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Micromechanism and mathematical model of stress sensitivity in tight reservoirs of binary granular medium

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Petroleum Science 2024年第3期21卷 1780-1795页

作者： Jian-Bang Wu Sheng-Lai Yang Qiang Li Kun Yang Can Huang Dao-ping lv Wei Zhou State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing2249China Laboratoire de G eologie Ecole Normale Sup erieure/CNRS UMR8538PSL Research UniversityParis75005France Research Institute of Exploration and Development Xinjiang Oilfield CompanyKaramay834000XinjiangChina

Research on reservoir rock stress sensitivity has traditionally focused on unary granular structures,neglecting the binary nature of real reservoirs,especially tight *** the stresssensitive behavior and mathematical characterization of binary granular media remains a challenging *** this study,we conducted online-NMR experiments to investigate the permeability and porosity evolution as well as stress-sensitive control mechanisms in tight sandy conglomerate *** results revealed stress sensitivity coefficients between 0.042 and 0.098 and permeability damage rates ranging from 65.6%to 90.9%,with an average pore compression coefficient of 0.0168—0.0208 MPa ***-scale compression occurred in three stages:filling,compression,and compaction,with matrix pores playing a dominant role in pore *** stress sensitivity of binary granular media was found to be influenced by the support structure and particle *** stress sensitivity was associated with small fine particle size,high fines content,high uniformity coefficient of particle size,high plastic deformation,and low Young's ***-supported samples exhibited a high irreversible permeability damage rate(average=74.2%)and stress sensitivity coefficients(average=0.089),with pore spaces more *** contrast,grain-supported samples showed low stress sensitivity coefficients(average=0.021)at high stress *** on the experiments,we developed a mathematical model for stress sensitivity in binary granular media,considering binary granular properties and nested interactions using Hertz contact deformation and Poiseuille *** describing the change in activity content of fines under stress,we characterized the non-stationary state of compressive deformation in the binary granular structure and classified the reservoir into three *** model was applied for production prediction using actual data from the Mahu reservoir in China,showing that the e

关键词： Stress sensitivity Binary granular medium Tight reservoir Online-NMR Reservoir energy retention rate

Application of neutrophil-lymphocyte ratio and red blood cell distribution width in diabetes mellitus complicated with heart failure

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World Journal of Diabetes 2024年第6期15卷 1226-1233页

作者： Jie Pang Lin-Yan Qian ping lv Xiao-Ru Che Heart Center Department of Cardiovascular MedicineZhejiang Provincial People’s Hospital(The Affiliated People’s Hospital)Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Accumulating clinical evidence has shown that diabetes mellitus(DM)is a serious risk factor for cardiovascular disorders and an important factor for adverse cardiovascular *** To explore the value of the combined determination of the neutrophil-lymphocyte ratio(NLR)and red blood cell distribution width(RDW)in the early diagnosis and prognosis evaluation of DM complicated with heart failure(HF).METHODS We retrospectively analyzed clinical data on 65 patients with type 2 DM(T2DM)complicated with HF(research group,Res)and 60 concurrent patients with uncomplicated T2DM(control group,Con)diagnosed at Zhejiang Provincial People’s Hospital between January 2019 and December *** NLR and RDW values were determined and comparatively analyzed,and their levels in T2DM+HF patients with different cardiac function grades were *** receiver operating characteristic(ROC)curves were plotted to determine the NLR and RDW values(alone and in combination)for the early diagnosis of *** correlation between NLR and RDW with the presence or absence of cardiac events was also *** Higher NLR and RDW levels were identified in the Res vs the Con groups(P<0.05).The NLR and RDW increased gradually and synchronously with the deterioration of cardiac function in the Res group,with marked differences in their levels among patients with grade II,III,and IV HF(P<0.05).ROC curve analysis revealed that NLR combined with RDW detection had an area under the curve of 0.915,a sensitivity of 76.9%,and a specificity of 100%for the early diagnosis of ***,HF patients with cardiac events showed higher NLR and RDW values compared with HF patients without cardiac *** NLR and RDW were useful laboratory indicators for the early diagnosis of DM complicated with HF,and their joint detection was beneficial for improving diagnostic ***,NLR and RDW values were directly proportional to patient outcomes.

