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Gradient microstructure and superior strength-ductility synergy of AZ61 magnesium alloy bars processed by radial forging with different deformation temperatures

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Journal of materials Science & Technology 2024年第3期170卷 65-77页

作者： Jingfeng Zou Lifeng ma Yanchun Zhu Ling Qin Yuan Yuan School of Mechanical Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Heavy machinery Engineering Research Center of the Ministry Education Taiyuan University of Science and TechnologyTaiyuan 030024China Department of Engineering University of HullCottingham RdHull HU67RXUK National Engineering Research Center for magnesium Alloys Chongqing UniversityChongqing 400044China

Gradient microstructure modification is a cost-efficient strategy for high strength without compromising ductility,which is urgently needed in the fundamental science of engineering *** this study,heterogeneous structures of AZ61 alloy bars with anisotropic gradients(with different grain size distributions from the surface to the center)were observed to exhibit strong strength-ductility synergies under different deformation tem *** results reveal that the grain refinement process under mediumlow temperature deformation conditions(≤350℃)consists of four transition stages along the radial direction,i.e.,twin activations and deformation band formations,dislocation cells and pile-ups,ultrafine sub-grains,and randomly orientated quasi-micron *** deformation temperatures have a great influence on twin activations and deformation band formations,and the high temperature can easily provoke the initiation of non-basal *** deformation bands were determined as a primary nucleation site due to their highly unstable dislocation hindrance *** in combination with the Radial forging(RF)deformation process,the differences of dynamic precipitates can be attributed to microstructural difference and solubility limit of Al at different tem *** summarizing the tensile test results,the sample forged at 350℃exhibited the best strength-ductility synergy,exhibiting the highest elongation(EL)of 23.2%with a 251 MPa yield strength(YS)and 394 MPa ultimate tensile strength(UTS)in center region,and combined with the highest strength value of 256 MPa YS and 420 MPa UTS in the center region,while the EL was slightly degraded to 19.8%.

关键词： Gradient microstructure Radial forging Strength-ductility synergy magnesium alloy Strengthening mechanism

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Requirements ranking based on crowd-sourcing high-end product USs

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Journal of Systems Engineering and Electronics 2024年第1期35卷 94-104页

作者： ma Yufeng DOU Yajie XU Xiangqian JiA Qingyang TAN Yuejin College of Systems Engineering National University of Defense TechnologyChangsha 410003China

Based on the characteristics of high-end products,crowd-sourcing user stories can be seen as an effective means of gathering requirements,involving a large user base and generating a substantial amount of unstructured *** key challenge lies in transforming abstract user needs into specific ones,requiring integration and ***,we propose a topic mining-based approach to categorize,summarize,and rank product requirements from user ***,after determining the number of story categories based on py LDAvis,we initially classify“i want to”phrases within user ***,classic topic models are applied to each category to generate their names,defining each post-classification user story category as a ***,a weighted ranking function is devised to calculate the importance of each ***,we validate the effectiveness and feasibility of the proposed method using 2966 crowd-sourced user stories related to smart home systems.

关键词： high-end product complex system crowd-sourcing user stories topic mining requirements ranking

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PAPS: Progressive Attention-Based Pan-sharpening

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iEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 391-404页

作者： Yanan Jia Qiming Hu Renwei Dian Jiayi ma Xiaojie Guo College of intelligence and Computing Tianjin UniversityTianjin 300350 China iEEE School of Robotics Hunan UniversityChangsha 410082China Electronic information School Wuhan UniversityWuhan 430072China

Pan-sharpening aims to seek high-resolution multispectral(HRMS) images from paired multispectral images of low resolution(LRMS) and panchromatic(PAN) images, the key to which is how to maximally integrate spatial and spectral information from PAN and LRMS images. Following the principle of gradual advance, this paper designs a novel network that contains two main logical functions, i.e., detail enhancement and progressive fusion, to solve the problem. More specifically, the detail enhancement module attempts to produce enhanced MS results with the same spatial sizes as corresponding PAN images, which are of higher quality than directly up-sampling LRMS *** a better MS base(enhanced MS) and its PAN, we progressively extract information from the PAN and enhanced MS images, expecting to capture pivotal and complementary information of the two modalities for the purpose of constructing the desired HRMS. Extensive experiments together with ablation studies on widely-used datasets are provided to verify the efficacy of our design, and demonstrate its superiority over other state-of-the-art methods both quantitatively and qualitatively. Our code has been released at https://***/JiaYN1/PAPS.

