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Bat-derived oligopeptide LE6 inhibits the contact-kinin pathway and harbors anti-thromboinflammation and stroke potential

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Zoological Research 2024年第5期45卷 1001-1012页

作者： Li-na Cha Juan Yang Jin-Ai Gao Xin Lu xiao-Long Chang Rebecca Caroline Thuku Qi Liu Qiu-Min Lu Dong-Sheng Li Ren Lai Ming-Qian Fang Engineering Laboratory of Peptides of Chinese Academy of Sciences Key Laboratory of Bioactive Peptides of Yunnan ProvinceKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesNational Resource Center for Non-Human PrimatesNational Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Key Laboratory of Genetic Evolution&Animal ModelsSino-African Joint Research Centerand New Cornerstone Science LaboratoryKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China School of Molecular Medicine Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China First Affiliated Hospital of Kunming Medical University KunmingYunnan 650032China

Thrombosis and inflammation are primary contributors to the onset and progression of ischemic *** contact-kinin pathway,initiated by plasma kallikrein(PK)and activated factor XII(FXIIa),functions bidirectionally with the coagulation and inflammation cascades,providing a novel target for therapeutic drug development in ischemic *** this study,we identified a bat-derived oligopeptide from Myotis myotis(Borkhausen,1797),designated LE6(Leu-Ser-Glu-Glu-Pro-Glu,702 Da),with considerable potential in stroke therapy due to its effects on the contact kinin ***,LE6 demonstrated significant inhibitory effects on PK and FXIIa,with inhibition constants of 43.97μmol/L and 6.37μmol/L,*** vitro analyses revealed that LE6 prolonged plasma recalcification time and activated partial thromboplastin *** murine models,LE6 effectively inhibited carrageenan-induced mouse tail thrombosis,FeCl3-induced carotid artery thrombosis,and photochemically induced intracerebral ***,LE6 significantly decreased inflammation and stroke injury in transient middle cerebral artery occlusion ***,the low toxicity,hemolytic activity,and bleeding risk of LE6,along with its synthetic simplicity,underscore its clinical *** conclusion,as an inhibitor of FXIIa and PK,LE6 offers potential therapeutic benefits in stroke treatment by mitigating inflammation and preventing thrombus formation.

关键词： PK FXIIa Anti-thromboinflammation Ischemic stroke therapies Oligopeptide

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难点注意力感知红外小目标检测网络

中国光学（中英文） 2024年第3期17卷 538-547页

作者：王伯霄宋延嵩董小娜长春理工大学光电工程学院吉林长春130000 长春理工大学空间光电技术研究所吉林长春130000

随着飞行器机动性能的提升,多帧红外小目标检测方法不足以满足检测要求。近年来,基于深度学习的单帧红外小目标检测方法取得了巨大成功。然而,红外小目标通常缺少形状特征,而且边界与背景模糊不清,给准确分割带来了一定的挑战。针对上... 详细信息

随着飞行器机动性能的提升,多帧红外小目标检测方法不足以满足检测要求。近年来,基于深度学习的单帧红外小目标检测方法取得了巨大成功。然而,红外小目标通常缺少形状特征,而且边界与背景模糊不清,给准确分割带来了一定的挑战。针对上述问题,本文提出难点注意力感知红外小目标检测网络。通过基于点的区域建议模块获取目标潜在区域,同时滤除多余背景。为实现高质量分割、细化掩码边界模块、判断粗掩码中无序、非局部难以分辨点,融合这些难点的多尺度特征,进行逐像素注意力建模。最后,由点检测头对难点注意力感知特征重新预测,生成精细分割掩码。在公开数据集NUDT-SIRST和IRDST上进行测试,平均精度均值mAP达到87.4和63.4,F值达到0.8935和0.7056。本文提出的难点注意力感知红外小目标检测网络可在多检测场景、多目标形态下实现准确分割,抑制误报信息,同时控制计算开销。

关键词：目标检测深度学习红外成像红外小目标检测注意力机制

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Gestational diabetes mellitus combined with fulminant type 1 diabetes mellitus, four cases of double diabetes: A case report

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World Journal of Clinical Cases 2024年第4期12卷 787-794页

作者： Hui Li Yun Chai Wei-Hong Guo Yu-Meng Huang xiao-na Zhang Wen-Li Feng Qing He Jin Cui Ming Liu Department of Endocrinology and Metabolism Tianjin Medical University General HospitalTianjin 300052China

