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Exploration of pathogenic microorganism within the small intestine of necrotizing enterocolitis

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World Journal of Pediatrics 2024年第2期20卷 165-172页

作者： Yan Wang Kun Jiang Qiao Xia Xia Kang Shan Wang Ji-Hong Yu Wen-Feng Ni xiao-Qin Qi Ying-na Zhang Jin-Bao Han Gang Liu Lei Hou Zhi-Chun Feng Liu-Ming Huang Clinical Biobank Center Medical Innovation Research Division of ChinesePLA General HospitalBeijingChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Senior Department of Pediatrics The Seventh Medical Center of PLA General HospitalBeijing 100700China Department of Neurology The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Emergency Center National Center for Children's HealthBeijing Children's HospitalCapital Medical UniversityBeijing 100045China

Background Necrotizing enterocolitis(NEC)is the most common severe gastrointestinal emergency in *** designed this study to identify the pathogenic microorganisms of NEC in the microbiota of the small intestine of *** Using the 16S ribosomal Dna(rDna)sequencing method,we compared and analyzed the structure and diversity of microbiotas in the intestinal feces of different groups of neonates:patients undergoing jejunostomy to treat NEC(NP group),neonates undergoing jejunostomy to treat other conditions(NN group),and neonates with NEC undergoing conservative treatment(NC group).We took intestinal feces and saliva samples from patients at different time *** The beta diversities of the NP,NN,and NC groups were all *** comparing the beta diversities between different time points in the NP group,we found similar beta diversities at time points El to E3 but significant differences between the E2-E3 and E4 time points:the abundances of Klebsiella and Enterococcus(Proteobacteria)were higher at the E1-E3 time points;the abundance of Escherichia-Shigella(Proteobacteria)increased at the E2 time point,and the abundance of Klebsiella decreased significantly,whereas that of Streptococcus increased significantly at the E4 time *** Our results suggest that the pathological changes of intestinal necrosis in the small intestine of infants with NEC are not directly caused by excessive proliferation of pathogenic bacteria in the small *** sources of microbiota in the small intestine of neonates,especially in premature infants,may be affected by multiple factors.

关键词： Microbiota Necrotizing enterocolitis-Small intestine 16S rDna

基于线性结构模型的古塔刚度中心识别方法研究

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工程力学 2024年第6期41卷 154-163,201页

作者：曹笑楠杨娜白凡北京交通大学土木建筑工程学院北京100044 结构风工程与城市风环境北京市重点实验室北京100044

基于动力测试的古塔结构状态评估是其预防性保护工作的重要一环。该文结合动力测试方法,提出了一种基于线性结构模型进行古塔刚度中心识别的方法。基于偏心结构动力学理论凝练了非同轴刚度偏心的古塔计算模型与特征方程;基于Bayesian理... 详细信息

基于动力测试的古塔结构状态评估是其预防性保护工作的重要一环。该文结合动力测试方法,提出了一种基于线性结构模型进行古塔刚度中心识别的方法。基于偏心结构动力学理论凝练了非同轴刚度偏心的古塔计算模型与特征方程;基于Bayesian理论线性结构识别模型的推导及Gibbs抽样开展了结构物理参数识别,并结合经典算例对识别结果进行了验证;将该方法应用到我国重点保护文物开元寺塔的刚度中心识别中。

关键词：古塔结构刚度中心线性结构识别模型 Bayesian理论物理参数识别

Robust autofocusing propagation in turbulence

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Chinese Physics B 2024年第6期33卷 370-375页

作者：刘娜娜谭柳陈凯健洪佩龙莫小明邹炳锁任煜轩梁毅 Guangxi Key Laboratory for Relativistic Astrophysics Center on Nanoenergy ResearchSchool of Physical Science and TechnologyGuangxi UniversityNanning 530004China School of Mathematics and Physics Anqing Normal UniversityAnqing 246133China Institute for Translational Brain Research MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200032China