关键词： High-resolution multispectral image image fusion pan-sharpening progressive enhancement

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Opportunities and challenges of CD47-targeted therapy in cancer immunotherapy

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Oncology Research 2024年第1期32卷 49-60页

作者： QiUQiANG CHEN XUEJUN GUO WENXUE ma Key laboratory for Translational Medicine The First Affiliated HospitalHuzhou University School of MedicineHuzhou313000China Department of Hematology Puyang Youtian General HospitalPuyang457001China Department of Medicine Moores Cancer CenterSanford Stem Cell InstituteUniversity of California San DiegoLa JollaSan Diego92093USA

Cancer immunotherapy has emerged as a promising strategy for the treatment of cancer,with the tumor microenvironment(TME)playing a pivotal role in modulating the immune ***47,a cell surface protein,has been identified as a crucial regulator of the TME and a potential therapeutic target for cancer ***,the precise functions and implications of CD47 in the TME during immunotherapy for cancer patients remain incompletely *** comprehensive review aims to provide an overview of CD47’s multifaced role in TME regulation and immune evasion,elucidating its impact on various types of immunotherapy outcomes,including checkpoint inhibitors and CAR T-cell ***,CD47-targeted therapies offer a promising avenue for improving cancer treatment outcomes,especially when combined with other immunotherapeutic *** review also discusses current and potential CD47-targeted therapies being explored for cancer treatment and delves into the associated challenges and opportunities inherent in targeting *** the demonstrated effectiveness of CD47-targeted therapies,there are potential problems,including unintended effects on healthy cells,hematological toxicities,and the development if ***,further research efforts are warranted to fully understand the underlying mechanisms of resistance and to optimize CD47-targeted therapies through innovative combination approaches,ultimately improving cancer treatment ***,this comprehensive review highlights the significance of CD47 as a promising target for cancer immunotherapy and provides valuable insight into the challenges and opportunities in developing effective CD47-targeted therapies for cancer treatment.

关键词： CD47 Cancer immunotherapy CD47-targeted therapies Tumor microenvironment macrophage Cancer cell immune evasion Checkpoint inhibitors CAR T-cell therapy Cancer treatment outcomes

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Exploring the molecular mechanisms and potential therapeutic strategies of ferroptosis in ovarian cancer

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BiOCELL 2024年第3期48卷 379-386页

作者： LiSHA ma WANQi SHAO WEiLi ZHU Department of Gynecology Jiaxing University Master Degree Cultivation BaseZhejiang Chinese Medical UniversityJiaxingChina Department of Gynecology Jiaxing University Affiliated Women and Children’s HospitalJiaxingChina

The morbidity rate of ovarian cancer,a malignant tumour in gynaecological tumours,is rising,and it is considered to be the most lethal *** majority of patients are typically diagnosed during the advanced stages of the illness due to the elusive characteristics of ovarian cancer and an absence of highly sensitive and speciﬁc diagnostic *** excision of the lesions,along with chemotherapy,is the conventional treatment for ovarian cancer;however,resistance to platinum-based chemotherapeutic drugs and molecular targeted therapies frequently *** the survival rate and prognosis of patients with end-stage or recurring ovarian cancer requires the identiﬁcation of new therapeutic targets due to the absence of efﬁcient medications,and this has emerged as a highly demanding *** have demonstrated that ferroptosis effectively hinders the proliferation of ovarian cancer and induces the demise of malignant *** is composed of the cystine/glutamate antiporter system(the system Xc-)and glutathione peroxidase 4(GPX4).Solute carrier family 7 member 11(SLC7A11)and solute carrier family 3 member 2(SLC3A2)play crucial roles in the regulation of ferroptosis by facilitating the uptake of cystine into cells and the efﬂux of glutamate out of cells,*** cells,GPX4 is the exclusive enzyme employed for reducing liposomal peroxide through glutathione peroxidase *** occurrence of ferroptosis in ovarian cancer is strongly associated with three main pathways,namely,the GPX4-glutathione(GSH)protective pathway,the ferroptosis suppressor protein 1(FSP1)-coenzyme Q10(CoQ10)protective pathway,and the guanosine 5'-triphosphate cyclohydrolase i(GCH1)protective *** ovarian cancer cells,the postsynaptic density-95,discs-large,zona occludens 1(PDZ)-binding motif-angiopoietin-like 4-nicotinamide adenine dinucleotide phosphate oxidases 2(TAZ-ANGPTL4-NOX2)pathway can be regulated by Yes-associated protein(YAP)/TAZ,a downstream