BACKGROUND Fulminant type 1 diabetes mellitus(FT1DM)that occurs during pregnancy or the perinatal period is known as pregnancy-related FT1DM(PF),always without history of abnormal glucose ***,we present four patients who developed FT1DM during treatment but were first diagnosed with gestational diabetes mellitus(GDM).CASE SUMMARY The clinical data of four patients with GDM combined with FT1DM admitted to our hospital between July 2018 and April 2021 were collected,and the patients and their infants were followed *** patients were diagnosed with GDM during the second trimester and were *** blood glucose level elevated suddenly during the third trimester and then were diagnosed with *** patients had an insulin allergy,and two had symptoms of upper respiratory tract infection before *** patient developed ketoacidosis,and three developed *** patients had cesarean section deliveries,and two had vaginal *** growth and development of the infants were normal.C-peptide levels were lower than those at onset,suggesting progressive impairment of islet *** frequencies of the DRB109:01,DQB103:03,DQA103:02,DPA101:03,DPA102:02,DPB105:01,DRB401:03,G 01:01,and G 01:04 human leukocyte antigen(HLA)-G alleles were high in the present *** In comparison with pregnancy-associated FT1DM(PF),patients with GDM combined with FT1DM had an older age of onset,higher body mass index,slower onset,fewer prodromal symptoms,and less *** pathogenesis may be due to various factors affecting the already fragileβ-cells of GDM patients with genetically susceptible class II HLA *** speculate that GDM combined with FT1DM during pregnancy,referred to as“double diabetes,”is a subtype of PF with its own unique characteristics that should be investigated further.

关键词： Fulminant type 1 diabetes mellitus Gestational diabetes mellitus Pregnancy-related fulminant type 1 diabetes mellitus Double diabetes Case report

Effect of psychological nursing intervention on anxiety level and quality of life in patients with gastrointestinal peptic ulcer

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2953-2960页

作者： xiao-Rong Zhang Yan-Song Li Ya-na Xu Department of Neurology Wuhan Fourth HospitalWuhan 430030Hubei ProvinceChina Department of Nursing Bengbu Railway Police CollegeBengbu 233000Anhui ProvinceChina

BACKGROUND Peptic ulcer is a common gastrointestinal disease,and psychological intervention has an important influence on its occurrence and *** To investigate the effect of psychological nursing intervention on the anxiety level and quality of life of patients with gastrointestinal peptic *** Two groups of patients with peptic ulcer were selected from January to December 2012,with 60 cases in each group,and psychological nursing intervention and routine treatment were respectively *** nursing interven-tions include cognitive behavioral therapy,psychological support and relaxation ***-rating anxiety scale(SAS)and quality of life questionnaire were used to evaluate the anxiety level and quality of life of patients before,during and after *** The SAS scores of the experimental group significantly decreased over the course of treatment,from 52.3 before treatment to 30.5 after treatment,while SAS scores of the control group did not change ***,the experimental group's quality of life score(SF-36)significantly improved over the course of treatment,from 65.2 to 85.2,while the control group remained *** analysis showed that sex and age had no significant influence on the effect of *** men and women,young and old,showed similar trends in anxiety relief and improved quality of life after *** Psychological nursing-based intervention program has a positive effect on the anxiety level and quality of life of patients with gastrointestinal peptic ulcer.

关键词： Gastrointestinal peptic ulcer Psychological nursing Anxiety level Quality of life Cognitive behavioral therapy

Association of tumor budding with clinicopathological features and prognostic value in stage III-IV colorectal cancer

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World Journal of Gastroenterology 2024年第2期30卷 158-169页

作者： Yue-Hao Luo Zhe-Cheng Yan Jia-Ying Liu Xin-Yi Li Ming Yang Jun Fan Bo Huang Cheng-Gong Ma xiao-na Chang Xiu Nie Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