Turbulence in complex environments such as the atmosphere and biological media has always been a great challenge to the application of beam propagation in optical communication, optical trapping and manipulation. To overcome this challenge, this study comprehensively investigates the robust propagation of traditional Gaussian and autofocusing beams in turbulent environments. In order to select stable beams that exhibit high intensity and high field gradient at the focal position in complex environments, Kolmogorov turbulence theory is used to simulate the propagation of beams in atmospheric turbulence based on the multi-phase screen method. We systematically analyze the intensity fluctuations, the variation of the coherence factor and the change in the scintillation index with propagation distance. The analysis reveals that the intensity fluctuations of autofocusing beams are significantly smaller than those of Gaussian beams, and the coherence of autofocusing beams is better than that of Gaussian beams under turbulence. Moreover, autofocusing beams exhibit less oscillation than Gaussian beams, indicating that autofocusing beams propagate in complex environments with less distortion and intensity fluctuation. Overall, this work clearly demonstrates that autofocusing beams exhibit higher stability in propagation compared with Gaussian beams, showing great promise for applications such as optical trapping and manipulation in complex environments.

关键词： propagation beams autofocusing turbulence

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从工具法到保障法:刑事诉讼法的功能转型

河北学刊 2024年第3期44卷 9-15页

作者：魏晓娜中国人民大学刑事法律科学研究中心

《刑事诉讼法》的制定和历次修改都是统一历史进程的一部分,应当从历史发展中寻找修改的方向。刑事诉讼法曾经被视为阶级斗争的“刀把子”和打击犯罪的工具,程序规则的构建也以专门机关办案为中心,个体行使权利的空间十分有限。以“尊... 详细信息

《刑事诉讼法》的制定和历次修改都是统一历史进程的一部分,应当从历史发展中寻找修改的方向。刑事诉讼法曾经被视为阶级斗争的“刀把子”和打击犯罪的工具,程序规则的构建也以专门机关办案为中心,个体行使权利的空间十分有限。以“尊重和保障人权”入法为标志,刑事诉讼法的功能发生转型,日益成为权利保障法。但迄今为止,这种转型尚未完成,刑事诉讼法中仍遗留不少以“刀把子”思维为底层逻辑的制度。在本轮刑事诉讼法修改中,应当依据权利保障法的定位对这样的制度进行识别并加以改革。

关键词：人权保障强制性措施羁押期限证人出庭

进口与国产血竭的电子鼻检测方法及判别模式研究

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中华中医药杂志 2017年第2期32卷 825-827页

作者：吕晓娜刘杰杨瑶珺李梦王文祎李红霞北京中医药大学中药学院北京100102

目的:利用电子鼻技术研究进口与国产血竭的气味检测方法,采用判别因子分析(DFA)方法,以达到准确、快速鉴别进口与国产血竭的目的。方法:通过正交试验对进口与国产血竭样品粉碎粒度、检测样品量、顶空进样量、孵化时间、孵化温度等重要... 详细信息

目的:利用电子鼻技术研究进口与国产血竭的气味检测方法,采用判别因子分析(DFA)方法,以达到准确、快速鉴别进口与国产血竭的目的。方法:通过正交试验对进口与国产血竭样品粉碎粒度、检测样品量、顶空进样量、孵化时间、孵化温度等重要因素进行筛选,确定进口与国产血竭电子鼻检测的最佳条件;并采用DFA判别模型对数据进行分析。结果:建立了进口与国产血竭的电子鼻检测方法,得到二者气味识别指纹图谱,建立了进口与国产血竭的DFA判别模式。结论:本实验采用电子鼻技术建立了进口与国产血竭准确而快速的鉴别方法,为中药真伪的快速鉴别及气味的科学化、标准化研究提供了新的思路。

关键词：进口血竭国产血竭电子鼻检测方法判别模式

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互惠合作系统的非对称性和不确定性

Journal of Plant Ecology 2024年第1期17卷 172-186页

作者： Rui-Wu Wang An-na Shi xiao-Wei Zhang Min Liu K.Charlotte Jandér Derek W.Dunn School of Ecology and Environment Northwestern Polytechnical UniversityXi’an 710072China Faculty of Education University of MalayaKuala Lumpur 50400Malaysia College of Life Sciences Shaanxi Normal UniversityXi’an 710119China Department of Organismic and Evolutionary Biology Harvard UniversityMA 02138USA College of Life Sciences Northwest UniversityXi’an 710069China

过去的几十年里,尽管对互惠合作系统稳定性的理解取得了较大的进展,但在解释互惠关系如何保持稳定方面仍然存在两个基本问题。(i)如何解决互惠合作双方之间的资源冲突?(ii)当存在不怎么合作和/或完全不合作的共生体时,为什么合作的共生... 详细信息

