillo-Cisneros C.D. Gómez-Esparza H.M. Medrano-Prieto R. Martínez-Sánchez Advanced Materials Research Center (CIMAV) National Laboratory of Nanotechnology

The research of rare earths for the synthesis of materials with improved mechanical performance is of great interest when they are considered for potential applications in the automotive industry. In this regard, the effect on the mechanical properties and microstmcture of the automotive A356 aluminum alloy reinforced with 0.2 （wt.%） AI-6Ce-3la （ACL） was investigated. The ACL was added to the melted A356 alloy in the as-received condition and processed by mechanical milling. In the second route, the effect of the ACL processed by mechanical milling and powder metallurgy techniques was investigated, and compared with the results ob- tained from the A356 alloy strengthened with ACL in the as-received condition. Microstmctural properties were evaluated by means of X-ray diffraction in order to observe the solubility of Ce/la in the A1 matrix. In addition, electron microscopy was employed in or- der to investigate the effect of milling time on the size and morphology of la/Ce phase under milling process. Mechanical properties of the A356 alloy modified with ACL were measured by hardness and tensile test. For comparison unmodified specimens of the A356 were characterized according to the previous procedure. The microstructural and mechanical characterization was carried out in specimens alter solution and artificial aging. Observations in scanning electron microscopy indicated a homogeneous dispersion of la/Ce phases by using both routes; however, mechanical results, in the modified A356 alloy with the ACL in the as-received condi- tion, showed an improvement in the mechanical performance of the A356 alloy over that reinforced with the ACL mechanically milled.

关键词： A356 rare earths mechanical milling mechanical properties

Multi-object optimization design for differential and grading toothed roll crusher using a genetic algorithm

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Journal of China University of Mining and Technology 2008年第2期18卷 316-320页

作者： ZHAO la-la WANG Zhong-bin ZANG Feng School of Mechanical and Electrical Engineering China University of Mining and Technology Xuzhou Jiangsu 221008 China

Our differential and grading toothed roll crusher blends the advantages of a toothed roll crusher and a jaw crusher and possesses characteristics of great crushing,high breaking efficiency,multi-sieving and has,for the moment,made up for the short- comings of the toothed roll *** moving jaw of the crusher is a crank-rocker *** optimizing the dynamic per- formance and improving the cracking capability of the crusher,a mathematical model was established to optimize the transmission angleγand to minimize the travel characteristic value m of the moving *** algorithm is used to optimize the crusher crank-rocker mechanism for multi-object design and an optimum result is *** to the implementation,it is shown that the performance of the crusher and the cracking capability of the moving jaw have been improved.

关键词： differential and grading toothed roll crusher crank-rocker mechanism genetic algorithm multi-object optimization

Rheology Study of Suspension Formed by Different Nano-size Y-TZP

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Journal of Materials Science & Technology 1997年第4期13卷 348-350页

作者： Sun, J Gao, la Guo, JK CHINESE ACAD SCI SHANGHAI INST CERAMSHANGHAI 200050PEOPLES R CHINA

The rheological properties of slurries formed by different nano-size Y-TZP have been studied. The viscosity is sensitive to solid loading especially for high solid content level. The dispersant NH(4)PAA can improve the flowability efficiently. The smaller ceramic particles need to adsorb more dispersant to the flowability. Under the same solid content, the smaller the particles, the higher the viscosity of its slurry.

关键词： Rheology

Flexible Transparent Near-Infrared Photodetector Based on 2D Ti_(3)C_(2) MXene-Te Van der Waals Heterostructures

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Chinese Journal of Chemistry 2021年第8期39卷 2141-2146页

作者： Chuqiao Hu la Li Guozhen Shen Key laboratory for Superlattices and Microstructures Institute of SemiconductorsChinese Academy of Sciences&Center of Materials Science and Optoelectronic EngineeringUniversity of Chinese Academy of SciencesBeijing 100083China

Ti_(3)C_(2) MXe ne servi ng as superior electrical con ductors prese nts more specific performa nee such as tran spar ency,con ductivity tha n gold(Au),and even could form a heterostructure with active materials of the functional ***,a Ti_(3)C_(2) MXene-Te microplate van der Waals heterostructure based tran spare nt near-i nfrared photodetector(PD)is exploited.