关键词： Ovarian cancer Ferroptosis Therapy

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Design of new chemicals for advanced electrolytes

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Science China Chemistry 2024年第5期67卷 1378-1380页

作者： Haoran Cheng Zheng ma Qian Li Jun Ming State Key laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China University of Science and Technology of China Hefei 230026China

This highlight is inspired by a recent article in Nature Energy in which Liu and co-workers [1] from Tsinghua University designed a new asymmetric lithium salt (i.e., lithium 1,1,1-trifluoro-N-[2-[2-(2-methoxy ethoxy)ethoxy]ethyl] methanesulfonamide (Li FEA)) and applied it as a new lithium-salt additive in the conventional carbonate-based electrolyte,overcoming the incompatibility issue of carbonate electrolytes with lithium metal in lithium metal batteries (LMBs),even achieving a fast-charging feature.

关键词： lithium carbonate electrolyte

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Control of aluminum distribution in ZSM-5 zeolite for enhancement of its catalytic performance for propane aromatization

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Frontiers of Chemical Science and Engineering 2024年第8期18卷 15-24页

作者： Zhao ma Dezhi Shi Sen Wang Mei Dong Weibin Fan State Key laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China University of Chinese Academy of Sciences Beijing 100049China

Regulation of aluminum distribution in zeolite framework is an effective method for improving its catalytic performance for propane ***,we found that recrystallization and post-realuminization of ZSM-5 cannot only create hollow structures to enhance the diffusion ability,but also adjust the content and position of paired aluminum species in its *** characterizations results confirmed that increase of paired aluminum content and inducement of more aluminum atoms sited in the intersection cavity are beneficial to the formation of aromatic products in propane *** a result,the hollow-structured ZSM-5 zeolite with more paired aluminum(H-200-hollow)showed higher propane conversion and aromatics selectivity than other samples at the same *** catalytic performance of H-200-hollow can be further improved by ion-exchanging with a small amount of ga(iii)*** propane conversion and aromatics selectivity of ga-200-hollow reached as high as 95%and 70%,respectively,at 540°C and 1 atm.

关键词： propane aromatization zeolite aluminum distribution recrystallization and post-realuminization

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Survival effects of antibiotic exposure during the larval and adult stages in the West Nile virus vector Culex pipiens

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insect Science 2024年第2期31卷 542-550页

作者： marta garrigos mario garrido manuel Morales-Yuste Josuémartinez-de la Puente Jesus Veiga Faculty of Pharmacy Department of ParasitologyUniversity of GranadaGranadaSpain CiBER de Epidemiologia y Salud Publica(CiBERESP) MadridSpain

The ability of mosquitoes to transmit a pathogen is affected,among other factors,by their survival rate,which is partly modulated by their *** microbiota is acquired during the larval phase and modified during their development and adult feeding behavior,being highly dependent on environmental *** residues including antibiotics are widespread pollutants potentially being present in mosquito breeding waters likely affecting their ***,we used Culex pipiens mosquitoes to assess the impact of antibiotic exposure during the larval and adult stages on the survival rate of adult ***-collected larvae were randomly assigned to two treatments:larvae maintained in water supplemented with antibiotics and control *** adults were subsequently assigned to each of two treatments,fed with sugar solution with antibiotics and fed only with sugar solution(controls).larval exposure to antibiotics significantly increased the survival rate of adult females that received a control *** addition,the effect of adult exposure to antibiotics on the survival rate of both male and female mosquitoes depended on the number of days that larvae fed ad libitum in the laboratory before *** particular,shorter larval ad libitum feeding periods reduced the survival rate of antibiotic-treated adult mosquitoes compared with those that emerged after a longer larval feeding *** differences were not found in control adult *** results extend the current understanding of the impact of antibiotic exposure of mosquitoes on a key component of vectorial capacity,that is the vector survival rate.