过去的几十年里,尽管对互惠合作系统稳定性的理解取得了较大的进展,但在解释互惠关系如何保持稳定方面仍然存在两个基本问题。(i)如何解决互惠合作双方之间的资源冲突?(ii)当存在不怎么合作和/或完全不合作的共生体时,为什么合作的共生体没有被不合作的个体竞争排斥掉?过去许多关于互惠稳定性的解释都假设互惠合作双方的相互作用是对称的。然而,在大多数共生关系中,宿主和共生体之间的相互作用在不同水平上表现出不同程度的非对称性。本文我们回顾了互惠合作系统中的三种主要的非对称相互作用:(i)收益非对称,也就是合作双方的实力非对称性;(ii)潜在进化速率非对称性;(iii)宿主和共生体之间的信息非对称性。我们认为,互惠合作系统非对称性有助于解释合作和冲突行为的不确定性(合作与竞争的内生不确定性),以及为什么宿主和共生体都呈现出多样化的表型特征,而合作仍可占主导地位。

关键词：互利共生不对称相互作用宿主惩罚进化速率欺骗

Cytisine N-methylene-(5，7，4’-trihydroxy)-isoflavone induces neural stem cell proliferation and reverses cognitive deficits in early Alzheimer's disease models via canonical Wnt/β-catenin pathway

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Food Science and Human Wellness 2024年

作者： Yang-Yang Lu xiao-Wan Li Zhi-Ping Qin Wen-Jing Sun Yong-Biao Li Shao-Bo Liu Lu Lu Rong-Fei Yang na-na Zhang Yi-Ting Liu Jun Zhang Qing-Shan Liu Key Laboratory of Ethnomedicine for Ministry of Education， Center on Translational Neuroscience， Minzu University of China Center for Life Sciences， School of Life Science and Technology， Harbin Institute of Technology Department of Ophthalmology， Shandong Provincial Hospital Affiliated to Shandong First Medical University

Alzheimer’s disease (AD) is a degenerative disease of the central nervous system. It results in cognitive dysfunction due to the loss of functional neurons and a deficit of new neurons， which can lead to death in severe cases. Repairing damaged neurons by promoting hippocampal neurogenesis has become therapeutic modality to combat neurodegenerative diseases. The novel isoflavone alkaloid LY01， found in the edible fruits of Sophora alopecuroides L.， has various neuroprotective effects. However， the molecular mechanism by which it promotes the proliferation of endogenous neural stem cells (NSCs) is not yet precisely known. The effects of LY01 were investigated in vivo and in vitro. In vivo experiments showed that LY01 could counteract the toxic damage of Aβ， enhance the learning ability and memory capacity of 5×FAD mice， and improve the morphology of neurons in the hippocampal region. In vitro experiments showed that LY01 was effective against antioxidant damage， improved the cell morphology of C17.2 mouse NSCs after hydrogen peroxide injury， and increased cell viability. Both in vitro and in vivo experiments promoted NSC proliferation by upregulating the mRna and protein levels of the critical genes of the Wnt/β-catenin pathway， which increased levels of doublecortin to facilitate new neuronal generation. This indicates that the ability of LY01 to counteract Aβ toxicity and alleviate oxidative damage in early AD is associated with activation of the Wnt/β-catenin signaling pathway to promote NSC proliferation and thus repair damaged neurons.

关键词：

Transcutaneous electrical acupoint stimulation benefits postoperative pain relief of oocyte retrieval:A randomized controlled trial

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Journal of Integrative Medicine 2024年第1期22卷 32-38页

作者： Li-ying Liu Yang Su Rong-rong Wang Yuan-yuan Lai Lei Huang Yi-ting Li Xin-yue Tao Meng-hua Su xiao-yan Zheng Shi-chen Huang Yong-na Wu Si-yi Yu Fan-rong Liang Jie Yang Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu 610000Sichuan ProvinceChina Traditional Chinese Medicine Department Sichuan Jinxin Xi’nan Women's and Children's HospitalChengdu 610000Sichuan ProvinceChina