关键词： Semiconductors Ti_(3)C_(2)T_(x)MXene Transparent electronics Tellurium Flexible near infrared photodetector Conducting materials

Scattering and absorption imaging of a highly fractured fluid-filled seismogenetic volume in a region of slow deformation

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Geoscience Frontiers 2020年第3期11卷 989-998页

作者： Ferdinando Napolitano Luca de Siena Anna Gervasi Ignazio Guerra Roberto Scarpa Mario la Rocca Dipartimento di Fisica“E.R.Caianiello” Universita Degli Studi di SalernoVia Giovanni Paolo IIFiscianoSA84084Italy Institute of Geosciences Johannes Gutenberg University MainzJ.-J.-Becher-Weg 21MainzD-55128Germany University of Aberdeen School of GeosciencesGeology and Petroleum GeologyMeston BuildingKing’s CollegeAberdeenScotlandAB243UEUK Dipartimento di Biologia Ecologia e Scienze Della TerraUniversit a Della CalabriaPonte P.BucciArcavacata di RendeCS87036Italy Istituto Nazionale di Geofisica e Vulcanologia Sezione di Rende(CS)Ponte P.BucciArcavacata di RendeCS87036Italy

Regions of slow strain often produce swarm-like sequences,characterized by the lack of a clear mainshockaftershock *** comprehension of their underlying physical mechanisms is challenging and still *** used seismic recordings from the last Pollino swarm(2010-2014) and nearby to separate and map seismic scattering(from P peak-delays) and absorption(from late-time coda-wave attenuation) at different frequencies in the Pollino range and ***-scattering and high-absorption anomalies are markers of a fluid-filled fracture volume extending from SE to NW(1.5-6 Hz) across the *** increasing frequency,these anomalies approximately cover the area where the strongest earthquakes occurred from the sixteenth century until *** our interpretation,the NW fracture propagation ends where carbonates of the Lucanian Apennines begin,as marked by a high-scattering and low-absorption *** the highest frequency(12 Hz) the anomalies widen southward in the middle of the range,consistently marking the faults active during the recent Pollino *** results suggest that fracture healing has closed small-scale fractures across the SE faults that were active in the past centuries,and that the propagation of fluids may have played a crucial role in triggering the 2010-2014 Pollino *** that the fluid propagation ended at the carbonates barrier in the NW direction,fractures opened new paths to the South,favoring the nucleation of the last Pollino ***,the recently active faults in the middle of the seismogenic volume are marked by a high-scattering and highabsorption *** work provides evidence that attenuation parameters may track shape and dynamics of fluid-filled fracture networks in fault areas.

关键词： Polling Seismic attenuation Scattering Fluids Fractures Healing

Hispanic Patients with Primary Biliary Cholangitis Have decreased Access to Care Compared to Non-Hispanics

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Journal of Clinical and Translational Hepatology 2020年第4期8卷 391-396页

作者： Atoosa rabiee Nathalie A Pena Polanco Aymara Fernandez de la Vara Cynthia Levy department of Gastroenterology and Hepatology VA Medical CenterWashington DCUSA Divison of Digestive Health and Liver Diseases department of Medicine University of Miami Miller School of Medicine USA department of Medicine Jackson Memorial HospitalUniversity of MiamiMiamiFLUSA

