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Qili Qiangxin, a compound herbal medicine formula, alleviates hypoxia-reoxygenation-induced apoptotic and autophagic cell death via suppression of ROS/AMPK/mTOR pathway in vitro

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Journal of Integrative Medicine 2022年第4期20卷 365-375页

作者： Cai-lian Fan Wan-jun Cai Meng-nan Ye Miao Chen Yi Dai Department of Cardiology the First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhou 510632Guangdong ProvinceChina College of Pharmacy Jinan UniversityGuangzhou 510632Guangdong ProvinceChina

Objective: Qili Qiangxin(QLQX), a compound herbal medicine formula, is used effectively to treat congestive heart failure in China. However, the molecular mechanisms of the cardioprotective effect are still unclear. This study explores the cardioprotective effect and mechanism of QLQX using the hypoxiareoxygenation(H/R)-induced myocardial injury ***: The main chemical constituents of QLQX were analyzed using high-performance liquid chromatography-evaporative light-scattering detection. The model of H/R-induced myocardial injury in H9c2 cells was developed to simulate myocardial ischemia–reperfusion injury. Apoptosis, autophagy,and generation of reactive oxygen species(ROS) were measured to assess the protective effect of QLQX. Proteins related to autophagy, apoptosis and signalling pathways were detected using Western ***: Apoptosis, autophagy and the excessive production of ROS induced by H/R were significantly reduced after treating the H9c2 cells with QLQX. QLQX treatment at concentrations of 50 and 250 μg/mL caused significant reduction in the levels of LC3Ⅱ and p62 degradation(P < 0.05), and also suppressed the AMPK/mTOR signalling pathway. Furthermore, the AMPK inhibitor Compound C(at 0.5 μmol/L),and QLQX(250 μg/mL) significantly inhibited H/R-induced autophagy and apoptosis(P < 0.01), while AICAR(an AMPK activator, at 0.5 mmol/L) increased cardiomyocyte apoptosis and autophagy and abolished the anti-apoptotic effect of QLQX. Similar phenomena were also observed on the expressions of apoptotic and autophagic proteins, demonstrating that QLQX reduced the apoptosis and autophagy in the H/R-induced injury model via inhibiting the AMPK/mTOR pathway. Moreover, ROS scavenger,N-Acetyl-L-cysteine(NAC, at 2.5 mmol/L), significantly reduced H/R-triggered cell apoptosis and autophagy(P < 0.01). Meanwhile, NAC treatment down-regulated the ratio of phosphorylation of AMPK/AMPK(P < 0.01), which showed a similar effect to ***: QLQX plays a

关键词： Herbal medicine Qili Qiangxin formula Hypoxia–reoxygenation Reactive oxygen species Autophagy Apoptosis AMPK/mTOR pathway

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A bosom friend afar brings a distant land near

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Voice of Friendship 2020年第4期 31-33页

作者： lyu yanxia 不详

From early 2020,the sudden and unprecedented COVID-19 pandemic has been raging around the *** the face of the worst global infectious disease in a century,the Chinese people,led by the Communist Party of China and the Chinese government,have worked in solidarityto fight against the *** strategic results have been achieved in combating the epidemic in China,and in about three months,social life began to return gradually to normal.

关键词： return friend distant

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Spatiotemporal coding of natural odors in the olfactory bulb

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第11期24卷 1057-1061页

作者： Mengxue LIU nan JIANG Yingqian SHI Ping WANG Liujing ZHUANG Biosensor National Special Laboratory Key Laboratory for Biomedical Engineering of Education MinistryDepartment of Biomedical EngineeringZhejiang UniversityHangzhou310027China The MOE Frontier Science Center for Brain Science&Brain-machine Integration Zhejiang UniversityHangzhou310027China State Key Laboratory of Transducer Technology Chinese Academy of SciencesShanghai200050China

Smell that exists in the natural environment is composed of numerous odor molecules(Bushdid et al.,2014).The mammalian olfactory system can accurately identify environmental olfactory cues,including those related to f... 详细信息

关键词： emotional coding Spatiotemporal

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二维编织包芯绳索的结构与拉伸性能

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纺织学报 2012年第3期33卷 48-52页

作者：赵倩娟焦亚男天津工业大学复合材料研究所天津300160 天津工业大学天津市和教育部先进纺织复合材料重点实验室天津300160

针对空间网状可展开天线对高强高模绳索的需求,研制了二维编织包芯结构绳索。采用岛津万能试验机对不同编织工艺参数的试样进行拉伸性能测试,分析包芯绳索不同于其他结构绳索的拉伸断裂机制和破坏模式。结果表明:二维编织包芯结构绳索,... 详细信息

