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A nanoagent for concurrent therapy of breast cancer bone metastasis and cancer-induced bone pain through SLC7A11 interruption and photodynamic therapy

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Chinese Chemical Letters 2024年第2期35卷 295-299页

作者： Qi Fu Zhongming Lian Mengya Niu yaru Huang Yanqiu Ai Long He Dandan Zhang Cuixia Zheng Jian-Jun Yang Lei Wang Dandan Tian Department of Anesthesiology Pain and Perioperative MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Translational Medical Center of Huaihe Hospital Henan UniversityKaifeng 475004China Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationSchool of Pharmaceutical SciencesZhengzhou UniversityZhengzhou 450001China

Bone metastasis,a life-threatening complication of advanced breast cancer,is often accompanied by debilitating pain(cancer-induced bone pain,CIBP)that severely impairs life quality and *** concurrent treatment of bone metastases and CIBP remains a clinical challenge because the therapeutic options are *** this study,we construct a near-infrared light-activated nano-therapeutic system to meet this *** detail,sorafenib(SRF)and photosensitizer(chlorin e6,Ce6)are encapsulated into mesoporous hydroxyapatite nanoparticles(HANPs),which are further functionalized with hyaluronic acid(HA)to obtain HA-SRF/Ce6@HANPs *** designed nanoplatform destroys tumor cells in vitro and in vivo via the synergism of SRF(interrupting the exchange of cystine/glutamate by inhibiting SLC7A11)and photodynamic therapy(PDT,inducing reactive oxygen species generation).The decrease in tumor burden and reduction of extracellular glutamate significantly attenuate CIBP in mice model with developing bone ***,the combination of HA-SRF/Ce6@HANPs and PDT inhibit osteoclasts activation,promote osteoblast differentiation and accelerate bone ***,the nanoagent with good biocompatibility may provide an effective therapy method for the concurrent treatment of breast cancer bone metastasis and CIBP.

关键词： Breast cancer bone metastasis Cancer-induced bone pain Cystine/glutamate antiporter Sorafenib Photodynamic therapy

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Improving VQA via Dual-Level Feature Embedding Network

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Intelligent Automation & Soft Computing 2024年第3期39卷 397-416页

作者： yaru Song Huahu Xu Dikai Fang School of Computer Engineering and Science Shanghai UniversityShanghai200444China

Visual Question Answering(VQA)has sparked widespread interest as a crucial task in integrating vision and *** primarily uses attention mechanisms to effectively answer questions to associate relevant visual regions with input *** detection-based features extracted by the object detection network aim to acquire the visual attention distribution on a predetermined detection frame and provide object-level insights to answer questions about foreground objects more ***,it cannot answer the question about the background forms without detection boxes due to the lack of fine-grained details,which is the advantage of grid-based *** this paper,we propose a Dual-Level Feature Embedding(DLFE)network,which effectively integrates grid-based and detection-based image features in a unified architecture to realize the complementary advantages of both ***,in DLFE,In DLFE,firstly,a novel Dual-Level Self-Attention(DLSA)modular is proposed to mine the intrinsic properties of the two features,where Positional Relation Attention(PRA)is designed to model the position ***,we propose a Feature Fusion Attention(FFA)to address the semantic noise caused by the fusion of two features and construct an alignment graph to enhance and align the grid and detection ***,we use co-attention to learn the interactive features of the image and question and answer questions more *** method has significantly improved compared to the baseline,increasing accuracy from 66.01%to 70.63%on the test-std dataset of VQA 1.0 and from 66.24%to 70.91%for the test-std dataset of VQA 2.0.