BACKGROUND Tumor budding(TB)has emerged as a promising independent prognostic biomarker in colorectal cancer(CRC).The prognostic role of TB has been extensively studied and currently affects clinical decision making in patients with stage I and II ***,existing prognostic studies on TB in stage III CRC have been confined to small retrospective cohort ***,this study investigated the correlation among TB categories,clinicopathological features,and prognosis in stage III-IV CRC to further enhance the precision and individualization of treatment through refined prognostic risk *** To analyze the relationship between TB categories and clinicopathological characteristics and assess their prognostic value in stage III-IV CRC to further refine the prognostic risk stratification of stage III-IV *** The clinical data of 547 CRC patients were collected for this retrospective *** at the front edge of the tumor buds was counted according to the 2016 International Tumor Budding Consensus Conference *** Multivariate Cox proportional hazards regression analysis demonstrated that chemotherapy(P=0.004),clinical stage IV(Pnal lymph node metastases(P=0.004),left-sided colonic cancer(P=0.040),and Bd 2-3(P=0.002)were independent prognostic factors in patients with stage III-IV ***,the density of tumor infiltrating lymphocytes was higher in Bd 1 than in Bd 2-3,both in the tumor stroma and its invasive *** TB has an independent predictive prognostic value in patients with stage III-IV *** is recommended to complete the TB report of stage III-IV CRC cases in the standardized pathological report to further refine risk stratification.

关键词： Tumor budding Tumor infiltrating lymphocytes Colorectal cancer Survival analysis Prognosis

How to manage and avoid revision after unicompartmental knee arthroplasty?

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World Journal of Clinical Cases 2024年第31期12卷 6428-6430页

作者： na Hao Ke-xiao Yu Jin-Wei Ran Department of Orthopedics Chongqing Hospital of Traditional Chinese MedicineChongqing 400021China

The article by Zhao et al presents a retrospective case series on the reasons for initial revision after unicompartmental knee arthroplasty(UKA).Clarifying the reasons that may cause UKA revision can further reduce the rate of revision UKA,focusing on gasket dislocation,osteophytes,intra-articular loose bodies,and tibial prosthesis *** article provides valuable insights,not only by detailing the revision status of 13 patients who underwent revision after initial UKA but also by providing a comprehensive analysis of the incidence of revision after initial *** reviewing and analyzing the causes,they established references for the early detection of risk factors for revision in clinical practice and for formulating surgical strategies and rehabilitation *** commentary emphasizes the need for a meticulous understanding and an analysis of the revision rate following initial UKA and related management *** implant rates,regional variation,and benefits of uncemented Oxford UKA have been explored,particularly in terms of bone preservation,appropriate surgical techniques,and weight management to control complications and improve patient prognosis.

关键词： Unicompartmental knee arthroplasty First revision Incidence Complications Editorial

Opportunities for production and property research of neutron-rich nuclei around N=126 at HIAF

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Nuclear Science and Techniques 2024年第6期35卷 101-113页

作者： Shao-Bo Ma Li-na Sheng Xue-Heng Zhang Shi-Tao Wang Kai-Long Wang Chun-Wang Ma Hool-Jin Ong Zhi-Yu Sun Shu-Wen Tang Yu-Hong Yu Xin-Tong Du xiao-Bao Wei Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China University of Chinese Academy of Sciences Beijing 100049China College of Physics Henan Normal UniversityXinxiang 453007China Institute of Nuclear Science and Technology Henan Academy of ScienceZhengzhou 450046China Joint-Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsLanzhou 730000China Research Center for Nuclear Physics Osaka UniversityOsaka 567-0047Japan RIKEN Nishina Center Saitama 351-0198Japan Northwest Normal University Lanzhou 730070China

The study of nuclide production and its properties in the N=126 neutron-rich region is prevalent in nuclear physics and astrophysics *** upcoming High-energy FRagment Separator(HFRS)at the High-Intensity heavy-ion Accelerator Facility(HIAF),an in-flight separator at relativistic energies,is characterized by high beam intensity,large ion-optical acceptance,high magnetic rigidity,and high momentum resolution *** provides an opportunity to study the production and properties of neutron-rich nuclei around N=*** this paper,an experimental scheme is proposed to produce neutron-rich nuclei around N=126 and simultaneously measure their mass and lifetime based on the HFRS separator;the feasibility of this scheme is evaluated through *** results show that under the high-resolution optical mode,many new neutron-rich nuclei approaching the r-process abundance peak around A=195 can be produced for the first time,and many nuclei with unknown masses and lifetimes can be produced with high *** the time-of-flight corrected by the measured dispersive position and energy loss information,the cocktails produced from 208 Pb fragmentation can be unambiguously ***,the masses of some neutron-rich nuclei near N=126 can be measured with high precision using the time-of-flight magnetic rigidity *** indicates that the HIAF-HFRS facility has the potential for the production and property research of neutron-rich nuclei around N=126,which is of great significance for expanding the chart of nuclides,developing nuclear theories,and understanding the origin of heavy elements in the universe.

