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Testosterone replacement therapy and vascular thromboembolic events: a systematic review and meta-analysis

Asian Journal of Andrology 2024年第2期26卷 144-154页

作者： Rossella Cannarella Carmelo Gusmano Claudia Leanza Vincenzo garofalo Andrea Crafa Federica Barbagallo Rosita A Condorelli Sandro la Vignera Aldo E Calogero Department of Clinical and Experimental Medicine University of CataniaCatania 95123Italy Glickman Urological&Kidney institute Cleveland Clinic FoundationClevelandOH44195USA

To evaluate the relationship between testosterone replacement therapy(TRT)and arterial and/or venous thrombosis in patients with pre-treatment total testosterone(TT)<12 nmol i^(-1),we performed a meta-analysis followi... 详细信息

To evaluate the relationship between testosterone replacement therapy(TRT)and arterial and/or venous thrombosis in patients with pre-treatment total testosterone(TT)i^(-1),we performed a meta-analysis following the Population intervention Comparison Outcome ***:men with TTi^(-1) or clear mention of hypogonadism in the inclusion criteria of patients;intervention:TRT;comparison:placebo or no therapy;outcomes:arterial thrombotic events(stroke,myocardial infarction[Mi],upper limbs,and lower limbs),VTE(deep vein thrombosis[DVT],portal vein thrombosis,splenic thrombosis,and pulmonary embolism),and mortality.A total of 2423 abstracts were assessed for ***-four studies,including 14 randomized controlled trials(RCTs),were finally included,with a total of 4027 and 310288 hypotestosteronemic male patients,from RCTs and from observational studies,*** on RCT-derived data,TRT did not influence the risk of arterial thrombosis(odds ratio[OR]=1.27,95%confidence interval[Ci]:0.47-3.43,P=0.64),stroke(OR=1.34,95%Ci:0.09-18.97,P=0.83),Mi(OR=0.51,95%Ci:0.11-2.31,P=0.39),VTE(OR=1.42,95%Ci:0.22-9.03,P=0.71),pulmonary embolism(OR=1.38,95%Ci:0.27-7.04,P=0.70),and mortality(OR=0.70,95%Ci:0.20-2.38,P=0.56).Meanwhile,when only observational studies are considered,a significant reduction in the risk of developing arterial thrombotic events,Ml,venous thromboembolism,and mortality was *** risk for DVT remains uncertain,due to the paucity of RCT-based *** in men with TTi^(-1) is safe from the risk of adverse cardiovascular *** studies specifically assessing the risk of DVT in men on TRT are needed.

关键词： hypogonadism testosterone testosterone replacement therapy thromboembolism thrombosis TRT

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A machine learning-based strategy for predicting the mechanical strength of coral reef limestone using X-ray computed tomography

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2790-2800页

作者： Kai Wu Qingshan Meng Ruoxin Li Le Luo Qin Ke ChiWang Chenghao ma State Key laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China State Key laboratory of Water Resources and Hydropower Engineering Science Institute of Engineering Risk and Disaster PreventionWuhan UniversityWuhan430072China

Different sedimentary zones in coral reefs lead to significant anisotropy in the pore structure of coral reef limestone(CRL),making it difficult to study mechanical *** X-ray computed tomography(CT),112 CRL samples were utilized for training the support vector machine(SVM)-,random forest(RF)-,and back propagation neural network(BPNN)-based models,***,the machine learning model was embedded into genetic algorithm(ga)for parameter optimization to effectively predict uniaxial compressive strength(UCS)of *** indicate that the BPNN model with five hidden layers presents the best training effect in the data set of *** SVM-based model shows a tendency to overfitting in the training set and poor generalization ability in the testing *** RF-based model is suitable for training CRL samples with large *** of Pearson correlation coefficient matrix and the percentage increment method of performance metrics shows that the dry density,pore structure,and porosity of CRL are strongly correlated to ***,the P-wave velocity is almost uncorrelated to the UCS,which is significantly distinct from the law for homogenous *** addition,the pore tensor proposed in this paper can effectively reflect the pore structure of coral framework limestone(CFL)and coral boulder limestone(CBL),realizing the quantitative characterization of the heterogeneity and anisotropy of *** pore tensor provides a feasible idea to establish the relationship between pore structure and mechanical behavior of CRL.