关键词： Neutrophil-lymphocyte ratio Red blood cell distribution width Type 2 diabetes Heart failure Early diagnosis

Expression level of myocardial enzymes in patients with schizophrenia: Predictive value in the occurrence of violence

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World Journal of Psychiatry 2024年第9期14卷 1346-1353页

作者： Wei-Min He Xin-Yuan Zhang Wei-Gen Xie Dan-ping lv Qun-Di Shen Department of Rehabilitation Ward Shaoxing Seventh People's HospitalShaoxing 312000Zhejiang ProvinceChina Department of Laboratory Shaoxing Seventh People's HospitalShaoxing 312000Zhejiang ProvinceChina Department of Medical Shaoxing Seventh People's HospitalShaoxing 312000Zhejiang ProvinceChina Department of General Affairs Shaoxing Seventh People's HospitalShaoxing 312000Zhejiang ProvinceChina

BACKGROUND Schizophrenic patients are prone to violence,frequent recurrence,and difficult to *** and behavioral abnormalities during the onset of the disease,resulting in active myocardial enzyme *** To explored the expression level of myocardial enzymes in patients with schizo-phrenia and its predictive value in the occurrence of *** A total of 288 patients with schizophrenia in our hospital from February 2023 to January 2024 were selected as the research object,and 100 healthy people were selected as the control ***’information,clinical data,and labo-ratory examination data were *** to Modified Overt Aggression Scale score,patients were further divided into the violent(123 cases)and non-violent group(165 cases).RESULTS The comparative analysis revealed significant differences in serum myocardial enzyme levels between patients with schizophrenia and healthy *** the schizophrenia group,the violent and non-violent groups also exhibited different levels of serum myocardial *** levels of myocardial enzymes in the non-violent group were lower than those in the violent group,and the patients in the latter also displayed aggressive behavior in the *** Previous aggressive behavior and the level of myocardial enzymes are of great significance for the diagnosis and prognosis analysis of violent behavior in patients with *** detecting changes in these indicators,we can gain a more comprehensive understanding of a patient’s condition and treatment.

关键词： Schizophrenia Myocardial enzyme index Act of violence Predict Violence prediction Aggressive behavior Clinical data analysis Biochemical markers

Enhanced activation of peroxymonosulfate on layered molybdenum disulfide loaded with Co–La bimetallic oxide for efficient degradation of chloramphenicol

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Rare Metals 2024年第9期43卷 4628-4635页

作者： Yu-Ning Fan Yun-Qiu Zhang San-Shuang Gao Zeng-Hui Bi Yin Wang Shu-Xing Zhou Qian Liu Tian-ping lv Guang-Zhi Hu Institute for Ecological Research and Pollution Control of Plateau Lakes School of Ecology and Environmental ScienceYunnan University Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices Hubei University of Arts and Science Institute for Advanced Study Chengdu University

The use of transition metal-activated peroxymonosulfate（PMS） as an advanced oxidation technology has gained recognition. This study developed a catalyst using cobaltDlanthanum bimetallic oxide supported on layered molybdenum disulfide （Mo S2） as a carrier. The CoDLa/Mo S2catalyst was synthesised through coprecipitation, followed by calcination with an optimised metal ratio of Co:La=2:1 to activate PMS and degrade trace chloramphenicol（CAP） in water. The chemical composition of the catalyst was confirmed using X-ray diffraction （XRD） and X-ray photoelectron spectroscopy （XPS）. At catalyst and PMS dosages of 0.1 and 0.5 g·L-1, respectively, the degradation rate of CAP was 95% with in 30 min. The catalyst exhibitedstrong resistance to most interfering anions and maintained a high degradation rate at p H 3D11. Liquid chromatographyDmass spectrometry analysis revealed the potential degradation pathways of CAP in the CoDLa/Mo S2（2:1）/PMS system. For other pollutants, such as oxytetracycline,complete degradation was achieved within 20 min,demonstrating the broad applicability of the CoDLa/Mo S2（2:1）/PMS system for the degradation and removal of antibiotic organic contaminants. This study offers a feasible approach for the degradation of antibiotic organic pollutants, including CAP, in natural water bodies.