关键词： HFRS Fragmentation Neutron-rich nuclei around N=126 Mass measurement Lifetime

Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways

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Military Medical Research 2024年第4期11卷 500-520页

作者： Kun Zhang Meng-Xia Zhang xiao-Xiang Meng Jing Zhu Jia-Jun Wang Yi-Fan He Ye-Hua Li Si-Cong Zhao Zhe-Min Shi Li-na Zheng Tao Han Wei Hong Department of Histology and Embryology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Department of Hepatology and Gastroenterology Tianjin Union Medical CenterTianjin Medical UniversityTianjin Union Medical Center Affiliated to Nankai UniversityTianjin 300000China

Background:G-protein coupled receptors(GPCRs)are recognized as attractive targets for drug ***,it remains poorly understood how GPCRs,except for a few chemokine receptors,regulate the progression of liver ***,we aimed to reveal the role of GPR65,a proton-sensing receptor,in liver fibrosis and to elucidate the underlying ***:The expression level of GPR65 was evaluated in both human and mouse fibrotic ***,Gpr65-deficient mice were treated with either bile duct ligation(BDL)for 21 d or carbon tetrachloride(CCl4)for 8 weeks to investigate the role of GPR65 in liver fibrosis.A combination of experimental approaches,including Western blotting,quantitative real-time reverse transcription-polymerase chain reaction(qRT-PCR),and enzyme-linked immunosorbent assay(ELISA),confocal microscopy and rescue studies,were used to explore the underlying mechanisms of GPR65’s action in liver ***,the therapeutic potential of GPR65 inhibitor in the development of liver fibrosis was ***:We found that hepatic macrophage(HM)-enriched GPR65 was upregulated in both human and mouse fibrotic ***,knockout of Gpr65 significantly alleviated BDL-and CCl4-induced liver inflammation,injury and fibrosis in vivo,and mouse bone marrow transplantation(BMT)experiments further demonstrated that the protective effect of Gpr65knockout is primarily mediated by bone marrow-derived macrophages(BMMs).Additionally,in vitro data demonstrated that Gpr65 silencing and GPR65 antagonist inhibited,while GPR65 overexpression and application of GPR65 endogenous and exogenous agonists enhanced the expression and release of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and transforming growth factor-β(TGF-β),all of which subsequently promoted the activation of hepatic stellate cells(HSCs)and the damage of hepatocytes(HCs).Mechanistically,GPR65 overexpression,the acidic pH and GPR65 exogenous agonist induced up-regulation of

关键词： GPR65 Hepatic fibrosis Hepatic macrophages Inflammation c-Jun N-terminal kinase Nuclear factorκB

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城市开通高铁能否吸引入境旅游

国际贸易问题 2024年第7期 91-105页

作者：肖挺郭娜江西财经大学国际经贸学院

本文以高铁开通的“准自然实验”为契机,选取中国地级城市的面板数据,采用双重差分法评估了城市开通高铁对吸引境外游客入境旅游的作用。研究发现,高铁显著带动了城市入境旅游业的发展,通过引入工具变量进行内生性处理后的结果依然稳健... 详细信息

本文以高铁开通的“准自然实验”为契机,选取中国地级城市的面板数据,采用双重差分法评估了城市开通高铁对吸引境外游客入境旅游的作用。研究发现,高铁显著带动了城市入境旅游业的发展,通过引入工具变量进行内生性处理后的结果依然稳健。异质性检验结果表明,相比于中西部地区,高铁对于东部地区入境旅游外汇收入以及游客人数的正向作用更为突出。此外,作为交通节点的城市,其向外发散的高铁路线数量也会对该市入境旅游业的发展产生不同程度的影响;不同时速的高速铁路对入境旅游的影响存在差异。机制检验表明,高铁主要通过提高城市的对外开放水平和服务供给水平来带动入境旅游业发展。文本的研究丰富了运输经济学的理论应用,为我国入境旅游业发展提供了重要的现实依据。

关键词：高铁入境旅游对外开放水平交通节点