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SARS-CoV-2 infection in people with pre-existing liver disease:Further research is warranted

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World Journal of Gastroenterology 2021年第45期27卷 7855-7858页

作者： Henu Kumar Verma LVKS Bhaskar Department of Immunopathology Institute of lungs Biology and DiseaseComprehensive Pneumology CenterNeuherberg 85764MunichGermany Zoology Guru Ghasidas VishwavidyalayaBilaspur 495001ChhattisgarhIndia

Patients with severe liver disease who have been infected with severe acute respiratory syndrome coronavirus-2(coronavirus disease 2019)frequently develop acute respiratory distress syndrome and multiple organ failure,with a high mortality rate,as a result of the hyper-proinflammatory state known as the cytokine storm.Clinicians must recognize cytokine storms earlier to avoid intensive care admission and multi-organ damage,a critical life-threatening condition with prognostic and therapeutic implications.

关键词： Cytokine storm Liver disease Angiotensin-converting enzyme 2 Therapeutics Inflammatory markers

Gender differences in the relationship between alcohol consumption and gastric cancer risk are uncertain and not well-delineated

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 2216-2218页

作者： Henu Kumar Verma LVKS Bhaskar Department of Immunopathology Institute of lungs Biology and DiseaseComprehensive Pneumology CenterHelmholtz ZentrumNeuherberg 85764MunichGermany Department of Zoology Guru Ghasidas VishwavidyalayaBilaspur 495001ChhattisgarhIndia

The role of alcoholic and other beverage consumption in the etiology of gastric cancer is unknown.Several studies have summarized and established a significant association between heavy alcohol consumption and gastric... 详细信息

关键词： Alcohol Gastric cancer Meta-analysis Gender and alcohol intake Alcohol consumption

Viral hepatitis: A global burden needs future directions for the management

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World Journal of Gastroenterology 2022年第16期28卷 1718-1721页

作者： Henu Kumar Verma Kiran Prasad Pramod Kumar bhaskar lvks Department of Immunopathology Institute of Lungs Biology and DiseaseComprehensive Pneumology CenterHelmholtz ZentrumMunich 80331BayrenGermany Department of Zoology Guru Ghasidas VishwavidyalayaBilaspur 495001ChhattisgarhIndia Department of Drug Delivery Institute of Lung Biology and DiseaseHelmholtz Research CenterMunich 80331BayrenGermany

Viral hepatitis is an acute or chronic liver disease due to the infection from Hepatitis A,B,C,D and E viruses.It can cause severe liver damage such as cirrhosis,liver failure and liver cancer.To avoid such fatal complications,hepatitis patients must be diagnosed,pathologized and treated as soon as possible.Furthermore,these hepatitis viruses infect through different routes,resulting in distinct disease pathologies,severity and even the need for specific treatment strategies to combat the infection.

关键词： Viral hepatitis Vaccination Chronic Acute Viral therapy

Management of SARS-CoV-2 infection is a major challenge in patients with lymphoid malignancies: Warrants a clear therapeutic strategy

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World Journal of Virology 2022年第4期11卷 204-207页

作者： Tarun Sahu Henu Kumar Verma bhaskar lvks Physiology All India Institute of Medical ScienceRaipur 492001ChhattisgarhIndia Department of Immunopathology Institute of Lung Health and ImmunityComprehensive Pneumology CenterHelmholtz ZentrumMunich 80331BayrenGermany Zoology Guru Ghasidas VishwavidyalayaBilaspur 495001ChhattisgarhIndia

Patients with lymphoid malignancies are at a higher risk of coronavirus disease 2019(COVID-19)infection due to their immunocompromised state and results in higher mortality rates in these patients.Anti-CD 20 therapy is one of the leading causes of immunosuppression that worsens in COVID-19 cases.COVID-19 vaccines,on the other hand,appear to be less beneficial to these patients.Appropriate treatment and recommendations are required for these COVID-19 patients with lymphoid malignancies.

关键词： COVID-19 Lymphoid malignancy Lymphoma Vaccination Immunosuppression

Emerging perspectives on RNA virus-mediated infections:from pathogenesis to therapeutic interventions

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World Journal of Virology 2023年第5期12卷 242-255页

作者： Pratik Mohanty Poojarani Panda Rakesh Kumar Acharya Babita Pande LVKS Bhaskar Henu Kumar Verma Department of Bioscience and Bioengineering Indian Institute of TechnologyGuwahati 781039AssamIndia Life Science National Institute of TechnologyRourkela 769008OdishaIndia Department of Zoology Guru Ghasidas VishwavidyalayaBilaspurBilaspur 495009ChhattisgarhIndia Department of Physiology All India Institute of Medical ScienceRaipur 492001chhattisgarhIndia Lung Health and Immunity Helmholtz Zentrum MunichMunich 85764BayrenGermany

RNA viruses continue to pose significant threats to global public health,necessitating a profound understanding of their pathogenic mechanisms and the development of effective therapeutic interventions.This manuscript provides a comprehensive overview of emerging perspectives on RNA virus-mediated infections,spanning from the intricate intricacies of viral pathogenesis to the forefront of innovative therapeutic strategies.A critical exploration of antiviral drugs sets the stage,highlighting the diverse classes of compounds that target various stages of the viral life cycle,underscoring the ongoing efforts to combat viral infections.Central to this discussion is the exploration of RNA-based therapeutics,with a spotlight on messenger RNA(mRNA)-based approaches that have revolutionized the landscape of antiviral interventions.Furthermore,the manuscript delves into the intricate world of delivery systems,exploring innovative technologies designed to enhance the efficiency and safety of mRNA vaccines.By analyzing the challenges and advancements in delivery mechanisms,this review offers a roadmap for future research and development in this critical area.Beyond conventional infectious diseases,the document explores the expanding applications of mRNA vaccines,including their promising roles in cancer immunotherapy and personalized medicine approaches.This manuscript serves as a valuable resource for researchers,clinicians,and policymakers alike,offering a nuanced perspective on RNA virus pathogenesis and the cutting-edge therapeutic interventions.By synthesizing the latest advancements and challenges,this review contributes significantly to the ongoing discourse in the field,driving the development of novel strategies to combat RNA virus-mediated infections effectively.

关键词： RNA virus Infections Therapeutics Drug target Pathogenesis