关键词： Coral reef limestone(CRL) machine learning Pore tensor X-ray computed tomography(CT)

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Core-shell design of UiO66-Fe_(3)O_(4) configured with EDTA-assisted washing for rapid adsorption and simple recovery of heavy metal pollutants from soil

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Journal of Environmental Sciences 2024年第5期139卷 556-568页

作者： Xi Wang Asif Hussain Qingqing Li Mingyu ma Juan Wu Mingqiang Deng Jie Yang Dengxin Li Department of Environmental Science and Engineering Donghua UniversityShanghai 201620China Department of Environmental Science Federal Urdu University of ArtsScience and Technology75300 KarachiPakistan Shanghai Academy of Environmental Sciences Shanghai 200233China

The coupling of washing with adsorption process can be adopted for the treatment of soils contaminated with heavy metals ***,the complex environment of soil and the competitive behavior of leaching chemicals considerably restrain adsorption capacity of adsorbent material during washing process,which demands a higher resistance of the adsorbents to *** this study,we synthesized strongly magnetic,high specific surface area(573.49 m^(2)/g)UiO66 composites(i.e.,UiO66-Fe_(3)O_(4))using hydrothermal *** UiO66-Fe_(3)O_(4) was applied as an adsorbent during the ethylene diamine tetraacetic acid(EDTA)-assisted washing process of contaminated *** incorporation of UiO66-Fe_(3)O_(4)results in rapid heavy metal removal and recovery from the soil under low concentrations of washing agent(0.001 mol/L)with reduced residual heavy metal mobility of soil after ***,UiO66-Fe_(3)O_(4)can quickly recollect by an external magnet,which offers a simple and inexpensive recovery method for heavy metals from contaminated ***,UiO66-Fe_(3)O_(4)configuration with EDTA-assisted washing process showed opportunities for heavy metals contaminated sites.

关键词： UiO66 composites Metal-EDTA complexes EDTA-assisted washing Heavy metals recovery Soil

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Recent progress on impact induced reaction mechanism of reactive alloys

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Defence Technology（防务技术） 2024年第7期37卷 69-95页

作者： Yansong Yang Chuanting Wang Yuanpei Meng Yue ma Lei Guo Yuan He Zhichao Sun Yong He School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094JiangsuChina

in recent years,in order to improve the destructive effectiveness of munitions,the use of new types of destructive elements is an important way to improve destructive *** a new type of reactive material,reactive alloy contains a large portion of reactive metal elements(Al,Mg,Ti,Zr,etc.),which breaks up under high-velocity impact conditions,generating a large number of high-temperature combustible fragments,which undergo a violent combustion reaction with *** with traditional metal polymers(Al-PTFE)and other reactive composites,it has higher density and strength,excellent mechanical properties and broader application ***,researchers have mainly investigated the impact energy release mechanism of reactive alloys through impact tests,and found that there are several important stages in the process of the material from fragmentation to reaction,i.e.,impact fragmentation of the material,rapid heating and combustion *** paper focuses on three problems that need to be solved in the impact-induced energy release process of reactive alloys,namely:the fragmentation mechanism and size distribution law of the fragments produced by the impact of the material on the target,the relationship between the transient temperatures and the size of the fragments,and the reaction temperatures and size thresholds of the fragments to undergo the chemical *** current status of the research of the above problems is reviewed,some potential directions to reveal the impact induced reaction mechanism of reactive alloy is discussed.