Background Transvaginal oocyte retrieval is frequently followed by adverse events related to anesthesia and the *** research showed that transcutaneous electrical acupoint stimulation(TEAS)can relieve intraoperative pain and postoperative *** This study examined whether TEAS can alleviate pain and relieve adverse symptoms after oocyte ***,setting,participants and interventions Altogether 128 patients were randomly divided into the TEAS group and the mock TEAS *** two groups received a 30-minute-long TEAS or mock TEAS treatment that began 30 min after oocyte *** outcome measures The primary outcome was the visual analog scale(VAS)pain *** outcomes were pressure pain threshold,McGill score,pain rating index(PRI),present pain intensity(PPI),VAS stress score,VAS anxiety score,and postoperative adverse *** The baseline characteristics of the two groups were comparable(P>0.05).The VAS pain scores of the TEAS group were lower than those of the mock TEAS group at 60 and 90 min after oocyte retrieval(P0.05).The TEAS group was superior to the mock TEAS group for relieving postoperative adverse symptoms(P<0.05).Conclusion TEAS treatment can relieve postoperative pain and postoperative adverse symptoms for patients undergoing oocyte retrieval.

关键词： Transcutaneous electrical acupoint stimulation Fertilization Embryo transfer Oocyte retrieval Pain Randomized controlled trial

有氧运动和白藜芦醇对糖尿病肾病大鼠肾组织炎症和凋亡的影响

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天然产物研究与开发 2024年第6期36卷 946-953页

作者：孙晓娟吴安楠侯娜李娜咸阳师范学院体育学院咸阳712000 西安体育学院研究生部西安710068

探讨有氧运动和白藜芦醇对2型糖尿病大鼠肾组织炎症和凋亡的影响及其作用机制。选取SD大鼠65只,采用高糖高脂喂养结合化学诱导法建立糖尿病大鼠模型,将大鼠随机分为模型组、运动组、药物组和运动药物组,设立对照组。运动组大鼠完成连续... 详细信息

探讨有氧运动和白藜芦醇对2型糖尿病大鼠肾组织炎症和凋亡的影响及其作用机制。选取SD大鼠65只,采用高糖高脂喂养结合化学诱导法建立糖尿病大鼠模型,将大鼠随机分为模型组、运动组、药物组和运动药物组,设立对照组。运动组大鼠完成连续8周的跑台运动,药物组大鼠采用白藜芦醇药液灌胃,每天给药1次,连续8周。8周结束,测血糖、24 h尿白蛋白(24 hours urine protein,24 h-UP)定量、血肌酐(serum creatinine,Scr)和血尿素氮(blood urea nitrogen,BUN)等指标变化;TUNEL法检测肾组织细胞凋亡数量;ELISA检测与炎症反应有关白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-1β(interleukin-1β,IL-1β)的表达;免疫组化法检测凋亡因子B淋巴细胞瘤-2(B cell lymphoma-2,Bcl-2)、Bcl-2相关X蛋白质(Bcl-2-associated X protein,Bax)、半胱天冬蛋白酶-3(cysteinyl aspartate specific proteinase 3,Caspase-3)的表达水平;蛋白免疫印迹(Western blot)法检测信号通路蛋白NF-κBp65的表达水平。结果显示,与对照组比较,模型组的Scr、BUN、血糖、24 h尿蛋白、炎症相关因子IL-6、IL-1β、TNF-α水平升高(P<0.05);肾脏细胞凋亡明显增多,肾脏Bax、Caspase-3、信号通路蛋白NF-κBp65表达显著上升,Bcl-2表达明显下降(P<0.05)。分别施与有氧运动与白藜芦醇干预,运动组、药物组和运动药物组的Scr、BUN、血糖、24 h尿蛋白、IL-6、IL-1β、TNF-α水平均有不同程度的下降(P<0.05);肾脏细胞凋亡明显减少,Bax、Caspase-3、NF-κBp65表达显著下降(P<0.05),Bcl-2表达显著升高(P<0.05),且运动药物组的变化更明显。研究结果提示有氧运动、白藜芦醇单独或联合干预对糖尿病肾病大鼠肾脏有一定的保护作用,其机制可能与抑制NF-κBp65的活化,降低炎症因子水平,抑制肾脏细胞凋亡有关。有氧运动联合白藜芦醇干预减轻肾脏病理损伤的效果优于单一的有氧运动或白藜芦醇干预。

关键词： 2型糖尿病有氧运动白藜芦醇炎症细胞凋亡