关键词： Visual question answering multi-modal feature processing attention mechanisms cross-model fusion

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Heat-inducible SlWRKY3 confers thermotolerance by activating the SlGRXS1 gene cluster in tomato

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Horticultural Plant Journal 2024年第2期10卷 515-531页

作者： Ying Wang Wenxian Gai Liangdan Yuan Lele Shang Fangman Li Zhao Gong Pingfei Ge yaru Wang Jinbao Tao Xingyu Zhang Haiqiang Dong Yuyang Zhang National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops Huazhong Agricultural UniversityWuhanHubei 430070China Hubei Hongshan Laboratory WuhanHubei 430070China

High temperature stress is one of the major environmental factors that affect the growth and development of plants. Although WRKY transcription factors play a critical role in stress responses, there are few studies on the regulation of heat stress by WRKY transcription factors,especially in tomato. Here, we identified a group I WRKY transcription factor, SlWRKY3, involved in thermotolerance in tomato. First, SlWRKY3 was induced and upregulated under heat stress. Accordingly, overexpression of SlWRKY3 led to an increase, whereas knock-out of SlWRKY3 resulted in decreased tolerance to heat stress. Overexpression of SlWRKY3 accumulated less reactive oxygen species(ROS), whereas knock-out of SlWRKY3 accumulated more ROS under heat stress. This indicated that SlWRKY3 positively regulates heat stress in tomato. In addition,SlWRKY3 activated the expression of a range of abiotic stress-responsive genes involved in ROS scavenging, such as a SlGRXS1 gene *** analysis showed that SlWRKY3 can bind to the promoters of the SlGRXS1 gene cluster and activate their expression. Collectively, these results imply that SlWRKY3 is a positive regulator of thermotolerance through direct binding to the promoters of the SlGRXS1 gene cluster and activating their expression and ROS scavenging.

关键词： Tomato WRKY transcription factor SlWRKY3 Thermotolerance SlGRXS1 Gene cluster Abiotic stress

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Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin Luo Caiyan Wei yaru Qiao Jiming Xie Xianchao Pan Juan Xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

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An Intelligent Bridge Multi-Dimension Deflection IoT Monitoring System Based on Laser Datum and Imaging

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Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： Dan Zhao Huifeng Wang Hao Du Haoyi Cheng Lu Peng yaru Liang He Huang Yunmeng Li School of Electronic &Control Engineering Chang'an University Research Institute of Highway Ministry of Transport State Key Laboratory of Traction Power Southwest Jiaotong University

Aiming at the all-weather automatic monitoring of bridge structure health monitoring， an embedded bridge multi-dimensional (horizontal and vertical) deflection monitoring system based on dual laser references is proposed. The controller turns on the laser reference transmitter through instructions to emit the laser reference. The intelligent target system located in the middle of the span will calculate the multi-dimensional deflection and deformation information of the bridge structure according to the laser spot projected on the diffuse optical target， and pass this information through the wireless network communication unit transmits to the cloud platform to realize real-time monitoring of the bridge structure status and other parameters. Through the laboratory platform， it is found that the measurement error of this method is less than 300 μm， and the data update rate is less than 66 ms， which meets the requirements of bridge structural health monitoring. This method solves the problem of low efficiency of artificial bridge deflection monitoring， realizes all-weather online real-time monitoring of bridge deflection detection， and ensures the accuracy and efficiency of the measurement system.

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Molecular characterization and structure basis of a malonyltransferase with both substrate promiscuity and catalytic regiospecificity from Cistanche tubulosa

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2333-2348页

作者： Xiao Liu Yuyu Liu Xiping Xu Wenqian Huang yaru Yan Yingxia Wang Weisheng Tian Ting Mo Xiaoxue Cui Jun Li She-Po Shi Pengfei Tu Modern Research Center for Traditional Chinese Medicine Beijing Research Institute of Chinese MedicineBeijing University of Chinese MedicineBeijing 100029China Modern Research Center for Traditional Chinese Medicine School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing 100029China