关键词： Reactive alloys impact Fragmentation mass and size distribution Shock temperature rise Adiabatic shear Combustion

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Effect of cobalt substitution for nickel on microstructural evolution and hydrogen storage properties of la_(0.66)Mg_(0.34)Ni_(3.5-x)Co_(x) alloys

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Journal of Rare Earths 2024年第5期42卷 930-939,I0004页

作者： Xincong He Huazhou Hu Ruizhu Tang Wenhao Zhou Houqun Xiao Xiaoxuan Zhang Chuanming ma Qingjun Chen School of Rare Earths University Science&Technology of ChinaHefei230026China Key laboratory of Rare Earths Chinese Academy of SciencesJiangxi Institute of Rare EarthsGanjiang Innovation AcademyChinese Academy of SciencesGanzhou341000China

Superlattice hydrogen storage alloys offer a compelling advantage with rapid hydriding rate and high storage ***,its practical applications face challenges including complex structure,low dehydriding capacity,and cyclic *** this work,we successfully prepared la_(0.66)Mg_(0.34)Ni_(3.5-x)Co_(x) superlattice hydrogen storage alloys with enhanced dehydriding capacity and stability by partially substituting Co for Ni.X-ray diffraction(XRD)refinements analysis reveals the presence of(la,Mg)_(3)Ni_(9),(la,Mg)_5Ni_(19),and laNi_(5) phases within the *** Co substitution in the la_(0.06)Mg_(0.34)Ni_(3.4)Co_(0.1)alloy,there is a significant increase in content of the(la,Mg)_(3)Ni_(9) phase and a reduction in the hysteresis factor,resulting in an improved reversible hydrogen storage capacity from 1.45 wt%to 1.60 wt%.The dehydriding kinetics of the alloy is controlled by diffusion model with an activation energy of 8.40 kJ/***,the dehydriding enthalpy value of the Co-substituted alloy decreases from 30.84 to 29.85 kJ/***,the cycling performance of the alloy after Co substitution exhibits excellent stability,with a capacity retention rate of 92.3%after 100 *** findings provide valuable insights for the development of cost-effective hydrogen storage materials.

关键词： Superlattice hydrogen storage alloy Co substitution Microstructure Kinetics Thermodynamics Rare earths

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Study of the reaction mechanism for preparing powdered activated coke with SO_(2)adsorption capability via one-step rapid activation method under flue gas atmosphere

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Chinese Journal of Chemical Engineering 2024年第1期65卷 158-168页

作者： Binxuan Zhou Jingcai Chang Jun Li Jinglan Hong Tao Wang Liqiang Zhang Ping Zhou Chunyuan ma School of Environmental Science and Engineering Shandong UniversityQingdao 266237China School of Energy and Power Engineering Shandong UniversityJinan 250061China Weihai Research institute of industrial Technology of Shandong University Weihai 264209China

in this study,the impact of different reaction times on the preparation of powdered activated carbon(PAC)using a one-step rapid activation method under flue gas atmosphere is investigated,and the underlying reaction mechanism is *** indicate that the reaction process of this method can be divided into three stages:stage i is the rapid release of volatiles and the rapid consumption of O_(2),primarily occurring within a reaction time range of 0-0.5 s;stage ii is mainly the continuous release and diffusion of volatiles,which is the carbonization and activation coupling reaction stage,and the carbonization process is the main in this *** stage mainly occurs at the reaction time range of 0.5 -2.0 s when SL-coal is used as material,and that is 0.5-3.0 s when JJ-coal is used as material;stage iii is mainly the activation stage,during which activated components diffuse to both the surface and interior of *** stage mainly involves the reaction stage of CO_(2)and H2O(g)activation,and it mainly occurs at the reaction time range of 2.0-4.0 s when SL-coal is used as material,and that is 3.0-4.0 s when JJ-coal is used as ***,the main function of the first two stages is to provide more diffusion channels and contact surfaces/activation sites for the diffusion and activation of the activated components in the third *** the reaction mechanism would serve as a crucial reference and foundation for designing the structure,size of the reactor,and optimal positioning of the activator nozzle in PAC preparation.