Background and Aims:Hispanic patients with primary bili-ary cholangitis (PBC) have reduced rates of biochemical re-sponse to ursodeoxycholic acid (UDCA) and increased risk of disease progression compared to non-Hispanic patients. In this study, we sought to identify differences in demographics, comorbidities, environmental risk factors and socioeconomic status between Hispanic and non-Hispanic patients with PBC. Methods: In a case control study, we analyzed data from Hispanic (n=37 females and 1 male) and non-Hispanic (n=54 females and 4 males) patients with PBC seen at the University of Miami/Jackson Memorial Hospital from January 1998 through January 2013. Data were obtained by filling out a questionnaire either via phone call, mail, or e-mail. Odds ratios were calculated to measure the association between exposure and ***: Baseline demographics, environmental risk factors and comorbidities were similar be-tween Hispanic and non-Hispanic patients with PBC. Hispanic patients were less likely to be married and fewer Hispanics had education beyond high school level compared to non-His-panics. Sixty four percent of Hispanic patients had a house-hold income of less than$50000, compared to 19.5% of non-Hispanics. Fewer Hispanic patients with PBC had health insur-ance coverage compared to non-Hispanics (86.5% vs. 98.1%;odds ratio: 0.1, 95% confidence interval: 0-0.9). Conclusions: Differences in disease severity and response to therapy observed in prior studies could not be explained by environmental exposures. In addition to genetic variation, socioeconomic discrepancies (access to care) may further ex-plain these differences.

关键词： Primary biliary cholangitis Ethnicity Health disparity

Safe Foods for Celiac People

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Food and Nutrition Sciences 2014年第9期5卷 787-800页

作者： Carlos Osella Maria de la.torre Hugo Sánchez Instituto de Tecnología de Alimentos Facultad de Ingeniería Química Universidad Nacional del Litoral Santa Fe Argentina

Celiac Disease is a chronic entheropathy produced by gluten intolerance, more precisely to certain proteins called prolamines, which causes atrophy of intestinal villi, malabsorption and clinical symptoms that can appear in both childhood and adulthood. This pathogeny, results from the interaction of genetic, immunologic and environmental factors, which produce the lesions on the mucosa of the proximal small intestine. It is important to estimate the maximum gluten content that could be present in supposedly “gluten-free” foods, a limit of 20 mg/Kg is admitted. Rice flour, sorghum flour, starches, hydrocolloids, soy flour and dairy products are analyzed for carrying out the manufacture of gluten-free products, such as bread, noodles and others.

关键词： Celiac Disease Gluten-Free Products raw Materials for Celiac People

Genotoxicity evaluation of two derived products from Allium extracts:s-propylmercaptocysteine and s-propyl mercaptoglutathione

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Food Bioscience 2023年第3期53卷 1603-1611页

作者： Antonio Cascajosa-Lir Concepción Medrano-Padial Ana Isabel Prieto Alberto Baños José M.de la.torre Angeles Jos Ana M.Cameán Área de Toxicología Facultad de FarmaciaUniversidad de SevillaProfesor García González n 241012SevilleSpain DMC Research Center Camino de Jayena 8218620AlhendínSpain

Propyl-propane-thiosulfonate(PTSO)is one of the main organosulfur compounds present in Allium essential oils with a widely documented biological *** this reason,it could be used as a food and feed additive in the agri-food industry.A genotoxicity evaluation of substances and their metabolites present in food is necessary to guarantee the consumer’s health following the recommendations of the European Food Safety Authority(EFSA).To evaluate the toxicological profile of derivatives of PTSO,the cytotoxicity,an Ames test,a micronucleus test and the comet assay were *** showed that non-cytotoxic effects were observed in Caco-2 exposed to s-propyl mercaptocysteine(CSSP)and s-propyl mercaptoglutathione(GSSP)(0-450μM).The mutagenicity index remained in the range of 0.6-1.4 for both compounds,showing no mutagenic effects for the concentrations of 5000-312.5μg GSSP/plate and 250-15.63μg CSSP/***,the%binucleated cells with micronuclei were 1.3-2.2 and 1.6-2.7 for GSSP and GSSP,*** comet assays there was no DNA-genotoxic or oxidative damage in a concentration range of 112.5-450μ***,we can conclude that these compounds are not genotoxic at the conditions *** results support that the presence of CSSP and GSSP in the food/feed is not of concern,although further studies are needed to complete their safety profile.

关键词： Cytotoxicity Genotoxicity Mutagenicity Organosulfur compounds Allium Propyl-propane-thiosulfonate