针对空间网状可展开天线对高强高模绳索的需求,研制了二维编织包芯结构绳索。采用岛津万能试验机对不同编织工艺参数的试样进行拉伸性能测试,分析包芯绳索不同于其他结构绳索的拉伸断裂机制和破坏模式。结果表明:二维编织包芯结构绳索,外观均匀,结构稳定,纤维强力利用率高,可以满足绳索高强高模,低延伸率和轻质的要求;编织工艺参数对包芯绳索的强力和断裂伸长率影响较大,编织角大的编织纱对芯纱包缠紧密,芯纱纤维比例大的绳索可以发挥包芯结构的优势;试样在拉伸过程中,芯纱是主要的承力部分,编织纱对芯纱起到束缚和保护作用。

关键词：二维编织包芯绳索 Kevlar49 拉伸性能

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Facile Fabrication of Cellulosic Paper-based Composites with Temperature-controlled Hydrophobicity and Excellent Mechanical Strength

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Paper And Biomaterials 2020年第2期5卷 20-27页

作者： Tongtong Yun Yilin Wang Jie Lu Yi Cheng yanna lyu Haisong Wang School of Light Industry and Chemical Engineering Dalian Polytechnic UniversityDalianLiaoning Province116034China

In this paper,we presented a novel strategy to employ a plantderived carbohydrate polymer,i.e.,cellulose,to prepare a hydrophobic *** was used as a scaffold,and ethylene-propylene side by side(ES)fiber was thermally melted and then coated on the cellulose surface to achieve *** results revealed that the thermocoating ES fibers greatly increased the water contact angle of the cellulose scaffold from 25°to 153°while simultaneously enhanced the wet tensile strength of the composite approximately 6.7-fold(drying temperature of 170℃)compared with the pure cellulose *** particular,compared with other related research,the prepared cellulose-based composite possessed excellent hydrophobicity and superior mechanical strength,which introduces a new chemical engineering approach to prepare hydrophobic cellulose-based functional materials.

关键词： cellulose ES fiber paper-based composites hydrophobicity mechanical strength

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Association of CDH11 with Autism Spectrum Disorder Revealed by Matched-gene Co-expression Analysis and Mouse Behavioral Studies

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Neuroscience Bulletin 2022年第1期38卷 29-46页

作者： nan Wu Yue Wang Jing-yan Jia Yi-Hsuan Pan Xiao-Bing Yuan Key Laboratory of Brain Functional Genomics of Shanghai and the Ministry of Education Institute of Brain Functional GenomicsSchool of Life Science and the Collaborative Innovation Center for Brain ScienceEast China Normal UniversityShanghai200062China Hussman Institute for Autism Baltimore21201USA Department of Anatomy and Neurobiology University of Maryland School of MedicineBaltimore21201USA

A large number of putative risk genes for autism spectrum disorder(ASD)have been *** functions of most of these susceptibility genes in developing brains remain unknown,and causal relationships between their variation and autism traits have not been *** aim of this study was to predict putative risk genes at the whole-genome level based on the analysis of gene co-expression with a group of high-confidence ASD risk genes(hcASDs).The results showed that three gene features–gene size,mRNA abundance,and guanine-cytosine content–affect the genome-wide co-expression profiles of *** circumvent the interference of these features in gene co-expression analysis,we developed a method to determine whether a gene is significantly co-expressed with hcASDs by statistically comparing the co-expression profile of this gene with hcASDs to that of this gene with permuted gene sets of feature-matched *** method is referred to as"matched-gene co-expression analysis"(MGCA).With MGCA,we demonstrated the convergence in developmental expression profiles of hcASDs and improved the efficacy of risk gene *** results of analysis of two recently-reported ASD candidate genes,CDH11 and CDH9,suggested the involvement of CDH11,but not CDH9,in *** with this prediction,behavioral studies showed that Cdh11-null mice,but not Cdh9-null mice,have multiple autism-like behavioral *** study highlights the power of MGCA in revealing ASD-associated genes and the potential role of CDH11 in ASD.

关键词： CDH11 Autism spectrum disorder Gene co-expression analysis Matched-gene co-expression analysis

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Antiferromagnetic element Mn modified PtCo truncated octahedral nanoparticles with enhanced activity and durability for direct methanol fuel cells

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nano Research 2019年第10期12卷 2520-2527页

作者： Qiqi Zhang Jialong Liu Tianyu Xia Jie Qi Haochang lyu Baoyuan Luo Rongming Wang Yizhong Guo Lihua Wang and Shouguo Wang Beijing Advanced Innovation Center for Materials Genome Engineering School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029China Key Laboratory of Material Physics of Ministry of Education School of Physics and EngineeringZhengzhou UniversityZhengzhou 450052China Institute far multidisciplinary Innovation University of Science and Technology BeijingBeijing 100083China Beijng Key Lab cf Microstructure and Property of Advanced Materials Beijing University of TechnologyBeijing 100124China