Enzymatic malonylation of natural glycosides provides a promising alternative method for drug-like malonylated glycosides ***,the catalytic potential and structural basis of plant malonyltransferase are far from being fully *** work identified a new malonyltransferase CtMaT1 from Cistanche *** displayed unprecedented mono-and/or di-malonylation activity toward diverse glucosides with different aglycons.A“one-pot”system by CtMaT1 and a malonyl-CoA synthetase was established to biosynthesize nine new malonylated *** investigations revealed that CtMaT1 possesses an adequately spacious acyl-acceptor pocket capable of accommodating diverse ***,it recognizes malonyl-CoA through strong electrotactic and hydrogen ***/MM calculation revealed the H167-mediated SN2 reaction mechanism of CtMaT1,while dynamic simulations detected the formation of stable hydrogen bonds between the glucose-6-OH group and H167,resulting in its high malonylation *** energy profiles of two isomeric glycosides highlighted lower reaction energy barriers towards glucoside substrates,emphasizing CtMaT1's preference for ***,a mutant CtMaT1H36A with notably increased di-malonylation activity was *** underlying molecular mechanism was illuminated through MM/GBSA binding free energy *** study significantly advances the understanding of plant acyltransferases from both functional and protein structural perspectives,while also providing a versatile tool for enzymatic malonylation applications in pharmacology.

关键词： Plant acyltransferase Malonyltransferase Malonylated glycosides Enzymatic catalysis Enzyme promiscuity

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钙质砂的SHPB实验技术及其动态力学性能

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爆炸与冲击 2018年第6期38卷 1262-1270页

作者：吕亚茹王明洋魏久淇廖斌河海大学力学与材料学院江苏南京210098 香港科技大学土木与环境学系香港999077 陆军工程大学爆炸冲击防灾减灾国家重点实验室江苏南京210007

开展了11组南海钙质砂和福建石英砂的分离式霍普金森压杆(SHPB)实验,试样相对密实度为90%,厚度分别为10、30和50 mm,得到了冲击荷载下钙质砂和石英砂的应变率时程曲线、应变时程曲线和应力应变关系。实验结果表明:通过严格装样技术可以... 详细信息

开展了11组南海钙质砂和福建石英砂的分离式霍普金森压杆(SHPB)实验,试样相对密实度为90%,厚度分别为10、30和50 mm,得到了冲击荷载下钙质砂和石英砂的应变率时程曲线、应变时程曲线和应力应变关系。实验结果表明:通过严格装样技术可以减小实验设备产生的误差,改变试样厚度、子弹长度、整形器等是实现钙质砂应力平衡和恒应变率的主要手段。在相同的密实度和加载条件下,钙质砂的体积模量和剪切模量约为石英砂的10%,压缩强度和抗剪强度约为石英砂的30%。冲击荷载作用下钙质砂的动态力学性能与石英砂存在较大的差异,因此不能将已有石英砂的研究结果直接用于钙质砂。

关键词：钙质砂霍普金森压杆冲击特性应力应变曲线

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Portable Structure Surface Crack Detection System Based on Android Platform

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Wuhan University Journal of Natural Sciences 2024年第2期29卷 154-164页

作者： WANG Huifeng PENG Haonan TANG Yu GUAN Yueyuan LIANG yaru WANG Lisha ZHAO Yu WANG Xiaoyan GAO Rong HUANG He School of Electronics and Control Engineering Chang'an UniversityXi'an 710000ShaanxiChina Research Institute of Highway Ministry of Transport Beijing 100000China State Key Laboratory of Traction Power Southwest Jiaotong UniversityChengdu 610000SichuanChina Highway School Chang'an UniversityXi'an 710000ShaanxiChina

Cracks,potholes,and other defects often occur on infrastructure such as bridges,among which cracks are one of the most frequent *** have diverse shapes and are difficult to *** manual inspection methods are inefficient and have low accuracy,while automated inspection machines are bulky and inconvenient to carry and *** on the shortcomings of existing detection technologies,this paper proposes a portable structural surface crack detection system based on the Android platform using a portable hand-held image acquisition *** system captures cracks on the structure's surface and obtains high-definition crack ***,these images are transmitted to portable smartphone terminals through ***,the image is pre-processed using weighted averaging,grayscale linear transformation,and adaptive median ***,the improved Canny edge detection algorithm is applied to identify crack information,and the edge segmentation algorithm is used to determine the crack ***,based on camera calibration,the pixels are converted into the length data required for actual *** results show that the system is easy to operate,and it not only has crack storage and tracking functions,but also can effectively measure the crack width on the surface of *** measurement accuracy of this system reaches the sub-pixel level,and in actual testing,compared with the crack width gauge,the maximum relative error does notexceed6.25%.