关键词： Catalysts

资本市场开放与企业策略性创新行为——基于外部监督的分析

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技术经济与管理研究 2024年第3期 93-100页

作者：吕志平新疆财经大学新疆乌鲁木齐830012

文章立足于“沪港通”的制度背景,选取2010—2022年沪深A股非金融上市公司为研究对象,研究资本市场开放与企业策略性创新行为的关系。实证研究发现:第一,资本市场开放能提高授权专利中发明专利的占比,显著改善企业专利结构,提高专利质量... 详细信息

文章立足于“沪港通”的制度背景,选取2010—2022年沪深A股非金融上市公司为研究对象,研究资本市场开放与企业策略性创新行为的关系。实证研究发现:第一,资本市场开放能提高授权专利中发明专利的占比,显著改善企业专利结构,提高专利质量;第二,从外部监督的角度机制分析发现,资本市场开放会通过增加监管机构和媒体监督产生聚光灯效应,进而减少通过策略性创新的市值管理行为;第三,动机分析发现,在资本市场开放下,企业出于防范崩盘风险和向市场传递特质性信息的目的,会减少策略性创新行为,提高专利质量;第四,资本市场开放对非国有企业和信息不对称较高的企业策略性创新行为抑制作用更加明显。本研究对于充分利用资本市场开放助力实体经济发展,推动企业实质性创新具有借鉴意义。

关键词：资本市场开放策略性创新监督机制企业创新创新行为

Caveolin‑1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease

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Military Medical Research 2024年第2期11卷 206-227页

作者： Guang-Hui Deng Chao-Feng Wu Yun-Jia Li Hao Shi Wei-Chao Zhong Mu-Keng Hong Jun-Jie Li Jia-Min Zhao Chang Liu Meng-Chen Qin Zhi-Yun Zeng Wei-Min Zhang Ken Kin Lam Yung Zhi-ping lv Lei Gao Department of Gastroenterology Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510315China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China Department of Hepatology Cancer CenterIntegrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510315China Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033GuangdongChina Department of Biology Hong Kong Baptist UniversityKowloon TongKowloonHong Kong SAR 999077China

Background:Nonalcoholic fatty liver disease(NAFLD)is associated with disordered lipid and iron *** previous study has substantiated the pivotal role of Caveolin-1(Cav-1)in protecting hepatocytes and mediating iron metabolism in the *** study aimed to explore the specific mechanisms underlying the regulation of iron metabolism by Cav-1 in ***:Hepatocyte-specific Cav-1 overexpression mice and knockout mice were used in this ***-1-knockdown of RAW264.7 cells and mouse primary hepatocytes were performed to verify the changes in ***,a high-fat diet and palmitic acid plus oleic acid treatment were utilized to construct a NAFLD model in vivo and in vitro,respectively,while a high-iron diet was used to construct an in vivo iron overload ***,iron concentration,the expression of Cav-1 and iron metabolism-related proteins in liver tissue or serum were detected using iron assay kit,Prussian blue staining,Western blotting,immunofluorescence staining,immunohistochemical staining and *** related indicators of lipid metabolism and oxidative stress were evaluated by the corresponding reagent kit and ***:Significant disorder of lipid and iron metabolism occurred in *** expression of Cav-1 was decreased in NAFLD hepatocytes(P<0.05),accompanied by iron metabolism ***-1 enhanced the iron storage capacity of hepatocytes by activating the ferritin light chain/ferritin heavy chain pathway in NAFLD,subsequently alleviating the oxidative stress induced by excess ferrous ions in the ***,CD68^(+) CD163^(+) macrophages expressing Cav-1 were found to accelerate iron accumulation in the liver,which was contrary to the effect of Cav-1 in *** correlations were also observed between the serum Cav-1 concentration and the serum iron-related protein levels in NAFLD patients and healthy volunteers(P<0.05).Conclusions:These findings confirm that Cav-1 is an essential target protein that reg

关键词： Caveolin-1 Nonalcoholic fatty liver disease Iron metabolism Ferritin Oxidative stress