关键词： antibiotics avian malaria microbiota mosquitoes vector competence vector survival

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Transcranial magneto-Acoustic Stimulation Attenuates Synaptic Plasticity impairment through the Activation of Piezo1 in Alzheimer’s Disease Mouse Model

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Research 2024年第1期2023卷 81-95页

作者： Fangxuan Chu Ruxin Tan Xin Wang Xiaoqing Zhou Ren ma Xiaoxu ma Ying Li Ruixu Liu Chunlan Zhang Xu Liu Tao Yin Zhipeng Liu institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin300192China Tianjin institutes of Health Science Tianjin301600China Neuroscience Center Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing100730China

The neuropathological features of Alzheimer’s disease include amyloid *** emerging evidence suggests that Piezo1,a mechanosensitive cation channel,plays a critical role in transforming ultrasound-related mechanical stimuli through its trimeric propeller-like structure,but the importance of Piezo1-mediated mechanotransduction in brain functions is less ***,apart from mechanical stimulation,Piezo1 channels are strongly modulated by *** assume that Piezo1 may play a role in converting mechanical and electrical signals,which could induce the phagocytosis and degradation of Aβ,and the combined effect of mechanical and electrical stimulation is superior to single mechanical ***,we design a transcranial magneto-acoustic stimulation(TmaS)system,based on transcranial ultrasound stimulation(TUS)within a magnetic field that combines a magnetoacoustic coupling effect electric field and the mechanical force of ultrasound,and applied it to test the above hypothesis in 5xFAD *** tests,in vivo electrophysiological recordings,Golgi–Cox staining,enzyme-linked immunosorbent assay,immunofluorescence,immunohistochemistry,real-time quantitative PCR,Western blotting,RNA sequencing,and cerebral blood flow monitoring were used to assess whether TmaS can alleviate the symptoms of AD mouse model by activating Piezo1.

关键词： stimulation Alzheimer Piezo1

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Covalent Organic Framework with Predesigned Single-ion Traps for Highly Efficient Palladium Recovery from Wastes

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CCS Chemistry 2024年第8期6卷 1908-1919页

作者： Yinghui Xie Qiuyu Rong Caimei Wen Xiaolu Liu Mengjie Hao Zhongshan Chen Hui Yang Geoffrey i.N.Waterhouse Shengqian ma Xiangke Wang College of Environmental Science and Engineering North China Electric Power UniversityBeijing 102206 School of Chemical Sciences The University of AucklandAuckland 1142 Department of Chemistry University of North TexasDentonTexas 76201

The recovery of palladium from waste streams is of importance for metal recycling and environmental ***,we present a“single-ion trap”strategy for efficiently recovering Pd(ii)from superacidic solutions and laboratory *** was realized by rational design and synthesis of an antiparallel stacked covalent organic framework(ACOF)with hydrazine-carbonyl sites and pyridine sites for cooperative Pd(ii)*** single-ion traps provided Lewis base sites with a high Pd(ii)binding affinity,enabling the trapping of Pd(ii)ions under a wide range of *** developed ACOF-1 adsorbent demonstrated fast kinetics,excellent selectivity,and a high adsorption capacity of 412.9±14.2 mg/g for Pd(ii)in a 3M HNO_(3) *** applied in a packed column,ACOF-1 dynamically captured Pd(ii)from3M HNO_(3) solutions or laboratorywastes containing trace amounts of palladium and many other metals,realizing extraction efficiencies of 232.9 and 320.9 mg/g,*** experimental and theoretical studies revealed that the single-ion traps offered exceptionally strong binding of Pd(ii)under both acidic and high ionic strength conditions,enabling selective adsorptive behavior not accessible using traditional ***,the general design strategy reported here could be used to create porous adsorbents for the capture of other precious metals.

关键词： antiparallel stacking covalent organic frameworks binding affinity selective adsorption Pd(ii)recovery

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