关键词： structural crack portable image processing detection accuracy crack parameter

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基于点阵离焦估计的三维成像方法

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激光与光电子学进展 2024年第14期61卷 100-110页

作者：陈豪李宏宁赵海高雅孺杨鑫云南师范大学物理与电子信息学院

传统基于调制度测量的三维成像方法需要同步控制正弦条纹的移动和焦距的变化，该方法拍摄数量较多、结构和控制较为复杂。在调制度测量轮廓术基础上提出一种基于点阵离焦估计的三维成像方法。所提方法投影逐步变焦的点阵图样，通过被测... 详细信息

传统基于调制度测量的三维成像方法需要同步控制正弦条纹的移动和焦距的变化，该方法拍摄数量较多、结构和控制较为复杂。在调制度测量轮廓术基础上提出一种基于点阵离焦估计的三维成像方法。所提方法投影逐步变焦的点阵图样，通过被测表面亮度序列的改变提取调制信息，并建立调制序列最大位置与深度的对应关系，从而提取三维信息。详细分析其理论过程，并搭建相应实验平台进行验证。实验结果表明，所提方法能较为准确地恢复物体高度，相比传统方法，结构更简单，控制更方便。

关键词：点阵投影离焦三维测量光学测量调制度

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GhWDL3 is involved in the formation and development of fiber cell morphology in upland cotton(Gossypium hirsutum L.)

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Journal of Cotton Research 2024年第1期7卷 58-68页

作者： CHEN Baojun TIAN Zailong FU Guoyong ZHANG Ai SUN yaru WANG Jingjing PAN Zhaoe LI Hongge HU Daowu XIA Yingying HE Shoupu DU Xiongming Zhengzhou Research Base National Key Laboratory of Cotton Bio-Breeding and Integrated UtilizationZhengzhou UniversityZhengzhouHenan 450001China National Key Laboratory of Cotton Bio-Breeding and Integrated Utilization Institute of Cotton ResearchChinese Academy of Agricultural SciencesAnyangHenan 455000China National Supercomputing Center in Zhengzhou Zhengzhou UniversityZhengzhouHenan 450001China

Background Cotton fiber is a model tissue for studying microtubule-associated proteins(MAPs).The Xklp2(TPX2)proteins that belong to the novel MAPs member mainly participate in the formation and development of microtubule(MT).However,there is a lack of studies concerning the systematic characterization of the TPX2 genes family in ***,the identification and portrayal of *** TPX2 genes can provide key targets for molecular manipula-tion in the breeding of cotton fiber *** In this study,TPX2 family genes were classified into two distinct subclasses TPXLs and MAP genes WAVE DAMP-ENED2-LIKE(WDLs)and quite conservative in ***3 was significantly up-regulated in 15 days post anthe-sis fibers of ZRI-015(an upland cotton with longer and stronger fiber).GhWDL3 promotes all stem hairs to become straight when overexpressed in Arabidopsis,which may indirectly regulate cotton fiber cell morphology during fiber *** induced gene silencing(VIGS)results showed that GhWDL3 inhibited fiber cell elongation at fiber development periods through regulating the expression of cell wall related *** These results reveal that GhWDL3 regulated cotton fiber cell elongation and provide crucial information for the further investigation in the regulatory mechanisms/networks of cotton fiber length.

关键词： Upland cotton GhWDL3 Fiber length TPX2 Cytoskeleton Microtubule-associated proteins(MAPs)

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