关键词： Reaction mechanism Powdered activated coke preparation SO_(2)adsorption One-step rapid activation Flue gas atmosphere

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Covalently bonded ternary photocatalyst comprising MoSe_(2)/black phosphorus nanosheet/graphitic carbon nitride for efficient moxifloxacin degradation

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Chinese Chemical Letters 2024年第9期35卷 356-359页

作者： Yuhao ma Yufei Zhou Mingchuan Yu Cheng Fang Shaoxia Yang Junfeng Niu College of Environmental Science and Engineering North China Electric Power UniversityBeijing 102206China College of Water Conservancy and Hydropower Engineering North China Electric Power UniversityBeijing 102206China Global Centre for Environmental Remediation(GCER) University of NewcastleCallaghanNSW 2308Australia

Covalently bonded bridging between different semiconductors is a remarkable approach to improve the transfer of charge carriers at *** this study,we designed a ternary heterojunction(MBG)combining of molybdenum diselenide(Mo Se_(2)),black phosphorus nanosheets(Bpn)and graphitic carbon nitride(GCN).Among this MBG of Mo Se_(2)/Bpn/GCN,(i)the covalently bonded bridging effect between Bpn/GCN facilitates directional charge carrier transfer,meanwhile(ii)a Z-scheme heterojunction is formed between Mo Se_(2)/GCN to enhance the separation of photogenerated ***,(iii)this composite exhibits an increased absorption for visible *** this MBG,photocatalytic degradation of over 98%of moxifloxacin is achieved within 20 min,with O_(2)·-confirmed as the primary photocatalytic active *** findings provide novel insights into the construction of efficient heterojunction by covalently bonded bridging.

关键词： Ternary heterojunction Black phosphorus nanosheets Covalent bond Photocatalytic degradation Graphitic carbon nitride

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Synergistic promotion of particulate matter reduction and production performance via adjusting electrochemical reactions in the zinc electrolysis industry

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Frontiers of Environmental Science & Engineering 2024年第1期18卷 23-33页

作者： Zizhen ma Jingkun Jiang Lei Duan Jianguo Deng Fuyuan Xu Zehui Li Linhua Jiang Ning Duan School of Environmental and Municipal Engineering Qingdao University of TechnologyQingdao 266520China State Key Joint laboratory of Environmental Simulation and Pollution Control School of the EnvironmentTsinghua UniversityBeijing 100084China State Key laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China School of Physics Peking UniversityBeijing 100871China

Heavy particulate matter (PM) pollution and high energy consumption are the bottlenecks of hydrometallurgy, especially in the electrolysis process. Therefore, an urgent need is to explore PM reduction methods with production performance co-benefits. This study presents three PM reduction methods based on controlling operating parameters, i.e., lowering electrolyte temperature, H2SO4 concentration, and current density of the cathode. The optimized conditions were also investigated using the response surface methodology to balance the PM reduction effect and Zn production. The results showed that lowering electrolyte temperature is the most efficient, with an 89.0% reduction in the PM generation flux (GFPM). Reducing H2SO4 concentration led to the minimum side effects on the current efficiency of Zn deposition (CEZn) or power consumption (PC). With the premise of non-deteriorating CEZn and PC, GFPM can be reduced by 86.3% at the optimal condition (electrolyte temperature = 295 K, H2SO4 = 110 g/L, current density = 373 A/m^(2)). in addition, the reduction mechanism was elucidated by comprehensively analyzing bubble characteristics, electrochemical reactions, and surface tension. Results showed that lower electrolyte temperature inhibited the oxygen evolution reaction (OER) and compressed gas volume. Lower H2SO4 concentration inhibited the hydrogen evolution reaction (HER) and reduced electrolyte surface tension. Lower current density inhibited both OER and HER by decreasing the reaction current. The inhibited gas evolutions reduced the microbubbles’ number and size, thereby reducing GFPM. These results may provide energy-efficient PM reduction methods and theoretical hints of exploring cleaner PM reduction approaches for industrial electrolysis.