Pt-based magnetic nano catalysts are one of the most suitable cand idates for electrocatalytic materials due to their high electrochemistry activity and ***,the inferior durability prevents them from being scaled-up,limiting their commercial ***,an antiferromagnetic element Mn was introduced into PtCo nanostructured alloy to synthesize uniform Mn-PtCo truncated octahedral nanoparticles(TONPs)by one-pot *** results show that Mn can tune the blocking temperature of Mn-PtCo TONPs due to its an tiferromag *** low temperatures,Mn-PtCo TONPs are ferromag netic,and the coercivity in creases gradually with in creasi ng Mn *** room temperature,the Mn-PtCo TONPs display superparamag netic behavior,which is greatly helpful for in dustrial *** doping can not only modify the electronic structure of PtCo TONPs but also enhanee electrocatalytic performance for methanol oxidation *** maximum specific activity of Mn-PtCo-3 reaches 8.1 A`m^-2,3.6 times of commercial Pt/C(2.2 A·m^-2)and 1.4 times of PtCo TONPs(5.6 A`m^-2),*** mass activity decreases by only 30%after 2,000 cycles,while it is 45%and 99%(nearly inactive)for PtCo TONPs and commercial Pt/C catalysts,respectively.

关键词： Mn-PtCo trun cated octahedral nano particles an tiferromag netic eleme nt magnetic properties electrocatalytic performa nee

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Highly-sensitive ethanol gas sensor based on poly dimethylsiloxane coated micro-nano fiber

Highly-sensitive ethanol gas sensor based on poly dimethylsi...

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第32届中国控制与决策会议

作者： Bufan Shi yang Sun Wanlu Zheng Naisi Zhu ya-nan Zhang College of Information Science and Engineering Northeastern University

Polydimethylsiloxane（PDMS） was coated on the surface of a non-adiabatic micro-nano fiber,and highly-sensitive ethanol gas concentration measurement was realized based on in-line Mach-Zehnder *** the concentration of ethanol gas changes,the PDMS will swell due to the adsorption characteristic of the PDMS film to ethanol gas,so that the interference wavelength of the micro-nano fiber mode *** monitoring the shift of the resonance wavelength,the concentration of the ethanol gas can be *** results of the ethanol gas sensor in the concentration range of 0-140 ppm show that the sensitivity of the sensor can reach 86.97 pm/ppm.

关键词： Fiber optic sensor PDMS Mach-Zehnder interference Micro-nano fiber Ethanol gas sensor

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Semi-custom methodology to fabricate transmission electron microscopy chip for in situ characterization of nanodevices and nanomaterials

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Science China(Technological Sciences) 2022年第4期65卷 817-825页

作者： YU BoCheng SUN Mei PAN RuHao TIAN JiaMin ZHENG FengYi HUANG Dong lyu FengJiao ZHANG ZhiTong LI JunJie CHEN Qing LI ZhiHong National Key Laboratory of nano/Micro Fabrication Technology School of Integrated CircuitsPeking UniversityBeijing 100871China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Key Laboratory for Physics and Chemistry of nanodevices and Department of Electronics Peking UniversityBeijing 100871China

The fabrication of nanodevices on the delicate membrane window of the TEM(transmission electron microscopy)chip has the risk of breakage failure,limiting in-depth research in this *** work proposed a methodology to address this issue,enabling secure in-situ transmission electron microscopic observation of many devices and materials that would otherwise be difficult to *** semi-custom TEM chip design and front-side protected release technology,a variety of nanodevices were successfully fabricated onto the window membrane of the TEM chip and studied in ***,the pressure tolerance of window membrane was investigated and enhanced with a reinforcing *** an example of typical applications,MoS;devices on the TEM chip have been fabricated and electron beam-induced gate modulation and irradiation damage effects,have been demonstrated.

关键词： in situ TEM TEM chip nanodevice membrane window nanomaterial

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Effects of final rolling temperature and coiling temperature on precipitates and microstructure of high-strength low-alloy pipeline steel

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Journal of Iron and Steel Research International 2022年第8期29卷 1236-1244页

作者： ya-dong Wang Zheng-hua Tang Su-fen Xiao Charles WSiyasiya Tao Wei Department of Materials Science and Engineering Sichuan UniversityChengdu 610065SichuanChina Department of Materials Science and Metallurgical Engineering University of PretoriaPretoria 0028South Africa

The strength-to-weight ratio is an important property of high-strength low-alloy(HSLA)steel in pipeline,whose precipitation strengthening can be *** final rolling temperature(FRT)and coiling temperature(CT)are the key process parameters in the control of precipitates and *** cooling rate was fixed at 10℃/s,and the effects of deformation and coiling temperatures on precipitates and microstructure of Ti-Nb microalloyed HSLA steel were investigated through thermo-mechanical controlled processing on Gleeble *** microstructure is mainly acicular ferrite with high density dislocation and several microns *** size and volume fraction of the precipitates were studied under transmission electron *** results showed that the diameter of the precipitates was in the range between 4 and 240 *** optimized combination of parameters is FRT of 820℃and CT of 550℃,and the volume fraction of precipitates obtained under this process is 0.59%.

关键词： Precipitate Thermo-mechanical controlled processing Final rolling temperature Coiling temperature High-strength low-alloy steel (Ti,Nb)C

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