我国产业结构优化升级对全球价值链嵌入的影响——基于对外开放的调节效应分析

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商业经济研究 2024年第6期 139-142页

作者：刘思锐吕萍哈尔滨商业大学经济学院黑龙江哈尔滨150028 黑龙江科技大学黑龙江哈尔滨150027

优化产业结构升级是提升我国在全球产业发展中竞争力的重要基础。本文从产业结构合理化和产业结构高级化两个维度研究了产业结构优化升级对我国全球价值链嵌入的影响,并进一步考察了对外开放的调节效应。研究发现,产业结构优化升级对我... 详细信息

优化产业结构升级是提升我国在全球产业发展中竞争力的重要基础。本文从产业结构合理化和产业结构高级化两个维度研究了产业结构优化升级对我国全球价值链嵌入的影响,并进一步考察了对外开放的调节效应。研究发现,产业结构优化升级对我国全球价值链嵌入会产生显著的正向赋能作用,但不同类型的产业结构优化升级对我国全球价值链嵌入的边际赋能效应存在一定的差异。相比较而言,产业结构高级化对我国全球价值链嵌入的边际赋能效应更强;进一步地发现,对外开放的调节效应存在,对外开放能够提升我国产业结构优化升级对全球价值链嵌入的边际赋能作用,但同样在不同类型产业结构优化升级对全球价值链嵌入的影响中表现出差异化的调节效应,在产业结构高级化对我国全球价值链嵌入影响中的调节效应更强。最后,本文从政策引领支持产业结构优化升级、走出去拓展国际市场、进一步深化对外开放三个层面提出了针对性的建议。

关键词：产业结构优化升级全球价值链价值链嵌入对外开放调节效应

基于西南雷达拼图的航路叠加绘制系统关键技术及其实现

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气象水文海洋仪器 2024年第4期41卷 134-137页

作者：吕萍中国民用航空西南地区空中交通管理局气象中心成都610202

为了满足空管部门提出的将天气信息与航路信息融合的需求,减轻强对流天气发生时管制运行人员的资料查询负担,文章利用C#图像处理技术,搭建了一套叠加西南地区重要航路数据及西南雷达拼图生成融合雷达图形产品的系统,并阐明了航路提取、... 详细信息

为了满足空管部门提出的将天气信息与航路信息融合的需求,减轻强对流天气发生时管制运行人员的资料查询负担,文章利用C#图像处理技术,搭建了一套叠加西南地区重要航路数据及西南雷达拼图生成融合雷达图形产品的系统,并阐明了航路提取、图像叠加绘制、实时监控西南雷达拼图更新情况、用户界面实现等关键技术。

关键词：西南雷达拼图航路信息提取航路叠加图像处理软件设计

石墨烯吸附材料结构性质解析及其在菜籽油脱色中的应用

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粮油食品科技 2024年第4期32卷 105-111页

作者：李晓澄吕亚萍叶展南京航空航天大学材料科学与技术学院江苏南京210016 江南大学食品学院江苏无锡214122

为了克服活性白土在油脂工业脱色中的操作温度高、残油率大、废白土处理困难等缺点,开发超强吸附材料石墨烯作为新型吸附剂用于油脂脱色。采用扫描电子显微镜、傅立叶红外光谱仪和显微共聚焦拉曼光谱仪等仪器对石墨烯纳米片(GNP)和氧化... 详细信息

为了克服活性白土在油脂工业脱色中的操作温度高、残油率大、废白土处理困难等缺点,开发超强吸附材料石墨烯作为新型吸附剂用于油脂脱色。采用扫描电子显微镜、傅立叶红外光谱仪和显微共聚焦拉曼光谱仪等仪器对石墨烯纳米片(GNP)和氧化石墨烯(GO)的结构与表面性质分析进行了表征。在明确石墨烯材料结构特征的基础上,将其用于菜籽油的脱色,并探讨了石墨烯种类、添加量,反应压力、温度以及反应时间等因素对石墨烯在油脂体系脱色效果的影响。结果表明:与GO相比,GNP对菜籽油脱色效果更佳,并且在低温(45℃)条件下对油脂中叶绿素表现出独特吸附性能。单因素结果表明,在GNP添加量2.0%(wt)、温度45℃、吸附时间5min的优化条件下,GNP可以脱除油中80.6%的叶绿素。GNP作吸附剂用于油脂脱色具有反应温度低、吸附时间短的优势,在油脂低温适度加工中具有潜在应用前景。

关键词：石墨烯结构性质菜籽油叶绿素低温脱色

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