关键词： Zinc electrolysis Particulate matter Energy consumption Operating parameters Bubble characteristic Electrochemical reaction

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Mechanical properties of multi-scale germanium specimens from space solar cells under electron irradiation

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Chinese Journal of Aeronautics 2024年第1期37卷 173-185页

作者： Jian QiU maliya HEiNi Jusha ma Wenjia HAN Xunchun WANG Jun YiN Yan SHi Cunfa gaO State Key laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China School of Chemistry and Civil Engineering Shaoguan UniversityShaoguan 512005China Key laboratory of Functional materials and Devices for Special Environments of Chinese Academy of Sciences Chinese Academy of SciencesUrumqi 830011China Shanghai institute of Space Power-Sources Shanghai 200245China

During long-term service in space,gallium Arsenide(gaAs)solar cells are directly exposed to electron irradiation which usually causes a dramatic decrease in their *** the multilayer structure of solar cells,the germanium(Ge)layer occupies the majority of the thickness as the *** to the intrinsic brittleness of semiconductor material,there exist various defects during the preparation and assembly of solar cells,the influences of which tend to be intensified by the irradiation *** this work,first,Ge specimens for mechanical tests were prepared at scales from microscopic to ***,after different doses of electron irradiation,the mechanical properties of the Ge specimens were *** experimental results demonstrate that electron irradiation has an obvious effect on the mechanical property variation of Ge in diverse *** four-point bending test indicates that the elastic modulus,fracture strength,and maximum displacement of the Ge specimens all increase,and reach the maximum value at the irradiation dose of 1×10^(15)e/cm^(2).The micrometer scale cantilever and nanoindentation tests present similar trends for Ge specimens after *** Force Microscope(AFM)also observed the change in surface ***,a fitting model was established to characterize the relation between modulus change and electron irradiation dose.

关键词： Electron irradiation Germanium Mechanical properties Multi-scale Space solar cells

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Litter quality and decomposer complexity co-drive effect of drought on decomposition

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Forest Ecosystems 2024年第3期11卷 329-338页

作者： Shumei Wang Junwei Luan Siyu Li Jinhao ma Lin Chen Yi Wang Shirong Liu Sanya Research Base International Centre for Bamboo and RattanSanya572022China institute of Resources and Environment Key Laboratory of Bamboo and Rattan Science and Technology of National Forestry and Grassland AdministrationInternational Centre for Bamboo and RattanBeijing100102China Key laboratory of Forest Ecology and Environment of National Forestry and Grassland Administration Ecology and Nature Conservation InstituteChinese Academy of ForestryBeijing100091China Experimental Center of Tropical Forestry Chinese Academy of ForestryPingxiang532600China institute of Qinghai-Tibetan Plateau Southwest Minzu UniversityChengdu610041China

Litter decomposition is key to ecosystem carbon(C)and nutrient cycling,but this process is anticipated to weaken due to projected more extensive and prolonged *** how litter quality and decomposer community complexity regulate decomposition in response to drought is less ***,in a five-year manipulative drought experiment in a masson pine forest,leaf litter from four subtropical tree species(Quercus griffthii Hook.f.&Thomson ex Miq.,Acacia mangium Willd.,Pinus massoniana lamb.,Castanopsis hystrix Miq.)representing different qualities was decomposed for 350 d in litterbags of three different mesh sizes(i.e.,0.05,1,and 5 mm),respectively,under natural conditions and a 50%throughfall rain exclusion *** of increasing mesh sizes discriminate decomposer communities(i.e.,microorganisms,microorganisms and mesofauna,microorganisms and meso-and macrofauna)that access the litter and represent an increasing *** amount of litter C and nitrogen(N)loss,and changes in their ratio(C/N_(loss)),as well as small and medium-sized decomposers including microorganisms,nematodes,and arthropods,were *** found that drought did not affect C and N loss but decreased C/N_(loss)(i.e.,decomposer N use efficiency)of leaf litter irrespective of litter quality and decomposer ***,changes in the C/N_(loss)and the drought effect on C loss were both dependent on litter quality,while drought and decomposer complexity interactively affected litter C and N *** decomposer community complexity enhanced litter decomposition and allowing additional access of meso-and macro-fauna to litterbags mitigated the negative drought effect on the microbial-driven ***,both the increased diversity and altered trophic structure of nematode due to drought contributed to the mitigation effects via cascading *** results show that litter quality and soil decomposer community complexity co-drive the effect of

关键词： Arthropod Drought Decomposer community Nutrient cycling Nematode

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